Polyoxometalates in Biomedicine: Update and Overview
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Čolović, Mirjana B.
Lacković, Milan
Lalatović, Jovana
Mougharbel, Ali S.
Kortz, Ulrich

Krstić, Danijela Z.

Article (Published version)

© 2020 Bentham Science
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Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic. Methods: The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords. Results: This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered. Conclusion: Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the be...st of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solution-stable POMs employing physiological conditions and concentrations.
Keywords:
Antibacterial / Antitumor / Antiviral / Biomedicine / Normoglycemic activities / PolyoxometalatesSource:
Current Medicinal Chemistry, 2020, 27, 3, 362-379Funding / projects:
- German Research Council (DFG) [KO-2288/20-1]
- Studies of enzyme interactions with toxic and pharmacologically active molecules (RS-172023)
- bilateral project Serbia-Germany [451-03-01038/2015-09/16, DAAD-PPP]
- CMST COST Action [CM1203 (PoCheMoN)]
- German Research Council (DFG) [KO-2288/16-1]
DOI: 10.2174/0929867326666190827153532
ISSN: 0929-8673
PubMed: 31453779
WoS: 000514833000004
Scopus: 2-s2.0-85079777687
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VinčaTY - JOUR AU - Čolović, Mirjana B. AU - Lacković, Milan AU - Lalatović, Jovana AU - Mougharbel, Ali S. AU - Kortz, Ulrich AU - Krstić, Danijela Z. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10139 AB - Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic. Methods: The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords. Results: This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered. Conclusion: Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the best of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solution-stable POMs employing physiological conditions and concentrations. T2 - Current Medicinal Chemistry T1 - Polyoxometalates in Biomedicine: Update and Overview VL - 27 IS - 3 SP - 362 EP - 379 DO - 10.2174/0929867326666190827153532 ER -
@article{ author = "Čolović, Mirjana B. and Lacković, Milan and Lalatović, Jovana and Mougharbel, Ali S. and Kortz, Ulrich and Krstić, Danijela Z.", year = "2020", abstract = "Background: Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of interest in the fields of catalysis, electronics, magnetic materials and nanotechnology. Moreover, POMs were shown to exhibit biological activities in vitro and in vivo, such as antitumor, antimicrobial, and antidiabetic. Methods: The literature search for this peer-reviewed article was performed using PubMed and Scopus databases with the help of appropriate keywords. Results: This review gives a comprehensive overview of recent studies regarding biological activities of polyoxometalates, and their biomedical applications as promising anti-viral, anti-bacterial, anti-tumor, and anti-diabetic agents. Additionally, their putative mechanisms of action and molecular targets are particularly considered. Conclusion: Although a wide range of biological activities of Polyoxometalates (POMs) has been reported, they are to the best of our knowledge not close to a clinical trial or a final application in the treatment of diabetes or infectious and malignant diseases. Accordingly, further studies should be directed towards determining the mechanism of POM biological actions, which would enable fine-tuning at the molecular level, and consequently efficient action towards biological targets and as low toxicity as possible. Furthermore, biomedical studies should be performed on solution-stable POMs employing physiological conditions and concentrations.", journal = "Current Medicinal Chemistry", title = "Polyoxometalates in Biomedicine: Update and Overview", volume = "27", number = "3", pages = "362-379", doi = "10.2174/0929867326666190827153532" }
Čolović, M. B., Lacković, M., Lalatović, J., Mougharbel, A. S., Kortz, U.,& Krstić, D. Z.. (2020). Polyoxometalates in Biomedicine: Update and Overview. in Current Medicinal Chemistry, 27(3), 362-379. https://doi.org/10.2174/0929867326666190827153532
Čolović MB, Lacković M, Lalatović J, Mougharbel AS, Kortz U, Krstić DZ. Polyoxometalates in Biomedicine: Update and Overview. in Current Medicinal Chemistry. 2020;27(3):362-379. doi:10.2174/0929867326666190827153532 .
Čolović, Mirjana B., Lacković, Milan, Lalatović, Jovana, Mougharbel, Ali S., Kortz, Ulrich, Krstić, Danijela Z., "Polyoxometalates in Biomedicine: Update and Overview" in Current Medicinal Chemistry, 27, no. 3 (2020):362-379, https://doi.org/10.2174/0929867326666190827153532 . .