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Hypothyroidism and Risk of Cardiovascular Disease

Gluvić, Zoran; Zafirović, Sonja; Obradović, Milan M.; Sudar-Milovanović, Emina; Rizzo, Manfredi; Isenović, Esma R.

TY  - JOUR
AU  - Gluvić, Zoran
AU  - Zafirović, Sonja
AU  - Obradović, Milan M.
AU  - Sudar-Milovanović, Emina
AU  - Rizzo, Manfredi
AU  - Isenović, Esma R.
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10409
AB  - Thyroid hormones (TH) have a significant impact on cellular oxidative metabolism. Besides that,they maintain vascular homeostasis by positive effects on endothelial and vascular smooth muscle cells. Subclinical(SCH) and clinical (CH) hypothyroidism influences target organs by changing their morphology andfunction and impaired blood and oxygen supply induced by accelerated atherosclerosis. The increased risk ofacceleration and extension of atherosclerosis in patients with SCH and CH could be explained by dyslipidemia,diastolic hypertension, increased arterial stiffness, endothelial dysfunction, and altered blood coagulation. Instabilityof atherosclerotic plaque in hypothyroidism could cause excessive activity of the elements of innateimmunity, which are characterized by the significant presence of macrophages in atherosclerotic plaques, increasednuclear factor kappa B (NFkB) expression, and elevated levels of tumor necrosis factor α (TNF-α) andmatrix metalloproteinase (MMP) 9, with reduced interstitial collagen; all of them together creates inflammationmilieu, resulting in plaque rupture. Optimal substitution by levothyroxine (LT4) restores biochemical euthyroidism.In postmenopausal women and elderly patients with hypothyroidism and associated vascularcomorbidity, excessive LT4 substitution could lead to atrial rhythm disorders and osteoporosis. Therefore, it isof interest to maintain thyroid-stimulating hormone (TSH) levels in the reference range, thus eliminating thedeleterious effects of lower or higher TSH levels on the cardiovascular system. This review summarizes the recentliterature on subclinical and clinical hypothyroidism and atherosclerotic cardiovascular disease and discussesthe effects of LT4 replacement therapy on restoring biochemical euthyroidism and atherosclerosis processes.
T2  - Current Pharmaceutical Design
T1  - Hypothyroidism and Risk of Cardiovascular Disease
VL  - 28
IS  - 25
SP  - 2065
EP  - 2072
DO  - 10.2174/1381612828666220620160516
ER  - 
@article{
author = "Gluvić, Zoran and Zafirović, Sonja and Obradović, Milan M. and Sudar-Milovanović, Emina and Rizzo, Manfredi and Isenović, Esma R.",
abstract = "Thyroid hormones (TH) have a significant impact on cellular oxidative metabolism. Besides that,they maintain vascular homeostasis by positive effects on endothelial and vascular smooth muscle cells. Subclinical(SCH) and clinical (CH) hypothyroidism influences target organs by changing their morphology andfunction and impaired blood and oxygen supply induced by accelerated atherosclerosis. The increased risk ofacceleration and extension of atherosclerosis in patients with SCH and CH could be explained by dyslipidemia,diastolic hypertension, increased arterial stiffness, endothelial dysfunction, and altered blood coagulation. Instabilityof atherosclerotic plaque in hypothyroidism could cause excessive activity of the elements of innateimmunity, which are characterized by the significant presence of macrophages in atherosclerotic plaques, increasednuclear factor kappa B (NFkB) expression, and elevated levels of tumor necrosis factor α (TNF-α) andmatrix metalloproteinase (MMP) 9, with reduced interstitial collagen; all of them together creates inflammationmilieu, resulting in plaque rupture. Optimal substitution by levothyroxine (LT4) restores biochemical euthyroidism.In postmenopausal women and elderly patients with hypothyroidism and associated vascularcomorbidity, excessive LT4 substitution could lead to atrial rhythm disorders and osteoporosis. Therefore, it isof interest to maintain thyroid-stimulating hormone (TSH) levels in the reference range, thus eliminating thedeleterious effects of lower or higher TSH levels on the cardiovascular system. This review summarizes the recentliterature on subclinical and clinical hypothyroidism and atherosclerotic cardiovascular disease and discussesthe effects of LT4 replacement therapy on restoring biochemical euthyroidism and atherosclerosis processes.",
journal = "Current Pharmaceutical Design",
title = "Hypothyroidism and Risk of Cardiovascular Disease",
volume = "28",
number = "25",
pages = "2065-2072",
doi = "10.2174/1381612828666220620160516"
}
Gluvić, Z., Zafirović, S., Obradović, M. M., Sudar-Milovanović, E., Rizzo, M.,& Isenović, E. R..Hypothyroidism and Risk of Cardiovascular Disease. in Current Pharmaceutical Design, 28(25), 2065-2072.
https://doi.org/10.2174/1381612828666220620160516
Gluvić Z, Zafirović S, Obradović MM, Sudar-Milovanović E, Rizzo M, Isenović ER. Hypothyroidism and Risk of Cardiovascular Disease. in Current Pharmaceutical Design.28(25):2065-2072.
doi:10.2174/1381612828666220620160516 .
Gluvić, Zoran, Zafirović, Sonja, Obradović, Milan M., Sudar-Milovanović, Emina, Rizzo, Manfredi, Isenović, Esma R., "Hypothyroidism and Risk of Cardiovascular Disease" in Current Pharmaceutical Design, 28, no. 25:2065-2072,
https://doi.org/10.2174/1381612828666220620160516 . .
3
1

Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction

Mačvanin, Mirjana T.; Stanimirović, Julijana; Isenović, Esma R.

TY  - JOUR
AU  - Mačvanin, Mirjana T.
AU  - Stanimirović, Julijana
AU  - Isenović, Esma R.
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10545
AB  - Timely and accurate evaluation of clinical parameters associated with endothelial dysfunctionis critical in diagnosing and treating atherosclerosis, which represents a severe health problem, accountingfor at least 30% of deaths globally. A critical early event in the pathogenesis of atherosclerosis is the oxidativemodification of low-density lipoprotein (LDL). Oxidized LDL (OxLDL) represents numerouschanges in lipid and apolipoprotein B (apo B) fractions of LDLs generated by lipid peroxidation. Anotherindicator of perturbed vascular homeostasis is homocysteine (Hcy), an amino acid containing sulfhydrylgroup,an intermediate methionine and cysteine biosynthesis product. The total level of Hcy in plasmacorrelates better than cholesterol with the risk of cardiovascular disease. In addition, nitric oxide (NO)plays an essential role in regulating vascular physiological homeostasis due to its involvement in intravascularfree radical and oxidant reactions. Reduced NO decreases oxidative stress in the vascular wall,which reduces the rate of LDL oxidation and the expression of redox-sensitive genes involved in atherogenesis.Endothelial dysfunction is typically associated with increased levels of OxLDL, decreased nitricoxide (NO), and hyperhomocysteinemia. Thus, OxLDL, Hcy, and NO are representative parameters ofoxidative stress and endothelial dysfunction. Considering the important role of oxLDL, Hcy and NO inoxidative stress, atherogenesis and accompanying endothelial dysfunction, the challenge of the presentwork was to systematically present available methods for reliable measurement of these parameters andassess their potential for the use in the clinical setting. Here we present a comprehensive overview ofanalytical methods for measuring OxLDL, HCy, and NO in biological samples and discuss their advantagesand potential problems regarding their application in clinical settings.
T2  - Current Analytical Chemistry
T1  - Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction
VL  - 18
IS  - 10
SP  - 1040
EP  - 1056
DO  - 10.2174/1573411018666220827142613
ER  - 
@article{
author = "Mačvanin, Mirjana T. and Stanimirović, Julijana and Isenović, Esma R.",
abstract = "Timely and accurate evaluation of clinical parameters associated with endothelial dysfunctionis critical in diagnosing and treating atherosclerosis, which represents a severe health problem, accountingfor at least 30% of deaths globally. A critical early event in the pathogenesis of atherosclerosis is the oxidativemodification of low-density lipoprotein (LDL). Oxidized LDL (OxLDL) represents numerouschanges in lipid and apolipoprotein B (apo B) fractions of LDLs generated by lipid peroxidation. Anotherindicator of perturbed vascular homeostasis is homocysteine (Hcy), an amino acid containing sulfhydrylgroup,an intermediate methionine and cysteine biosynthesis product. The total level of Hcy in plasmacorrelates better than cholesterol with the risk of cardiovascular disease. In addition, nitric oxide (NO)plays an essential role in regulating vascular physiological homeostasis due to its involvement in intravascularfree radical and oxidant reactions. Reduced NO decreases oxidative stress in the vascular wall,which reduces the rate of LDL oxidation and the expression of redox-sensitive genes involved in atherogenesis.Endothelial dysfunction is typically associated with increased levels of OxLDL, decreased nitricoxide (NO), and hyperhomocysteinemia. Thus, OxLDL, Hcy, and NO are representative parameters ofoxidative stress and endothelial dysfunction. Considering the important role of oxLDL, Hcy and NO inoxidative stress, atherogenesis and accompanying endothelial dysfunction, the challenge of the presentwork was to systematically present available methods for reliable measurement of these parameters andassess their potential for the use in the clinical setting. Here we present a comprehensive overview ofanalytical methods for measuring OxLDL, HCy, and NO in biological samples and discuss their advantagesand potential problems regarding their application in clinical settings.",
journal = "Current Analytical Chemistry",
title = "Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction",
volume = "18",
number = "10",
pages = "1040-1056",
doi = "10.2174/1573411018666220827142613"
}
Mačvanin, M. T., Stanimirović, J.,& Isenović, E. R..Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction. in Current Analytical Chemistry, 18(10), 1040-1056.
https://doi.org/10.2174/1573411018666220827142613
Mačvanin MT, Stanimirović J, Isenović ER. Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction. in Current Analytical Chemistry.18(10):1040-1056.
doi:10.2174/1573411018666220827142613 .
Mačvanin, Mirjana T., Stanimirović, Julijana, Isenović, Esma R., "Methods for Measurements of Oxidized LDL, Homocysteine and Nitric Oxide as Clinical Parameters of Oxidative Stress and Endothelial Dysfunction" in Current Analytical Chemistry, 18, no. 10:1040-1056,
https://doi.org/10.2174/1573411018666220827142613 . .

