Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment

Spasojević, Dragica; Zmejkoski, Danica; Glamočlija, Jasmina; Nikolić, Miloš M.; Soković, Marina; Milošević, Verica; Jarić, Ivana; Stojanović, Marijana; Marinković, Emilija; Barisani-Asenbauer, Talin; Prodanović, Radivoje; Jovanović, Miloš; Radotić, Ksenija

doi:10.1016/j.ijantimicag.2016.08.014

Само за регистроване кориснике

2016

Аутори

Spasojević, Dragica
Zmejkoski, Danica

Glamočlija, Jasmina
Nikolić, Miloš M.

Soković, Marina
Milošević, Verica
Jarić, Ivana
Stojanović, Marijana

Marinković, Emilija
Barisani-Asenbauer, Talin

Prodanović, Radivoje

Jovanović, Miloš
Radotić, Ksenija

Чланак у часопису (Објављена верзија)

Метаподаци

Приказ свих података о документу

Апстракт

Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Кључне речи:

Lignin model polymer / Alginate / Antimicrobial activity / Bacterial biofilm / Wound treatment

Извор:
International Journal of Antimicrobial Agents, 2016, 48, 6, 732-735

Финансирање / пројекти:

Синтеза, процесирање и карактеризација наноструктурних материјала за примену у области енергије, механичког инжењерства, заштите животне стредине и биомедицине (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
Испитивања односа структура-функција у ћелијском зиду биљака и измене структуре зида ензимским инжењерингом (RS-MESTD-Basic Research (BR or ON)-173017)
Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)

DOI: 10.1016/j.ijantimicag.2016.08.014

ISSN: 0924-8579; 1872-7913

PubMed: 27742207

WoS: 000389520700024

Scopus: 2-s2.0-85000995852

[ Google Scholar ]



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TY - JOUR
AU - Spasojević, Dragica
AU - Zmejkoski, Danica
AU - Glamočlija, Jasmina
AU - Nikolić, Miloš M.
AU - Soković, Marina
AU - Milošević, Verica
AU - Jarić, Ivana
AU - Stojanović, Marijana
AU - Marinković, Emilija
AU - Barisani-Asenbauer, Talin
AU - Prodanović, Radivoje
AU - Jovanović, Miloš
AU - Radotić, Ksenija
PY - 2016
UR - https://vinar.vin.bg.ac.rs/handle/123456789/1336
AB - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
T2 - International Journal of Antimicrobial Agents
T1 - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
VL - 48
IS - 6
SP - 732
EP - 735
DO - 10.1016/j.ijantimicag.2016.08.014
ER -

@article{
author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolić, Miloš M. and Soković, Marina and Milošević, Verica and Jarić, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Miloš and Radotić, Ksenija",
year = "2016",
abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.",
journal = "International Journal of Antimicrobial Agents",
title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment",
volume = "48",
number = "6",
pages = "732-735",
doi = "10.1016/j.ijantimicag.2016.08.014"
}

Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolić, M. M., Soković, M., Milošević, V., Jarić, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents, 48(6), 732-735.
https://doi.org/10.1016/j.ijantimicag.2016.08.014

Spasojević D, Zmejkoski D, Glamočlija J, Nikolić MM, Soković M, Milošević V, Jarić I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735.
doi:10.1016/j.ijantimicag.2016.08.014 .

Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolić, Miloš M., Soković, Marina, Milošević, Verica, Jarić, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Miloš, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735,
https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .