Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?
2021
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Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since 2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs) expression patterns are introduced in recent years as factors that might predict survival in patients with glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results: Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict acute radiotoxicity, while miRNAs expression levels that could p...redict radiation toxicity in glioblastoma are still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased. Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity.
Ključne reči:
acute radiotoxicity / cancer / glioblastoma / miRNAIzvor:
SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts, 2021, 19-19Izdavač:
- Belgrade : Serbian Association for Cancer Research (SDIR)
Napomena:
- 5th Congress of the Serbian Association for Cancer Research with International Participation SDIR-5, Virtual event, December 3, Belgrade, 2021.
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Institucija/grupa
VinčaTY - CONF AU - Stepanović, Aleksandar AU - Petrović, Nina AU - Arsenijević, Tatjana AU - Nikitović, Marina PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12412 AB - Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since 2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs) expression patterns are introduced in recent years as factors that might predict survival in patients with glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results: Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict acute radiotoxicity, while miRNAs expression levels that could predict radiation toxicity in glioblastoma are still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased. Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity. PB - Belgrade : Serbian Association for Cancer Research (SDIR) C3 - SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts T1 - Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma? SP - 19 EP - 19 UR - https://hdl.handle.net/21.15107/rcub_vinar_12412 ER -
@conference{ author = "Stepanović, Aleksandar and Petrović, Nina and Arsenijević, Tatjana and Nikitović, Marina", year = "2021", abstract = "Background: Standard treatment of the glioblastoma patients is implemented with Stupp’s protocol since 2005, but 2-years survival of the patients are still at low percentage. Even with implementation of modern radiotherapy techniques, acute radiotoxicity is still observed in these patients. Micro RNAs (miRNAs) expression patterns are introduced in recent years as factors that might predict survival in patients with glioblastoma, as well as cancer treatment related side effects. Material and methods: The data used in this review were conducted from research papers in PUBMED/MEDLINE databases with a special focus on role of miRNAs in cancer and with emphasis on brain tumors correlated to acute radiotoxicity. Results: Inflammation due to oxidative stress via free radicals is one of the mechanisms of radiation injury of irradiated cells and may correlate with toxicity. MiRNAs expression in prostate cancer patients may predict acute radiotoxicity, while miRNAs expression levels that could predict radiation toxicity in glioblastoma are still under investigation. However, it has been shown that miRNA levels like miR-16, miR 21, miR-19a and miR-22 are increased after radiation in glioma, while levels of miR-107, miR-181a are decreased. Conclusion: Recent studies have shown that miRNAs may have role as potent indicator of radiotoxicity in cancer patients. To date, there is no available data about acute brain radiotoxicity and its correlation with expression levels of mRNAs in patients with GB. There is a emerge need for further investigation on role of radioresponsive miRNAs in glioblastoma patients with acute radiotoxicity.", publisher = "Belgrade : Serbian Association for Cancer Research (SDIR)", journal = "SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts", title = "Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?", pages = "19-19", url = "https://hdl.handle.net/21.15107/rcub_vinar_12412" }
Stepanović, A., Petrović, N., Arsenijević, T.,& Nikitović, M.. (2021). Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts Belgrade : Serbian Association for Cancer Research (SDIR)., 19-19. https://hdl.handle.net/21.15107/rcub_vinar_12412
Stepanović A, Petrović N, Arsenijević T, Nikitović M. Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?. in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts. 2021;:19-19. https://hdl.handle.net/21.15107/rcub_vinar_12412 .
Stepanović, Aleksandar, Petrović, Nina, Arsenijević, Tatjana, Nikitović, Marina, "Can miRNA expression patterns predict radiotoxicity in patients with glioblastoma?" in SDIR- 5 : 5th Congress of the serbian association for cancer research : Book of abstracts (2021):19-19, https://hdl.handle.net/21.15107/rcub_vinar_12412 .