Cytotoxicity of Platinum(Iv) and Palladium(Ii) Complexes with Meso-1,2-Diphenyl-Ethylenediamine-N,N -Di-3-Propanoic Acid. Crystal Structure of [Pd(1,2-Dpheddp)] Complex
AuthorsMijajlovic, Marina Z.
Nikolic, Milos V.
Jevtic, Verica V.
Ratkovic, Zoran R.
Novaković, Slađana B.
Bogdanović, Goran A.
Trifunovic, Srecko R.
Radic, Gordana P.
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The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N-di-3-propanoic acid (H-2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and Bl6F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 mu M of platinum(IV) complex in the B16F1 cell line.
Keywords:meso-1 / platinum(IV) complex / palladium(II) complex / crystal structure / cytotoxicity / 2-diphenyl-ethylenediamine-N / N -di-3-propanoic acid
Source:Macedonian Journal of Chemistry and Chemical Engineering, 2016, 35, 1, 79-86
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