TY  - JOUR
AU  - Đačanin Far, Ljubica
AU  - Ćirić, Aleksandar
AU  - Sekulić, Milica
AU  - Periša, Jovana
AU  - Ristić, Zoran
AU  - Antić, Željka
AU  - Dramićanin, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10551
AB  - YNbO4:xEu3+ powders (0.1, 0.25, 0.5, 0.75, 1, 3, 5, 7.5, 10, 15, 20 mol %) were synthesized by a solid-state reaction, after homogenization in a vibrational mill. All the samples crystallize in a monoclinic Fergusonite-beta-(Y) structure (C2/c space group), with 45–65 nm crystallite sizes and show a strong orange/red luminescence with 5D0 excited state lifetimes of around 0.6 ms. Photoluminescence emission spectra showed no concentration quenching within the examined concentration range. Judd–Ofelt intensity parameters show a slight increase with rising concentration, up to Ω2 = 8.13∙10−20 cm2, Ω4 = 2.67∙10−20 cm2, and Ω6 is concentration invariant with the 0.35∙10−20 cm2 value. Emission lifetimes of the 5D0 state are almost constant with ∼0.6 ms, and a slight decrease is observed with the highest concentrations. The intrinsic quantum yield of all the samples is about 0.5.
T2  - Optik
T1  - Judd-Ofelt description of radiative properties of YNbO4 activated with different Eu3+ concentrations
VL  - 272
SP  - 170398
DO  - 10.1016/j.ijleo.2022.170398
ER  - 

@article{
author = "Đačanin Far, Ljubica and Ćirić, Aleksandar and Sekulić, Milica and Periša, Jovana and Ristić, Zoran and Antić, Željka and Dramićanin, Miroslav",
year = "2023",
abstract = "YNbO4:xEu3+ powders (0.1, 0.25, 0.5, 0.75, 1, 3, 5, 7.5, 10, 15, 20 mol %) were synthesized by a solid-state reaction, after homogenization in a vibrational mill. All the samples crystallize in a monoclinic Fergusonite-beta-(Y) structure (C2/c space group), with 45–65 nm crystallite sizes and show a strong orange/red luminescence with 5D0 excited state lifetimes of around 0.6 ms. Photoluminescence emission spectra showed no concentration quenching within the examined concentration range. Judd–Ofelt intensity parameters show a slight increase with rising concentration, up to Ω2 = 8.13∙10−20 cm2, Ω4 = 2.67∙10−20 cm2, and Ω6 is concentration invariant with the 0.35∙10−20 cm2 value. Emission lifetimes of the 5D0 state are almost constant with ∼0.6 ms, and a slight decrease is observed with the highest concentrations. The intrinsic quantum yield of all the samples is about 0.5.",
journal = "Optik",
title = "Judd-Ofelt description of radiative properties of YNbO4 activated with different Eu3+ concentrations",
volume = "272",
pages = "170398",
doi = "10.1016/j.ijleo.2022.170398"
}

Đačanin Far, L., Ćirić, A., Sekulić, M., Periša, J., Ristić, Z., Antić, Ž.,& Dramićanin, M.. (2023). Judd-Ofelt description of radiative properties of YNbO4 activated with different Eu3+ concentrations. in Optik, 272, 170398.
https://doi.org/10.1016/j.ijleo.2022.170398

Đačanin Far L, Ćirić A, Sekulić M, Periša J, Ristić Z, Antić Ž, Dramićanin M. Judd-Ofelt description of radiative properties of YNbO4 activated with different Eu3+ concentrations. in Optik. 2023;272:170398.
doi:10.1016/j.ijleo.2022.170398 .

Đačanin Far, Ljubica, Ćirić, Aleksandar, Sekulić, Milica, Periša, Jovana, Ristić, Zoran, Antić, Željka, Dramićanin, Miroslav, "Judd-Ofelt description of radiative properties of YNbO4 activated with different Eu3+ concentrations" in Optik, 272 (2023):170398,
https://doi.org/10.1016/j.ijleo.2022.170398 . .

TY  - JOUR
AU  - Milićević, Bojana R.
AU  - Periša, Jovana
AU  - Ristić, Zoran
AU  - Milenković, Katarina
AU  - Antić, Željka
AU  - Smits, Krisjanis
AU  - Kemere, Meldra
AU  - Vitols, Kaspars
AU  - Sarakovskis, Anatolijs
AU  - Dramićanin, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10590
AB  - We report the procedure for hydrothermal synthesis of ultrasmall Yb3+/Tm3+ co-doped Sr2LaF7 (SLF) upconversion phosphors. These phosphors were synthesized by varying the concentrations of Yb3+ (x = 10, 15, 20, and 25 mol%) and Tm3+ (y = 0.75, 1, 2, and 3 mol%) with the aim to analyze their emissions in the near IR spectral range. According to the detailed structural analysis, Yb3+ and Tm3+ occupy the La3+ sites in the SLF host. The addition of Yb3+/Tm3+ ions has a huge impact on the lattice constant, particle size, and PL emission properties of the synthesized SLF nanophosphor. The results show that the optimal dopant concentrations for upconversion luminescence of Yb3+/Tm3+ co-doped SLF are 20 mol% Yb3+ and 1 mol% Tm3+ with EDTA as the chelating agent. Under 980 nm light excitation, a strong upconversion emission of Tm3+ ions around 800 nm was achieved. In addition, the experimental photoluminescence lifetime of Tm3+ emission in the SLF host is reported. This study discovered that efficient near IR emission from ultrasmall Yb3+/Tm3+ co-doped SLF phosphors may have potential applications in the fields of fluorescent labels in bioimaging and security applications.
T2  - Nanomaterials
T1  - Hydrothermal Synthesis and Properties of Yb3+/Tm3+ Doped Sr2LaF7 Upconversion Nanoparticles
VL  - 13
IS  - 1
SP  - 30
DO  - 10.3390/nano13010030
ER  - 

@article{
author = "Milićević, Bojana R. and Periša, Jovana and Ristić, Zoran and Milenković, Katarina and Antić, Željka and Smits, Krisjanis and Kemere, Meldra and Vitols, Kaspars and Sarakovskis, Anatolijs and Dramićanin, Miroslav",
year = "2023",
abstract = "We report the procedure for hydrothermal synthesis of ultrasmall Yb3+/Tm3+ co-doped Sr2LaF7 (SLF) upconversion phosphors. These phosphors were synthesized by varying the concentrations of Yb3+ (x = 10, 15, 20, and 25 mol%) and Tm3+ (y = 0.75, 1, 2, and 3 mol%) with the aim to analyze their emissions in the near IR spectral range. According to the detailed structural analysis, Yb3+ and Tm3+ occupy the La3+ sites in the SLF host. The addition of Yb3+/Tm3+ ions has a huge impact on the lattice constant, particle size, and PL emission properties of the synthesized SLF nanophosphor. The results show that the optimal dopant concentrations for upconversion luminescence of Yb3+/Tm3+ co-doped SLF are 20 mol% Yb3+ and 1 mol% Tm3+ with EDTA as the chelating agent. Under 980 nm light excitation, a strong upconversion emission of Tm3+ ions around 800 nm was achieved. In addition, the experimental photoluminescence lifetime of Tm3+ emission in the SLF host is reported. This study discovered that efficient near IR emission from ultrasmall Yb3+/Tm3+ co-doped SLF phosphors may have potential applications in the fields of fluorescent labels in bioimaging and security applications.",
journal = "Nanomaterials",
title = "Hydrothermal Synthesis and Properties of Yb3+/Tm3+ Doped Sr2LaF7 Upconversion Nanoparticles",
volume = "13",
number = "1",
pages = "30",
doi = "10.3390/nano13010030"
}

Milićević, B. R., Periša, J., Ristić, Z., Milenković, K., Antić, Ž., Smits, K., Kemere, M., Vitols, K., Sarakovskis, A.,& Dramićanin, M.. (2023). Hydrothermal Synthesis and Properties of Yb3+/Tm3+ Doped Sr2LaF7 Upconversion Nanoparticles. in Nanomaterials, 13(1), 30.
https://doi.org/10.3390/nano13010030

Milićević BR, Periša J, Ristić Z, Milenković K, Antić Ž, Smits K, Kemere M, Vitols K, Sarakovskis A, Dramićanin M. Hydrothermal Synthesis and Properties of Yb3+/Tm3+ Doped Sr2LaF7 Upconversion Nanoparticles. in Nanomaterials. 2023;13(1):30.
doi:10.3390/nano13010030 .

Milićević, Bojana R., Periša, Jovana, Ristić, Zoran, Milenković, Katarina, Antić, Željka, Smits, Krisjanis, Kemere, Meldra, Vitols, Kaspars, Sarakovskis, Anatolijs, Dramićanin, Miroslav, "Hydrothermal Synthesis and Properties of Yb3+/Tm3+ Doped Sr2LaF7 Upconversion Nanoparticles" in Nanomaterials, 13, no. 1 (2023):30,
https://doi.org/10.3390/nano13010030 . .

TY  - JOUR
AU  - Papan Đaniš, Jelena
AU  - Periša, Jovana
AU  - Hribar Boštjančič, Patricija
AU  - Mihajlovski, Katarina
AU  - Lazić, Vesna M.
AU  - Dramićanin, Miroslav
AU  - Lisjak, Darja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10639
AB  - Colloidal stabilization of magnetic nanoparticles is one of the most important steps in the preparation of magnetic nanoparticles for potential biomedical applications. A special kind of magnetic nanoparticle are barium hexaferrite nanoplatelets (BSHF NPLs) with a hexagonal shape and a permanent magnetic moment. One strategy for the stabilization of BHF in aqueous media is to use coatings. In our research, we used an eco-friendly tannic acid, as a coating on BSHF NPLs. As-prepared BSHF NPLs coated with tannic acid were examined with transmission electron microscopy, infrared and UV-Vis spectroscopy, electro-kinetic measurements, and their room-temperature magnetic properties were measured. Stable colloids were tested in two biological complex media and antimicrobial properties of the material were examined. To enhance the antimicrobial properties of our material, we used tannic acid as a platform for the in-situ production of silver on BSHF NPLs. New hybrid material with silver also possesses magnetic properties and excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Barium hexaferrite nanoplatelets with polyphenol coatings for versatile applications as a stable, magnetic, and antimicrobial colloid
VL  - 224
SP  - 113198
DO  - 10.1016/j.colsurfb.2023.113198
ER  - 

@article{
author = "Papan Đaniš, Jelena and Periša, Jovana and Hribar Boštjančič, Patricija and Mihajlovski, Katarina and Lazić, Vesna M. and Dramićanin, Miroslav and Lisjak, Darja",
year = "2023",
abstract = "Colloidal stabilization of magnetic nanoparticles is one of the most important steps in the preparation of magnetic nanoparticles for potential biomedical applications. A special kind of magnetic nanoparticle are barium hexaferrite nanoplatelets (BSHF NPLs) with a hexagonal shape and a permanent magnetic moment. One strategy for the stabilization of BHF in aqueous media is to use coatings. In our research, we used an eco-friendly tannic acid, as a coating on BSHF NPLs. As-prepared BSHF NPLs coated with tannic acid were examined with transmission electron microscopy, infrared and UV-Vis spectroscopy, electro-kinetic measurements, and their room-temperature magnetic properties were measured. Stable colloids were tested in two biological complex media and antimicrobial properties of the material were examined. To enhance the antimicrobial properties of our material, we used tannic acid as a platform for the in-situ production of silver on BSHF NPLs. New hybrid material with silver also possesses magnetic properties and excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Barium hexaferrite nanoplatelets with polyphenol coatings for versatile applications as a stable, magnetic, and antimicrobial colloid",
volume = "224",
pages = "113198",
doi = "10.1016/j.colsurfb.2023.113198"
}

Papan Đaniš, J., Periša, J., Hribar Boštjančič, P., Mihajlovski, K., Lazić, V. M., Dramićanin, M.,& Lisjak, D.. (2023). Barium hexaferrite nanoplatelets with polyphenol coatings for versatile applications as a stable, magnetic, and antimicrobial colloid. in Colloids and Surfaces. B: Biointerfaces, 224, 113198.
https://doi.org/10.1016/j.colsurfb.2023.113198

Papan Đaniš J, Periša J, Hribar Boštjančič P, Mihajlovski K, Lazić VM, Dramićanin M, Lisjak D. Barium hexaferrite nanoplatelets with polyphenol coatings for versatile applications as a stable, magnetic, and antimicrobial colloid. in Colloids and Surfaces. B: Biointerfaces. 2023;224:113198.
doi:10.1016/j.colsurfb.2023.113198 .

Papan Đaniš, Jelena, Periša, Jovana, Hribar Boštjančič, Patricija, Mihajlovski, Katarina, Lazić, Vesna M., Dramićanin, Miroslav, Lisjak, Darja, "Barium hexaferrite nanoplatelets with polyphenol coatings for versatile applications as a stable, magnetic, and antimicrobial colloid" in Colloids and Surfaces. B: Biointerfaces, 224 (2023):113198,
https://doi.org/10.1016/j.colsurfb.2023.113198 . .

