Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA
Authors
Milosavljević, Slobodan
Đorđević, Iris

Mandić, Boris

Tešević, Vele V.

Stanković, Miroslava

Todorović, Nina

Novaković, Miroslav M.

Article (Published version)
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In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.
Keywords:
flavonoids / Cotinus coggygria Scop. / DNA protective activity / cytokinesis-block micronucleus assaySource:
Natural Product Communications, 2021, 16, 12, 1-8Funding / projects:
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200168 (University of Belgrade, Faculty of Chemistry) (RS-200168)
- Serbian Academy of Sciences and Arts [Grant No. F188]
DOI: 10.1177/1934578X211067289
ISSN: 1934-578X; 1555-9475
WoS: 000735775300001
Scopus: 2-s2.0-85122088724
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VinčaTY - JOUR AU - Milosavljević, Slobodan AU - Đorđević, Iris AU - Mandić, Boris AU - Tešević, Vele V. AU - Stanković, Miroslava AU - Todorović, Nina AU - Novaković, Miroslav M. PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10107 AB - In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds. T2 - Natural Product Communications T1 - Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA VL - 16 IS - 12 SP - 1 EP - 8 DO - 10.1177/1934578X211067289 ER -
@article{ author = "Milosavljević, Slobodan and Đorđević, Iris and Mandić, Boris and Tešević, Vele V. and Stanković, Miroslava and Todorović, Nina and Novaković, Miroslav M.", year = "2021", abstract = "In continuation of our study on Cotinus coggygria from Serbia, 10 known flavonoids (1-10) were isolated from the methylene chloride/ methanol extract of the heartwood. They were tested for in vitro protective effect against chromosome aberrations in peripheral human lymphocytes, using the cytokinesis-block micronucleus assay. All tested compounds (in minimal doses of 1 μg/mL) exerted a beneficial effect by decreasing DNA damage of human lymphocytes in the range of 24.2% to 54.5%, better than the radio protectant control, amifostine. Functional groups, such as 3′,4′-dihydroxyphenyl (catechol), 5-OH, 3-OH, and 4-keto in flavonoids (3-keto in aurones), which play a key role in antioxidant activity, are proposed to be responsible for the DNA protective activity of the tested compounds.", journal = "Natural Product Communications", title = "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA", volume = "16", number = "12", pages = "1-8", doi = "10.1177/1934578X211067289" }
Milosavljević, S., Đorđević, I., Mandić, B., Tešević, V. V., Stanković, M., Todorović, N.,& Novaković, M. M.. (2021). Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications, 16(12), 1-8. https://doi.org/10.1177/1934578X211067289
Milosavljević S, Đorđević I, Mandić B, Tešević VV, Stanković M, Todorović N, Novaković MM. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA. in Natural Product Communications. 2021;16(12):1-8. doi:10.1177/1934578X211067289 .
Milosavljević, Slobodan, Đorđević, Iris, Mandić, Boris, Tešević, Vele V., Stanković, Miroslava, Todorović, Nina, Novaković, Miroslav M., "Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA" in Natural Product Communications, 16, no. 12 (2021):1-8, https://doi.org/10.1177/1934578X211067289 . .