Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots
2023
Преузимање 🢃
Аутори
Dorontić, SlađanaJovanović, Svetlana
Jovanović Vučetić, Svetlana
Todorović Marković, Biljana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Due to the exponential growth of bacterial infection as well as resistance toward most antibiotics, the development of new materials for treatment is urgently needed. In recent years, graphene quantum dots (GQDs) have been identified as promising carbon nanomaterial for eco-friendly antibacterial applications due to their optical and chemical stability, non-toxicity, and biocompatibility. One of the reported GQD’s antimicrobial mechanisms is the photo-induced production of singlet oxygen (1O2). Under light exposure, GQDs transfer the energy to molecular oxygen from the surrounding medium. Oxygen molecules transform to their excited form 1O2, which causes oxidative stress in bacterial cells and reduces their viability. In this study, pristine GQDs were produced in an easy, one-step electrochemical top-down approach using graphite electrodes as a starting material. Carboxyl groups of GQDs are modified using a carbodiimide coupling reaction catalyzed by 1-ethyl-3- (3-dimethylaminopropyl)c...arbodiimide (EDC), with ethylenediamine (EDA) as an amine. In the next step, these NH2 terminated dots were decorated with gold nanoparticles (AuNPs) by the same EDC coupling procedure. Abillity of GQDs-AuNP nanocomposite to generate singlet oxygen upon blue light (470 nm) was investigated by UV-Vis spectroscopy and 9,10- anthracenediylbis-(methylene)dimalonic acid (ABDA) as selective 1O2 traping agent. After 2 hours of blue light illumination, the band at 420 nm charachterisic for ABDA was completly disaperided only in the presence of the GQD-AuNPs indicating good prooxidative potential of composite. Photoinduced antibacterial effects of GQD-AuNPs were studied using minimum inhibitory concentration (MIC) test which showed great antibacterial activity against several bacterial strains.
Извор:
21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts, 2023, 48-48Издавач:
- Belgrade : Institute of Technical Sciences of SASA
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- PHOTOGUN4MICROBES - Are photoactive nanoparticles salvation for global infectional treath? (RS-ScienceFundRS-Ideje-7741955)
Напомена:
- Twenty-First Young Researchers’ Conference - Materials Science and Engineering: Program and the Book of Abstracts; November 29 – December 1, 2023, Belgrade, Serbia
Колекције
Институција/група
VinčaTY - CONF AU - Dorontić, Slađana AU - Jovanović, Svetlana AU - Jovanović Vučetić, Svetlana AU - Todorović Marković, Biljana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12321 AB - Due to the exponential growth of bacterial infection as well as resistance toward most antibiotics, the development of new materials for treatment is urgently needed. In recent years, graphene quantum dots (GQDs) have been identified as promising carbon nanomaterial for eco-friendly antibacterial applications due to their optical and chemical stability, non-toxicity, and biocompatibility. One of the reported GQD’s antimicrobial mechanisms is the photo-induced production of singlet oxygen (1O2). Under light exposure, GQDs transfer the energy to molecular oxygen from the surrounding medium. Oxygen molecules transform to their excited form 1O2, which causes oxidative stress in bacterial cells and reduces their viability. In this study, pristine GQDs were produced in an easy, one-step electrochemical top-down approach using graphite electrodes as a starting material. Carboxyl groups of GQDs are modified using a carbodiimide coupling reaction catalyzed by 1-ethyl-3- (3-dimethylaminopropyl)carbodiimide (EDC), with ethylenediamine (EDA) as an amine. In the next step, these NH2 terminated dots were decorated with gold nanoparticles (AuNPs) by the same EDC coupling procedure. Abillity of GQDs-AuNP nanocomposite to generate singlet oxygen upon blue light (470 nm) was investigated by UV-Vis spectroscopy and 9,10- anthracenediylbis-(methylene)dimalonic acid (ABDA) as selective 1O2 traping agent. After 2 hours of blue light illumination, the band at 420 nm charachterisic for ABDA was completly disaperided only in the presence of the GQD-AuNPs indicating good prooxidative potential of composite. Photoinduced antibacterial effects of GQD-AuNPs were studied using minimum inhibitory concentration (MIC) test which showed great antibacterial activity against several bacterial strains. PB - Belgrade : Institute of Technical Sciences of SASA C3 - 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts T1 - Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots SP - 48 EP - 48 UR - https://hdl.handle.net/21.15107/rcub_vinar_12321 ER -
@conference{ author = "Dorontić, Slađana and Jovanović, Svetlana and Jovanović Vučetić, Svetlana and Todorović Marković, Biljana", year = "2023", abstract = "Due to the exponential growth of bacterial infection as well as resistance toward most antibiotics, the development of new materials for treatment is urgently needed. In recent years, graphene quantum dots (GQDs) have been identified as promising carbon nanomaterial for eco-friendly antibacterial applications due to their optical and chemical stability, non-toxicity, and biocompatibility. One of the reported GQD’s antimicrobial mechanisms is the photo-induced production of singlet oxygen (1O2). Under light exposure, GQDs transfer the energy to molecular oxygen from the surrounding medium. Oxygen molecules transform to their excited form 1O2, which causes oxidative stress in bacterial cells and reduces their viability. In this study, pristine GQDs were produced in an easy, one-step electrochemical top-down approach using graphite electrodes as a starting material. Carboxyl groups of GQDs are modified using a carbodiimide coupling reaction catalyzed by 1-ethyl-3- (3-dimethylaminopropyl)carbodiimide (EDC), with ethylenediamine (EDA) as an amine. In the next step, these NH2 terminated dots were decorated with gold nanoparticles (AuNPs) by the same EDC coupling procedure. Abillity of GQDs-AuNP nanocomposite to generate singlet oxygen upon blue light (470 nm) was investigated by UV-Vis spectroscopy and 9,10- anthracenediylbis-(methylene)dimalonic acid (ABDA) as selective 1O2 traping agent. After 2 hours of blue light illumination, the band at 420 nm charachterisic for ABDA was completly disaperided only in the presence of the GQD-AuNPs indicating good prooxidative potential of composite. Photoinduced antibacterial effects of GQD-AuNPs were studied using minimum inhibitory concentration (MIC) test which showed great antibacterial activity against several bacterial strains.", publisher = "Belgrade : Institute of Technical Sciences of SASA", journal = "21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts", title = "Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots", pages = "48-48", url = "https://hdl.handle.net/21.15107/rcub_vinar_12321" }
Dorontić, S., Jovanović, S., Jovanović Vučetić, S.,& Todorović Marković, B.. (2023). Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts Belgrade : Institute of Technical Sciences of SASA., 48-48. https://hdl.handle.net/21.15107/rcub_vinar_12321
Dorontić S, Jovanović S, Jovanović Vučetić S, Todorović Marković B. Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots. in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts. 2023;:48-48. https://hdl.handle.net/21.15107/rcub_vinar_12321 .
Dorontić, Slađana, Jovanović, Svetlana, Jovanović Vučetić, Svetlana, Todorović Marković, Biljana, "Plasmon induced enhancement of photoinduced antibacterial activity of graphene quantum dots" in 21st Young Researchers' Conference Materials Sciences and Engineering : program and the book of abstracts (2023):48-48, https://hdl.handle.net/21.15107/rcub_vinar_12321 .