TY  - JOUR
AU  - Ćirić, Aleksandar
AU  - van Swieten, Thomas
AU  - Periša, Jovana
AU  - Meijerink, Andries
AU  - Dramićanin, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11066
AB  - Luminescence thermometry is the most versatile remote temperature sensing technique and can be employed from living cells to large surfaces and from cryogenic temperatures to the melting points of metals. Ongoing research aims to optimize the sensitivity of the ratio between the emission intensity from two coupled excited states. However, this approach is inherently limited to temperature-dependent processes involving only the excited states. Here, we develop a novel measurement technique, called luminescence intensity ratio squared (LIR2) for the Yb3+/Er3+ pair, that combines the temperature sensitivity of ground- and excited-state populations. We use Y3Al5O12:Er3+,Yb3+ nanoparticles as a promising model system with both visible and infrared emissions. To apply our method, we record two luminescence spectra at different excitation wavelengths and determine the LIR2 using one emission in each of the two spectra. The LIR2 testing with Y3Al5O12 nanoparticles showed a sensitivity increase of 70% in the visible region and an impressive 230% increase in the NIR region compared to the conventional LIR method. This enhances the measurement precision by a factor of 1.5–2.5. The LIR2 based on the visible upconversion emission is particularly useful for measurements of high temperatures, while the LIR2 based on the downshifted ∼1.5 μm emission may revolutionize temperature measurements of biological samples in the range of physiological temperatures.
T2  - Journal of Applied Physics
T1  - Twofold increase in the sensitivity of Er3+/Yb3+ Boltzmann thermometer
VL  - 133
IS  - 19
SP  - 194501
DO  - 10.1063/5.0149757
ER  - 

@article{
author = "Ćirić, Aleksandar and van Swieten, Thomas and Periša, Jovana and Meijerink, Andries and Dramićanin, Miroslav",
year = "2023",
abstract = "Luminescence thermometry is the most versatile remote temperature sensing technique and can be employed from living cells to large surfaces and from cryogenic temperatures to the melting points of metals. Ongoing research aims to optimize the sensitivity of the ratio between the emission intensity from two coupled excited states. However, this approach is inherently limited to temperature-dependent processes involving only the excited states. Here, we develop a novel measurement technique, called luminescence intensity ratio squared (LIR2) for the Yb3+/Er3+ pair, that combines the temperature sensitivity of ground- and excited-state populations. We use Y3Al5O12:Er3+,Yb3+ nanoparticles as a promising model system with both visible and infrared emissions. To apply our method, we record two luminescence spectra at different excitation wavelengths and determine the LIR2 using one emission in each of the two spectra. The LIR2 testing with Y3Al5O12 nanoparticles showed a sensitivity increase of 70% in the visible region and an impressive 230% increase in the NIR region compared to the conventional LIR method. This enhances the measurement precision by a factor of 1.5–2.5. The LIR2 based on the visible upconversion emission is particularly useful for measurements of high temperatures, while the LIR2 based on the downshifted ∼1.5 μm emission may revolutionize temperature measurements of biological samples in the range of physiological temperatures.",
journal = "Journal of Applied Physics",
title = "Twofold increase in the sensitivity of Er3+/Yb3+ Boltzmann thermometer",
volume = "133",
number = "19",
pages = "194501",
doi = "10.1063/5.0149757"
}

Ćirić, A., van Swieten, T., Periša, J., Meijerink, A.,& Dramićanin, M.. (2023). Twofold increase in the sensitivity of Er3+/Yb3+ Boltzmann thermometer. in Journal of Applied Physics, 133(19), 194501.
https://doi.org/10.1063/5.0149757

Ćirić A, van Swieten T, Periša J, Meijerink A, Dramićanin M. Twofold increase in the sensitivity of Er3+/Yb3+ Boltzmann thermometer. in Journal of Applied Physics. 2023;133(19):194501.
doi:10.1063/5.0149757 .

Ćirić, Aleksandar, van Swieten, Thomas, Periša, Jovana, Meijerink, Andries, Dramićanin, Miroslav, "Twofold increase in the sensitivity of Er3+/Yb3+ Boltzmann thermometer" in Journal of Applied Physics, 133, no. 19 (2023):194501,
https://doi.org/10.1063/5.0149757 . .

TY  - JOUR
AU  - Piotrowski, Wojciech M.
AU  - Marin, Riccardo
AU  - Szymczak, Maja
AU  - Martín Rodríguez, Emma
AU  - Ortgies, Dirk H.
AU  - Rodríguez-Sevilla, Paloma
AU  - Dramićanin, Miroslav
AU  - Jaque, Daniel
AU  - Marciniak, Lukasz
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10546
AB  - Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.
T2  - Advanced Optical Materials
T1  - Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom
VL  - 11
IS  - 3
SP  - 2202366
DO  - 10.1002/adom.202202366
ER  - 

@article{
author = "Piotrowski, Wojciech M. and Marin, Riccardo and Szymczak, Maja and Martín Rodríguez, Emma and Ortgies, Dirk H. and Rodríguez-Sevilla, Paloma and Dramićanin, Miroslav and Jaque, Daniel and Marciniak, Lukasz",
year = "2023",
abstract = "Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.",
journal = "Advanced Optical Materials",
title = "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom",
volume = "11",
number = "3",
pages = "2202366",
doi = "10.1002/adom.202202366"
}

Piotrowski, W. M., Marin, R., Szymczak, M., Martín Rodríguez, E., Ortgies, D. H., Rodríguez-Sevilla, P., Dramićanin, M., Jaque, D.,& Marciniak, L.. (2023). Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials, 11(3), 2202366.
https://doi.org/10.1002/adom.202202366

Piotrowski WM, Marin R, Szymczak M, Martín Rodríguez E, Ortgies DH, Rodríguez-Sevilla P, Dramićanin M, Jaque D, Marciniak L. Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials. 2023;11(3):2202366.
doi:10.1002/adom.202202366 .

Piotrowski, Wojciech M., Marin, Riccardo, Szymczak, Maja, Martín Rodríguez, Emma, Ortgies, Dirk H., Rodríguez-Sevilla, Paloma, Dramićanin, Miroslav, Jaque, Daniel, Marciniak, Lukasz, "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom" in Advanced Optical Materials, 11, no. 3 (2023):2202366,
https://doi.org/10.1002/adom.202202366 . .

TY  - JOUR
AU  - Racu, Andrei V.
AU  - Ristić, Zoran
AU  - Ćirić, Aleksandar
AU  - Ðorđević, Vesna
AU  - Buse, Gabriel
AU  - Poienar, Maria
AU  - Gutmann, Michael J.
AU  - Ivashko, Oleh
AU  - Stef, Marius
AU  - Vizman, Daniel
AU  - Dramićanin, Miroslav
AU  - Piasecki, Michal
AU  - Brik, Mikhail G.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10561
AB  - The understanding of complex relationships between luminescent properties, local symmetry of an emitting center, and the host crystal structure provides a better insight into optical properties of materials. In this work, the alkaline earths CaF2 and BaF2 fluoride crystals doped with 0.1 mol% ErF3 were investigated. The crystals structure has been studied using a synchrotron and laboratory X-ray diffraction. The C3v and C4v sites symmetry were determined using erbium probed high resolution emission spectroscopy (HRPL) at low temperature (LT) of 10 K. The considerable difference in room temperature (RT) optical properties for CaF2 compared to BaF2 crystals was observed. Such difference in absorption intensity of 4.7 times of erbium 4G11/2 manifold in UV, and 7.5 times in green emission from 4S3/2 manifold, could be due to the distinction in the host crystals cationic radius (ΔrCa,Ba) and the dopant-host ionic radius (ΔrCa-Er, ΔrBa-Er). Those Δr differences influence the structure and lead to the following symmetry formation: In CaF2, the C4v and C3v isolated centers were identified, with the determined Er3+- F−i bond lengths of 2.734 Å and 4.735 Å respectively; In BaF2, only C3v isolated centers were identified with the determined Er3+- F−i bond lengths of 5.380 Å. The present work is the first study that takes into account correlations of optical properties, the local symmetry and the structure in mentioned fluorides crystals, and it could be a step forward in the lanthanide doped optical materials systematics.
T2  - Optical Materials
T1  - Analysis of site symmetries of Er3+ doped CaF2 and BaF2 crystals by high resolution photoluminescence spectroscopy
VL  - 136
SP  - 113337
DO  - 10.1016/j.optmat.2022.113337
ER  - 

@article{
author = "Racu, Andrei V. and Ristić, Zoran and Ćirić, Aleksandar and Ðorđević, Vesna and Buse, Gabriel and Poienar, Maria and Gutmann, Michael J. and Ivashko, Oleh and Stef, Marius and Vizman, Daniel and Dramićanin, Miroslav and Piasecki, Michal and Brik, Mikhail G.",
year = "2023",
abstract = "The understanding of complex relationships between luminescent properties, local symmetry of an emitting center, and the host crystal structure provides a better insight into optical properties of materials. In this work, the alkaline earths CaF2 and BaF2 fluoride crystals doped with 0.1 mol% ErF3 were investigated. The crystals structure has been studied using a synchrotron and laboratory X-ray diffraction. The C3v and C4v sites symmetry were determined using erbium probed high resolution emission spectroscopy (HRPL) at low temperature (LT) of 10 K. The considerable difference in room temperature (RT) optical properties for CaF2 compared to BaF2 crystals was observed. Such difference in absorption intensity of 4.7 times of erbium 4G11/2 manifold in UV, and 7.5 times in green emission from 4S3/2 manifold, could be due to the distinction in the host crystals cationic radius (ΔrCa,Ba) and the dopant-host ionic radius (ΔrCa-Er, ΔrBa-Er). Those Δr differences influence the structure and lead to the following symmetry formation: In CaF2, the C4v and C3v isolated centers were identified, with the determined Er3+- F−i bond lengths of 2.734 Å and 4.735 Å respectively; In BaF2, only C3v isolated centers were identified with the determined Er3+- F−i bond lengths of 5.380 Å. The present work is the first study that takes into account correlations of optical properties, the local symmetry and the structure in mentioned fluorides crystals, and it could be a step forward in the lanthanide doped optical materials systematics.",
journal = "Optical Materials",
title = "Analysis of site symmetries of Er3+ doped CaF2 and BaF2 crystals by high resolution photoluminescence spectroscopy",
volume = "136",
pages = "113337",
doi = "10.1016/j.optmat.2022.113337"
}

Racu, A. V., Ristić, Z., Ćirić, A., Ðorđević, V., Buse, G., Poienar, M., Gutmann, M. J., Ivashko, O., Stef, M., Vizman, D., Dramićanin, M., Piasecki, M.,& Brik, M. G.. (2023). Analysis of site symmetries of Er3+ doped CaF2 and BaF2 crystals by high resolution photoluminescence spectroscopy. in Optical Materials, 136, 113337.
https://doi.org/10.1016/j.optmat.2022.113337

Racu AV, Ristić Z, Ćirić A, Ðorđević V, Buse G, Poienar M, Gutmann MJ, Ivashko O, Stef M, Vizman D, Dramićanin M, Piasecki M, Brik MG. Analysis of site symmetries of Er3+ doped CaF2 and BaF2 crystals by high resolution photoluminescence spectroscopy. in Optical Materials. 2023;136:113337.
doi:10.1016/j.optmat.2022.113337 .

Racu, Andrei V., Ristić, Zoran, Ćirić, Aleksandar, Ðorđević, Vesna, Buse, Gabriel, Poienar, Maria, Gutmann, Michael J., Ivashko, Oleh, Stef, Marius, Vizman, Daniel, Dramićanin, Miroslav, Piasecki, Michal, Brik, Mikhail G., "Analysis of site symmetries of Er3+ doped CaF2 and BaF2 crystals by high resolution photoluminescence spectroscopy" in Optical Materials, 136 (2023):113337,
https://doi.org/10.1016/j.optmat.2022.113337 . .

