Show simple item record

dc.creatorRodic, Marko V.
dc.creatorLeovac, Vukadin M.
dc.creatorJoyanovic, Ljiljana S.
dc.creatorSpasojević, Vojislav
dc.creatorJoksović, Milan D.
dc.creatorStanojković, Tatjana P.
dc.creatorMatić, Ivana Z.
dc.creatorVojinović-Ješić, Ljiljana S.
dc.creatorMarković, Violeta
dc.date.accessioned2018-03-01T16:52:02Z
dc.date.available2018-03-01T16:52:02Z
dc.date.issued2016
dc.identifier.issn0223-5234 (print)
dc.identifier.issn1768-3254 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1053
dc.description.abstractThree novel copper complexes with tridentate N2O ligand di(2-pyridil) ketone 1-adamantoyl hydrazone (Addpy) of the formula [(Cu2Cu2I)-Cu-II(Addpy)(2)Br-2(mu-Br-4)] (1), catena-poly[CuCl(mu-Addpy)(mu-Cl)CuCl2](n) (2) and [Cu(Addpy)(NCS)(2)] (3) were synthesized. Complexes are characterized by X-ray crystallography, spectral (UV-Vis, FTIR), electrochemical (CV) analyses, and magnetochemical measurements. Investigation of anticancer potential of Cu(II) complexes, mode of cell death, apoptosis, and inhibition of angiogenesis were performed. All tested malignant cell lines (HeLa, LS174, A549, K562, and MDA-MB-231) showed high sensitivity to the examined Cu(II) complexes. It has been shown that the complexes induce apoptosis in the caspase 3-dependent manner, whereas the anti-angiogenic effects of 1, 2, and 3 have been confirmed in EA.hy926 cells using a tube formation assay. (C) 2016 Elsevier Masson SAS. All rights reserved.en
dc.relationProvincial Secretariat for Science and Technological Development of Vojvodina
dc.rightsrestrictedAccessen
dc.sourceEuropean Journal of Medicinal Chemistryen
dc.subjectHydrazonesen
dc.subjectCopper(II) complexesen
dc.subjectCaspase-3en
dc.subjectAngiogenesisen
dc.subjectPhysico-chemical characterizationen
dc.titleSynthesis, characterization, cytotoxicity and antiangiogenic activity of copper(II) complexes with 1-adamantoyl hydrazone bearing pyridine ringsen
dc.typearticleen
dcterms.abstractЛеовац, Вукадин М.; Родиц, Марко В.; Марковиц, Виолета; Спасојевић Војислав; Јоксовиц, Милан Д.; Станојковиц, Татјана; Јоyановиц, Љиљана С.; Матиц, Ивана З.; Војиновиц-Јесиц, Љиљана С.;
dc.citation.volume115
dc.citation.spage75
dc.citation.epage81
dc.identifier.wos000375360800007
dc.identifier.doi10.1016/j.ejmech.2016.03.003
dc.citation.rankM21
dc.identifier.pmid27084495
dc.identifier.scopus2-s2.0-84962278744


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record