The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer

Marinković, Aleksandar; Vuksanović, Marija M.; Karić, Nataša; Đokić, Veljko; Popović, Mina; Jančić-Heinemann, Radmila; Tomić, Nataša

TY  - JOUR
AU  - Marinković, Aleksandar
AU  - Vuksanović, Marija M.
AU  - Karić, Nataša
AU  - Đokić, Veljko
AU  - Popović, Mina
AU  - Jančić-Heinemann, Radmila
AU  - Tomić, Nataša
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9761
AB  - As a renewable resource, starch is considered to be fully biodegradable and nonpolluting to the environment but the hygroscopicity of starch is the main disadvantage for wider applicability in the production of a polymer-based material. Hydrophobically modified starch prepared using natural-based plasticizers/modifiers in a first step ([-]-diisopropyl D-tartrate [DiPT], ricinoleic acid [RA] and epoxidized soybean oil [ESO]), and maleated polypropylene (MAPP) in a second step contributed to better compatibility, and thus reinforcing of composites. Tailored processing conditions, structural/morphological properties, hydrophobicity, and water-resistance of the modified starch were established. In addition, the Charpy impact and tensile strength of composites, based on poly(ethylene-co-acrylic acid) (EAA) and modified starches, were determined. Increased tensile strength and Young modulus of the composite using starch-modified with DiPT-MAPP, that is, 3 and 83%, respectively, indicated the possible applicability of obtained materials.
T2  - Polymer Composites
T1  - The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer
DO  - 10.1002/pc.25903
ER  - 
@article{
author = "Marinković, Aleksandar and Vuksanović, Marija M. and Karić, Nataša and Đokić, Veljko and Popović, Mina and Jančić-Heinemann, Radmila and Tomić, Nataša",
abstract = "As a renewable resource, starch is considered to be fully biodegradable and nonpolluting to the environment but the hygroscopicity of starch is the main disadvantage for wider applicability in the production of a polymer-based material. Hydrophobically modified starch prepared using natural-based plasticizers/modifiers in a first step ([-]-diisopropyl D-tartrate [DiPT], ricinoleic acid [RA] and epoxidized soybean oil [ESO]), and maleated polypropylene (MAPP) in a second step contributed to better compatibility, and thus reinforcing of composites. Tailored processing conditions, structural/morphological properties, hydrophobicity, and water-resistance of the modified starch were established. In addition, the Charpy impact and tensile strength of composites, based on poly(ethylene-co-acrylic acid) (EAA) and modified starches, were determined. Increased tensile strength and Young modulus of the composite using starch-modified with DiPT-MAPP, that is, 3 and 83%, respectively, indicated the possible applicability of obtained materials.",
journal = "Polymer Composites",
title = "The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer",
doi = "10.1002/pc.25903"
}
Marinković, A., Vuksanović, M. M., Karić, N., Đokić, V., Popović, M., Jančić-Heinemann, R.,& Tomić, N..The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer. in Polymer Composites.
https://doi.org/10.1002/pc.25903
Marinković A, Vuksanović MM, Karić N, Đokić V, Popović M, Jančić-Heinemann R, Tomić N. The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer. in Polymer Composites..
doi:10.1002/pc.25903 .
Marinković, Aleksandar, Vuksanović, Marija M., Karić, Nataša, Đokić, Veljko, Popović, Mina, Jančić-Heinemann, Radmila, Tomić, Nataša, "The effect of natural modifiers for starch hydrophobization on performance of composite based on ethylene acrylic acid copolymer" in Polymer Composites,
https://doi.org/10.1002/pc.25903 . .
4
2
3

Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom

Piotrowski, Wojciech M.; Marin, Riccardo; Szymczak, Maja; Martín Rodríguez, Emma; Ortgies, Dirk H.; Rodríguez-Sevilla, Paloma; Dramićanin, Miroslav; Jaque, Daniel; Marciniak, Lukasz

TY  - JOUR
AU  - Piotrowski, Wojciech M.
AU  - Marin, Riccardo
AU  - Szymczak, Maja
AU  - Martín Rodríguez, Emma
AU  - Ortgies, Dirk H.
AU  - Rodríguez-Sevilla, Paloma
AU  - Dramićanin, Miroslav
AU  - Jaque, Daniel
AU  - Marciniak, Lukasz
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10546
AB  - Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.
T2  - Advanced Optical Materials
T1  - Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom
IS  - inPress
SP  - 2202366
DO  - 10.1002/adom.202202366
ER  - 
@article{
author = "Piotrowski, Wojciech M. and Marin, Riccardo and Szymczak, Maja and Martín Rodríguez, Emma and Ortgies, Dirk H. and Rodríguez-Sevilla, Paloma and Dramićanin, Miroslav and Jaque, Daniel and Marciniak, Lukasz",
abstract = "Lifetime-based luminescence thermometry has been shown to enable accurate deep-tissue monitoring of temperature changes – even at the in vivo level – in a minimally invasive way. However, major limiting factors to the performance of this approach are short lifetimes and poor brightness. These are characteristics, respectively, of semiconductor nanocrystals and lanthanide-doped nanoparticles, of which most luminescent nanothermometers are made. To address these limitations, the composition of luminescent nanothermometers co-doped with transition metal (Mn5+) and Er3+ ions are designed and optimized. The salient features of these nanothermometers are strong, near-infrared emission and long, temperature-dependent photoluminescence lifetime. The potential of these luminescent nanophosphors for thermal sensing is then showcased by monitoring a thermal gradient using a one-of-a-kind piece of equipment designed for lifetime-based luminescence thermometry measurements. The combination of the newly developed nanothermometers and the custom-made instrument allows for obtaining 2D thermal maps both in the absence and presence of tissue phantoms mimicking the optical properties of the skin. The results presented in this study thus provide credible foundations for the deployment of lifetime-based thermometry for accurate deep-tissue thermal mapping at the preclinical level.",
journal = "Advanced Optical Materials",
title = "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom",
number = "inPress",
pages = "2202366",
doi = "10.1002/adom.202202366"
}
Piotrowski, W. M., Marin, R., Szymczak, M., Martín Rodríguez, E., Ortgies, D. H., Rodríguez-Sevilla, P., Dramićanin, M., Jaque, D.,& Marciniak, L..Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials(inPress), 2202366.
https://doi.org/10.1002/adom.202202366
Piotrowski WM, Marin R, Szymczak M, Martín Rodríguez E, Ortgies DH, Rodríguez-Sevilla P, Dramićanin M, Jaque D, Marciniak L. Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom. in Advanced Optical Materials.(inPress):2202366.
doi:10.1002/adom.202202366 .
Piotrowski, Wojciech M., Marin, Riccardo, Szymczak, Maja, Martín Rodríguez, Emma, Ortgies, Dirk H., Rodríguez-Sevilla, Paloma, Dramićanin, Miroslav, Jaque, Daniel, Marciniak, Lukasz, "Mn5+ Lifetime-Based Thermal Imaging in the Optical Transparency Windows Through Skin-Mimicking Tissue Phantom" in Advanced Optical Materials, no. inPress:2202366,
https://doi.org/10.1002/adom.202202366 . .