TY  - JOUR
AU  - Radovanović, Lidija
AU  - Radovanović, Željko
AU  - Simović, Bojana
AU  - Vasić, Milica V.
AU  - Balanč, Bojana
AU  - Dapčević, Aleksandra
AU  - Dramićanin, Miroslav
AU  - Rogan, Jelena
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10873
AB  - A biphasic [Mn(dipya)(H2O)4](tpht)/{[Zn(dipya)(tpht)]·H2O}n com­plex material, I (dipya = 2,2’-dipyridylamine, tpht2– = dianion of terephthalatic acid) was synthesized by ligand exchange reaction and characterized by XRPD and FTIR spectroscopy. A ZnO/ZnMn2O4 composite, II, has been prepared via thermal decomposition of I in an air atmosphere at 450 °C. XRPD, FTIR and FESEM analyses of II revealed the simultaneous presence of spherical nano­particles of wurtzite ZnO and elongated nanoparticles of spinel ZnMn2O4. The specific surface area of II was determined by the BET method, whereas the volume and average size of the mesopores were calculated in accordance with the BJH method. The measurements of the mean size, polydispersity index and zeta potential showed colloidal instability of II. Two band gap values of 2.4 and 3.3 eV were determined using UV–Vis diffuse reflectance spectroscopy, while the measurements of photoluminescence revealed that II is active in the blue region of the visible spectrum. Testing of composite II as a pigmentary material showed that it can be used for the colouring of a ceramic glaze.
T2  - Journal of the Serbian Chemical Society
T1  - Structure and properties of ZnO/ZnMn2O4 composite obtained by thermal decomposition of terephthalate precursor: Scientific paper
VL  - 88
IS  - 3
DO  - 10.2298/JSC221102090R
ER  - 

@article{
author = "Radovanović, Lidija and Radovanović, Željko and Simović, Bojana and Vasić, Milica V. and Balanč, Bojana and Dapčević, Aleksandra and Dramićanin, Miroslav and Rogan, Jelena",
year = "2023",
abstract = "A biphasic [Mn(dipya)(H2O)4](tpht)/{[Zn(dipya)(tpht)]·H2O}n com­plex material, I (dipya = 2,2’-dipyridylamine, tpht2– = dianion of terephthalatic acid) was synthesized by ligand exchange reaction and characterized by XRPD and FTIR spectroscopy. A ZnO/ZnMn2O4 composite, II, has been prepared via thermal decomposition of I in an air atmosphere at 450 °C. XRPD, FTIR and FESEM analyses of II revealed the simultaneous presence of spherical nano­particles of wurtzite ZnO and elongated nanoparticles of spinel ZnMn2O4. The specific surface area of II was determined by the BET method, whereas the volume and average size of the mesopores were calculated in accordance with the BJH method. The measurements of the mean size, polydispersity index and zeta potential showed colloidal instability of II. Two band gap values of 2.4 and 3.3 eV were determined using UV–Vis diffuse reflectance spectroscopy, while the measurements of photoluminescence revealed that II is active in the blue region of the visible spectrum. Testing of composite II as a pigmentary material showed that it can be used for the colouring of a ceramic glaze.",
journal = "Journal of the Serbian Chemical Society",
title = "Structure and properties of ZnO/ZnMn2O4 composite obtained by thermal decomposition of terephthalate precursor: Scientific paper",
volume = "88",
number = "3",
doi = "10.2298/JSC221102090R"
}

Radovanović, L., Radovanović, Ž., Simović, B., Vasić, M. V., Balanč, B., Dapčević, A., Dramićanin, M.,& Rogan, J.. (2023). Structure and properties of ZnO/ZnMn2O4 composite obtained by thermal decomposition of terephthalate precursor: Scientific paper. in Journal of the Serbian Chemical Society, 88(3).
https://doi.org/10.2298/JSC221102090R

Radovanović L, Radovanović Ž, Simović B, Vasić MV, Balanč B, Dapčević A, Dramićanin M, Rogan J. Structure and properties of ZnO/ZnMn2O4 composite obtained by thermal decomposition of terephthalate precursor: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(3).
doi:10.2298/JSC221102090R .

Radovanović, Lidija, Radovanović, Željko, Simović, Bojana, Vasić, Milica V., Balanč, Bojana, Dapčević, Aleksandra, Dramićanin, Miroslav, Rogan, Jelena, "Structure and properties of ZnO/ZnMn2O4 composite obtained by thermal decomposition of terephthalate precursor: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 3 (2023),
https://doi.org/10.2298/JSC221102090R . .

TY  - JOUR
AU  - Elzbieciak-Piecka, K.
AU  - Piotrowski, Wojciech M.
AU  - Dramićanin, Miroslav
AU  - Marciniak, Lukasz
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10875
AB  - Finding thermal history phosphors with high sensitivity and a consistent readout is required for reliable thermal history determination with high temperature resolution. This work presents a new thermal history phosphor based on the luminescence of Eu3+ ions in LaVO4 to meet these requirements. As demonstrated, raising the annealing temperature causes a structural phase transition from a low-temperature tetragonal phase to a high-temperature single-stranded phase. The associated change in the local point symmetry of the crystallographic site occupied by Eu3+ ions result in a significant decrease in the emission intensity ratio of the 5D0 → 7F2 band relative to the 5D0 → 7F1 band, which enables the development of the ratiometric thermal history phosphor with the relative sensitivity of 0.38% °C−1 at 800 °C. Its applicative potential for thermal history readout was proved in the proof-of-concept experiment.
T2  - Dalton Transactions
T1  - Understanding the power of luminescence ratiometric thermal history indicators driven by phase transitions: the case of Eu3+ doped LaVO4
DO  - 10.1039/D3DT00601H
ER  - 

@article{
author = "Elzbieciak-Piecka, K. and Piotrowski, Wojciech M. and Dramićanin, Miroslav and Marciniak, Lukasz",
year = "2023",
abstract = "Finding thermal history phosphors with high sensitivity and a consistent readout is required for reliable thermal history determination with high temperature resolution. This work presents a new thermal history phosphor based on the luminescence of Eu3+ ions in LaVO4 to meet these requirements. As demonstrated, raising the annealing temperature causes a structural phase transition from a low-temperature tetragonal phase to a high-temperature single-stranded phase. The associated change in the local point symmetry of the crystallographic site occupied by Eu3+ ions result in a significant decrease in the emission intensity ratio of the 5D0 → 7F2 band relative to the 5D0 → 7F1 band, which enables the development of the ratiometric thermal history phosphor with the relative sensitivity of 0.38% °C−1 at 800 °C. Its applicative potential for thermal history readout was proved in the proof-of-concept experiment.",
journal = "Dalton Transactions",
title = "Understanding the power of luminescence ratiometric thermal history indicators driven by phase transitions: the case of Eu3+ doped LaVO4",
doi = "10.1039/D3DT00601H"
}

Elzbieciak-Piecka, K., Piotrowski, W. M., Dramićanin, M.,& Marciniak, L.. (2023). Understanding the power of luminescence ratiometric thermal history indicators driven by phase transitions: the case of Eu3+ doped LaVO4. in Dalton Transactions.
https://doi.org/10.1039/D3DT00601H

Elzbieciak-Piecka K, Piotrowski WM, Dramićanin M, Marciniak L. Understanding the power of luminescence ratiometric thermal history indicators driven by phase transitions: the case of Eu3+ doped LaVO4. in Dalton Transactions. 2023;.
doi:10.1039/D3DT00601H .

Elzbieciak-Piecka, K., Piotrowski, Wojciech M., Dramićanin, Miroslav, Marciniak, Lukasz, "Understanding the power of luminescence ratiometric thermal history indicators driven by phase transitions: the case of Eu3+ doped LaVO4" in Dalton Transactions (2023),
https://doi.org/10.1039/D3DT00601H . .

TY  - JOUR
AU  - Alrebdi, Tahani A.
AU  - Alodhayb, Abdullah N.
AU  - Ristić, Zoran
AU  - Dramićanin, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10931
AB  - Herein, we investigate the performance of single- and multiparametric luminescence thermometry founded on the temperature-dependent spectral features of Ca6BaP4O17:Mn5+ near-infrared emission. The material was prepared by a conventional steady-state synthesis, and its photoluminescence emission was measured from 7500 to 10,000 cm−1 over the 293–373 K temperature range in 5 K increments. The spectra are composed of the emissions from 1E → 3A2 and 3T2 → 3A2 electronic transitions and Stokes and anti-Stokes vibronic sidebands at 320 cm−1 and 800 cm−1 from the maximum of 1E → 3A2 emission. Upon temperature increase, the 3T2 and Stokes bands gained in intensity while the maximum of 1E emission band is redshifted. We introduced the procedure for the linearization and feature scaling of input variables for linear multiparametric regression. Then, we experimentally determined accuracies and precisions of the luminescence thermometry based on luminescence intensity ratios between emissions from the 1E and 3T2 states, between Stokes and anti-Stokes emission sidebands, and at the 1E energy maximum. The multiparametric luminescence thermometry involving the same spectral features showed similar performance, comparable to the best single-parameter thermometry.
T2  - Sensors
T1  - Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission
VL  - 23
IS  - 8
SP  - 3839
DO  - 10.3390/s23083839
ER  - 

@article{
author = "Alrebdi, Tahani A. and Alodhayb, Abdullah N. and Ristić, Zoran and Dramićanin, Miroslav",
year = "2023",
abstract = "Herein, we investigate the performance of single- and multiparametric luminescence thermometry founded on the temperature-dependent spectral features of Ca6BaP4O17:Mn5+ near-infrared emission. The material was prepared by a conventional steady-state synthesis, and its photoluminescence emission was measured from 7500 to 10,000 cm−1 over the 293–373 K temperature range in 5 K increments. The spectra are composed of the emissions from 1E → 3A2 and 3T2 → 3A2 electronic transitions and Stokes and anti-Stokes vibronic sidebands at 320 cm−1 and 800 cm−1 from the maximum of 1E → 3A2 emission. Upon temperature increase, the 3T2 and Stokes bands gained in intensity while the maximum of 1E emission band is redshifted. We introduced the procedure for the linearization and feature scaling of input variables for linear multiparametric regression. Then, we experimentally determined accuracies and precisions of the luminescence thermometry based on luminescence intensity ratios between emissions from the 1E and 3T2 states, between Stokes and anti-Stokes emission sidebands, and at the 1E energy maximum. The multiparametric luminescence thermometry involving the same spectral features showed similar performance, comparable to the best single-parameter thermometry.",
journal = "Sensors",
title = "Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission",
volume = "23",
number = "8",
pages = "3839",
doi = "10.3390/s23083839"
}

Alrebdi, T. A., Alodhayb, A. N., Ristić, Z.,& Dramićanin, M.. (2023). Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission. in Sensors, 23(8), 3839.
https://doi.org/10.3390/s23083839

Alrebdi TA, Alodhayb AN, Ristić Z, Dramićanin M. Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission. in Sensors. 2023;23(8):3839.
doi:10.3390/s23083839 .

Alrebdi, Tahani A., Alodhayb, Abdullah N., Ristić, Zoran, Dramićanin, Miroslav, "Comparison of Performance between Single- and Multiparameter Luminescence Thermometry Methods Based on the Mn5+ Near-Infrared Emission" in Sensors, 23, no. 8 (2023):3839,
https://doi.org/10.3390/s23083839 . .

TY  - JOUR
AU  - Rajačić, Milica M.
AU  - Todorović, Dragana J.
AU  - Andrić, Velibor Đ.
AU  - Nikolić, Jelena K.
AU  - Janković, Marija M.
AU  - Pantelić, Gordana K.
AU  - Vukanac, Ivana S.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11065
AB  - In accordance with ISO/IEC 17025:2017, the testing laboratory needs to verify its ability to properly perform methods. For radiological testing, the sampling does not affect the results directly, but it has to ensure that sample adequately represents the tested material. To verify the procedure, a sampling of red mud and bauxite ore was conducted. All samples were measured in identical geometry by HPGe spectrometer. The counting rates per unit mass in the recorded spectra were compared. For each measurement series, the mean and standard deviations of respected peaks were calculated, as well as average and standard deviation of all series. The obtained results of each individual series were considered satisfactory, i.e. sampling procedure ensures the representativeness of the bulk material, if it is within ± two standard deviations of the average of the mean values.
T2  - Radiation Protection Dosimetry
T1  - Verification of the sampling procedure for radioactivity analysis of waste and industrial material
VL  - 199
IS  - 8-9
SP  - 941
EP  - 946
DO  - 10.1093/rpd/ncad095
ER  - 

@article{
author = "Rajačić, Milica M. and Todorović, Dragana J. and Andrić, Velibor Đ. and Nikolić, Jelena K. and Janković, Marija M. and Pantelić, Gordana K. and Vukanac, Ivana S.",
year = "2023",
abstract = "In accordance with ISO/IEC 17025:2017, the testing laboratory needs to verify its ability to properly perform methods. For radiological testing, the sampling does not affect the results directly, but it has to ensure that sample adequately represents the tested material. To verify the procedure, a sampling of red mud and bauxite ore was conducted. All samples were measured in identical geometry by HPGe spectrometer. The counting rates per unit mass in the recorded spectra were compared. For each measurement series, the mean and standard deviations of respected peaks were calculated, as well as average and standard deviation of all series. The obtained results of each individual series were considered satisfactory, i.e. sampling procedure ensures the representativeness of the bulk material, if it is within ± two standard deviations of the average of the mean values.",
journal = "Radiation Protection Dosimetry",
title = "Verification of the sampling procedure for radioactivity analysis of waste and industrial material",
volume = "199",
number = "8-9",
pages = "941-946",
doi = "10.1093/rpd/ncad095"
}

Rajačić, M. M., Todorović, D. J., Andrić, V. Đ., Nikolić, J. K., Janković, M. M., Pantelić, G. K.,& Vukanac, I. S.. (2023). Verification of the sampling procedure for radioactivity analysis of waste and industrial material. in Radiation Protection Dosimetry, 199(8-9), 941-946.
https://doi.org/10.1093/rpd/ncad095

Rajačić MM, Todorović DJ, Andrić VĐ, Nikolić JK, Janković MM, Pantelić GK, Vukanac IS. Verification of the sampling procedure for radioactivity analysis of waste and industrial material. in Radiation Protection Dosimetry. 2023;199(8-9):941-946.
doi:10.1093/rpd/ncad095 .

Rajačić, Milica M., Todorović, Dragana J., Andrić, Velibor Đ., Nikolić, Jelena K., Janković, Marija M., Pantelić, Gordana K., Vukanac, Ivana S., "Verification of the sampling procedure for radioactivity analysis of waste and industrial material" in Radiation Protection Dosimetry, 199, no. 8-9 (2023):941-946,
https://doi.org/10.1093/rpd/ncad095 . .

