Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines
Само за регистроване кориснике
2024
Аутори
Todosijević, AnkaBugarinović, Jovana
Pešić, Marko
Stevanović, Dragana
Damljanović, Ivan
Mihailović, Vladimir
Srećković, Nikola
Novaković, Slađana B.
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Bogdanović, Goran A.
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Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
The pyrazoline pharmacophore is the source of numerous biological activities. The synthesis and biological evaluation of new pyrazoline heterocycles is the first step in the development of new potential drugs. Therefore, ferrocene-containing 1-(thio)acetyl pyrazolines were synthesized to test their in vitro antimicrobial activity. All new heterocycles were characterized by standard spectroscopy methods due to confirmation of the structures. In addition, single-crystal X-ray analyses were performed for three representative pyrazole derivatives. Their electrochemical properties were investigated by cyclic voltammetry indicating a reversible one-electron redox couple originating from the ferrocene/ferrocenium pair. All obtained products were evaluated for their antibacterial and antifungal activity. It has been shown that pyrazolines have slightly better antifungal activity compared with their antibacterial activity.
Кључне речи:
Ferrocene / 2-Pyrazolines / X-ray analysis / Electrochemistry / Antimicrobial activityИзвор:
Polyhedron, 2024, 258, 117028-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200122 (Универзитет у Крагујевцу, Природно-математички факултет) (RS-MESTD-inst-2020-200122)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200383 (Универзитет у Нишу, Пољопривредни факултет, Крушевац) (RS-MESTD-inst-2020-200383)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Колекције
Институција/група
VinčaTY - JOUR AU - Todosijević, Anka AU - Bugarinović, Jovana AU - Pešić, Marko AU - Stevanović, Dragana AU - Damljanović, Ivan AU - Mihailović, Vladimir AU - Srećković, Nikola AU - Novaković, Slađana B. AU - Bogdanović, Goran A. PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/13262 AB - The pyrazoline pharmacophore is the source of numerous biological activities. The synthesis and biological evaluation of new pyrazoline heterocycles is the first step in the development of new potential drugs. Therefore, ferrocene-containing 1-(thio)acetyl pyrazolines were synthesized to test their in vitro antimicrobial activity. All new heterocycles were characterized by standard spectroscopy methods due to confirmation of the structures. In addition, single-crystal X-ray analyses were performed for three representative pyrazole derivatives. Their electrochemical properties were investigated by cyclic voltammetry indicating a reversible one-electron redox couple originating from the ferrocene/ferrocenium pair. All obtained products were evaluated for their antibacterial and antifungal activity. It has been shown that pyrazolines have slightly better antifungal activity compared with their antibacterial activity. T2 - Polyhedron T1 - Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines VL - 258 SP - 117028 DO - 10.1016/j.poly.2024.117028 ER -
@article{ author = "Todosijević, Anka and Bugarinović, Jovana and Pešić, Marko and Stevanović, Dragana and Damljanović, Ivan and Mihailović, Vladimir and Srećković, Nikola and Novaković, Slađana B. and Bogdanović, Goran A.", year = "2024", abstract = "The pyrazoline pharmacophore is the source of numerous biological activities. The synthesis and biological evaluation of new pyrazoline heterocycles is the first step in the development of new potential drugs. Therefore, ferrocene-containing 1-(thio)acetyl pyrazolines were synthesized to test their in vitro antimicrobial activity. All new heterocycles were characterized by standard spectroscopy methods due to confirmation of the structures. In addition, single-crystal X-ray analyses were performed for three representative pyrazole derivatives. Their electrochemical properties were investigated by cyclic voltammetry indicating a reversible one-electron redox couple originating from the ferrocene/ferrocenium pair. All obtained products were evaluated for their antibacterial and antifungal activity. It has been shown that pyrazolines have slightly better antifungal activity compared with their antibacterial activity.", journal = "Polyhedron", title = "Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines", volume = "258", pages = "117028", doi = "10.1016/j.poly.2024.117028" }
Todosijević, A., Bugarinović, J., Pešić, M., Stevanović, D., Damljanović, I., Mihailović, V., Srećković, N., Novaković, S. B.,& Bogdanović, G. A.. (2024). Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines. in Polyhedron, 258, 117028. https://doi.org/10.1016/j.poly.2024.117028
Todosijević A, Bugarinović J, Pešić M, Stevanović D, Damljanović I, Mihailović V, Srećković N, Novaković SB, Bogdanović GA. Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines. in Polyhedron. 2024;258:117028. doi:10.1016/j.poly.2024.117028 .
Todosijević, Anka, Bugarinović, Jovana, Pešić, Marko, Stevanović, Dragana, Damljanović, Ivan, Mihailović, Vladimir, Srećković, Nikola, Novaković, Slađana B., Bogdanović, Goran A., "Synthesis, characterization, and antimicrobial activity of novel ferrocene-containing 1-(thio)acetyl pyrazolines" in Polyhedron, 258 (2024):117028, https://doi.org/10.1016/j.poly.2024.117028 . .