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In Silico Exploration of CD200 as a Therapeutic Target for COVID-19
dc.creator | Perović, Vladimir R. | |
dc.creator | Glišić, Sanja | |
dc.creator | Veljković, Milena | |
dc.creator | Paessler, Slobodan | |
dc.creator | Veljković, Veljko | |
dc.date.accessioned | 2024-07-11T08:57:05Z | |
dc.date.available | 2024-07-11T08:57:05Z | |
dc.date.issued | 2024 | |
dc.identifier.issn | 2076-2607 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/13448 | |
dc.description.abstract | SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemic. The presented study, performed by using the informational spectrum method (ISM), representing an electronic biology-based tool for analysis of protein–protein interactions, identified the highly conserved region of spike protein (SP) from SARS-CoV-2 virus, which is essential for recognition and targeting between the virus and its protein interactors on the target cells. This domain is suggested as a promising target for the drug therapy and vaccines, which could be effective against all currently circulating variants of SARS-CoV-2 viruses. The analysis of the virus/host interaction, performed by the ISM, also revealed OX-2 membrane glycoprotein (CD200) as a possible interactor of SP, which could serve as a novel therapeutic target for COVID-19 disease. © 2024 by the authors. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Microorganisms | en |
dc.subject | COVID-19 | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | variants | en |
dc.subject | vaccine | en |
dc.subject | therapeutic target | en |
dc.subject | CD200 | en |
dc.title | In Silico Exploration of CD200 as a Therapeutic Target for COVID-19 | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.volume | 12 | |
dc.citation.issue | 6 | |
dc.citation.spage | 1185 | |
dc.identifier.doi | 10.3390/microorganisms12061185 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85197145413 | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/37338/microorganisms-12-01185.pdf |