TY  - JOUR
AU  - Janković, Marija M.
AU  - Jelić, Ivana
AU  - Rajačić, Milica
AU  - Krneta-Nikolić, Jelena D.
AU  - Vukanac, Ivana
AU  - Dimović, Slavko
AU  - Sarap, Nataša
AU  - Šljivić-Ivanović, Marija Z.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10933
AB  - This work presents the natural radioactivity distribution of 21 surface soil samples taken in the city of Novi Sad, Serbia. The analysis for radioactivity was performed using a gas low-level proportional counter for gross alpha and gross beta activity, while the specific activities of radionuclides were determined using HPGe detectors. The gross alpha activity of 20 samples was below the minimum detectable concentration (MDC), while in 1 sample it was 243 Bq kg−1; the gross beta activity ranged from the MDC (11 samples) to 566 Bq kg−1. The gamma spectrometry measurements showed naturally occurring radionuclides 226Ra, 232Th, 40K, and 238U in all investigated samples, with average values (Bq kg−1) of 33.9, 36.7, 513.8, and 34.7, respectively. Natural radionuclide 235U was detected in 18 samples with activity concentrations in the range of 1.3–4.1 Bq kg−1, while in the other 3 samples, the values were below the MDC. The artificial 137Cs radionuclide was detected in 90 percent of the samples, with a maximum value of 21 Bq kg−1, while the other artificial radionuclides were not detected. Based on the obtained concentrations of natural radionuclides, hazard indexes were estimated, and radiological health risk was assessed. The results present the absorbed gamma dose rate in the air, annual effective dose, radium equivalent activity, external hazard index, and lifetime cancer risk.
T2  - Toxics
T1  - Distribution of Natural Radionuclides and 137Cs in Urban Soil Samples from the City of Novi Sad, Serbia-Radiological Risk Assessment
VL  - 11
IS  - 4
SP  - 345
DO  - 10.3390/toxics11040345
ER  - 

@article{
author = "Janković, Marija M. and Jelić, Ivana and Rajačić, Milica and Krneta-Nikolić, Jelena D. and Vukanac, Ivana and Dimović, Slavko and Sarap, Nataša and Šljivić-Ivanović, Marija Z.",
year = "2023",
abstract = "This work presents the natural radioactivity distribution of 21 surface soil samples taken in the city of Novi Sad, Serbia. The analysis for radioactivity was performed using a gas low-level proportional counter for gross alpha and gross beta activity, while the specific activities of radionuclides were determined using HPGe detectors. The gross alpha activity of 20 samples was below the minimum detectable concentration (MDC), while in 1 sample it was 243 Bq kg−1; the gross beta activity ranged from the MDC (11 samples) to 566 Bq kg−1. The gamma spectrometry measurements showed naturally occurring radionuclides 226Ra, 232Th, 40K, and 238U in all investigated samples, with average values (Bq kg−1) of 33.9, 36.7, 513.8, and 34.7, respectively. Natural radionuclide 235U was detected in 18 samples with activity concentrations in the range of 1.3–4.1 Bq kg−1, while in the other 3 samples, the values were below the MDC. The artificial 137Cs radionuclide was detected in 90 percent of the samples, with a maximum value of 21 Bq kg−1, while the other artificial radionuclides were not detected. Based on the obtained concentrations of natural radionuclides, hazard indexes were estimated, and radiological health risk was assessed. The results present the absorbed gamma dose rate in the air, annual effective dose, radium equivalent activity, external hazard index, and lifetime cancer risk.",
journal = "Toxics",
title = "Distribution of Natural Radionuclides and 137Cs in Urban Soil Samples from the City of Novi Sad, Serbia-Radiological Risk Assessment",
volume = "11",
number = "4",
pages = "345",
doi = "10.3390/toxics11040345"
}

Janković, M. M., Jelić, I., Rajačić, M., Krneta-Nikolić, J. D., Vukanac, I., Dimović, S., Sarap, N.,& Šljivić-Ivanović, M. Z.. (2023). Distribution of Natural Radionuclides and 137Cs in Urban Soil Samples from the City of Novi Sad, Serbia-Radiological Risk Assessment. in Toxics, 11(4), 345.
https://doi.org/10.3390/toxics11040345

Janković MM, Jelić I, Rajačić M, Krneta-Nikolić JD, Vukanac I, Dimović S, Sarap N, Šljivić-Ivanović MZ. Distribution of Natural Radionuclides and 137Cs in Urban Soil Samples from the City of Novi Sad, Serbia-Radiological Risk Assessment. in Toxics. 2023;11(4):345.
doi:10.3390/toxics11040345 .

Janković, Marija M., Jelić, Ivana, Rajačić, Milica, Krneta-Nikolić, Jelena D., Vukanac, Ivana, Dimović, Slavko, Sarap, Nataša, Šljivić-Ivanović, Marija Z., "Distribution of Natural Radionuclides and 137Cs in Urban Soil Samples from the City of Novi Sad, Serbia-Radiological Risk Assessment" in Toxics, 11, no. 4 (2023):345,
https://doi.org/10.3390/toxics11040345 . .

TY  - JOUR
AU  - Suljovrujić, Edin H.
AU  - Krstić, Milena P.
AU  - Rogić Miladinović, Zorana
AU  - Petrović, Silvana D.
AU  - Leskovac, Andreja
AU  - Stamboliev, Georgi
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11063
AB  - Hydrogels with oligo(ethylene glycol) (OEG), oligo(propylene glycol) (OPG), and for the first time with combined OEG/OPG pendant chains within the methacrylate (MA) network, were synthesized and the swelling behavior, thermal properties, microstructure, and genotoxicity were investigated. Prior to hydrogel fabrication, an optimized method was developed for oligo(propylene glycol) methacrylate (OPGMA), i.e., oligomer with an LCST below a temperature at which synthesis occurs, indicating that proper preparation and tuning of reaction conditions were required. PEG6MA and PPG5MA homopolymers, as well as P(EG6/PG5)MA copolymer hydrogel, were produced by gamma radiation-induced polymerization and crosslinking of OEG and OPG monomers from the monomer-solvent mixture by using different water/ethanol composition as a solvent and by exposing the reaction mixture to various radiation doses. The combination of OEG and OPG pendant chains within the same network was advantageous in that it allowed an easy tuning of the phase transition temperature. Thus, the volume phase transition (VPT) at temperatures above 70 °C observed in the case of PEG6MA, and in the case of PPG5MA at temperatures below 15 °C, could easily be tuned close to physiological temperatures for P(EG6/PG5)MA hydrogel. Finally, all obtained thermoresponsive hydrogels showed non-genotoxic and non-cytotoxic properties, which indicate promising potential for biomedical applications.
T2  - Reactive and Functional Polymers
T1  - Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications
VL  - 189
SP  - 105612
DO  - 10.1016/j.reactfunctpolym.2023.105612
ER  - 

@article{
author = "Suljovrujić, Edin H. and Krstić, Milena P. and Rogić Miladinović, Zorana and Petrović, Silvana D. and Leskovac, Andreja and Stamboliev, Georgi",
year = "2023",
abstract = "Hydrogels with oligo(ethylene glycol) (OEG), oligo(propylene glycol) (OPG), and for the first time with combined OEG/OPG pendant chains within the methacrylate (MA) network, were synthesized and the swelling behavior, thermal properties, microstructure, and genotoxicity were investigated. Prior to hydrogel fabrication, an optimized method was developed for oligo(propylene glycol) methacrylate (OPGMA), i.e., oligomer with an LCST below a temperature at which synthesis occurs, indicating that proper preparation and tuning of reaction conditions were required. PEG6MA and PPG5MA homopolymers, as well as P(EG6/PG5)MA copolymer hydrogel, were produced by gamma radiation-induced polymerization and crosslinking of OEG and OPG monomers from the monomer-solvent mixture by using different water/ethanol composition as a solvent and by exposing the reaction mixture to various radiation doses. The combination of OEG and OPG pendant chains within the same network was advantageous in that it allowed an easy tuning of the phase transition temperature. Thus, the volume phase transition (VPT) at temperatures above 70 °C observed in the case of PEG6MA, and in the case of PPG5MA at temperatures below 15 °C, could easily be tuned close to physiological temperatures for P(EG6/PG5)MA hydrogel. Finally, all obtained thermoresponsive hydrogels showed non-genotoxic and non-cytotoxic properties, which indicate promising potential for biomedical applications.",
journal = "Reactive and Functional Polymers",
title = "Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications",
volume = "189",
pages = "105612",
doi = "10.1016/j.reactfunctpolym.2023.105612"
}

Suljovrujić, E. H., Krstić, M. P., Rogić Miladinović, Z., Petrović, S. D., Leskovac, A.,& Stamboliev, G.. (2023). Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications. in Reactive and Functional Polymers, 189, 105612.
https://doi.org/10.1016/j.reactfunctpolym.2023.105612

Suljovrujić EH, Krstić MP, Rogić Miladinović Z, Petrović SD, Leskovac A, Stamboliev G. Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications. in Reactive and Functional Polymers. 2023;189:105612.
doi:10.1016/j.reactfunctpolym.2023.105612 .

Suljovrujić, Edin H., Krstić, Milena P., Rogić Miladinović, Zorana, Petrović, Silvana D., Leskovac, Andreja, Stamboliev, Georgi, "Optimization of thermoresponsive hydrogels based on oligomers with lower critical solution temperature (LCST) far below/above physiological temperatures for biomedical applications" in Reactive and Functional Polymers, 189 (2023):105612,
https://doi.org/10.1016/j.reactfunctpolym.2023.105612 . .

TY  - JOUR
AU  - Batalović, Katarina
AU  - Radaković, Jana
AU  - Kuzmanović, Bojana
AU  - Medić-Ilić, Mirjana
AU  - Paskaš Mamula, Bojana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11062
AB  - The development of novel materials for hydrogen storage and conversion applications is expected to facilitate the transition to clean energy. In particular, near-ambient hydrogen storage, thermal energy storage, and lithium conversion electrodes are selected in this study as the applications for which the development of novel Mg-containing materials is of great importance. We utilize a machine learning model, based on the graph neural network, developed for predicting hydride formation enthalpy in intermetallic compounds, to perform high-throughput screening based on the atomic composition and crystal structure of the starting intermetallic compounds. Trends and structure-property relations are discussed, as well as the possibilities for tailoring the stability of Mg-containing hydrides by alloying. For 636 compounds identified as stable by DFT calculations, we predict hydride formation enthalpy and equilibrium potential of metal hydride conversion electrode for Li-ion batteries. Based on the predicted enthalpy of hydride formation, 32 intermetallics are identified as suitable for near-ambient hydrogen storage applications. Among them, MgBe13, seen as a promising material to achieve a high gravimetric density of hydrogen, is additionally studied using DFT. Further investigation of the Na-Mg-Al alloys is proposed as a good route in the search for new thermal energy storage materials. Binary Mg-containing intermetallics are discussed as conversion-type negative electrodes in Li-ion batteries.
T2  - Journal of Energy Storage
T1  - Machine learning-based high-throughput screening of Mg-containing alloys for hydrogen storage and energy conversion applications
VL  - 68
SP  - 107720
DO  - 10.1016/j.est.2023.107720
ER  - 

@article{
author = "Batalović, Katarina and Radaković, Jana and Kuzmanović, Bojana and Medić-Ilić, Mirjana and Paskaš Mamula, Bojana",
year = "2023",
abstract = "The development of novel materials for hydrogen storage and conversion applications is expected to facilitate the transition to clean energy. In particular, near-ambient hydrogen storage, thermal energy storage, and lithium conversion electrodes are selected in this study as the applications for which the development of novel Mg-containing materials is of great importance. We utilize a machine learning model, based on the graph neural network, developed for predicting hydride formation enthalpy in intermetallic compounds, to perform high-throughput screening based on the atomic composition and crystal structure of the starting intermetallic compounds. Trends and structure-property relations are discussed, as well as the possibilities for tailoring the stability of Mg-containing hydrides by alloying. For 636 compounds identified as stable by DFT calculations, we predict hydride formation enthalpy and equilibrium potential of metal hydride conversion electrode for Li-ion batteries. Based on the predicted enthalpy of hydride formation, 32 intermetallics are identified as suitable for near-ambient hydrogen storage applications. Among them, MgBe13, seen as a promising material to achieve a high gravimetric density of hydrogen, is additionally studied using DFT. Further investigation of the Na-Mg-Al alloys is proposed as a good route in the search for new thermal energy storage materials. Binary Mg-containing intermetallics are discussed as conversion-type negative electrodes in Li-ion batteries.",
journal = "Journal of Energy Storage",
title = "Machine learning-based high-throughput screening of Mg-containing alloys for hydrogen storage and energy conversion applications",
volume = "68",
pages = "107720",
doi = "10.1016/j.est.2023.107720"
}

Batalović, K., Radaković, J., Kuzmanović, B., Medić-Ilić, M.,& Paskaš Mamula, B.. (2023). Machine learning-based high-throughput screening of Mg-containing alloys for hydrogen storage and energy conversion applications. in Journal of Energy Storage, 68, 107720.
https://doi.org/10.1016/j.est.2023.107720

Batalović K, Radaković J, Kuzmanović B, Medić-Ilić M, Paskaš Mamula B. Machine learning-based high-throughput screening of Mg-containing alloys for hydrogen storage and energy conversion applications. in Journal of Energy Storage. 2023;68:107720.
doi:10.1016/j.est.2023.107720 .

