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Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta

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2016
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Authors
Bundalo, Maja M.
Živković, Maja
Romić, Snježana Đ.
Tepavčević, Snežana
Korićanac, Goran
Đurić, Tamara
Stanković, Aleksandra
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Abstract
Introduction: The cardiovascular renin-angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD). Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression. Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT(2)R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT(1)R axis was overexpressed in the FRD male rats aortae, while only AT(1)R was upregulated in the FRD ...female rats aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD. Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.

Keywords:
Angiotensin-converting enzyme / angiotensin receptor / aorta / diet / fructose / gender differences / heart / protein expression / rat / renin-angiotensin system
Source:
Journal of the Renin-Angiotensin-Aldosterone System, 2016, 17, 2
Projects:
  • Genetic basis of human vascular and inflammatory diseases (RS-175085)
  • Role of steroid hormones in neuroendocrine adaptation to stress and pathophysiology of metabolic syndrome - molecular mechanisms and clinical implications (RS-41009)

DOI: 10.1177/1470320316642915

ISSN: 1470-3203; 1752-8976

PubMed: 27121972

WoS: 000378273800003

Scopus: 2-s2.0-84976465970
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http://vinar.vin.bg.ac.rs/handle/123456789/1132
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