The importance of population susceptibility to air pollution: gene candidate approach
Апстракт
The effects of environmental exposures might be transmitted to cellular level through mechanisms that could vary between individuals. Gene polymorphism in GSTM1/GSTT1, both deletions in the gene, showed the significant influence in genetic association studies of air pollution. In order to analyze the association of GSTT1/GSTM1 polymorphism with respiratory and cardiovascular disease in regard to air- pollution, for the first time we detected the presence of GSTM1/GSTT1 deletion in two different environmental risk factors' populations, Belgrade and Obrenovac. The groups consisted of 71 (Belgrade)/89 (Obrenovac) participants. Genotyping was performed by multiplex PCR. The frequencies of “null” genotypes for GSTM1/GSTT1 were not significantly different between the two investigated groups (47.89%/44.94%, 15.49%/17.98%, respectively). In conclusion, the frequencies of detected “null” genotypes in investigated two population subsets of Serbian origin was similar and in range with the frequen...cies in other Caucasian populations.
Извор:
2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings, 2009, 38-42Издавач:
- NILU - Norwegian Institute for Air Research
Финансирање / пројекти:
- Serbian Government [Research Grant TR23040]
Напомена:
- WeBIOPATR Workshop : August 31 - September 2, Mokra Gora, 2009.
Колекције
Институција/група
VinčaTY - CONF AU - Stanković, A. AU - Đurđević, V. AU - Kolaković, Ana AU - Stojković, Lj. AU - Živković, M. PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12699 AB - The effects of environmental exposures might be transmitted to cellular level through mechanisms that could vary between individuals. Gene polymorphism in GSTM1/GSTT1, both deletions in the gene, showed the significant influence in genetic association studies of air pollution. In order to analyze the association of GSTT1/GSTM1 polymorphism with respiratory and cardiovascular disease in regard to air- pollution, for the first time we detected the presence of GSTM1/GSTT1 deletion in two different environmental risk factors' populations, Belgrade and Obrenovac. The groups consisted of 71 (Belgrade)/89 (Obrenovac) participants. Genotyping was performed by multiplex PCR. The frequencies of “null” genotypes for GSTM1/GSTT1 were not significantly different between the two investigated groups (47.89%/44.94%, 15.49%/17.98%, respectively). In conclusion, the frequencies of detected “null” genotypes in investigated two population subsets of Serbian origin was similar and in range with the frequencies in other Caucasian populations. PB - NILU - Norwegian Institute for Air Research C3 - 2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings T1 - The importance of population susceptibility to air pollution: gene candidate approach SP - 38 EP - 42 UR - https://hdl.handle.net/21.15107/rcub_vinar_12699 ER -
@conference{ author = "Stanković, A. and Đurđević, V. and Kolaković, Ana and Stojković, Lj. and Živković, M.", year = "2009", abstract = "The effects of environmental exposures might be transmitted to cellular level through mechanisms that could vary between individuals. Gene polymorphism in GSTM1/GSTT1, both deletions in the gene, showed the significant influence in genetic association studies of air pollution. In order to analyze the association of GSTT1/GSTM1 polymorphism with respiratory and cardiovascular disease in regard to air- pollution, for the first time we detected the presence of GSTM1/GSTT1 deletion in two different environmental risk factors' populations, Belgrade and Obrenovac. The groups consisted of 71 (Belgrade)/89 (Obrenovac) participants. Genotyping was performed by multiplex PCR. The frequencies of “null” genotypes for GSTM1/GSTT1 were not significantly different between the two investigated groups (47.89%/44.94%, 15.49%/17.98%, respectively). In conclusion, the frequencies of detected “null” genotypes in investigated two population subsets of Serbian origin was similar and in range with the frequencies in other Caucasian populations.", publisher = "NILU - Norwegian Institute for Air Research", journal = "2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings", title = "The importance of population susceptibility to air pollution: gene candidate approach", pages = "38-42", url = "https://hdl.handle.net/21.15107/rcub_vinar_12699" }
Stanković, A., Đurđević, V., Kolaković, A., Stojković, Lj.,& Živković, M.. (2009). The importance of population susceptibility to air pollution: gene candidate approach. in 2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings NILU - Norwegian Institute for Air Research., 38-42. https://hdl.handle.net/21.15107/rcub_vinar_12699
Stanković A, Đurđević V, Kolaković A, Stojković L, Živković M. The importance of population susceptibility to air pollution: gene candidate approach. in 2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings. 2009;:38-42. https://hdl.handle.net/21.15107/rcub_vinar_12699 .
Stanković, A., Đurđević, V., Kolaković, Ana, Stojković, Lj., Živković, M., "The importance of population susceptibility to air pollution: gene candidate approach" in 2nd International WeBIOPATR Workshop : "Particulate Matter-Research and Management" : Proceedings (2009):38-42, https://hdl.handle.net/21.15107/rcub_vinar_12699 .