Batalović, Katarina, Radaković, Jana, Kuzmanović, Bojana, Medić-Ilić, Mirjana, Paskaš Mamula, Bojana, "Machine learning-based high-throughput screening of Mg-containing alloys for hydrogen storage and energy conversion applications" in Journal of Energy Storage, 68 (2023):107720,
https://doi.org/10.1016/j.est.2023.107720 . .

TY  - CONF
AU  - Ivić, Zoran
AU  - Čevizović, Dalibor
AU  - Pržulj, Željko
AU  - Ivković, Ivana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10969
AB  - We present a theoretical prediction of a novel, nonEIT, mechanism for the achievement of a transparency window. It relies on an intrinsically nonlinear (soliton type) mechanism which may be exploited for the production of slow light, which may appear in a photonic band-gap structure: the infinite coupled cavity array (CCA), filled with two-level systems - qubits. Each cavity contains a single qubit. The most important prediction is substantial dependence of the pulse transparency on its width. In particular, the medium is opaque for very short pulses with carrier wave frequency below the photonic gap. When the pulse width exceeds the critical one, a twin transparency window separated by a finite band gap appears in the SIT pulse dispersion law. Both low-frequency TW and the SIT pulse band gap lie entirely within the polaritonic band gap.
PB  - IEEE
C3  - InfoTeh-Jahorina : 22. međunarodni simpozijum INFOTEH-JAHORINA 202; Mart 15-17
T1  - Dispersion Management of Light Pulse Transparency in Quantum Metamaterials
DO  - 10.1109/INFOTEH57020.2023.10094191
ER  - 

@conference{
author = "Ivić, Zoran and Čevizović, Dalibor and Pržulj, Željko and Ivković, Ivana",
year = "2023",
abstract = "We present a theoretical prediction of a novel, nonEIT, mechanism for the achievement of a transparency window. It relies on an intrinsically nonlinear (soliton type) mechanism which may be exploited for the production of slow light, which may appear in a photonic band-gap structure: the infinite coupled cavity array (CCA), filled with two-level systems - qubits. Each cavity contains a single qubit. The most important prediction is substantial dependence of the pulse transparency on its width. In particular, the medium is opaque for very short pulses with carrier wave frequency below the photonic gap. When the pulse width exceeds the critical one, a twin transparency window separated by a finite band gap appears in the SIT pulse dispersion law. Both low-frequency TW and the SIT pulse band gap lie entirely within the polaritonic band gap.",
publisher = "IEEE",
journal = "InfoTeh-Jahorina : 22. međunarodni simpozijum INFOTEH-JAHORINA 202; Mart 15-17",
title = "Dispersion Management of Light Pulse Transparency in Quantum Metamaterials",
doi = "10.1109/INFOTEH57020.2023.10094191"
}

Ivić, Z., Čevizović, D., Pržulj, Ž.,& Ivković, I.. (2023). Dispersion Management of Light Pulse Transparency in Quantum Metamaterials. in InfoTeh-Jahorina : 22. međunarodni simpozijum INFOTEH-JAHORINA 202; Mart 15-17
IEEE..
https://doi.org/10.1109/INFOTEH57020.2023.10094191

Ivić Z, Čevizović D, Pržulj Ž, Ivković I. Dispersion Management of Light Pulse Transparency in Quantum Metamaterials. in InfoTeh-Jahorina : 22. međunarodni simpozijum INFOTEH-JAHORINA 202; Mart 15-17. 2023;.
doi:10.1109/INFOTEH57020.2023.10094191 .

Ivić, Zoran, Čevizović, Dalibor, Pržulj, Željko, Ivković, Ivana, "Dispersion Management of Light Pulse Transparency in Quantum Metamaterials" in InfoTeh-Jahorina : 22. međunarodni simpozijum INFOTEH-JAHORINA 202; Mart 15-17 (2023),
https://doi.org/10.1109/INFOTEH57020.2023.10094191 . .

TY  - CONF
AU  - Mitrović, Nataša
AU  - Zarić, Marina
AU  - Martinović, Jelena
AU  - Guševac Stojanović, Ivana
AU  - Petrović, Snježana
AU  - Paunović, Marija
AU  - Vučić, Vesna
AU  - Grković, Ivana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11050
AB  - It is increasingly apparent that the prevention/treatment of neurodegenerative disorders is not only achieved through pharmacological therapy but also through the consumption of natural products. Flaxseed oil (or linseed oil, FSO) derived from the seeds of the flax (Linum usitatissimum L.) gained worldwide awareness as a neuroprotective agent due to its high content of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Thus, the aim of this study was to examine the preventive effects of dietary FSO in trimethyltin (TMT) - induced hippocampal neurodegeneration and gliosis in female Wistar rats. Animals were continuously treated with FSO (1 ml/kg, orally) for two weeks, then received a single dose of TMT (8 mg/kg, i.p.), and application of FSO continued for twenty-one days. Data have convincingly shown that FSO continuous treatment ameliorated TMT-induced neuronal loss in the CA3 hippocampal region and ameliorated astrogliosis and microgliosis. FSO treatment elevated all tested n-3 fatty acids in the hippocampus: α-linolenic acid (ALA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), and consequently increased total amount of n-3 PUFA. However, no changes in n-6 fatty acids due to FSO treatment were observed. Consequently, FSO lowered n-6/n-3 ratio compared to TMT, having a protective effect on fatty acid profile in hippocampus. These findings support beneficial neuroprotective properties of FSO against TMT-induced model of neurodegeneration and hint at a promising preventive use of FSO in hippocampal degeneration and dysfunction
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Dietary supplementation with flaxseed oil ameliorates trimethyltin (TMT)-induced neurodegeneration and gliosis in female Wistar rats
SP  - 81
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11050
ER  - 

@conference{
author = "Mitrović, Nataša and Zarić, Marina and Martinović, Jelena and Guševac Stojanović, Ivana and Petrović, Snježana and Paunović, Marija and Vučić, Vesna and Grković, Ivana",
year = "2023",
abstract = "It is increasingly apparent that the prevention/treatment of neurodegenerative disorders is not only achieved through pharmacological therapy but also through the consumption of natural products. Flaxseed oil (or linseed oil, FSO) derived from the seeds of the flax (Linum usitatissimum L.) gained worldwide awareness as a neuroprotective agent due to its high content of omega-3 polyunsaturated fatty acids (n-3 PUFAs). Thus, the aim of this study was to examine the preventive effects of dietary FSO in trimethyltin (TMT) - induced hippocampal neurodegeneration and gliosis in female Wistar rats. Animals were continuously treated with FSO (1 ml/kg, orally) for two weeks, then received a single dose of TMT (8 mg/kg, i.p.), and application of FSO continued for twenty-one days. Data have convincingly shown that FSO continuous treatment ameliorated TMT-induced neuronal loss in the CA3 hippocampal region and ameliorated astrogliosis and microgliosis. FSO treatment elevated all tested n-3 fatty acids in the hippocampus: α-linolenic acid (ALA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA), and consequently increased total amount of n-3 PUFA. However, no changes in n-6 fatty acids due to FSO treatment were observed. Consequently, FSO lowered n-6/n-3 ratio compared to TMT, having a protective effect on fatty acid profile in hippocampus. These findings support beneficial neuroprotective properties of FSO against TMT-induced model of neurodegeneration and hint at a promising preventive use of FSO in hippocampal degeneration and dysfunction",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Dietary supplementation with flaxseed oil ameliorates trimethyltin (TMT)-induced neurodegeneration and gliosis in female Wistar rats",
pages = "81",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11050"
}

Mitrović, N., Zarić, M., Martinović, J., Guševac Stojanović, I., Petrović, S., Paunović, M., Vučić, V.,& Grković, I.. (2023). Dietary supplementation with flaxseed oil ameliorates trimethyltin (TMT)-induced neurodegeneration and gliosis in female Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 81.
https://hdl.handle.net/21.15107/rcub_vinar_11050

Mitrović N, Zarić M, Martinović J, Guševac Stojanović I, Petrović S, Paunović M, Vučić V, Grković I. Dietary supplementation with flaxseed oil ameliorates trimethyltin (TMT)-induced neurodegeneration and gliosis in female Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:81.
https://hdl.handle.net/21.15107/rcub_vinar_11050 .

Mitrović, Nataša, Zarić, Marina, Martinović, Jelena, Guševac Stojanović, Ivana, Petrović, Snježana, Paunović, Marija, Vučić, Vesna, Grković, Ivana, "Dietary supplementation with flaxseed oil ameliorates trimethyltin (TMT)-induced neurodegeneration and gliosis in female Wistar rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):81,
https://hdl.handle.net/21.15107/rcub_vinar_11050 .

TY  - CONF
AU  - Jovanović Macura, Irena
AU  - Đuričić, Ivana
AU  - Major, Tamara
AU  - Milanović, Desanka
AU  - Brkić, Marjana
AU  - Šobajić, Slađana
AU  - Kanazir, Selma
AU  - Ivković, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11049
AB  - Mfsd2a is expressed mainly in the endothelial cells and is an essential regulator of blood vessel transcytosis. Therefore, decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Mfsd2a is also the main docosahexaenoic acid (DHA, C22:6n3) transporter. DHA, an omega-3 fatty acid, is one of the main structural lipids of the neuronal and vascular retina, crucial for the normal functioning of photoreceptors (PRs). However, the capacity of the retina to synthesize DHA is limited, and the maintenance of retinal DHA content relies on the uptake from bloodborne lipids. The currently recommended FO doses yielded low PUFAs tissue bioavailability, and supplementation with higher doses has been increasingly recommended. Nevertheless, the effects of higher FO doses on retinal Mfsd2a expression and blood vessels coverage are unknown. Western blot and qPCR analyses showed that high dose FO supplementation increased Mfsd2a expression in the retina. Immunohistochemical analyses of Mfsd2a expression on retinal blood vessels (labeled with 488-conjugated Lycopersicon esculentum, lectin) and subsequent ImageJ analyses revealed 1.32-fold increase in the Mfsd2a retinal blood vessel coverage. In the same time the pericyte blood vessel coverage (CD13+ cells) was not affected with FO supplementation, and the increase in Mfsd2a blood vessel expression is not the result of the increased pericyte coverage. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels that can serve either as prophylaxis in the healthy eye or as an adjuvant in developing targeted manipulations of the barrier during diseases.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - The high-dose fish oil (FO) supplementation increased Mfsd2a expression in the retina of healthy mice
SP  - 66
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11049
ER  - 

@conference{
author = "Jovanović Macura, Irena and Đuričić, Ivana and Major, Tamara and Milanović, Desanka and Brkić, Marjana and Šobajić, Slađana and Kanazir, Selma and Ivković, Sanja",
year = "2023",
abstract = "Mfsd2a is expressed mainly in the endothelial cells and is an essential regulator of blood vessel transcytosis. Therefore, decrease in Mfsd2a expression can be a risk factor for developing leaky blood vessels. Mfsd2a is also the main docosahexaenoic acid (DHA, C22:6n3) transporter. DHA, an omega-3 fatty acid, is one of the main structural lipids of the neuronal and vascular retina, crucial for the normal functioning of photoreceptors (PRs). However, the capacity of the retina to synthesize DHA is limited, and the maintenance of retinal DHA content relies on the uptake from bloodborne lipids. The currently recommended FO doses yielded low PUFAs tissue bioavailability, and supplementation with higher doses has been increasingly recommended. Nevertheless, the effects of higher FO doses on retinal Mfsd2a expression and blood vessels coverage are unknown. Western blot and qPCR analyses showed that high dose FO supplementation increased Mfsd2a expression in the retina. Immunohistochemical analyses of Mfsd2a expression on retinal blood vessels (labeled with 488-conjugated Lycopersicon esculentum, lectin) and subsequent ImageJ analyses revealed 1.32-fold increase in the Mfsd2a retinal blood vessel coverage. In the same time the pericyte blood vessel coverage (CD13+ cells) was not affected with FO supplementation, and the increase in Mfsd2a blood vessel expression is not the result of the increased pericyte coverage. Therefore, the high-dose FO supplementation emerges as the prophylactic fortifier of the retinal blood vessels that can serve either as prophylaxis in the healthy eye or as an adjuvant in developing targeted manipulations of the barrier during diseases.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "The high-dose fish oil (FO) supplementation increased Mfsd2a expression in the retina of healthy mice",
pages = "66",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11049"
}

Jovanović Macura, I., Đuričić, I., Major, T., Milanović, D., Brkić, M., Šobajić, S., Kanazir, S.,& Ivković, S.. (2023). The high-dose fish oil (FO) supplementation increased Mfsd2a expression in the retina of healthy mice. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 66.
https://hdl.handle.net/21.15107/rcub_vinar_11049

Jovanović Macura I, Đuričić I, Major T, Milanović D, Brkić M, Šobajić S, Kanazir S, Ivković S. The high-dose fish oil (FO) supplementation increased Mfsd2a expression in the retina of healthy mice. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:66.
https://hdl.handle.net/21.15107/rcub_vinar_11049 .

