Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis
Authors
Mavri, Maša
Glišić, Sanja

Senćanski, Milan

Vrecl, Milka
Rosenkilde, Mette M.

Spiess, Katja
Kubale, Valentina
Article (Published version)
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The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is preserved among BILF1 receptors, including the three BILF1 orthologs encoded by porcine lymphotropic herpesviruses (PLHV BILFs). This study aimed to understand the detailed mechanisms of BILF1 receptor constitutive internalization, to explore the translational potential of PLHV BILFs compared with EBV-BILF1.
Keywords:
BILF1 / Caveolin / Dynamin / EBV / Endocytosis / Internalization / PLHV1-2 / vGPCR / β-ArrestinSource:
Cellular and Molecular Biology Letters, 2023, 28, 1, 14-Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-200017)
- Slovenian-Serbian bilateral project [BI-RS/20-21-045]
- COST Action CA [18133 (ERNEST)]
- COST Action [18240 (Adher´n Rise)]
DOI: 10.1186/s11658-023-00427-y
ISSN: 1689-1392
PubMed: 36810008
Scopus: 2-s2.0-85148755308
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VinčaTY - JOUR AU - Mavri, Maša AU - Glišić, Sanja AU - Senćanski, Milan AU - Vrecl, Milka AU - Rosenkilde, Mette M. AU - Spiess, Katja AU - Kubale, Valentina PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10682 AB - The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is preserved among BILF1 receptors, including the three BILF1 orthologs encoded by porcine lymphotropic herpesviruses (PLHV BILFs). This study aimed to understand the detailed mechanisms of BILF1 receptor constitutive internalization, to explore the translational potential of PLHV BILFs compared with EBV-BILF1. T2 - Cellular and Molecular Biology Letters T1 - Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis VL - 28 IS - 1 SP - 14 DO - 10.1186/s11658-023-00427-y ER -
@article{ author = "Mavri, Maša and Glišić, Sanja and Senćanski, Milan and Vrecl, Milka and Rosenkilde, Mette M. and Spiess, Katja and Kubale, Valentina", year = "2023", abstract = "The viral G-protein-coupled receptor (vGPCR) BILF1 encoded by the Epstein–Barr virus (EBV) is an oncogene and immunoevasin and can downregulate MHC-I molecules at the surface of infected cells. MHC-I downregulation, which presumably occurs through co-internalization with EBV-BILF1, is preserved among BILF1 receptors, including the three BILF1 orthologs encoded by porcine lymphotropic herpesviruses (PLHV BILFs). This study aimed to understand the detailed mechanisms of BILF1 receptor constitutive internalization, to explore the translational potential of PLHV BILFs compared with EBV-BILF1.", journal = "Cellular and Molecular Biology Letters", title = "Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis", volume = "28", number = "1", pages = "14", doi = "10.1186/s11658-023-00427-y" }
Mavri, M., Glišić, S., Senćanski, M., Vrecl, M., Rosenkilde, M. M., Spiess, K.,& Kubale, V.. (2023). Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis. in Cellular and Molecular Biology Letters, 28(1), 14. https://doi.org/10.1186/s11658-023-00427-y
Mavri M, Glišić S, Senćanski M, Vrecl M, Rosenkilde MM, Spiess K, Kubale V. Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis. in Cellular and Molecular Biology Letters. 2023;28(1):14. doi:10.1186/s11658-023-00427-y .
Mavri, Maša, Glišić, Sanja, Senćanski, Milan, Vrecl, Milka, Rosenkilde, Mette M., Spiess, Katja, Kubale, Valentina, "Patterns of human and porcine gammaherpesvirus-encoded BILF1 receptor endocytosis" in Cellular and Molecular Biology Letters, 28, no. 1 (2023):14, https://doi.org/10.1186/s11658-023-00427-y . .