Calcium messages in flagella are faster than messenger particles

Satarić, Miljko V.; Nemeš, Tomas; Zdravković, Slobodan

doi:10.1016/j.biosystems.2023.105003

Само за регистроване кориснике

2023

Аутори

Satarić, Miljko V.
Nemeš, Tomas

Zdravković, Slobodan

Чланак у часопису (Објављена верзија)

Метаподаци

Приказ свих података о документу

Апстракт

Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2＋ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2＋ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2＋ messengers. From the best of our knowledge, this is the first time that Ca2＋ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2＋ as tagged probe.

Кључне речи:

Ca ions / Calcium signaling / Microtubule / Reaction-diffusion equation

Извор:
Biosystems, 2023, 232, 105003-

Финансирање / пројекти:

Serbian Academy of Sciences and Arts [personal grant No. Φ134]
Department of Fundamental Sciences at the Faculty of Technical Sciences at the University of Novi Sad [project ‘‘Application of Fundamental Disciplines in Technical and Information Sciences’’]

DOI: 10.1016/j.biosystems.2023.105003

ISSN: 0303-2647

PubMed: 37625514

WoS: 001069845200001

Scopus: 2-s2.0-85168853511

[ Google Scholar ]

URI

https://vinar.vin.bg.ac.rs/handle/123456789/11445

Колекције

Институција/група

Vinča

TY  - JOUR
AU  - Satarić, Miljko V.
AU  - Nemeš, Tomas
AU  - Zdravković, Slobodan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11445
AB  - Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2＋ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2＋ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2＋ messengers. From the best of our knowledge, this is the first time that Ca2＋ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2＋ as tagged probe.
T2  - Biosystems
T1  - Calcium messages in flagella are faster than messenger particles
VL  - 232
SP  - 105003
DO  - 10.1016/j.biosystems.2023.105003
ER  -

@article{
author = "Satarić, Miljko V. and Nemeš, Tomas and Zdravković, Slobodan",
year = "2023",
abstract = "Calcium is one of the most versatile messengers for intracellular signaling. In the case of cilia and flagella calcium has the central role in transfer of communications between extracellular stimuli and intracellular formation of frequency modulated signal and their deciphering by target proteins. In this paper, the diffusion of fluorescently or otherwise tagged and un-tagged Ca2＋ particles is analyzed by solving the system of pertaining reaction–diffusion equations. We used Fourier transform tools to get asymptotic eigenfunctions for tagged (un-tagged) free and buffered Ca2＋ ions. We made some numerical estimations for diffusion coefficients corroborating the fact that messages diffuse faster than Ca2＋ messengers. From the best of our knowledge, this is the first time that Ca2＋ signaling in living cells is biophysically elaborated within the framework of model presented here. We suggest the experimental assay on the basis of radioactive Ca2＋ as tagged probe.",
journal = "Biosystems",
title = "Calcium messages in flagella are faster than messenger particles",
volume = "232",
pages = "105003",
doi = "10.1016/j.biosystems.2023.105003"
}

Satarić, M. V., Nemeš, T.,& Zdravković, S.. (2023). Calcium messages in flagella are faster than messenger particles. in Biosystems, 232, 105003.
https://doi.org/10.1016/j.biosystems.2023.105003

Satarić MV, Nemeš T, Zdravković S. Calcium messages in flagella are faster than messenger particles. in Biosystems. 2023;232:105003.
doi:10.1016/j.biosystems.2023.105003 .

Satarić, Miljko V., Nemeš, Tomas, Zdravković, Slobodan, "Calcium messages in flagella are faster than messenger particles" in Biosystems, 232 (2023):105003,
https://doi.org/10.1016/j.biosystems.2023.105003 . .