(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findi...ngs related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin’s role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.
TY - JOUR
AU - Mačvanin, Mirjana
AU - Rizzo, Manfredi
AU - Radovanović, Jelena N.
AU - Sonmez, Alper
AU - Paneni, Francesco
AU - Isenović, Esma R.
PY - 2022
UR - https://vinar.vin.bg.ac.rs/handle/123456789/10569
AB - (1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin’s role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.
T2 - Biomedicines
T1 - Role of Chemerin in Cardiovascular Diseases
VL - 10
IS - 11
SP - 2970
DO - 10.3390/biomedicines10112970
ER -
@article{
author = "Mačvanin, Mirjana and Rizzo, Manfredi and Radovanović, Jelena N. and Sonmez, Alper and Paneni, Francesco and Isenović, Esma R.",
year = "2022",
abstract = "(1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin’s role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.",
journal = "Biomedicines",
title = "Role of Chemerin in Cardiovascular Diseases",
volume = "10",
number = "11",
pages = "2970",
doi = "10.3390/biomedicines10112970"
}
Mačvanin, M., Rizzo, M., Radovanović, J. N., Sonmez, A., Paneni, F.,& Isenović, E. R.. (2022). Role of Chemerin in Cardiovascular Diseases. in Biomedicines, 10(11), 2970.
https://doi.org/10.3390/biomedicines10112970
Mačvanin M, Rizzo M, Radovanović JN, Sonmez A, Paneni F, Isenović ER. Role of Chemerin in Cardiovascular Diseases. in Biomedicines. 2022;10(11):2970.
doi:10.3390/biomedicines10112970 .
Mačvanin, Mirjana, Rizzo, Manfredi, Radovanović, Jelena N., Sonmez, Alper, Paneni, Francesco, Isenović, Esma R., "Role of Chemerin in Cardiovascular Diseases" in Biomedicines, 10, no. 11 (2022):2970,
https://doi.org/10.3390/biomedicines10112970 . .
