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dc.creatorBundalo, Maja M.
dc.creatorŽivković, Maja
dc.creatorĆulafić, Tijana
dc.creatorStojiljković, Mojca D.
dc.creatorKorićanac, Goran
dc.creatorStanković, Aleksandra
dc.date.accessioned2018-03-01T16:57:10Z
dc.date.available2018-03-01T16:57:10Z
dc.date.issued2015
dc.identifier.issn0015-5500
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1112
dc.description.abstractFructose-rich diet induces metabolic changes similar to those observed in metabolic syndrome. Among other matrix metalloproteinases, MMP-9 has an important role in adverse cardiac remodelling and might have a role in the development of cardiovascular disorders associated with metabolic syndrome. The changes of MMP-9 expression could be mediated via the NF kappa B pathway. In this study we investigated the effect of fructose-rich diet on MMP-9 expression in the heart of male and female rats, along with the effect of fructose-rich diet and oestradiol on MMP-9 expression in ovariectomized females. We further assessed the effect of fructose-rich diet and oestradiol on NF kappa B activation, measured as the level of p65 phosphorylation at Ser 276. The results showed that the diet regime did not affect the heart mass. Higher MMP-9 gene expression was found in cardiac tissue of male rats fed the fructose-rich diet than in females on the same diet regime. In ovariectomized females, fructose-rich diet upregulated MMP-9 protein and mRNA expression in the heart, as well as phosphorylation of the p65 subunit of NF kappa B at Ser 276. Oestradiol replacement therapy reverted these changes in the heart of ovariectomized females. This study has shown that oestradiol could revert the early molecular changes in MMP-9 expression induced by fructose-rich diet that occurred before cardiac hypertrophy development by decreasing phosphorylation of the NF kappa B p65 subunit at Ser 276.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41009/RS//
dc.rightsopenAccessen
dc.sourceFolia Biologicaen
dc.subjectfructose-rich dieten
dc.subjectmatrix metalloproteinase 9en
dc.subjectNF kappa Ben
dc.subjectoestradiolen
dc.subjecthearten
dc.subjectraten
dc.titleOestradiol Treatment Counteracts the Effect of Fructose-Rich Diet on Matrix Metalloproteinase 9 Expression and NF kappa B Activationen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractБундало Маја; Живковић Маја; Ћулафић Тијана; Стојиљковић Мојца; Корићанац Горан; Станковић Aлександра;
dc.citation.volume61
dc.citation.issue6
dc.citation.spage233
dc.citation.epage240
dc.identifier.wos000377553200004
dc.citation.rankM23
dc.identifier.pmid26789145
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84955578731
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs/bitstream/id/21411/fb2015a0030.pdf


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