Denture composite reinforced with short polyethylene terephthalate fibers

Perišić, Srđan; Kareem Ali Alzaroug, Azdihar; Kalevski, Katarina; Vuksanović, Marija M.; Volkov-Husović, Tatjana; Radović, Ivana; Radojević, Vesna

TY  - JOUR
AU  - Perišić, Srđan
AU  - Kareem Ali Alzaroug, Azdihar
AU  - Kalevski, Katarina
AU  - Vuksanović, Marija M.
AU  - Volkov-Husović, Tatjana
AU  - Radović, Ivana
AU  - Radojević, Vesna
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10053
AB  - Polymer matrix composite materials have found application in dentistry because of good mechanical properties, aesthetic, easy processing, and possibilities of the repair. Acrylates are materials used to make and repair dentures. Reinforcements in the form of short glass or polymer fibers are added to improve the mechanical properties of dental polymers. In this study, the processing of composite material with a polymer matrix from commercial auto-polymerized acrylate Simgal, with reinforcement in the form of short poly(ethylene terephthalate) (PET) fibers was examined. Samples were processed in three series: pure Simgal, Simgal/PET 1 wt% and Simgal/PET 3 wt%. The influence of the reinforcement in the form of short PET fibers on the mechanical properties of composite materials was investigated. Strength and hardness were tested by impact testing and Vickers microhardness, and it was shown that there is an increase in absorbed energy and hardness. The modulus was reduced by the addition of PET fibers and by increasing the amount of fibers in the composite. The increase in the amount of PET fibers also resulted in a smaller loss of surface mass of the samples compared to the pure matrix by 63% and 93%, respectively. Cavitation test revealed better cavitation resistance of composites than the pure acrylate.
T2  - Polymer Composites
T1  - Denture composite reinforced with short polyethylene terephthalate fibers
DO  - 10.1002/pc.26397
ER  - 
@article{
author = "Perišić, Srđan and Kareem Ali Alzaroug, Azdihar and Kalevski, Katarina and Vuksanović, Marija M. and Volkov-Husović, Tatjana and Radović, Ivana and Radojević, Vesna",
abstract = "Polymer matrix composite materials have found application in dentistry because of good mechanical properties, aesthetic, easy processing, and possibilities of the repair. Acrylates are materials used to make and repair dentures. Reinforcements in the form of short glass or polymer fibers are added to improve the mechanical properties of dental polymers. In this study, the processing of composite material with a polymer matrix from commercial auto-polymerized acrylate Simgal, with reinforcement in the form of short poly(ethylene terephthalate) (PET) fibers was examined. Samples were processed in three series: pure Simgal, Simgal/PET 1 wt% and Simgal/PET 3 wt%. The influence of the reinforcement in the form of short PET fibers on the mechanical properties of composite materials was investigated. Strength and hardness were tested by impact testing and Vickers microhardness, and it was shown that there is an increase in absorbed energy and hardness. The modulus was reduced by the addition of PET fibers and by increasing the amount of fibers in the composite. The increase in the amount of PET fibers also resulted in a smaller loss of surface mass of the samples compared to the pure matrix by 63% and 93%, respectively. Cavitation test revealed better cavitation resistance of composites than the pure acrylate.",
journal = "Polymer Composites",
title = "Denture composite reinforced with short polyethylene terephthalate fibers",
doi = "10.1002/pc.26397"
}
Perišić, S., Kareem Ali Alzaroug, A., Kalevski, K., Vuksanović, M. M., Volkov-Husović, T., Radović, I.,& Radojević, V..Denture composite reinforced with short polyethylene terephthalate fibers. in Polymer Composites.
https://doi.org/10.1002/pc.26397
Perišić S, Kareem Ali Alzaroug A, Kalevski K, Vuksanović MM, Volkov-Husović T, Radović I, Radojević V. Denture composite reinforced with short polyethylene terephthalate fibers. in Polymer Composites..
doi:10.1002/pc.26397 .
Perišić, Srđan, Kareem Ali Alzaroug, Azdihar, Kalevski, Katarina, Vuksanović, Marija M., Volkov-Husović, Tatjana, Radović, Ivana, Radojević, Vesna, "Denture composite reinforced with short polyethylene terephthalate fibers" in Polymer Composites,
https://doi.org/10.1002/pc.26397 . .
1
1

Novel boron-rich aluminum nitride advanced ceramic materials

Zagorac, Dejan; Zagorac, Jelena B.; Fonović, Matej; Prikhna, Tatiana; Matović, Branko

TY  - JOUR
AU  - Zagorac, Dejan
AU  - Zagorac, Jelena B.
AU  - Fonović, Matej
AU  - Prikhna, Tatiana
AU  - Matović, Branko
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10399
AB  - Aluminum nitride (AlN) and boron nitride (BN) are well-known ceramic materials with numerous valuable properties, whereas recently there is a growing field of research on the AlN/BN advanced ceramic materials. Here, we present a study on boron-rich AlN, structural and electronic properties, and structure–property relationship. Several AlxB1−xN solid solutions (x = 1, .875, .75, and .625) have been investigated, and structure optimization has been performed for four different structure types: h-BN, wurtzite, sphalerite, and rock salt. First-principles calculations were performed using hybrid B3LYP functional. New modifications and compounds have been predicted as a function of boron concentration in AlN, and especially, interesting phase transitions were found at extreme pressure conditions. Electronic properties and band structures were computed, and the possibility for bandgap tuning has been discovered. The present study, and especially the structure–property relationship, gives new possibilities for bandgap engineering in boron-rich AlN electroceramic materials.
T2  - International Journal of Applied Ceramic Technology
T1  - Novel boron-rich aluminum nitride advanced ceramic materials
DO  - 10.1111/ijac.14152
ER  - 
@article{
author = "Zagorac, Dejan and Zagorac, Jelena B. and Fonović, Matej and Prikhna, Tatiana and Matović, Branko",
abstract = "Aluminum nitride (AlN) and boron nitride (BN) are well-known ceramic materials with numerous valuable properties, whereas recently there is a growing field of research on the AlN/BN advanced ceramic materials. Here, we present a study on boron-rich AlN, structural and electronic properties, and structure–property relationship. Several AlxB1−xN solid solutions (x = 1, .875, .75, and .625) have been investigated, and structure optimization has been performed for four different structure types: h-BN, wurtzite, sphalerite, and rock salt. First-principles calculations were performed using hybrid B3LYP functional. New modifications and compounds have been predicted as a function of boron concentration in AlN, and especially, interesting phase transitions were found at extreme pressure conditions. Electronic properties and band structures were computed, and the possibility for bandgap tuning has been discovered. The present study, and especially the structure–property relationship, gives new possibilities for bandgap engineering in boron-rich AlN electroceramic materials.",
journal = "International Journal of Applied Ceramic Technology",
title = "Novel boron-rich aluminum nitride advanced ceramic materials",
doi = "10.1111/ijac.14152"
}
Zagorac, D., Zagorac, J. B., Fonović, M., Prikhna, T.,& Matović, B..Novel boron-rich aluminum nitride advanced ceramic materials. in International Journal of Applied Ceramic Technology.
https://doi.org/10.1111/ijac.14152
Zagorac D, Zagorac JB, Fonović M, Prikhna T, Matović B. Novel boron-rich aluminum nitride advanced ceramic materials. in International Journal of Applied Ceramic Technology..
doi:10.1111/ijac.14152 .
Zagorac, Dejan, Zagorac, Jelena B., Fonović, Matej, Prikhna, Tatiana, Matović, Branko, "Novel boron-rich aluminum nitride advanced ceramic materials" in International Journal of Applied Ceramic Technology,
https://doi.org/10.1111/ijac.14152 . .

Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows

Masoničić, Zoran; Vašalić, Dragan; Grujić, Ivan; Divinić, Aleksandar; Pešić, Radivoje

