Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties
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2023
Authors
Janković, Bojan
Papović, Snežana

Vraneš, Milan

Knežević, Teodora
Pržulj, Sanja
Zeljković, Saša
Veličković, Suzana

Veljković, Filip

Jelić, Dijana

Article (Published version)

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A powdered PVA/CaCO3 nanocomposite carrier was successfully fabricated for effective loading of small bioactive molecules, such as vitamin D3 (VD3). Generation of, namely, VD3/PVA/CaCO3 nanocomposite scaffold was carried out through an adsorption mechanism as a loading route of an active compound onto a powder carrier. Developed composites were characterized by structural, morphological and thermal analyses techniques, such as X-ray powder diffraction (XRPD), Fourier-transform infrared (FTIR) spectroscopy, MALDI (matrix-assisted laser desorption/ionization) – mass spectrometry (MS), Brunauer–Emmett–Teller (BET) – NLDFT (Non-local Density Functional Theory) method, scanning electron microscopy (SEM), simultaneous TG-DTG and coupled TG-MS. XRD results showed that the average crystallite size of synthesized VD3/PVA/CaCO3 amounts 32.93 nm exhibiting microstrain presence, where PVA incorporation causes non-uniform calcite lattice distortion. SEM analysis showed that VD3/PVA/CaCO3 nanocompos...ite scaffold contains agglomerated rhomboidal calcite particles with VD3 particles of irregular shapes attached. Fabricated VD3/PVA/CaCO3 clearly showed the existence of calcite “staircase” dendrites as the aftermath of inhibiting the effect of impurities on the growth of crystals in normal directions. It was determined that the decomposition of PVA additionally enhances the thermal stability of VD3, through the stabilization effect by acting on van der Waal’s forces during polyene formation, confirmed by MALDI-TOF MS results.
Source:
Journal of Materials Science, 2023, 58, 15, 6580-6601Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-200017)
- Provincial Secretariat for Higher Education and Scientific Research [grant number 142-451-2545/2021- 01]
Institution/Community
VinčaTY - JOUR AU - Janković, Bojan AU - Papović, Snežana AU - Vraneš, Milan AU - Knežević, Teodora AU - Pržulj, Sanja AU - Zeljković, Saša AU - Veličković, Suzana AU - Veljković, Filip AU - Jelić, Dijana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10850 AB - A powdered PVA/CaCO3 nanocomposite carrier was successfully fabricated for effective loading of small bioactive molecules, such as vitamin D3 (VD3). Generation of, namely, VD3/PVA/CaCO3 nanocomposite scaffold was carried out through an adsorption mechanism as a loading route of an active compound onto a powder carrier. Developed composites were characterized by structural, morphological and thermal analyses techniques, such as X-ray powder diffraction (XRPD), Fourier-transform infrared (FTIR) spectroscopy, MALDI (matrix-assisted laser desorption/ionization) – mass spectrometry (MS), Brunauer–Emmett–Teller (BET) – NLDFT (Non-local Density Functional Theory) method, scanning electron microscopy (SEM), simultaneous TG-DTG and coupled TG-MS. XRD results showed that the average crystallite size of synthesized VD3/PVA/CaCO3 amounts 32.93 nm exhibiting microstrain presence, where PVA incorporation causes non-uniform calcite lattice distortion. SEM analysis showed that VD3/PVA/CaCO3 nanocomposite scaffold contains agglomerated rhomboidal calcite particles with VD3 particles of irregular shapes attached. Fabricated VD3/PVA/CaCO3 clearly showed the existence of calcite “staircase” dendrites as the aftermath of inhibiting the effect of impurities on the growth of crystals in normal directions. It was determined that the decomposition of PVA additionally enhances the thermal stability of VD3, through the stabilization effect by acting on van der Waal’s forces during polyene formation, confirmed by MALDI-TOF MS results. T2 - Journal of Materials Science T1 - Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties VL - 58 IS - 15 SP - 6580 EP - 6601 DO - 10.1007/s10853-023-08453-z ER -
@article{ author = "Janković, Bojan and Papović, Snežana and Vraneš, Milan and Knežević, Teodora and Pržulj, Sanja and Zeljković, Saša and Veličković, Suzana and Veljković, Filip and Jelić, Dijana", year = "2023", abstract = "A powdered PVA/CaCO3 nanocomposite carrier was successfully fabricated for effective loading of small bioactive molecules, such as vitamin D3 (VD3). Generation of, namely, VD3/PVA/CaCO3 nanocomposite scaffold was carried out through an adsorption mechanism as a loading route of an active compound onto a powder carrier. Developed composites were characterized by structural, morphological and thermal analyses techniques, such as X-ray powder diffraction (XRPD), Fourier-transform infrared (FTIR) spectroscopy, MALDI (matrix-assisted laser desorption/ionization) – mass spectrometry (MS), Brunauer–Emmett–Teller (BET) – NLDFT (Non-local Density Functional Theory) method, scanning electron microscopy (SEM), simultaneous TG-DTG and coupled TG-MS. XRD results showed that the average crystallite size of synthesized VD3/PVA/CaCO3 amounts 32.93 nm exhibiting microstrain presence, where PVA incorporation causes non-uniform calcite lattice distortion. SEM analysis showed that VD3/PVA/CaCO3 nanocomposite scaffold contains agglomerated rhomboidal calcite particles with VD3 particles of irregular shapes attached. Fabricated VD3/PVA/CaCO3 clearly showed the existence of calcite “staircase” dendrites as the aftermath of inhibiting the effect of impurities on the growth of crystals in normal directions. It was determined that the decomposition of PVA additionally enhances the thermal stability of VD3, through the stabilization effect by acting on van der Waal’s forces during polyene formation, confirmed by MALDI-TOF MS results.", journal = "Journal of Materials Science", title = "Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties", volume = "58", number = "15", pages = "6580-6601", doi = "10.1007/s10853-023-08453-z" }
Janković, B., Papović, S., Vraneš, M., Knežević, T., Pržulj, S., Zeljković, S., Veličković, S., Veljković, F.,& Jelić, D.. (2023). Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties. in Journal of Materials Science, 58(15), 6580-6601. https://doi.org/10.1007/s10853-023-08453-z
Janković B, Papović S, Vraneš M, Knežević T, Pržulj S, Zeljković S, Veličković S, Veljković F, Jelić D. Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties. in Journal of Materials Science. 2023;58(15):6580-6601. doi:10.1007/s10853-023-08453-z .
Janković, Bojan, Papović, Snežana, Vraneš, Milan, Knežević, Teodora, Pržulj, Sanja, Zeljković, Saša, Veličković, Suzana, Veljković, Filip, Jelić, Dijana, "Biomineral nanocomposite scaffold (CaCO3/PVA based) carrier for improved stability of vitamin D3: characterization analysis and material properties" in Journal of Materials Science, 58, no. 15 (2023):6580-6601, https://doi.org/10.1007/s10853-023-08453-z . .