Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting
Аутори
Radić, JelenaKožik, Bojana
Nikolić, Ivan
Kolarov-Bjelobrk, Ivana
Vasiljević, Tijana
Vranjković, Bojana
Despotović, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic
target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked
with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the
mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development.
We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of
the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal
transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis,
and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2
inhibitors and discuss their potential in HCC precision treatment.
Кључне речи:
hepatocellular carcinoma (HCC) / LOXL2 / tumor microenvironment (TME) / extracellular matrix (ECM) / ; LOXL2 inhibitors; target therapyИзвор:
International Journal of Molecular Sciences, 2023, 24, 14, 11745-
DOI: 10.3390/ijms241411745
ISSN: 1422-0067
PubMed: 37511503
Scopus: 2-s2.0-85166002777
Институција/група
VinčaTY - JOUR AU - Radić, Jelena AU - Kožik, Bojana AU - Nikolić, Ivan AU - Kolarov-Bjelobrk, Ivana AU - Vasiljević, Tijana AU - Vranjković, Bojana AU - Despotović, Sanja PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11377 AB - LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development. We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis, and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2 inhibitors and discuss their potential in HCC precision treatment. T2 - International Journal of Molecular Sciences T1 - Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting VL - 24 IS - 14 SP - 11745 DO - 10.3390/ijms241411745 ER -
@article{ author = "Radić, Jelena and Kožik, Bojana and Nikolić, Ivan and Kolarov-Bjelobrk, Ivana and Vasiljević, Tijana and Vranjković, Bojana and Despotović, Sanja", year = "2023", abstract = "LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked with an aggressive phenotype and represents a poor prognostic factor. Here, we focus on the mechanisms through which LOXL2 orchestrates multiple oncogenic functions in HCC development. We performed a review of the current knowledge on the roles LOXL2 performs in the modulation of the HCC tumor microenvironment, formation of premetastatic niches, and epithelial–mesenchymal transition. We also highlighted the complex interplay between LOXL2 and hypoxia, angiogenesis, and vasculogenic mimicry in HCC. At the end of the review, we summarize the current LOXL2 inhibitors and discuss their potential in HCC precision treatment.", journal = "International Journal of Molecular Sciences", title = "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting", volume = "24", number = "14", pages = "11745", doi = "10.3390/ijms241411745" }
Radić, J., Kožik, B., Nikolić, I., Kolarov-Bjelobrk, I., Vasiljević, T., Vranjković, B.,& Despotović, S.. (2023). Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences, 24(14), 11745. https://doi.org/10.3390/ijms241411745
Radić J, Kožik B, Nikolić I, Kolarov-Bjelobrk I, Vasiljević T, Vranjković B, Despotović S. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. in International Journal of Molecular Sciences. 2023;24(14):11745. doi:10.3390/ijms241411745 .
Radić, Jelena, Kožik, Bojana, Nikolić, Ivan, Kolarov-Bjelobrk, Ivana, Vasiljević, Tijana, Vranjković, Bojana, Despotović, Sanja, "Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting" in International Journal of Molecular Sciences, 24, no. 14 (2023):11745, https://doi.org/10.3390/ijms241411745 . .