TY  - CONF
AU  - Masoničić, Zoran
AU  - Vašalić, Dragan
AU  - Grujić, Ivan
AU  - Divinić, Aleksandar
AU  - Pešić, Radivoje
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10490
AB  - In this paper, some results concerning the evolution of the fluid flow pattern and flame propagation of various fuels in a particular combustion chamber with four tilted valves were elucidated. Flame propagation was represented by the evolution of spatial distribution of temperature in various cutplanes within combustion chamber. Flame front location was determined in the zones with maximum temperature gradient. All results were obtained by dint of multidimensional modeling of reactive flows in arbitrary geometry of IC engine combustion chamber with moving boundaries. The above mentioned results were analysed and presented for two different hydrocarbon fuels such as gasoline and methane and one alchocol based fuel such as ethanol. The results for all three fules considered were obtained by dint of eddy-viscosity model i.e. with standard k-ε model of turbulence. The interplay between fluid flow pattern and flame propagation is entirely invariant as regards fuel variation indicating that flame propagation through unburnet mixture considered fuels is not chemically controlled but controlled by dint of turbulent diffusion.
C3  - International Congress, Motor Vehicles & Motors 2020,
Kragujevac, Serbia,
October 8th - 9th, 2020
T1  - Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows
SP  - MVM2020-010
UR  - https://hdl.handle.net/21.15107/rcub_vinar_10490
ER  - 
@conference{
author = "Masoničić, Zoran and Vašalić, Dragan and Grujić, Ivan and Divinić, Aleksandar and Pešić, Radivoje",
abstract = "In this paper, some results concerning the evolution of the fluid flow pattern and flame propagation of various fuels in a particular combustion chamber with four tilted valves were elucidated. Flame propagation was represented by the evolution of spatial distribution of temperature in various cutplanes within combustion chamber. Flame front location was determined in the zones with maximum temperature gradient. All results were obtained by dint of multidimensional modeling of reactive flows in arbitrary geometry of IC engine combustion chamber with moving boundaries. The above mentioned results were analysed and presented for two different hydrocarbon fuels such as gasoline and methane and one alchocol based fuel such as ethanol. The results for all three fules considered were obtained by dint of eddy-viscosity model i.e. with standard k-ε model of turbulence. The interplay between fluid flow pattern and flame propagation is entirely invariant as regards fuel variation indicating that flame propagation through unburnet mixture considered fuels is not chemically controlled but controlled by dint of turbulent diffusion.",
journal = "International Congress, Motor Vehicles & Motors 2020,
Kragujevac, Serbia,
October 8th - 9th, 2020",
title = "Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows",
pages = "MVM2020-010",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10490"
}
Masoničić, Z., Vašalić, D., Grujić, I., Divinić, A.,& Pešić, R..Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows. in International Congress, Motor Vehicles & Motors 2020,
Kragujevac, Serbia,
October 8th - 9th, 2020, MVM2020-010.
https://hdl.handle.net/21.15107/rcub_vinar_10490
Masoničić Z, Vašalić D, Grujić I, Divinić A, Pešić R. Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows. in International Congress, Motor Vehicles & Motors 2020,
Kragujevac, Serbia,
October 8th - 9th, 2020.:MVM2020-010.
https://hdl.handle.net/21.15107/rcub_vinar_10490 .
Masoničić, Zoran, Vašalić, Dragan, Grujić, Ivan, Divinić, Aleksandar, Pešić, Radivoje, "Some aspects concerning application of alternative fuels as regards fluid flow pattern and flame propagation in particular combustion chamber with strong macro flows" in International Congress, Motor Vehicles & Motors 2020,
Kragujevac, Serbia,
October 8th - 9th, 2020:MVM2020-010,
https://hdl.handle.net/21.15107/rcub_vinar_10490 .

Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning

Zhou, Chao; Zhang, Youzhi; Stašić, Jelena; Liang, Yu; Chen, Xizhang; Trtica, Milan

TY  - JOUR
AU  - Zhou, Chao
AU  - Zhang, Youzhi
AU  - Stašić, Jelena
AU  - Liang, Yu
AU  - Chen, Xizhang
AU  - Trtica, Milan
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10541
AB  - High-entropy alloys (HEAs) have received much attention since presented in 2004. Machine learning (ML) can accelerate the research of new HEAs. At present, among the ML research methods used to predict the properties of HEAs, alloys are manufactured mainly by the melt-casting method. The existing ML methods do not use the process parameters of the manufacturing process as input features. Unlike the melt-casting method, additive manufacturing (AM) has promising applications with its ability to prototype and manufacture complex-shaped parts rapidly. The AM process parameters can significantly affect the performance of HEAs. The process parameters are a critical factor that must be considered for ML. Therefore, an ML method dependent on AM process parameters is proposed to predict the hardness of HEAs. The prediction results of six commonly used ML models are compared. The dependence of ML on process parameters is investigated. Four new HEAs are manufactured based on AM to verify the reliability of ML prediction results. The experimental results show that adding process parameters to ML improves the prediction accuracy by 4%. The prediction accuracy of ML reaches 89%, and the average prediction error for new HEAs is 3.83%.
T2  - Advanced Engineering Materials
T1  - Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning
SP  - 2201369
DO  - 10.1002/adem.202201369
ER  - 
@article{
author = "Zhou, Chao and Zhang, Youzhi and Stašić, Jelena and Liang, Yu and Chen, Xizhang and Trtica, Milan",
abstract = "High-entropy alloys (HEAs) have received much attention since presented in 2004. Machine learning (ML) can accelerate the research of new HEAs. At present, among the ML research methods used to predict the properties of HEAs, alloys are manufactured mainly by the melt-casting method. The existing ML methods do not use the process parameters of the manufacturing process as input features. Unlike the melt-casting method, additive manufacturing (AM) has promising applications with its ability to prototype and manufacture complex-shaped parts rapidly. The AM process parameters can significantly affect the performance of HEAs. The process parameters are a critical factor that must be considered for ML. Therefore, an ML method dependent on AM process parameters is proposed to predict the hardness of HEAs. The prediction results of six commonly used ML models are compared. The dependence of ML on process parameters is investigated. Four new HEAs are manufactured based on AM to verify the reliability of ML prediction results. The experimental results show that adding process parameters to ML improves the prediction accuracy by 4%. The prediction accuracy of ML reaches 89%, and the average prediction error for new HEAs is 3.83%.",
journal = "Advanced Engineering Materials",
title = "Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning",
pages = "2201369",
doi = "10.1002/adem.202201369"
}
Zhou, C., Zhang, Y., Stašić, J., Liang, Y., Chen, X.,& Trtica, M..Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning. in Advanced Engineering Materials, 2201369.
https://doi.org/10.1002/adem.202201369
Zhou C, Zhang Y, Stašić J, Liang Y, Chen X, Trtica M. Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning. in Advanced Engineering Materials.:2201369.
doi:10.1002/adem.202201369 .
Zhou, Chao, Zhang, Youzhi, Stašić, Jelena, Liang, Yu, Chen, Xizhang, Trtica, Milan, "Hardness Predicting of Additively Manufactured High-Entropy Alloys Based on Fabrication Parameter-Dependent Machine Learning" in Advanced Engineering Materials:2201369,
https://doi.org/10.1002/adem.202201369 . .

Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate

Ognjanović, Miloš; Stanković, Dalibor M.; Jaćimović, Željko K.; Kosović-Perutović, Milica; Mariano, José F. M. L.; Krehula, Stjepko; Musić, Svetozar; Antić, Bratislav

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor M.
AU  - Jaćimović, Željko K.
AU  - Kosović-Perutović, Milica
AU  - Mariano, José F. M. L.
AU  - Krehula, Stjepko
AU  - Musić, Svetozar
AU  - Antić, Bratislav
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10215
AB  - Nickel acetate tetrahydrate (NAT) sample series were used to modify screen-printed carbon electrodes (SPCE). The samples were hybrid Ni/NiO nanocomposites, where the NiO phase increased with an applied treatment temperature. Results of electrochemical measurements pointed that the Ni/NiO550/SPCE-modified electrode had the best analytical performance toward the detection of riboflavin (RF). The Ni/NiO550/SPCE-based sensor showed linear response with RF in the concentration range of 0.5–75 μM and 0.15 μM LOD in BRBS. Sensor offered fast response time, good repeatability, and selectivity with an RSD of 1.4 %. Our results show that the Ni:NiO nanocomposite ratio strongly influenced the electroanalytical performance of SPCE.
T2  - Electroanalysis
T1  - Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate
DO  - 10.1002/elan.202100602
ER  - 
@article{
author = "Ognjanović, Miloš and Stanković, Dalibor M. and Jaćimović, Željko K. and Kosović-Perutović, Milica and Mariano, José F. M. L. and Krehula, Stjepko and Musić, Svetozar and Antić, Bratislav",
abstract = "Nickel acetate tetrahydrate (NAT) sample series were used to modify screen-printed carbon electrodes (SPCE). The samples were hybrid Ni/NiO nanocomposites, where the NiO phase increased with an applied treatment temperature. Results of electrochemical measurements pointed that the Ni/NiO550/SPCE-modified electrode had the best analytical performance toward the detection of riboflavin (RF). The Ni/NiO550/SPCE-based sensor showed linear response with RF in the concentration range of 0.5–75 μM and 0.15 μM LOD in BRBS. Sensor offered fast response time, good repeatability, and selectivity with an RSD of 1.4 %. Our results show that the Ni:NiO nanocomposite ratio strongly influenced the electroanalytical performance of SPCE.",
journal = "Electroanalysis",
title = "Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate",
doi = "10.1002/elan.202100602"
}
Ognjanović, M., Stanković, D. M., Jaćimović, Ž. K., Kosović-Perutović, M., Mariano, J. F. M. L., Krehula, S., Musić, S.,& Antić, B..Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate. in Electroanalysis.
https://doi.org/10.1002/elan.202100602
Ognjanović M, Stanković DM, Jaćimović ŽK, Kosović-Perutović M, Mariano JFML, Krehula S, Musić S, Antić B. Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate. in Electroanalysis..
doi:10.1002/elan.202100602 .
Ognjanović, Miloš, Stanković, Dalibor M., Jaćimović, Željko K., Kosović-Perutović, Milica, Mariano, José F. M. L., Krehula, Stjepko, Musić, Svetozar, Antić, Bratislav, "Construction of Sensor for Submicromolar Detection of Riboflavin by Surface Modification of SPCE with Thermal Degradation Products of Nickel Acetate Tetrahydrate" in Electroanalysis,
https://doi.org/10.1002/elan.202100602 . .
1
3
2

Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature

Divović Matović, Branka; Knutson, Dan; Mitrović, Jelena; Stevanović, Vladimir; Stanojević, Boban; Savić, Snežana; Cook, James M.; Savić, Miroslav M.

