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dc.creatorJovanović, Snežana
dc.creatorObrencevic, Katarina
dc.creatorBugarčić, Živadin D.
dc.creatorPopović, Iva A.
dc.creatorŽakula, Jelena
dc.creatorPetrović, Biljana
dc.date.accessioned2018-03-01T17:05:30Z
dc.date.available2018-03-01T17:05:30Z
dc.date.issued2016
dc.identifier.issn1477-9226
dc.identifier.issn1477-9234
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/1208
dc.description.abstractTwo new dinuclear bimetallic complexes, [{PdCl(bipy)}{mu-(pyrazine)}{PtCl(bipy)}]Cl(ClO4) (1) (bipy is 2,2-=bipyridine) and [{PdCl(en)}{mu-(pyrazine)}{PtCl(en)}]Cl(ClO4) (2) (en is ethylenediamine), have been synthesized and characterized by elemental microanalysis, IR, H-1 NMR spectroscopy and MALDI-TOF mass spectrometry. The pK(a) values of the coordinated water molecules of the diaqua species were determined as well. Substitution reactions of complexes (1) and (2) with thiourea (Tu), L-methionine (L-Met), L-cysteine (L-Cys), L-histidine (L-His) and guanosine-5-monophosphate (5-GMP) were studied under the pseudo-first order conditions as a function of nucleophile concentration and temperature. The order of reactivity of nucleophiles was: Tu GT L-Met GT L-Cys GT L-His GT 5-GMP. Substitution reactions with Tu, L-Cys and L-His were followed by decomposition of bimetallic complexes to the corresponding substituted mononuclear complexes [Pd(N-N)(Nu)(2)] and [Pt(N-N)(Nu)(2)] (N-N = bipy, en), releasing the bridging ligand. However, the structures of starting bimetallic complexes were preserved during the reactions with L-Met and 5-GMP. The absorption spectroscopic study of interactions of calf-thymus DNA (CT-DNA) with complexes (1), (2) and [{PdCl(bipy)}{mu-(NH2(CH2)(6)H2N)} {PtCl(bipy)}] Cl(ClO4) (3), has shown that all the complexes exhibit high intrinsic binding constants (K-b = 10(4)-10(5) M-1). DNA-ethidium bromide (DNA-EB) fluorescence was quenched after addition of complexes (1), (2) or (3), indicating displacement of intercalating EB by complexes. All complexes have shown good binding affinity to bovine serum albumin protein (BSA). Chemosensitivity of A375 (human melanoma) and HeLa (human cervical cancer) cell lines toward complexes (1), (2) and (3) was analyzed by SRB assay. Complex (1) displayed significant inhibitory effect on the growth of both cell lines.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS//
dc.rightsrestrictedAccessen
dc.sourceDalton Transactionsen
dc.titleNew bimetallic palladium(II) and platinum(II) complexes: studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activityen
dc.typearticleen
dcterms.abstractОбренцевиц, Катарина; Поповић Ива; Бугарциц, Зивадин Д.; Жакула Јелена; Петровиц, Биљана; Јовановиц, Снезана;
dc.citation.volume45
dc.citation.issue31
dc.citation.spage12444
dc.citation.epage12457
dc.identifier.wos000381480900022
dc.identifier.doi10.1039/c6dt02226j
dc.citation.rankM21
dc.identifier.pmid27431616
dc.identifier.scopus2-s2.0-84982728928


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