Jovanović Macura, Irena, Đuričić, Ivana, Major, Tamara, Milanović, Desanka, Brkić, Marjana, Šobajić, Slađana, Kanazir, Selma, Ivković, Sanja, "The high-dose fish oil (FO) supplementation increased Mfsd2a expression in the retina of healthy mice" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):66,
https://hdl.handle.net/21.15107/rcub_vinar_11049 .

TY  - CONF
AU  - Zarić Kontić, Marina
AU  - Dragić, Milorad
AU  - Martinović, Jelena
AU  - Mihajlović, Katarina
AU  - Brkić, Željka
AU  - Mitrović, Nataša
AU  - Guševac Stojanović, Ivana
AU  - Grković, Ivana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11048
AB  - The benzodiazepine alprazolam (ALP) is commonly prescribed to treat anxiety, panic, and sleep disorders. However, ALP is often abused for prolonged periods of time, leading to severe side effects such as tolerance, dependence, and withdrawal syndrome. Previous literature data suggest that neuroadaptive changes at synaptic receptors, such as gammaaminobutyric acid receptor type A (GABAAR) and glutamatergic receptors, may be responsible for the occurrence and development of the aforementioned side effects. Therefore, the present study investigated the potential effects of prolonged ALP treatment (2 mg/kg, ip.) on the α1-subunit containing GABAAR and components of glutamatergic neurotransmission in the hippocampus of adult male Wistar rats. The study revealed behavioral changes consistent with a possible onset of tolerance and associated changes in the GABAergic and glutamatergic systems. The primary target of ALP, the α1-subunit containing GABAAR, was decreased indicating its potential downregulation by prolonged agonist (ALP) action. Considering studied glutamatergic components, an increase in NMDAR subunits, a decrease in vGlut1, and differential modulation of excitatory amino acid transporters 1 and 2 (EAAT1/2, in vivo and in vitro) were observed. These changes may all together indicate a compensatory mechanism due to the sustained suppression of glutamatergic neurons by enhanced inhibitory impulses from GABAergic neurons. The data presented provide valuable and, to our knowledge, the first information on components of glutamatergic neurotransmission after prolonged ALP treatment and their potential impact on the development of side effects. However, further research is needed to examine the observed changes in detail.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Long-term alprazolam treatment may cause tolerance development by modulating components of glutamatergic neurotransmission in the hippocampus of male Wistar rats
SP  - 60
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11048
ER  - 

@conference{
author = "Zarić Kontić, Marina and Dragić, Milorad and Martinović, Jelena and Mihajlović, Katarina and Brkić, Željka and Mitrović, Nataša and Guševac Stojanović, Ivana and Grković, Ivana",
year = "2023",
abstract = "The benzodiazepine alprazolam (ALP) is commonly prescribed to treat anxiety, panic, and sleep disorders. However, ALP is often abused for prolonged periods of time, leading to severe side effects such as tolerance, dependence, and withdrawal syndrome. Previous literature data suggest that neuroadaptive changes at synaptic receptors, such as gammaaminobutyric acid receptor type A (GABAAR) and glutamatergic receptors, may be responsible for the occurrence and development of the aforementioned side effects. Therefore, the present study investigated the potential effects of prolonged ALP treatment (2 mg/kg, ip.) on the α1-subunit containing GABAAR and components of glutamatergic neurotransmission in the hippocampus of adult male Wistar rats. The study revealed behavioral changes consistent with a possible onset of tolerance and associated changes in the GABAergic and glutamatergic systems. The primary target of ALP, the α1-subunit containing GABAAR, was decreased indicating its potential downregulation by prolonged agonist (ALP) action. Considering studied glutamatergic components, an increase in NMDAR subunits, a decrease in vGlut1, and differential modulation of excitatory amino acid transporters 1 and 2 (EAAT1/2, in vivo and in vitro) were observed. These changes may all together indicate a compensatory mechanism due to the sustained suppression of glutamatergic neurons by enhanced inhibitory impulses from GABAergic neurons. The data presented provide valuable and, to our knowledge, the first information on components of glutamatergic neurotransmission after prolonged ALP treatment and their potential impact on the development of side effects. However, further research is needed to examine the observed changes in detail.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Long-term alprazolam treatment may cause tolerance development by modulating components of glutamatergic neurotransmission in the hippocampus of male Wistar rats",
pages = "60",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11048"
}

Zarić Kontić, M., Dragić, M., Martinović, J., Mihajlović, K., Brkić, Ž., Mitrović, N., Guševac Stojanović, I.,& Grković, I.. (2023). Long-term alprazolam treatment may cause tolerance development by modulating components of glutamatergic neurotransmission in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 60.
https://hdl.handle.net/21.15107/rcub_vinar_11048

Zarić Kontić M, Dragić M, Martinović J, Mihajlović K, Brkić Ž, Mitrović N, Guševac Stojanović I, Grković I. Long-term alprazolam treatment may cause tolerance development by modulating components of glutamatergic neurotransmission in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:60.
https://hdl.handle.net/21.15107/rcub_vinar_11048 .

Zarić Kontić, Marina, Dragić, Milorad, Martinović, Jelena, Mihajlović, Katarina, Brkić, Željka, Mitrović, Nataša, Guševac Stojanović, Ivana, Grković, Ivana, "Long-term alprazolam treatment may cause tolerance development by modulating components of glutamatergic neurotransmission in the hippocampus of male Wistar rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):60,
https://hdl.handle.net/21.15107/rcub_vinar_11048 .

TY  - CONF
AU  - Martinović, Jelena
AU  - Zarić Kontić, Marina
AU  - Guševac Stojanović, Ivana
AU  - Mitrović, Nataša
AU  - Grković, Ivana
AU  - Stojanović, Zoran
AU  - Drakulić, Dunja
AU  - Samardžić, Janko
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11047
AB  - Zaleplon, a member of Z-drugs, is a pyrazolopyrimidine hypnotic with sedative, anxiolytic, anticonvulsant and muscle relaxant properties. Zaleplon is approved for the short-term management of insomnia since acting as positive γ-aminobutyric acid (GABA) receptor allosteric modulator increases efficacy of inhibition on brain excitability. Importantly, for the proper functioning of the brain a balance between inhibitory (i.e., GABAergic) and excitatory (i.e., glutamatergic) system must be accomplished. This may be fulfilled by control of presynaptic elements (synthesis or degradation of glutamate and GABA neurotransmitters, their compartmentation, releasing and recycling) and regulation of expression and function of glutamate and GABA receptors. Hence, we aimed to investigate effects of prolonged zaleplon treatment on the expression of proteins involved in the gabaergic and glutamatergic signalization in the hippocampus of adult male Wistar rats. Five-day intraperitoneal administration increased level of components of GABAergic signalization (glutamate decarboxylase 67-GAD67, vesicular GABA transporter-VGAT and α1 subunit of GABA receptor-GABAAα1). This was accompanied by increased level of glutamatergic components (vesicular glutamate transporter 1-vGlut1 and subunits of glutamate N-Methyl-d-aspartate receptor-NMDAR, namely NR1, NR2A, NR2B), which clearly indicate maintenance of balance between main inhibitory and excitatory neurotransmitters. Given the importance of equilibrium of these systems for neuronal excitability, synaptic plasticity and cognitive functions, as well as its involvement in the mood, feeding behavior, reproductive functions, pain sensitivity, aging, etc., the current and prospective pharmaceuticals increasingly rely on GABA/glutamate balance
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats
SP  - 59
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11047
ER  - 

@conference{
author = "Martinović, Jelena and Zarić Kontić, Marina and Guševac Stojanović, Ivana and Mitrović, Nataša and Grković, Ivana and Stojanović, Zoran and Drakulić, Dunja and Samardžić, Janko",
year = "2023",
abstract = "Zaleplon, a member of Z-drugs, is a pyrazolopyrimidine hypnotic with sedative, anxiolytic, anticonvulsant and muscle relaxant properties. Zaleplon is approved for the short-term management of insomnia since acting as positive γ-aminobutyric acid (GABA) receptor allosteric modulator increases efficacy of inhibition on brain excitability. Importantly, for the proper functioning of the brain a balance between inhibitory (i.e., GABAergic) and excitatory (i.e., glutamatergic) system must be accomplished. This may be fulfilled by control of presynaptic elements (synthesis or degradation of glutamate and GABA neurotransmitters, their compartmentation, releasing and recycling) and regulation of expression and function of glutamate and GABA receptors. Hence, we aimed to investigate effects of prolonged zaleplon treatment on the expression of proteins involved in the gabaergic and glutamatergic signalization in the hippocampus of adult male Wistar rats. Five-day intraperitoneal administration increased level of components of GABAergic signalization (glutamate decarboxylase 67-GAD67, vesicular GABA transporter-VGAT and α1 subunit of GABA receptor-GABAAα1). This was accompanied by increased level of glutamatergic components (vesicular glutamate transporter 1-vGlut1 and subunits of glutamate N-Methyl-d-aspartate receptor-NMDAR, namely NR1, NR2A, NR2B), which clearly indicate maintenance of balance between main inhibitory and excitatory neurotransmitters. Given the importance of equilibrium of these systems for neuronal excitability, synaptic plasticity and cognitive functions, as well as its involvement in the mood, feeding behavior, reproductive functions, pain sensitivity, aging, etc., the current and prospective pharmaceuticals increasingly rely on GABA/glutamate balance",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats",
pages = "59",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11047"
}

Martinović, J., Zarić Kontić, M., Guševac Stojanović, I., Mitrović, N., Grković, I., Stojanović, Z., Drakulić, D.,& Samardžić, J.. (2023). Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 59.
https://hdl.handle.net/21.15107/rcub_vinar_11047

Martinović J, Zarić Kontić M, Guševac Stojanović I, Mitrović N, Grković I, Stojanović Z, Drakulić D, Samardžić J. Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:59.
https://hdl.handle.net/21.15107/rcub_vinar_11047 .

Martinović, Jelena, Zarić Kontić, Marina, Guševac Stojanović, Ivana, Mitrović, Nataša, Grković, Ivana, Stojanović, Zoran, Drakulić, Dunja, Samardžić, Janko, "Prolonged zaleplon treatment enhance GABAergic and glutamatergic signaling in the hippocampus of male Wistar rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):59,
https://hdl.handle.net/21.15107/rcub_vinar_11047 .

TY  - CONF
AU  - Stanisavljević Ilić, Andrijana
AU  - Filipović, Dragana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11046
AB  - The alterations of gamma-aminobutyric acid (GABA) neurotransmission induced by psychosocial stress are implicated in the pathophysiology of major depressive disorder and anxiety. Olanzapine (Olz), an atypical antipsychotic, is used to treat psychiatric disorders. Since GABAergic signaling has been proposed as a potential therapeutic target for antipsychotics, we aimed to determine the susceptibility of different layers (1;2/3/4;5/6) in the retrosplenial cortex (RSC), including both granular c (RSGc) and dysgranular (RSD) subregions, in adult male rats exposed to chronic social isolation (CSIS) (six weeks), an animal model of depression, and/or treatment with Olz (7.5 mg/kg/day) (lasting 3 weeks of six-week CSIS), on the protein expression of parvalbumin interneurons, the largest class of GABAergic inhibitory neurons, and glutamate decarboxylase 67 (GAD67), as the main GABA-synthesizing enzyme. Results showed that CSIS decreased the number of GAD67 positive (GAD67+) cells in 5/6 layers of RSGc and increased in 1 and 2/3/4 layers of RSD, with no significant effect on PV positive (PV+) cells. Treatment with Olz in CSIS rats increased the number of GAD67+ cells in the 5/6 layers of the RSC and decreased in 1 and 2/3/4 layers of the RSD. Regarding PV+ cells, Olz treatment led to a decrease in 2/3/4 layers of RSD with no significant effect in RSGc. Overall, this study provided an insight into the neuroinhibitory transmission in the RSC, at the level of subregions and layers following CSIS and/or Olz treatment, and its involvement in the rat model of depression.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Olanzapine effects on parvalbumin/GAD67 protein expression in the layers of the retrosplenial cortex in chronically socially isolated rats
SP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11046
ER  - 

@conference{
author = "Stanisavljević Ilić, Andrijana and Filipović, Dragana",
year = "2023",
abstract = "The alterations of gamma-aminobutyric acid (GABA) neurotransmission induced by psychosocial stress are implicated in the pathophysiology of major depressive disorder and anxiety. Olanzapine (Olz), an atypical antipsychotic, is used to treat psychiatric disorders. Since GABAergic signaling has been proposed as a potential therapeutic target for antipsychotics, we aimed to determine the susceptibility of different layers (1;2/3/4;5/6) in the retrosplenial cortex (RSC), including both granular c (RSGc) and dysgranular (RSD) subregions, in adult male rats exposed to chronic social isolation (CSIS) (six weeks), an animal model of depression, and/or treatment with Olz (7.5 mg/kg/day) (lasting 3 weeks of six-week CSIS), on the protein expression of parvalbumin interneurons, the largest class of GABAergic inhibitory neurons, and glutamate decarboxylase 67 (GAD67), as the main GABA-synthesizing enzyme. Results showed that CSIS decreased the number of GAD67 positive (GAD67+) cells in 5/6 layers of RSGc and increased in 1 and 2/3/4 layers of RSD, with no significant effect on PV positive (PV+) cells. Treatment with Olz in CSIS rats increased the number of GAD67+ cells in the 5/6 layers of the RSC and decreased in 1 and 2/3/4 layers of the RSD. Regarding PV+ cells, Olz treatment led to a decrease in 2/3/4 layers of RSD with no significant effect in RSGc. Overall, this study provided an insight into the neuroinhibitory transmission in the RSC, at the level of subregions and layers following CSIS and/or Olz treatment, and its involvement in the rat model of depression.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Olanzapine effects on parvalbumin/GAD67 protein expression in the layers of the retrosplenial cortex in chronically socially isolated rats",
pages = "58",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11046"
}

Stanisavljević Ilić, A.,& Filipović, D.. (2023). Olanzapine effects on parvalbumin/GAD67 protein expression in the layers of the retrosplenial cortex in chronically socially isolated rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 58.
https://hdl.handle.net/21.15107/rcub_vinar_11046

Stanisavljević Ilić A, Filipović D. Olanzapine effects on parvalbumin/GAD67 protein expression in the layers of the retrosplenial cortex in chronically socially isolated rats. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:58.
https://hdl.handle.net/21.15107/rcub_vinar_11046 .