TY  - JOUR
AU  - Divović Matović, Branka
AU  - Knutson, Dan
AU  - Mitrović, Jelena
AU  - Stevanović, Vladimir
AU  - Stanojević, Boban
AU  - Savić, Snežana
AU  - Cook, James M.
AU  - Savić, Miroslav M.
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10454
AB  - Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective positive modulators at the PQ site of α6-containing GABAA receptors. PQs are also neutral modulators at the benzodiazepine site. We assessed the influence of PQ compounds from three structural groups (PZ-II-029 and related deuterated analogues DK-I-56-1, RV-I-029, DK-I-60-3 and DK-I-86-1; LAU 463 and related analogues DK-I-58-1 and DK-II-58-1; and DK-I-87-1), alone and in combination with diazepam, on the behaviour of male Sprague–Dawley rats. An excellent behavioural safety profile of all tested PQs was demonstrated in the spontaneous locomotor activity, rotarod, loss of righting reflex and pentylenetetrazol tests. In interaction studies, only PZ-II-029 and its analogues prevented the ataxic effects of the benzodiazepine, as assessed in the rotarod test and during monitoring of rat locomotor activity after awakening from the loss of righting reflex. Published electrophysiological profiles of PQ ligands imply that positive modulation elicited at α6-GABAA receptors that contain the γ2 and δ subunit, rather than their neutral modulatory action at the benzodiazepine site, may prevent the ataxic action of diazepam. Thus, PZ-II-029 and its deuterated analogues are not prone to untoward interactions with benzodiazepines and may indeed completely abolish their ataxic action, seen at therapeutic, and especially toxic concentrations.
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature
IS  - Inpress
DO  - 10.1111/bcpt.13801
ER  - 
@article{
author = "Divović Matović, Branka and Knutson, Dan and Mitrović, Jelena and Stevanović, Vladimir and Stanojević, Boban and Savić, Snežana and Cook, James M. and Savić, Miroslav M.",
abstract = "Several pyrazoloquinolinone (PQ) ligands were recently discovered as functionally selective positive modulators at the PQ site of α6-containing GABAA receptors. PQs are also neutral modulators at the benzodiazepine site. We assessed the influence of PQ compounds from three structural groups (PZ-II-029 and related deuterated analogues DK-I-56-1, RV-I-029, DK-I-60-3 and DK-I-86-1; LAU 463 and related analogues DK-I-58-1 and DK-II-58-1; and DK-I-87-1), alone and in combination with diazepam, on the behaviour of male Sprague–Dawley rats. An excellent behavioural safety profile of all tested PQs was demonstrated in the spontaneous locomotor activity, rotarod, loss of righting reflex and pentylenetetrazol tests. In interaction studies, only PZ-II-029 and its analogues prevented the ataxic effects of the benzodiazepine, as assessed in the rotarod test and during monitoring of rat locomotor activity after awakening from the loss of righting reflex. Published electrophysiological profiles of PQ ligands imply that positive modulation elicited at α6-GABAA receptors that contain the γ2 and δ subunit, rather than their neutral modulatory action at the benzodiazepine site, may prevent the ataxic action of diazepam. Thus, PZ-II-029 and its deuterated analogues are not prone to untoward interactions with benzodiazepines and may indeed completely abolish their ataxic action, seen at therapeutic, and especially toxic concentrations.",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature",
number = "Inpress",
doi = "10.1111/bcpt.13801"
}
Divović Matović, B., Knutson, D., Mitrović, J., Stevanović, V., Stanojević, B., Savić, S., Cook, J. M.,& Savić, M. M..Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature. in Basic & Clinical Pharmacology & Toxicology(Inpress).
https://doi.org/10.1111/bcpt.13801
Divović Matović B, Knutson D, Mitrović J, Stevanović V, Stanojević B, Savić S, Cook JM, Savić MM. Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature. in Basic & Clinical Pharmacology & Toxicology.(Inpress).
doi:10.1111/bcpt.13801 .
Divović Matović, Branka, Knutson, Dan, Mitrović, Jelena, Stevanović, Vladimir, Stanojević, Boban, Savić, Snežana, Cook, James M., Savić, Miroslav M., "Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti-diazepam-induced ataxia action as a structure-dependent feature" in Basic & Clinical Pharmacology & Toxicology, no. Inpress,
https://doi.org/10.1111/bcpt.13801 . .

Role of catalyst supports in biocatalysis

Manikandan, Soumya Koippully; Giannakoudakis, Dimitrios A.; Prekodravac, Jovana; Nair, Vaishakh; Colmenares, Juan Carlos

TY  - JOUR
AU  - Manikandan, Soumya Koippully
AU  - Giannakoudakis, Dimitrios A.
AU  - Prekodravac, Jovana
AU  - Nair, Vaishakh
AU  - Colmenares, Juan Carlos
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10383
AB  - Biocatalysis utilizes enzymes and microbial cells as catalysts for a wide range of applications in biotechnology. Immobilization of biocatalysts on various materials has several advantages, including the capacity for reuse, quick reaction termination, easy biocatalyst recovery and operational stability. The present article focuses on the use of material supports for developing immobilized biocatalysts in applications related to energy, environment and chemical synthesis. The work provides a comprehensive overview of a broad class of materials, including organic, inorganic and composites, that have been shown to be prosperous candidates to support the immobilization of enzymes and microbial cells. It also highlights the properties of nanomaterial support such as large surface area and comfort compartment for immobilization. The availability of different types of materials as catalyst support provides an opportunity to understand and develop efficient biocatalytic systems. The choice of selecting a catalyst support will mostly depend on the interaction of the material with the enzyme or microbial cell. Finally, potential challenges, future approaches in developing immobilized biocatalytic systems for various applications and novel material supports are suggested. © 2022 Society of Chemical Industry (SCI).
T2  - Journal of Chemical Technology & Biotechnology
T1  - Role of catalyst supports in biocatalysis
DO  - 10.1002/jctb.7177
ER  - 
@article{
author = "Manikandan, Soumya Koippully and Giannakoudakis, Dimitrios A. and Prekodravac, Jovana and Nair, Vaishakh and Colmenares, Juan Carlos",
abstract = "Biocatalysis utilizes enzymes and microbial cells as catalysts for a wide range of applications in biotechnology. Immobilization of biocatalysts on various materials has several advantages, including the capacity for reuse, quick reaction termination, easy biocatalyst recovery and operational stability. The present article focuses on the use of material supports for developing immobilized biocatalysts in applications related to energy, environment and chemical synthesis. The work provides a comprehensive overview of a broad class of materials, including organic, inorganic and composites, that have been shown to be prosperous candidates to support the immobilization of enzymes and microbial cells. It also highlights the properties of nanomaterial support such as large surface area and comfort compartment for immobilization. The availability of different types of materials as catalyst support provides an opportunity to understand and develop efficient biocatalytic systems. The choice of selecting a catalyst support will mostly depend on the interaction of the material with the enzyme or microbial cell. Finally, potential challenges, future approaches in developing immobilized biocatalytic systems for various applications and novel material supports are suggested. © 2022 Society of Chemical Industry (SCI).",
journal = "Journal of Chemical Technology & Biotechnology",
title = "Role of catalyst supports in biocatalysis",
doi = "10.1002/jctb.7177"
}
Manikandan, S. K., Giannakoudakis, D. A., Prekodravac, J., Nair, V.,& Colmenares, J. C..Role of catalyst supports in biocatalysis. in Journal of Chemical Technology & Biotechnology.
https://doi.org/10.1002/jctb.7177
Manikandan SK, Giannakoudakis DA, Prekodravac J, Nair V, Colmenares JC. Role of catalyst supports in biocatalysis. in Journal of Chemical Technology & Biotechnology..
doi:10.1002/jctb.7177 .
Manikandan, Soumya Koippully, Giannakoudakis, Dimitrios A., Prekodravac, Jovana, Nair, Vaishakh, Colmenares, Juan Carlos, "Role of catalyst supports in biocatalysis" in Journal of Chemical Technology & Biotechnology,
https://doi.org/10.1002/jctb.7177 . .
1
2

Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle

Đurić, Tamara; Kuveljić, Jovana; Đorđević, Ana; Dekleva, Milica; Stanković, Goran; Stanković, Aleksandra; Živković, Maja

