dc.creator | Banjac, Katarina | |
dc.creator | Obradović, MIlan | |
dc.creator | Zafirović, Sonja | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2024-07-16T12:33:58Z | |
dc.date.available | 2024-07-16T12:33:58Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 1734-1922 | |
dc.identifier.issn | 1896-9151 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/13489 | |
dc.description.abstract | Introduction: Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods: Male Wistar rats were treated with IGF-1 (50 μg/kg), and 24 h after injection hearts were excised. The level of interaction between Beclin-1 and the α1 subunit of sodium/potassium-adenosine triphosphates (Na+/K+-ATPase), and phosphorylated forms of IGF-1 receptor/insulin receptor (IGF-1R/IR), forkhead box protein O1 (FOXO1) and AMP-activated protein kinase (AMPK) were measured. Results: The results indicate that IGF-1 decreased Beclin-1’s association with Na+/K+-ATPase (p < 0.05), increased IGF-1R/IR and FOXO1 phosphorylation (p < 0.05), and decreased AMPK phosphorylation (p < 0.01) in rats’ hearts. Conclusions: The new IGF-1 therapy may control autosis and minimize cardiomyocyte mortality. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.source | Archives of Medical Science | |
dc.subject | Na+/K+-ATPase | en |
dc.subject | association of Na+/K+-ATPase and Beclin-1 | en |
dc.subject | cardiac autosis | en |
dc.subject | AMPK | en |
dc.subject | FOXO1 | en |
dc.title | Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction | en |
dc.type | article | en |
dc.rights.license | BY-NC-SA | |
dc.citation.volume | 20 | |
dc.citation.issue | 3 | |
dc.citation.spage | 1011 | |
dc.citation.epage | 1015 | |
dc.identifier.doi | 10.5114/aoms/177618 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85197813425 | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/37456/pdf-177618-112115.pdf | |