Stanisavljević Ilić, Andrijana, Filipović, Dragana, "Olanzapine effects on parvalbumin/GAD67 protein expression in the layers of the retrosplenial cortex in chronically socially isolated rats" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):58,
https://hdl.handle.net/21.15107/rcub_vinar_11046 .

TY  - CONF
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Pajović, Milica
AU  - Glavonić, Emilija
AU  - Živanović, Ana
AU  - Aleksić, Minja
AU  - Ivković, Sanja
AU  - Elliot, Evan
AU  - Adžić, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11045
AB  - There is accumulating evidence demonstrating effects of gastrointestinal microbiota on brain function and behavior, including depressive behavior. We have demonstrated that antidepressants, the main drugs used for alleviating depression, affect gut microbiota composition as well, and in this way partly contribute to improvement of depressive symptoms. Specifically, our results showed that several types of antidepressants reduced abundance of bacterial genera Ruminococcus, while supplementation with R. flavefaciens diminished antidepressant-induced decrease of depressive behavior. Treatment with R. flavefaciens affected cortical gene networks, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity, suggesting a mechanism for microbial regulation of antidepressant treatment efficiency. In further studies, we are aiming to delineate the role of gut microbiota in conveying the long-term effects of adolescent stress on development of anxiety and depressive behavior.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - The role of gut microbiota in depressive behavior and the effects of antidepressants
SP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11045
ER  - 

@conference{
author = "Lukić, Iva and Mitić, Miloš and Pajović, Milica and Glavonić, Emilija and Živanović, Ana and Aleksić, Minja and Ivković, Sanja and Elliot, Evan and Adžić, Miroslav",
year = "2023",
abstract = "There is accumulating evidence demonstrating effects of gastrointestinal microbiota on brain function and behavior, including depressive behavior. We have demonstrated that antidepressants, the main drugs used for alleviating depression, affect gut microbiota composition as well, and in this way partly contribute to improvement of depressive symptoms. Specifically, our results showed that several types of antidepressants reduced abundance of bacterial genera Ruminococcus, while supplementation with R. flavefaciens diminished antidepressant-induced decrease of depressive behavior. Treatment with R. flavefaciens affected cortical gene networks, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity, suggesting a mechanism for microbial regulation of antidepressant treatment efficiency. In further studies, we are aiming to delineate the role of gut microbiota in conveying the long-term effects of adolescent stress on development of anxiety and depressive behavior.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "The role of gut microbiota in depressive behavior and the effects of antidepressants",
pages = "44",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11045"
}

Lukić, I., Mitić, M., Pajović, M., Glavonić, E., Živanović, A., Aleksić, M., Ivković, S., Elliot, E.,& Adžić, M.. (2023). The role of gut microbiota in depressive behavior and the effects of antidepressants. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 44.
https://hdl.handle.net/21.15107/rcub_vinar_11045

Lukić I, Mitić M, Pajović M, Glavonić E, Živanović A, Aleksić M, Ivković S, Elliot E, Adžić M. The role of gut microbiota in depressive behavior and the effects of antidepressants. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:44.
https://hdl.handle.net/21.15107/rcub_vinar_11045 .

Lukić, Iva, Mitić, Miloš, Pajović, Milica, Glavonić, Emilija, Živanović, Ana, Aleksić, Minja, Ivković, Sanja, Elliot, Evan, Adžić, Miroslav, "The role of gut microbiota in depressive behavior and the effects of antidepressants" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):44,
https://hdl.handle.net/21.15107/rcub_vinar_11045 .

TY  - JOUR
AU  - Adžić, Miroslav
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Glavonić, Emilija
AU  - Dragićević, Nina
AU  - Ivković, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11044
AB  - Major depressive disorder (MDD) afflicts approximately 5 % of the world population, and about 30–50 % of patients who receive classical antidepressant medications do not achieve complete remission (treatment resistant depressive patients). Emerging evidence suggests that targeting opioid receptors mu (MOP), kappa (KOP), delta (DOP), and the nociceptin/orphanin FQ receptor (NOP) may yield effective therapeutics for stress-related psychiatric disorders. As depression and pain exhibit significant overlap in their clinical manifestations and molecular mechanisms involved, it is not a surprise that opioids, historically used to alleviate pain, emerged as promising and effective therapeutic options in the treatment of depression. The opioid signaling is dysregulated in depression and numerous preclinical studies and clinical trials strongly suggest that opioid modulation can serve as either an adjuvant or even an alternative to classical monoaminergic antidepressants. Importantly, some classical antidepressants require the opioid receptor modulation to exert their antidepressant effects. Finally, ketamine, a well-known anesthetic whose extremely efficient antidepressant effects were recently discovered, was shown to mediate its antidepressant effects via the endogenous opioid system. Thus, although opioid system modulation is a promising therapeutical venue in the treatment of depression further research is warranted to fully understand the benefits and weaknesses of such approach.
T2  - Life Sciences
T2  - Life SciencesLife Sciences
T1  - Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine
VL  - 326
SP  - 121803
DO  - 10.1016/j.lfs.2023.121803
ER  - 

@article{
author = "Adžić, Miroslav and Lukić, Iva and Mitić, Miloš and Glavonić, Emilija and Dragićević, Nina and Ivković, Sanja",
year = "2023",
abstract = "Major depressive disorder (MDD) afflicts approximately 5 % of the world population, and about 30–50 % of patients who receive classical antidepressant medications do not achieve complete remission (treatment resistant depressive patients). Emerging evidence suggests that targeting opioid receptors mu (MOP), kappa (KOP), delta (DOP), and the nociceptin/orphanin FQ receptor (NOP) may yield effective therapeutics for stress-related psychiatric disorders. As depression and pain exhibit significant overlap in their clinical manifestations and molecular mechanisms involved, it is not a surprise that opioids, historically used to alleviate pain, emerged as promising and effective therapeutic options in the treatment of depression. The opioid signaling is dysregulated in depression and numerous preclinical studies and clinical trials strongly suggest that opioid modulation can serve as either an adjuvant or even an alternative to classical monoaminergic antidepressants. Importantly, some classical antidepressants require the opioid receptor modulation to exert their antidepressant effects. Finally, ketamine, a well-known anesthetic whose extremely efficient antidepressant effects were recently discovered, was shown to mediate its antidepressant effects via the endogenous opioid system. Thus, although opioid system modulation is a promising therapeutical venue in the treatment of depression further research is warranted to fully understand the benefits and weaknesses of such approach.",
journal = "Life Sciences, Life SciencesLife Sciences",
title = "Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine",
volume = "326",
pages = "121803",
doi = "10.1016/j.lfs.2023.121803"
}

Adžić, M., Lukić, I., Mitić, M., Glavonić, E., Dragićević, N.,& Ivković, S.. (2023). Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine. in Life Sciences, 326, 121803.
https://doi.org/10.1016/j.lfs.2023.121803

Adžić M, Lukić I, Mitić M, Glavonić E, Dragićević N, Ivković S. Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine. in Life Sciences. 2023;326:121803.
doi:10.1016/j.lfs.2023.121803 .

Adžić, Miroslav, Lukić, Iva, Mitić, Miloš, Glavonić, Emilija, Dragićević, Nina, Ivković, Sanja, "Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine" in Life Sciences, 326 (2023):121803,
https://doi.org/10.1016/j.lfs.2023.121803 . .

TY  - CONF
AU  - Grković, Ivana
AU  - Dragić, Milorad
AU  - Mitrović, Nataša
AU  - Zarić Kontić, Marina
AU  - Martinović, Jelena
AU  - Guševac Stojanović, Ivana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11061
AB  - Adenosine 5'-triphosphate (ATP) and adenosine are versatile signaling molecules involved in many pathophysiological processes in the nervous system. They can be released from all types of brain cells in the extracellular space and activates purinergic receptors. Signaling via extracellular ATP is regulated by cell-surface located ectonucleotidases. Extracellular AMP resulting from the hydrolysis of ATP and ADP can in turn be hydrolyzed into adenosine by ecto-5'-nucleotidase (eN). We examined the involvement of purinergic signaling components in the rat model of trimethyltin (TMT)-induced hippocampal neurodegeneration (8mg/kg, single ip), which results in behavioral and neurological dysfunction similar as in Alzheimer's disease models. Enzyme histochemistry and immunohistochemistry (ir) showed that products of AMPase activity and eN-ir were accumulated in the neuronal strata, infiltrating within neuronal cell layers, depicting individual round-shaped elements that covered neuronal layers with pronounced cell death mostly at the late stage of TMT-induced neurodegeneration. Co-localization with Iba1+ specifically marked eN at amoeboid microglial cells. Neither of the tested pro-inflammatory cytokines (IL-1β, TNF-α, IL10) and C3 nor polarization marker iNOS was found in association with those Iba1/eN+ -cells. Iba1-ir cells co-localized with Arg1-ir and phagocytic marker CD68- ir. Marked induction of P2Y12R-, P2Y6R-, and P2X4-mRNA at the early stage of TMT-induced neurodegeneration might reflect the migration, and chemotaxis of microglia, while induction of P2X7R at amoeboid cells probably modulates their phagocytic role. These findings may contribute to a better understanding of the involvement of purinergic signaling components in the progression of neurodegenerative disorders that could be target molecules for development of novel therapies.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Ecto-5'-nucleotidase marks amoeboid microglial cells in the rat model of neurodegeneration
SP  - 120
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11061
ER  - 

@conference{
author = "Grković, Ivana and Dragić, Milorad and Mitrović, Nataša and Zarić Kontić, Marina and Martinović, Jelena and Guševac Stojanović, Ivana",
year = "2023",
abstract = "Adenosine 5'-triphosphate (ATP) and adenosine are versatile signaling molecules involved in many pathophysiological processes in the nervous system. They can be released from all types of brain cells in the extracellular space and activates purinergic receptors. Signaling via extracellular ATP is regulated by cell-surface located ectonucleotidases. Extracellular AMP resulting from the hydrolysis of ATP and ADP can in turn be hydrolyzed into adenosine by ecto-5'-nucleotidase (eN). We examined the involvement of purinergic signaling components in the rat model of trimethyltin (TMT)-induced hippocampal neurodegeneration (8mg/kg, single ip), which results in behavioral and neurological dysfunction similar as in Alzheimer's disease models. Enzyme histochemistry and immunohistochemistry (ir) showed that products of AMPase activity and eN-ir were accumulated in the neuronal strata, infiltrating within neuronal cell layers, depicting individual round-shaped elements that covered neuronal layers with pronounced cell death mostly at the late stage of TMT-induced neurodegeneration. Co-localization with Iba1+ specifically marked eN at amoeboid microglial cells. Neither of the tested pro-inflammatory cytokines (IL-1β, TNF-α, IL10) and C3 nor polarization marker iNOS was found in association with those Iba1/eN+ -cells. Iba1-ir cells co-localized with Arg1-ir and phagocytic marker CD68- ir. Marked induction of P2Y12R-, P2Y6R-, and P2X4-mRNA at the early stage of TMT-induced neurodegeneration might reflect the migration, and chemotaxis of microglia, while induction of P2X7R at amoeboid cells probably modulates their phagocytic role. These findings may contribute to a better understanding of the involvement of purinergic signaling components in the progression of neurodegenerative disorders that could be target molecules for development of novel therapies.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Ecto-5'-nucleotidase marks amoeboid microglial cells in the rat model of neurodegeneration",
pages = "120",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11061"
}

Grković, I., Dragić, M., Mitrović, N., Zarić Kontić, M., Martinović, J.,& Guševac Stojanović, I.. (2023). Ecto-5'-nucleotidase marks amoeboid microglial cells in the rat model of neurodegeneration. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 120.
https://hdl.handle.net/21.15107/rcub_vinar_11061

Grković I, Dragić M, Mitrović N, Zarić Kontić M, Martinović J, Guševac Stojanović I. Ecto-5'-nucleotidase marks amoeboid microglial cells in the rat model of neurodegeneration. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:120.
https://hdl.handle.net/21.15107/rcub_vinar_11061 .

Grković, Ivana, Dragić, Milorad, Mitrović, Nataša, Zarić Kontić, Marina, Martinović, Jelena, Guševac Stojanović, Ivana, "Ecto-5'-nucleotidase marks amoeboid microglial cells in the rat model of neurodegeneration" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):120,
https://hdl.handle.net/21.15107/rcub_vinar_11061 .

