Free radicals: Relationship to Human Diseases and Potential Therapeutic applications
Abstract
Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating... several diseases.
Keywords:
Free radicals / Mitochondria / Nitrosative stress / Oxidative stress / Pathophysiological conditions / Reactive oxygen species-modulating therapeuticsSource:
The International Journal of Biochemistry and Cell Biology, 2023, 154, 106346-Funding / projects:
DOI: 10.1016/j.biocel.2022.106346
ISSN: 1357-2725
PubMed: 36538984
Scopus: 2-s2.0-85144636616
Institution/Community
VinčaTY - JOUR AU - Zarić, Božidarka AU - Mačvanin, Mirjana AU - Isenović, Esma R. PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10562 AB - Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases. T2 - The International Journal of Biochemistry and Cell Biology T1 - Free radicals: Relationship to Human Diseases and Potential Therapeutic applications VL - 154 SP - 106346 DO - 10.1016/j.biocel.2022.106346 ER -
@article{ author = "Zarić, Božidarka and Mačvanin, Mirjana and Isenović, Esma R.", year = "2023", abstract = "Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.", journal = "The International Journal of Biochemistry and Cell Biology", title = "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications", volume = "154", pages = "106346", doi = "10.1016/j.biocel.2022.106346" }
Zarić, B., Mačvanin, M.,& Isenović, E. R.. (2023). Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology, 154, 106346. https://doi.org/10.1016/j.biocel.2022.106346
Zarić B, Mačvanin M, Isenović ER. Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology. 2023;154:106346. doi:10.1016/j.biocel.2022.106346 .
Zarić, Božidarka, Mačvanin, Mirjana, Isenović, Esma R., "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications" in The International Journal of Biochemistry and Cell Biology, 154 (2023):106346, https://doi.org/10.1016/j.biocel.2022.106346 . .