TY  - JOUR
AU  - Đurić, Tamara
AU  - Kuveljić, Jovana
AU  - Đorđević, Ana
AU  - Dekleva, Milica
AU  - Stanković, Goran
AU  - Stanković, Aleksandra
AU  - Živković, Maja
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10382
AB  - Background Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase−1 (MMP1) and −3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (−1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (−1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI. Methods The study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR-RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3–5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software. Results Haplotypes 2G-5A and 1G-6A were significantly and independently associated with MI compared with the reference haplotype 2G-6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI. Conclusion MMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.
T2  - Molecular Genetics & Genomic Medicine
T1  - Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle
SP  - e2022
DO  - 10.1002/mgg3.2022
ER  - 
@article{
author = "Đurić, Tamara and Kuveljić, Jovana and Đorđević, Ana and Dekleva, Milica and Stanković, Goran and Stanković, Aleksandra and Živković, Maja",
abstract = "Background Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase−1 (MMP1) and −3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (−1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (−1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI. Methods The study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR-RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3–5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software. Results Haplotypes 2G-5A and 1G-6A were significantly and independently associated with MI compared with the reference haplotype 2G-6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI. Conclusion MMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.",
journal = "Molecular Genetics & Genomic Medicine",
title = "Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle",
pages = "e2022",
doi = "10.1002/mgg3.2022"
}
Đurić, T., Kuveljić, J., Đorđević, A., Dekleva, M., Stanković, G., Stanković, A.,& Živković, M..Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle. in Molecular Genetics & Genomic Medicine, e2022.
https://doi.org/10.1002/mgg3.2022
Đurić T, Kuveljić J, Đorđević A, Dekleva M, Stanković G, Stanković A, Živković M. Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle. in Molecular Genetics & Genomic Medicine.:e2022.
doi:10.1002/mgg3.2022 .
Đurić, Tamara, Kuveljić, Jovana, Đorđević, Ana, Dekleva, Milica, Stanković, Goran, Stanković, Aleksandra, Živković, Maja, "Association of MMP1 and MMP3 haplotypes with myocardial infarction and echocardiographic parameters of the left ventricle" in Molecular Genetics & Genomic Medicine:e2022,
https://doi.org/10.1002/mgg3.2022 . .

The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement

Validžić, Ivana; Lojpur, Vesna; Mitrić, Miodrag

TY  - JOUR
AU  - Validžić, Ivana
AU  - Lojpur, Vesna
AU  - Mitrić, Miodrag
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10395
AB  - The operating characteristics of a commercial monocrystalline and amorphous Si-solar cell for outdoor and indoor applications with and without the use of the water flow lens (WFL) system are explored and reported. The cells are tested in indoor conditions with halogen and tungsten lamps, and additionally, in outdoor sun radiation. Changes in the spectra, investigation of the influence of higher and lower lighting, and indirect cooling of the solar cell are possibilities in the application of the used WFL system. After achieving the highest level of development and improvement for the Si-solar cell, as well as approaching theoretical maximum efficiency, it is obvious that efficiency gains can be made by better understanding additional light effects. Measurements made on monocrystalline Si-solar cells revealed that in the “focal point position” where intensity increases (above standard testing conditions [STC]), independently of indoor or outdoor lighting, huge improvements in ISC and VOC were observed. It was found that the ratios of the short-circuit current (ISC) and the input light energy (Pinput) are 5.2 and 24.8 for artificial light and 4.9 and 17.6 for outdoor light, without and with the use of the WFL system, respectively. The same trend after applying the WFL system was observed for the amorphous Si cell, except those oscillations were more pronounced at lower light intensities (far lower than STC), as expected. The ratios of ISC and Pinput are in the range of 5.1–5.3 and 10.5–26.5 without and with the use of the WFL system.
T2  - Environmental Progress & Sustainable Energy
T1  - The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement
SP  - e13967
DO  - 10.1002/ep.13967
ER  - 
@article{
author = "Validžić, Ivana and Lojpur, Vesna and Mitrić, Miodrag",
abstract = "The operating characteristics of a commercial monocrystalline and amorphous Si-solar cell for outdoor and indoor applications with and without the use of the water flow lens (WFL) system are explored and reported. The cells are tested in indoor conditions with halogen and tungsten lamps, and additionally, in outdoor sun radiation. Changes in the spectra, investigation of the influence of higher and lower lighting, and indirect cooling of the solar cell are possibilities in the application of the used WFL system. After achieving the highest level of development and improvement for the Si-solar cell, as well as approaching theoretical maximum efficiency, it is obvious that efficiency gains can be made by better understanding additional light effects. Measurements made on monocrystalline Si-solar cells revealed that in the “focal point position” where intensity increases (above standard testing conditions [STC]), independently of indoor or outdoor lighting, huge improvements in ISC and VOC were observed. It was found that the ratios of the short-circuit current (ISC) and the input light energy (Pinput) are 5.2 and 24.8 for artificial light and 4.9 and 17.6 for outdoor light, without and with the use of the WFL system, respectively. The same trend after applying the WFL system was observed for the amorphous Si cell, except those oscillations were more pronounced at lower light intensities (far lower than STC), as expected. The ratios of ISC and Pinput are in the range of 5.1–5.3 and 10.5–26.5 without and with the use of the WFL system.",
journal = "Environmental Progress & Sustainable Energy",
title = "The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement",
pages = "e13967",
doi = "10.1002/ep.13967"
}
Validžić, I., Lojpur, V.,& Mitrić, M..The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement. in Environmental Progress & Sustainable Energy, e13967.
https://doi.org/10.1002/ep.13967
Validžić I, Lojpur V, Mitrić M. The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement. in Environmental Progress & Sustainable Energy.:e13967.
doi:10.1002/ep.13967 .
Validžić, Ivana, Lojpur, Vesna, Mitrić, Miodrag, "The influence of the water flow lens system on the operating characteristics of monocrystalline and amorphous Si-solar cells for outdoor and indoor use: The photovoltaic improvement" in Environmental Progress & Sustainable Energy:e13967,
https://doi.org/10.1002/ep.13967 . .

Recent advances on smart glycoconjugate vaccines in infections and cancer

Anderluh, Marko; Berti, Francesco; Bzducha-Wróbel, Anna; Chiodo, Fabrizio; Colombo, Cinzia; Compostella, Federica; Durlik, Katarzyna; Ferhati, Xhenti; Holmdahl, Rikard; Jovanović, Dragana J.; Kaca, Wieslaw; Lay, Luigi; Marinovic-Cincovic, Milena; Marradi, Marco; Ozil, Musa; Polito, Laura; Reina, Josè Juan; Reis, Celso A.; Sackstein, Robert; Silipo, Alba; Švajger, Urban; Vaněk, Ondřej; Yamamoto, Fumiichiro; Richichi, Barbara; van Vliet, Sandra J.

TY  - JOUR
AU  - Anderluh, Marko
AU  - Berti, Francesco
AU  - Bzducha-Wróbel, Anna
AU  - Chiodo, Fabrizio
AU  - Colombo, Cinzia
AU  - Compostella, Federica
AU  - Durlik, Katarzyna
AU  - Ferhati, Xhenti
AU  - Holmdahl, Rikard
AU  - Jovanović, Dragana J.
AU  - Kaca, Wieslaw
AU  - Lay, Luigi
AU  - Marinovic-Cincovic, Milena
AU  - Marradi, Marco
AU  - Ozil, Musa
AU  - Polito, Laura
AU  - Reina, Josè Juan
AU  - Reis, Celso A.
AU  - Sackstein, Robert
AU  - Silipo, Alba
AU  - Švajger, Urban
AU  - Vaněk, Ondřej
AU  - Yamamoto, Fumiichiro
AU  - Richichi, Barbara
AU  - van Vliet, Sandra J.
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9834
AB  - Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the human immunodeficiency virus or to induce cellular T-cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as “tumor-associated carbohydrate antigens”. Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T-cell-independent antigens, not eliciting protective immunoglobulin G responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.
T2  - The FEBS Journal
T1  - Recent advances on smart glycoconjugate vaccines in infections and cancer
DO  - 10.1111/febs.15909
ER  - 
@article{
author = "Anderluh, Marko and Berti, Francesco and Bzducha-Wróbel, Anna and Chiodo, Fabrizio and Colombo, Cinzia and Compostella, Federica and Durlik, Katarzyna and Ferhati, Xhenti and Holmdahl, Rikard and Jovanović, Dragana J. and Kaca, Wieslaw and Lay, Luigi and Marinovic-Cincovic, Milena and Marradi, Marco and Ozil, Musa and Polito, Laura and Reina, Josè Juan and Reis, Celso A. and Sackstein, Robert and Silipo, Alba and Švajger, Urban and Vaněk, Ondřej and Yamamoto, Fumiichiro and Richichi, Barbara and van Vliet, Sandra J.",
abstract = "Vaccination is one of the greatest achievements in biomedical research preventing death and morbidity in many infectious diseases through the induction of pathogen-specific humoral and cellular immune responses. Currently, no effective vaccines are available for pathogens with a highly variable antigenic load, such as the human immunodeficiency virus or to induce cellular T-cell immunity in the fight against cancer. The recent SARS-CoV-2 outbreak has reinforced the relevance of designing smart therapeutic vaccine modalities to ensure public health. Indeed, academic and private companies have ongoing joint efforts to develop novel vaccine prototypes for this virus. Many pathogens are covered by a dense glycan-coat, which form an attractive target for vaccine development. Moreover, many tumor types are characterized by altered glycosylation profiles that are known as “tumor-associated carbohydrate antigens”. Unfortunately, glycans do not provoke a vigorous immune response and generally serve as T-cell-independent antigens, not eliciting protective immunoglobulin G responses nor inducing immunological memory. A close and continuous crosstalk between glycochemists and glycoimmunologists is essential for the successful development of efficient immune modulators. It is clear that this is a key point for the discovery of novel approaches, which could significantly improve our understanding of the immune system. In this review, we discuss the latest advancements in development of vaccines against glycan epitopes to gain selective immune responses and to provide an overview on the role of different immunogenic constructs in improving glycovaccine efficacy.",
journal = "The FEBS Journal",
title = "Recent advances on smart glycoconjugate vaccines in infections and cancer",
doi = "10.1111/febs.15909"
}
Anderluh, M., Berti, F., Bzducha-Wróbel, A., Chiodo, F., Colombo, C., Compostella, F., Durlik, K., Ferhati, X., Holmdahl, R., Jovanović, D. J., Kaca, W., Lay, L., Marinovic-Cincovic, M., Marradi, M., Ozil, M., Polito, L., Reina, J. J., Reis, C. A., Sackstein, R., Silipo, A., Švajger, U., Vaněk, O., Yamamoto, F., Richichi, B.,& van Vliet, S. J..Recent advances on smart glycoconjugate vaccines in infections and cancer. in The FEBS Journal.
https://doi.org/10.1111/febs.15909
Anderluh M, Berti F, Bzducha-Wróbel A, Chiodo F, Colombo C, Compostella F, Durlik K, Ferhati X, Holmdahl R, Jovanović DJ, Kaca W, Lay L, Marinovic-Cincovic M, Marradi M, Ozil M, Polito L, Reina JJ, Reis CA, Sackstein R, Silipo A, Švajger U, Vaněk O, Yamamoto F, Richichi B, van Vliet SJ. Recent advances on smart glycoconjugate vaccines in infections and cancer. in The FEBS Journal..
doi:10.1111/febs.15909 .
Anderluh, Marko, Berti, Francesco, Bzducha-Wróbel, Anna, Chiodo, Fabrizio, Colombo, Cinzia, Compostella, Federica, Durlik, Katarzyna, Ferhati, Xhenti, Holmdahl, Rikard, Jovanović, Dragana J., Kaca, Wieslaw, Lay, Luigi, Marinovic-Cincovic, Milena, Marradi, Marco, Ozil, Musa, Polito, Laura, Reina, Josè Juan, Reis, Celso A., Sackstein, Robert, Silipo, Alba, Švajger, Urban, Vaněk, Ondřej, Yamamoto, Fumiichiro, Richichi, Barbara, van Vliet, Sandra J., "Recent advances on smart glycoconjugate vaccines in infections and cancer" in The FEBS Journal,
https://doi.org/10.1111/febs.15909 . .
15
19
4
15