TY  - CONF
AU  - Bobić, Katarina
AU  - Guševac Stojanović, Ivana
AU  - Todorović, Ana
AU  - Veljković, Filip
AU  - Pejić, Snežana
AU  - Martinović, Jelena
AU  - Drakulić, Dunja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11060
AB  - Prolonged disturbance of cerebral blood flow causes metabolic insufficiency and neuronal hypofunction, for which there is still no adequate therapeutic strategy. In several animal models of neurodegenerative diseases, progesterone (P4), a potent gonadal steroid hormone, and its metabolites showed neuroprotective outcomes through reduction of oxidative stress and stabilization of membrane lipids and their downstream signalling. As P4 actions in rat striatum following permanent bilateral occlusion of both common carotid arteries are still uncertain, we investigated its capacity to reduce neuronal damage induced by permanent occlusion of both carotid arteries (2VO), focusing on several oxidative stress markers (end products of lipid peroxidation (LPP) and phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) intensity ratio) in crude synaptosomal fraction. Adult male Wistar rats were divided into groups: control ‒ sham operated animals treated with vehicle (commercial flax oil, 1 mg/kg) and permanently occluded animals subjected to either vehicle (commercial flax oil, 1 mg/kg) or P4 (dissolved in commercial flax oil, 1.7 mg/kg). Animals were subcutaneously injected for 7 days and sacrificed 4 h following the last treatment. LPP levels were determined spectrophotometrically, while PC/LPC intensity ratio was estimated by mass spectrometer. Obtained results indicate that P4 treatment alleviates 2VO – induced prooxidative changes by decreasing LPP levels and elevating PC/LPC intensity ratio, and returning them closer to levels observed in controls. According to our findings, P4 treatment in cerebral hypoperfusion model, via targeting striatal cell lipid components and altering lipid profile, might be implicated in reduction of oxidative stress and promotion of protective environment.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model
SP  - 118
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11060
ER  - 

@conference{
author = "Bobić, Katarina and Guševac Stojanović, Ivana and Todorović, Ana and Veljković, Filip and Pejić, Snežana and Martinović, Jelena and Drakulić, Dunja",
year = "2023",
abstract = "Prolonged disturbance of cerebral blood flow causes metabolic insufficiency and neuronal hypofunction, for which there is still no adequate therapeutic strategy. In several animal models of neurodegenerative diseases, progesterone (P4), a potent gonadal steroid hormone, and its metabolites showed neuroprotective outcomes through reduction of oxidative stress and stabilization of membrane lipids and their downstream signalling. As P4 actions in rat striatum following permanent bilateral occlusion of both common carotid arteries are still uncertain, we investigated its capacity to reduce neuronal damage induced by permanent occlusion of both carotid arteries (2VO), focusing on several oxidative stress markers (end products of lipid peroxidation (LPP) and phosphatidylcholine (PC) to lysophosphatidylcholine (LPC) intensity ratio) in crude synaptosomal fraction. Adult male Wistar rats were divided into groups: control ‒ sham operated animals treated with vehicle (commercial flax oil, 1 mg/kg) and permanently occluded animals subjected to either vehicle (commercial flax oil, 1 mg/kg) or P4 (dissolved in commercial flax oil, 1.7 mg/kg). Animals were subcutaneously injected for 7 days and sacrificed 4 h following the last treatment. LPP levels were determined spectrophotometrically, while PC/LPC intensity ratio was estimated by mass spectrometer. Obtained results indicate that P4 treatment alleviates 2VO – induced prooxidative changes by decreasing LPP levels and elevating PC/LPC intensity ratio, and returning them closer to levels observed in controls. According to our findings, P4 treatment in cerebral hypoperfusion model, via targeting striatal cell lipid components and altering lipid profile, might be implicated in reduction of oxidative stress and promotion of protective environment.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model",
pages = "118",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11060"
}

Bobić, K., Guševac Stojanović, I., Todorović, A., Veljković, F., Pejić, S., Martinović, J.,& Drakulić, D.. (2023). Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 118.
https://hdl.handle.net/21.15107/rcub_vinar_11060

Bobić K, Guševac Stojanović I, Todorović A, Veljković F, Pejić S, Martinović J, Drakulić D. Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:118.
https://hdl.handle.net/21.15107/rcub_vinar_11060 .

Bobić, Katarina, Guševac Stojanović, Ivana, Todorović, Ana, Veljković, Filip, Pejić, Snežana, Martinović, Jelena, Drakulić, Dunja, "Progesterone modulates striatal lipid profile in rat cerebral hypoperfusion model" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):118,
https://hdl.handle.net/21.15107/rcub_vinar_11060 .

TY  - CONF
AU  - Mitić, Miloš
AU  - Lukić, Iva
AU  - Glavonić, Emilija
AU  - Živanović, Ana
AU  - Mijović, Milica
AU  - Ivković, Sanja
AU  - Adžić, Miroslav
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11054
AB  - Adolescence is a critical period for neurodevelopment, and exposure to chronic stress during this stage can have long-lasting effects on physiological systems and mental health, particularly on depression. Recent studies report that stress affects the gutbrain axis, leading to changes in gut morphology and motility, nutrient absorption, and gut microbiome, which can be associated with development of depression. We investigated the impact of chronic unpredictable stress (CUS) in adolescence on depressive-like behavior and colon in adult mice. Male C57BL/6 mice were exposed to CUS, including different daily stressors such as social isolation, forced swim, and restraint stress, and others, during postnatal days 28-40. Control mice were housed under standard conditions. Behavioral assessments were conducted during adulthood (postnatal day 70), to evaluate depressive-like behavior. Alterations in mice colon were assessed by histopathological analysis. Our results revealed that mice exposed to CUS during adolescence have disrupted colon, including loss of colonic crypts and significantly increased presence of mucosa and submucosa in respect to controls. Changes in colon were associated with increased depressive-like behavior in CUS-mice compared to control mice. These findings suggest that CUS experienced in adolescence can disrupt colon morphology that is associated with depressive phenotype in adult mice, highlighting the importance of understanding the long-term consequences of chronic stress during this critical period of development as a potential risk for development of depression. Further research is needed to elucidate the underlying mechanisms and potential therapeutic interventions to mitigate the effects of stress on mental health and gut function
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Chronic unpredictable stress in adolescence causes disruption of colon morphology that is associated with depressive phenotype in adult mice
SP  - 85
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11054
ER  - 

@conference{
author = "Mitić, Miloš and Lukić, Iva and Glavonić, Emilija and Živanović, Ana and Mijović, Milica and Ivković, Sanja and Adžić, Miroslav",
year = "2023",
abstract = "Adolescence is a critical period for neurodevelopment, and exposure to chronic stress during this stage can have long-lasting effects on physiological systems and mental health, particularly on depression. Recent studies report that stress affects the gutbrain axis, leading to changes in gut morphology and motility, nutrient absorption, and gut microbiome, which can be associated with development of depression. We investigated the impact of chronic unpredictable stress (CUS) in adolescence on depressive-like behavior and colon in adult mice. Male C57BL/6 mice were exposed to CUS, including different daily stressors such as social isolation, forced swim, and restraint stress, and others, during postnatal days 28-40. Control mice were housed under standard conditions. Behavioral assessments were conducted during adulthood (postnatal day 70), to evaluate depressive-like behavior. Alterations in mice colon were assessed by histopathological analysis. Our results revealed that mice exposed to CUS during adolescence have disrupted colon, including loss of colonic crypts and significantly increased presence of mucosa and submucosa in respect to controls. Changes in colon were associated with increased depressive-like behavior in CUS-mice compared to control mice. These findings suggest that CUS experienced in adolescence can disrupt colon morphology that is associated with depressive phenotype in adult mice, highlighting the importance of understanding the long-term consequences of chronic stress during this critical period of development as a potential risk for development of depression. Further research is needed to elucidate the underlying mechanisms and potential therapeutic interventions to mitigate the effects of stress on mental health and gut function",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Chronic unpredictable stress in adolescence causes disruption of colon morphology that is associated with depressive phenotype in adult mice",
pages = "85",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11054"
}

Mitić, M., Lukić, I., Glavonić, E., Živanović, A., Mijović, M., Ivković, S.,& Adžić, M.. (2023). Chronic unpredictable stress in adolescence causes disruption of colon morphology that is associated with depressive phenotype in adult mice. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 85.
https://hdl.handle.net/21.15107/rcub_vinar_11054

Mitić M, Lukić I, Glavonić E, Živanović A, Mijović M, Ivković S, Adžić M. Chronic unpredictable stress in adolescence causes disruption of colon morphology that is associated with depressive phenotype in adult mice. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:85.
https://hdl.handle.net/21.15107/rcub_vinar_11054 .

Mitić, Miloš, Lukić, Iva, Glavonić, Emilija, Živanović, Ana, Mijović, Milica, Ivković, Sanja, Adžić, Miroslav, "Chronic unpredictable stress in adolescence causes disruption of colon morphology that is associated with depressive phenotype in adult mice" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):85,
https://hdl.handle.net/21.15107/rcub_vinar_11054 .

TY  - CONF
AU  - Virijević, Kristina
AU  - Spasojević, Nataša
AU  - Stefanović, Bojana
AU  - Ferizović, Harisa
AU  - Janković, Milica
AU  - Dronjak, Slađana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11053
AB  - Stress is a major precipitant of depression, the hippocampus (HPC) and prefrontal cortex (PFC) is the main structures affected by depressive disorders. Women are twice more likely to experience depression than men. The WKY rat strain has long been established as a model of depression. Initially bred from the Wistar (WI) rat as the control strain for the spontaneously hypertensive rat, WKY rats demonstrate an exaggerated stress response compared to other strains. WKY strain fails to respond to chronic antidepressant treatment after exposure to chronic mild stress (CMS) and is considered to be nonresponsive to antidepressant drugs. MAPK signaling pathway was most closely related to depression and antidepressant treatment. In the present study, we have examined the effects of CMS on behavior and p38 MAPK signaling in the hippocampus and the medial prefrontal cortex (mPFC) of female WKY rats. We used two very different behavioral tests: forced swim test (FST) and open field test (OFT). WKY unstressed controls exhibited increased immobility duration in the forced swim test and decreased activity in the open-field test compared to unstressed WI rats, while CMS did not further influence behavior. WKY showed increased expression of the p38 only in HPC and further exposure of WKY rats to CMS induces sustained-activation of p38 MAPK in this brain area. The present study demonstrated the brain region-specific protein signatures in the female WKY model with endogenous depression, providing novel insights into the pathogenesis of depression.
PB  - Belgrade : Serbian Neuroscience Society
C3  - 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
T1  - Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression
SP  - 84
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11053
ER  - 

@conference{
author = "Virijević, Kristina and Spasojević, Nataša and Stefanović, Bojana and Ferizović, Harisa and Janković, Milica and Dronjak, Slađana",
year = "2023",
abstract = "Stress is a major precipitant of depression, the hippocampus (HPC) and prefrontal cortex (PFC) is the main structures affected by depressive disorders. Women are twice more likely to experience depression than men. The WKY rat strain has long been established as a model of depression. Initially bred from the Wistar (WI) rat as the control strain for the spontaneously hypertensive rat, WKY rats demonstrate an exaggerated stress response compared to other strains. WKY strain fails to respond to chronic antidepressant treatment after exposure to chronic mild stress (CMS) and is considered to be nonresponsive to antidepressant drugs. MAPK signaling pathway was most closely related to depression and antidepressant treatment. In the present study, we have examined the effects of CMS on behavior and p38 MAPK signaling in the hippocampus and the medial prefrontal cortex (mPFC) of female WKY rats. We used two very different behavioral tests: forced swim test (FST) and open field test (OFT). WKY unstressed controls exhibited increased immobility duration in the forced swim test and decreased activity in the open-field test compared to unstressed WI rats, while CMS did not further influence behavior. WKY showed increased expression of the p38 only in HPC and further exposure of WKY rats to CMS induces sustained-activation of p38 MAPK in this brain area. The present study demonstrated the brain region-specific protein signatures in the female WKY model with endogenous depression, providing novel insights into the pathogenesis of depression.",
publisher = "Belgrade : Serbian Neuroscience Society",
journal = "8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade",
title = "Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression",
pages = "84",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11053"
}

Virijević, K., Spasojević, N., Stefanović, B., Ferizović, H., Janković, M.,& Dronjak, S.. (2023). Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade
Belgrade : Serbian Neuroscience Society., 84.
https://hdl.handle.net/21.15107/rcub_vinar_11053

Virijević K, Spasojević N, Stefanović B, Ferizović H, Janković M, Dronjak S. Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression. in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade. 2023;:84.
https://hdl.handle.net/21.15107/rcub_vinar_11053 .

Virijević, Kristina, Spasojević, Nataša, Stefanović, Bojana, Ferizović, Harisa, Janković, Milica, Dronjak, Slađana, "Chronic mild stress induces sustained-activation of p38 MAPK signaling in the female WKY rats with endogenous depression" in 8th Congress of Serbian neuroscience society with international participation : the book of abstracts; 31 May – 2 June; Belgrade (2023):84,
https://hdl.handle.net/21.15107/rcub_vinar_11053 .