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Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?

Authorized Users Only
2016
Authors
Zaletel, Ivan
Filipović, Dragana
Puškaš, Nela
Article (Published version)
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Abstract
The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the d...evelopment of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.

Keywords:
CA / CMS / dentate gyrus / PV plus interneurons / rat
Source:
Reviews in the Neurosciences, 2016, 27, 4, 397-409
Funding / projects:
  • Antioxidative defense, differentiation and regeneration potential of tissue specific mesenchymal stem cells during ageing (RS-175061)
  • Molecular mechanisms of cellular responses on pathological changes in central neuronal system and peripheral organs of mammals (RS-173044)

DOI: 10.1515/revneuro-2015-0042

ISSN: 0334-1763; 1607-8470

PubMed: 26751865

WoS: 000376682900005

Scopus: 2-s2.0-84974589134
[ Google Scholar ]
33
28
URI
https://vinar.vin.bg.ac.rs/handle/123456789/1088
Collections
  • WoS Import
Institution/Community
Vinča
TY  - JOUR
AU  - Zaletel, Ivan
AU  - Filipović, Dragana
AU  - Puškaš, Nela
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1088
AB  - The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.
T2  - Reviews in the Neurosciences
T1  - Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?
VL  - 27
IS  - 4
SP  - 397
EP  - 409
DO  - 10.1515/revneuro-2015-0042
ER  - 
@article{
author = "Zaletel, Ivan and Filipović, Dragana and Puškaš, Nela",
year = "2016",
abstract = "The hippocampus is a brain structure involved in the regulation of hypothalamic-pituitary-adrenal (HPA) axis and stress response. It plays an important role in the formation of declarative, spatial and contextual memory, as well as in the processing of emotional information. As a part of the limbic system, it is a very susceptible structure towards the effects of various stressors. The molecular mechanisms of structural and functional alternations that occur in the hippocampus under chronic stress imply an increased level of circulating glucocorticoids (GCs), which is an HPA axis response to stress. Certain data show that changes induced by chronic stress may be independent from the GCs levels, opening the possibility of existence of other poorly explored mechanisms and pathways through which stressors act. The hippocampal GABAergic parvalbumin-positive (PV+) interneurons represent an especially vulnerable population of neurons in chronic stress, which may be of key importance in the development of mood disorders. However, cellular and molecular hippocampal changes that arise as a consequence of chronic stress still represent a large and unexplored area. This review discusses the current knowledge about the PV+ interneurons of the hippocampus and the influence of chronic stress on this intriguing population of neurons.",
journal = "Reviews in the Neurosciences",
title = "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?",
volume = "27",
number = "4",
pages = "397-409",
doi = "10.1515/revneuro-2015-0042"
}
Zaletel, I., Filipović, D.,& Puškaš, N.. (2016). Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences, 27(4), 397-409.
https://doi.org/10.1515/revneuro-2015-0042
Zaletel I, Filipović D, Puškaš N. Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?. in Reviews in the Neurosciences. 2016;27(4):397-409.
doi:10.1515/revneuro-2015-0042 .
Zaletel, Ivan, Filipović, Dragana, Puškaš, Nela, "Chronic stress, hippocampus and parvalbumin-positive interneurons: what do we know so far?" in Reviews in the Neurosciences, 27, no. 4 (2016):397-409,
https://doi.org/10.1515/revneuro-2015-0042 . .

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