Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films
Autori
Marković, Zoran M.Budimir Filimonović, Milica
Milivojević, Dušan
Kovač, Janez
Todorović-Marković, Biljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, a...nd it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.
Ključne reči:
carbon polymerized dots / fullerene C60 / polyurethane / composite films / electrostatic force microscopy / viscoelastic microscopy / antibacterial / antibiofouling / photodynamic / reactive oxygen speciesIzvor:
Journal of Functional Biomaterials, 2024, 15, 3, 73-Finansiranje / projekti:
- PHOTOGUN4MICROBES - Are photoactive nanoparticles salvation for global infectional treath? (RS-ScienceFundRS-Ideje-7741955)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200030 (Naučni institut za veterinarstvo Srbije, Beograd) (RS-MESTD-inst-2020-200030)
- Slovenian Research Agency [P2-0082]
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Marković, Zoran M. AU - Budimir Filimonović, Milica AU - Milivojević, Dušan AU - Kovač, Janez AU - Todorović-Marković, Biljana PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12997 AB - The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms. T2 - Journal of Functional Biomaterials T1 - Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films VL - 15 IS - 3 SP - 73 DO - 10.3390/jfb15030073 ER -
@article{ author = "Marković, Zoran M. and Budimir Filimonović, Milica and Milivojević, Dušan and Kovač, Janez and Todorović-Marković, Biljana", year = "2024", abstract = "The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60. Detailed atomic force, electrostatic force and viscoelastic microscopy revealed topology, nanoelectrical and nanomechanical properties of used fillers and composites. A relationship between the electronic structure of the nanocarbon fillers and the antibacterial and antibiofouling activities of the composites was established. Thorough spectroscopic analysis of reactive oxygen species (ROS) generation was conducted for both composite films, and it was found that both of them were potent antibacterial agents against nosocomial bacteria (Klebsiela pneumoniae, Proteus mirabilis, Salmonela enterica, Enterococcus faecalis, Enterococcus epidermis and Pseudomonas aeruginosa). Antibiofouling testing of composite films indicated that the CPDs/PU composite films eradicated almost completely the biofilms of Pseudomonas aeruginosa and Staphylococcus aureus and about 50% of Escherichia coli biofilms.", journal = "Journal of Functional Biomaterials", title = "Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films", volume = "15", number = "3", pages = "73", doi = "10.3390/jfb15030073" }
Marković, Z. M., Budimir Filimonović, M., Milivojević, D., Kovač, J.,& Todorović-Marković, B.. (2024). Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films. in Journal of Functional Biomaterials, 15(3), 73. https://doi.org/10.3390/jfb15030073
Marković ZM, Budimir Filimonović M, Milivojević D, Kovač J, Todorović-Marković B. Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films. in Journal of Functional Biomaterials. 2024;15(3):73. doi:10.3390/jfb15030073 .
Marković, Zoran M., Budimir Filimonović, Milica, Milivojević, Dušan, Kovač, Janez, Todorović-Marković, Biljana, "Antibacterial and Antibiofouling Activities of Carbon Polymerized Dots/Polyurethane and C60/Polyurethane Composite Films" in Journal of Functional Biomaterials, 15, no. 3 (2024):73, https://doi.org/10.3390/jfb15030073 . .