The role of gut microbiota in depressive behavior and the effects of antidepressants
Authors
Lukić, Iva
Mitić, Miloš

Pajović, Milica
Glavonić, Emilija

Živanović, Ana
Aleksić, Minja
Ivković, Sanja

Elliot, Evan
Adžić, Miroslav

Conference object (Published version)

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There is accumulating evidence demonstrating effects of gastrointestinal microbiota on brain function and behavior, including depressive behavior. We have demonstrated that antidepressants, the main drugs used for alleviating depression, affect gut microbiota composition as well, and in this way partly contribute to improvement of depressive symptoms. Specifically, our results showed that several types of antidepressants reduced abundance of bacterial genera Ruminococcus, while supplementation with R. flavefaciens diminished antidepressant-induced decrease of depressive behavior. Treatment with R. flavefaciens affected cortical gene networks, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity, suggesting a mechanism for microbial regulation of antidepressant treatment efficiency. In further studies, we are aiming to delineate the role of gut microbiota in conveying the long-term effects of adolescent stre...ss on development of anxiety and depressive behavior.
Source:
8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade, 2023, 44-Publisher:
- Belgrade : Serbian Neuroscience Society
Institution/Community
VinčaTY - CONF AU - Lukić, Iva AU - Mitić, Miloš AU - Pajović, Milica AU - Glavonić, Emilija AU - Živanović, Ana AU - Aleksić, Minja AU - Ivković, Sanja AU - Elliot, Evan AU - Adžić, Miroslav PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11045 AB - There is accumulating evidence demonstrating effects of gastrointestinal microbiota on brain function and behavior, including depressive behavior. We have demonstrated that antidepressants, the main drugs used for alleviating depression, affect gut microbiota composition as well, and in this way partly contribute to improvement of depressive symptoms. Specifically, our results showed that several types of antidepressants reduced abundance of bacterial genera Ruminococcus, while supplementation with R. flavefaciens diminished antidepressant-induced decrease of depressive behavior. Treatment with R. flavefaciens affected cortical gene networks, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity, suggesting a mechanism for microbial regulation of antidepressant treatment efficiency. In further studies, we are aiming to delineate the role of gut microbiota in conveying the long-term effects of adolescent stress on development of anxiety and depressive behavior. PB - Belgrade : Serbian Neuroscience Society C3 - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade T1 - The role of gut microbiota in depressive behavior and the effects of antidepressants SP - 44 UR - https://hdl.handle.net/21.15107/rcub_vinar_11045 ER -
@conference{ author = "Lukić, Iva and Mitić, Miloš and Pajović, Milica and Glavonić, Emilija and Živanović, Ana and Aleksić, Minja and Ivković, Sanja and Elliot, Evan and Adžić, Miroslav", year = "2023", abstract = "There is accumulating evidence demonstrating effects of gastrointestinal microbiota on brain function and behavior, including depressive behavior. We have demonstrated that antidepressants, the main drugs used for alleviating depression, affect gut microbiota composition as well, and in this way partly contribute to improvement of depressive symptoms. Specifically, our results showed that several types of antidepressants reduced abundance of bacterial genera Ruminococcus, while supplementation with R. flavefaciens diminished antidepressant-induced decrease of depressive behavior. Treatment with R. flavefaciens affected cortical gene networks, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity, suggesting a mechanism for microbial regulation of antidepressant treatment efficiency. In further studies, we are aiming to delineate the role of gut microbiota in conveying the long-term effects of adolescent stress on development of anxiety and depressive behavior.", publisher = "Belgrade : Serbian Neuroscience Society", journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade", title = "The role of gut microbiota in depressive behavior and the effects of antidepressants", pages = "44", url = "https://hdl.handle.net/21.15107/rcub_vinar_11045" }
Lukić, I., Mitić, M., Pajović, M., Glavonić, E., Živanović, A., Aleksić, M., Ivković, S., Elliot, E.,& Adžić, M.. (2023). The role of gut microbiota in depressive behavior and the effects of antidepressants. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade Belgrade : Serbian Neuroscience Society., 44. https://hdl.handle.net/21.15107/rcub_vinar_11045
Lukić I, Mitić M, Pajović M, Glavonić E, Živanović A, Aleksić M, Ivković S, Elliot E, Adžić M. The role of gut microbiota in depressive behavior and the effects of antidepressants. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:44. https://hdl.handle.net/21.15107/rcub_vinar_11045 .
Lukić, Iva, Mitić, Miloš, Pajović, Milica, Glavonić, Emilija, Živanović, Ana, Aleksić, Minja, Ivković, Sanja, Elliot, Evan, Adžić, Miroslav, "The role of gut microbiota in depressive behavior and the effects of antidepressants" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):44, https://hdl.handle.net/21.15107/rcub_vinar_11045 .