In Silico Exploration of CD200 as a Therapeutic Target for COVID-19
Article (Published version)
Metadata
Show full item recordAbstract
SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemic. The presented study, performed by using the informational spectrum method (ISM), representing an electronic biology-based tool for analysis of protein–protein interactions, identified the highly conserved region of spike protein (SP) from SARS-CoV-2 virus, which is essential for recognition and targeting between the virus and its protein interactors on the target cells. This domain is suggested as a promising target for the drug therapy and vaccines, which could be effective against all currently circulating variants of SARS-CoV-2 viruses. The analysis of the virus/host interaction, performed by the ISM, also revealed OX-2 membrane glycoprotein (CD200) as a possible interactor of SP, which could serve as a novel therapeutic target for CO...VID-19 disease. © 2024 by the authors.
Keywords:
COVID-19 / SARS-CoV-2 / variants / vaccine / therapeutic target / CD200Source:
Microorganisms, 2024, 12, 6, 1185-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
Collections
Institution/Community
VinčaTY - JOUR AU - Perović, Vladimir R. AU - Glišić, Sanja AU - Veljković, Milena AU - Paessler, Slobodan AU - Veljković, Veljko PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/13448 AB - SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemic. The presented study, performed by using the informational spectrum method (ISM), representing an electronic biology-based tool for analysis of protein–protein interactions, identified the highly conserved region of spike protein (SP) from SARS-CoV-2 virus, which is essential for recognition and targeting between the virus and its protein interactors on the target cells. This domain is suggested as a promising target for the drug therapy and vaccines, which could be effective against all currently circulating variants of SARS-CoV-2 viruses. The analysis of the virus/host interaction, performed by the ISM, also revealed OX-2 membrane glycoprotein (CD200) as a possible interactor of SP, which could serve as a novel therapeutic target for COVID-19 disease. © 2024 by the authors. T2 - Microorganisms T1 - In Silico Exploration of CD200 as a Therapeutic Target for COVID-19 VL - 12 IS - 6 SP - 1185 DO - 10.3390/microorganisms12061185 ER -
@article{ author = "Perović, Vladimir R. and Glišić, Sanja and Veljković, Milena and Paessler, Slobodan and Veljković, Veljko", year = "2024", abstract = "SARS-CoV-2, the pathogen causing COVID-19, continues to pose a significant threat to public health and has had major economic implications. Developing safe and effective vaccines and therapies offers a path forward for overcoming the COVID-19 pandemic. The presented study, performed by using the informational spectrum method (ISM), representing an electronic biology-based tool for analysis of protein–protein interactions, identified the highly conserved region of spike protein (SP) from SARS-CoV-2 virus, which is essential for recognition and targeting between the virus and its protein interactors on the target cells. This domain is suggested as a promising target for the drug therapy and vaccines, which could be effective against all currently circulating variants of SARS-CoV-2 viruses. The analysis of the virus/host interaction, performed by the ISM, also revealed OX-2 membrane glycoprotein (CD200) as a possible interactor of SP, which could serve as a novel therapeutic target for COVID-19 disease. © 2024 by the authors.", journal = "Microorganisms", title = "In Silico Exploration of CD200 as a Therapeutic Target for COVID-19", volume = "12", number = "6", pages = "1185", doi = "10.3390/microorganisms12061185" }
Perović, V. R., Glišić, S., Veljković, M., Paessler, S.,& Veljković, V.. (2024). In Silico Exploration of CD200 as a Therapeutic Target for COVID-19. in Microorganisms, 12(6), 1185. https://doi.org/10.3390/microorganisms12061185
Perović VR, Glišić S, Veljković M, Paessler S, Veljković V. In Silico Exploration of CD200 as a Therapeutic Target for COVID-19. in Microorganisms. 2024;12(6):1185. doi:10.3390/microorganisms12061185 .
Perović, Vladimir R., Glišić, Sanja, Veljković, Milena, Paessler, Slobodan, Veljković, Veljko, "In Silico Exploration of CD200 as a Therapeutic Target for COVID-19" in Microorganisms, 12, no. 6 (2024):1185, https://doi.org/10.3390/microorganisms12061185 . .