Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?
Abstract
The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the d...evelopment of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.
Keywords:
CA / CMS / dentate gyrus / PV plus interneurons / ratSource:
Reviews in the Neurosciences, 2016, 27, 4, 397-409Funding / projects:
- Antioxidative defense, differentiation and regeneration potential of tissue specific mesenchymal stem cells during ageing (RS-175061)
- Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-173044)
DOI: 10.1515/revneuro-2015-0042
ISSN: 0334-1763; 1607-8470
PubMed: 26751865
WoS: 000376682900005
Scopus: 2-s2.0-84974589134
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VinčaTY - JOUR AU - Zaletel, Ivan AU - Filipović, Dragana AU - Puškaš, Nela PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1088 AB - The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons. T2 - Reviews in the Neurosciences T1 - Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far? VL - 27 IS - 4 SP - 397 EP - 409 DO - 10.1515/revneuro-2015-0042 ER -
@article{ author = "Zaletel, Ivan and Filipović, Dragana and Puškaš, Nela", year = "2016", abstract = "The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.", journal = "Reviews in the Neurosciences", title = "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?", volume = "27", number = "4", pages = "397-409", doi = "10.1515/revneuro-2015-0042" }
Zaletel, I., Filipović, D.,& Puškaš, N.. (2016). Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences, 27(4), 397-409. https://doi.org/10.1515/revneuro-2015-0042
Zaletel I, Filipović D, Puškaš N. Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences. 2016;27(4):397-409. doi:10.1515/revneuro-2015-0042 .
Zaletel, Ivan, Filipović, Dragana, Puškaš, Nela, "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?" in Reviews in the Neurosciences, 27, no. 4 (2016):397-409, https://doi.org/10.1515/revneuro-2015-0042 . .