Non-coding RNA and cholesteatoma

Jovanović, Ivan G.; Živković, Maja; Ješić, Snežana; Stanković, Aleksandra

TY  - JOUR
AU  - Jovanović, Ivan G.
AU  - Živković, Maja
AU  - Ješić, Snežana
AU  - Stanković, Aleksandra
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10115
AB  - Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.
T2  - Laryngoscope Investigative Otolaryngology
T2  - Laryngoscope Investigative Otolaryngology
T1  - Non-coding RNA and cholesteatoma
DO  - 10.1002/lio2.728
ER  - 
@article{
author = "Jovanović, Ivan G. and Živković, Maja and Ješić, Snežana and Stanković, Aleksandra",
abstract = "Objective Cholesteatoma is a challenging chronic pathology of the middle ear for which pharmacologic therapies have not been developed yet. Cholesteatoma occurrence depends on the interplay between genetic and environmental factors while master regulators orchestrating disease progression are still unknown. Therefore, in this review, we will discuss the diagnostic and therapeutic potential of non-coding RNAs (ncRNA) as a new class of regulatory molecules. Methods We have comprehensively reviewed all articles investigating ncRNAs, specifically micro RNAs (miRNAs) and long ncRNAs (lncRNA/circRNA) in cholesteatoma tissue. Results Candidate miRNA approaches indicated that miR-21 and let-7a are the major miRNAs involved in cholesteatoma growth, migration, proliferation, bone destruction, and apoptosis. Regulatory potential for the same biological processes was also observed for miR-203a. The NF-kB/miR-802/PTEN regulatory network was in relation to observed miR-21 activity in cholesteatoma as well. High throughput approaches revealed additional ncRNAs implicated in cholesteatoma pathology. Competitive endogenous RNA (ceRNA) analysis highlighted lncRNA/circRNA that could be “endogenous sponge” for miR-21 and let-7a based on the hypothesis that RNA transcripts can communicate with and regulate each other by using shared miRNA response elements. Conclusion In this review, we summarize the discoveries and role of ncRNA in major pathways in cholesteatoma and highlight the potential of miRNA-based therapeutics in the treatment of cholesteatoma. Level of Evidence: NA.",
journal = "Laryngoscope Investigative Otolaryngology, Laryngoscope Investigative Otolaryngology",
title = "Non-coding RNA and cholesteatoma",
doi = "10.1002/lio2.728"
}
Jovanović, I. G., Živković, M., Ješić, S.,& Stanković, A..Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology.
https://doi.org/10.1002/lio2.728
Jovanović IG, Živković M, Ješić S, Stanković A. Non-coding RNA and cholesteatoma. in Laryngoscope Investigative Otolaryngology..
doi:10.1002/lio2.728 .
Jovanović, Ivan G., Živković, Maja, Ješić, Snežana, Stanković, Aleksandra, "Non-coding RNA and cholesteatoma" in Laryngoscope Investigative Otolaryngology,
https://doi.org/10.1002/lio2.728 . .
1

Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer

Stojković, Goran; Jovanović, Ivan G.; Dimitrijević, Milovan; Jovanović, Jasmina; Tomanović, Nada; Stanković, Aleksandra; Arsović, Nenad; Boričić, Ivan; Zeljić, Katarina

TY  - JOUR
AU  - Stojković, Goran
AU  - Jovanović, Ivan G.
AU  - Dimitrijević, Milovan
AU  - Jovanović, Jasmina
AU  - Tomanović, Nada
AU  - Stanković, Aleksandra
AU  - Arsović, Nenad
AU  - Boričić, Ivan
AU  - Zeljić, Katarina
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10217
AB  - Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.
T2  - Oral Diseases
T1  - Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer
DO  - 10.1111/odi.14185
ER  - 
@article{
author = "Stojković, Goran and Jovanović, Ivan G. and Dimitrijević, Milovan and Jovanović, Jasmina and Tomanović, Nada and Stanković, Aleksandra and Arsović, Nenad and Boričić, Ivan and Zeljić, Katarina",
abstract = "Objectives This study aimed to experimentally validate dysregulated expression of miRNA candidates selected through updated meta-analysis of most commonly deregulated miRNAs in oral cancer and to explore their diagnostic and prognostic potential. Materials and methods Five miRNAs (miR-31-3p, miR-135b-5p, miR-18a-5p, miR-30a-5p and miR-139-5p) from updated meta-signature were selected for validation by qRT-PCR method in 35 oral cancer clinical specimens and adjacent non-cancerous tissue. Results Updated meta-analysis has identified 13 most commonly deregulated miRNAs in oral cancer. Seven miRNAs were consistently up-regulated (miR-21-5p, miR-31-3p, miR-135b-5p, miR-31-5p, miR-424-5p, miR-18a-5p and miR-21-3p), while five were down-regulated (miR-139-5p, miR-30a-3p, miR-375-3p, miR-376c-3p and miR-30a-5p). Increased expression of miR-31-3p and miR-135b-5p, and decreased expression of miR-139-5p and miR-30a-5p were confirmed in oral cancer compared to adjacent non-cancerous tissue. A three miRNAs combination (miR-31-3p, miR-139-5p and miR-30a-5p) gave the most promising diagnostic potential for discriminating oral cancer from non-cancerous tissue (AUC: 0.780 [95% CI: 0.673–0.886], p < 0.0005, sensitivity 94.3%, specificity 51.4%). High expression of miR-135b-5p, miR-18a-5p and miR-30a-5p was associated with poor survival (p = 0.003, p = 0.048, p = 0.016 respectively). Conclusion miR-31-3p, miR-139-5p and miR-30a-5p panel was confirmed as a potential diagnostic biomarker when distinguishing oral cancer from non-cancerous tissue. miR-135b-5p, miR-18a-5p and miR-30a-5p might serve as potential biomarkers of poor survival of oral cancer patients.",
journal = "Oral Diseases",
title = "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer",
doi = "10.1111/odi.14185"
}
Stojković, G., Jovanović, I. G., Dimitrijević, M., Jovanović, J., Tomanović, N., Stanković, A., Arsović, N., Boričić, I.,& Zeljić, K..Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases.
https://doi.org/10.1111/odi.14185
Stojković G, Jovanović IG, Dimitrijević M, Jovanović J, Tomanović N, Stanković A, Arsović N, Boričić I, Zeljić K. Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer. in Oral Diseases..
doi:10.1111/odi.14185 .
Stojković, Goran, Jovanović, Ivan G., Dimitrijević, Milovan, Jovanović, Jasmina, Tomanović, Nada, Stanković, Aleksandra, Arsović, Nenad, Boričić, Ivan, Zeljić, Katarina, "Meta-signature guided investigation of miRNA candidates as potential biomarkers of oral cancer" in Oral Diseases,
https://doi.org/10.1111/odi.14185 . .

Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol

Kovačević, Nikola; Dapčević, Aleksandra; Ivković, Branka; Kachrimanis, Kyriakos; Mitrić, Miodrag; Ibrić, Svetlana; Medarević, Đorđe

TY  - JOUR
AU  - Kovačević, Nikola
AU  - Dapčević, Aleksandra
AU  - Ivković, Branka
AU  - Kachrimanis, Kyriakos
AU  - Mitrić, Miodrag
AU  - Ibrić, Svetlana
AU  - Medarević, Đorđe
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9932
AB  - In this study, four low molecular weight (LMW) excipients, tryptophan (TRY), phenylalanine (PHE), lysine (LYS) and saccharin (SAC) were evaluated as co-formers to generate co-amorphous systems (CAMS) by ball milling with carvedilol (CRV). Mixtures of CRV and LMW excipient in 1:0.5, 1:1 and 1:2 drug:excipient molar ratios were ball milled and analysed by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform (FT-IR) infrared spectroscopy and dissolution testing. CAMS were formed by milling of a mixture of CRV with TRY in 1:2 M ratio and SAC in 1:1 M ratio, while amorphization of only CRV was achieved in other mixtures with SAC. In other samples containing TRY and PHE, milling resulted in partial amorphization, while LYS was the least suitable excipient for the amorphization of CRV. Unexpectedly, the highest supersaturation of CRV was achieved from samples containing CRV and LYS in 1:1 and 1:2 M ratios, despite the absence of a significant reduction in CRV crystallinity upon milling of these samples. Increase of hydrophobic surface area caused by milling of samples with TRY and PHE and agglomeration during dissolution testing of samples containing SAC are likely causes of poor dissolution performance of mixtures containing fully or partially amorphous CRV.
T2  - International Journal of Pharmaceutics
T1  - Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol
VL  - 608
DO  - 10.1016/j.ijpharm.2021.121033
ER  - 
@article{
author = "Kovačević, Nikola and Dapčević, Aleksandra and Ivković, Branka and Kachrimanis, Kyriakos and Mitrić, Miodrag and Ibrić, Svetlana and Medarević, Đorđe",
abstract = "In this study, four low molecular weight (LMW) excipients, tryptophan (TRY), phenylalanine (PHE), lysine (LYS) and saccharin (SAC) were evaluated as co-formers to generate co-amorphous systems (CAMS) by ball milling with carvedilol (CRV). Mixtures of CRV and LMW excipient in 1:0.5, 1:1 and 1:2 drug:excipient molar ratios were ball milled and analysed by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform (FT-IR) infrared spectroscopy and dissolution testing. CAMS were formed by milling of a mixture of CRV with TRY in 1:2 M ratio and SAC in 1:1 M ratio, while amorphization of only CRV was achieved in other mixtures with SAC. In other samples containing TRY and PHE, milling resulted in partial amorphization, while LYS was the least suitable excipient for the amorphization of CRV. Unexpectedly, the highest supersaturation of CRV was achieved from samples containing CRV and LYS in 1:1 and 1:2 M ratios, despite the absence of a significant reduction in CRV crystallinity upon milling of these samples. Increase of hydrophobic surface area caused by milling of samples with TRY and PHE and agglomeration during dissolution testing of samples containing SAC are likely causes of poor dissolution performance of mixtures containing fully or partially amorphous CRV.",
journal = "International Journal of Pharmaceutics",
title = "Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol",
volume = "608",
doi = "10.1016/j.ijpharm.2021.121033"
}
Kovačević, N., Dapčević, A., Ivković, B., Kachrimanis, K., Mitrić, M., Ibrić, S.,& Medarević, Đ..Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol. in International Journal of Pharmaceutics, 608.
https://doi.org/10.1016/j.ijpharm.2021.121033
Kovačević N, Dapčević A, Ivković B, Kachrimanis K, Mitrić M, Ibrić S, Medarević Đ. Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol. in International Journal of Pharmaceutics.608.
doi:10.1016/j.ijpharm.2021.121033 .
Kovačević, Nikola, Dapčević, Aleksandra, Ivković, Branka, Kachrimanis, Kyriakos, Mitrić, Miodrag, Ibrić, Svetlana, Medarević, Đorđe, "Potential application of low molecular weight excipients for amorphization and dissolution enhancement of carvedilol" in International Journal of Pharmaceutics, 608,
https://doi.org/10.1016/j.ijpharm.2021.121033 . .
4
1
4

Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease

Aranđelović, Jovana; Santrač, Anja; Batinić, Bojan; Todorović, Lidija; Stevanović, Vladimir; Tiruveedhula, Veera Venkata Naga Phani Babu; Sharmin, Dishary; Rashid, Farjana; Stanojević, Boban; Cook, James M.; Savić, Miroslav M.

TY  - JOUR
AU  - Aranđelović, Jovana
AU  - Santrač, Anja
AU  - Batinić, Bojan
AU  - Todorović, Lidija
AU  - Stevanović, Vladimir
AU  - Tiruveedhula, Veera Venkata Naga Phani Babu
AU  - Sharmin, Dishary
AU  - Rashid, Farjana
AU  - Stanojević, Boban
AU  - Cook, James M.
AU  - Savić, Miroslav M.
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10360
AB  - Aims GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABAA receptors (NAM and PAM, respectively) would affect social interaction, social, object and spatial memory, and neuroinflammation. Methods After 10-day treatment with PAM, NAM, or solvent, 6-month-old transgenic and non-transgenic 5xFAD mice underwent testing in a behavioral battery. Gene expressions of IL-1β, IL-6, TNF-α, GFAP, and IBA-1 were determined in hippocampus and prefrontal cortex by qPCR. Results PAM treatment impaired spatial learning in transgenic females compared to solvent-treated transgenic females, and social recognition in transgenic and non-transgenic males. NAM treatment declined social interaction in transgenic and non-transgenic males, while had beneficial effect on cognitive flexibility in non-transgenic males compared to solvent-treated non-transgenic males. Transgenic animals have not fully displayed cognitive symptoms, but neuroinflammation was confirmed. NAM reduced proinflammatory gene expressions in transgenic females and astrogliosis in transgenic males compared to pathological controls. Conclusion PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.
T2  - CNS Neuroscience & Therapeutics
T2  - CNS Neuroscience & Therapeutics
T1  - Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease
DO  - 10.1111/cns.13914
ER  - 
@article{
author = "Aranđelović, Jovana and Santrač, Anja and Batinić, Bojan and Todorović, Lidija and Stevanović, Vladimir and Tiruveedhula, Veera Venkata Naga Phani Babu and Sharmin, Dishary and Rashid, Farjana and Stanojević, Boban and Cook, James M. and Savić, Miroslav M.",
abstract = "Aims GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABAA receptors (NAM and PAM, respectively) would affect social interaction, social, object and spatial memory, and neuroinflammation. Methods After 10-day treatment with PAM, NAM, or solvent, 6-month-old transgenic and non-transgenic 5xFAD mice underwent testing in a behavioral battery. Gene expressions of IL-1β, IL-6, TNF-α, GFAP, and IBA-1 were determined in hippocampus and prefrontal cortex by qPCR. Results PAM treatment impaired spatial learning in transgenic females compared to solvent-treated transgenic females, and social recognition in transgenic and non-transgenic males. NAM treatment declined social interaction in transgenic and non-transgenic males, while had beneficial effect on cognitive flexibility in non-transgenic males compared to solvent-treated non-transgenic males. Transgenic animals have not fully displayed cognitive symptoms, but neuroinflammation was confirmed. NAM reduced proinflammatory gene expressions in transgenic females and astrogliosis in transgenic males compared to pathological controls. Conclusion PAM and NAM failed to exert favorable behavioral effects in transgenic animals. Suppression of neuroinflammation obtained with NAM calls for more studies with GABAergic ligands in amyloid beta- and/or tau-dependent models with prominent neuroinflammation.",
journal = "CNS Neuroscience & Therapeutics, CNS Neuroscience & Therapeutics",
title = "Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease",
doi = "10.1111/cns.13914"
}
Aranđelović, J., Santrač, A., Batinić, B., Todorović, L., Stevanović, V., Tiruveedhula, V. V. N. P. B., Sharmin, D., Rashid, F., Stanojević, B., Cook, J. M.,& Savić, M. M..Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics.
https://doi.org/10.1111/cns.13914
Aranđelović J, Santrač A, Batinić B, Todorović L, Stevanović V, Tiruveedhula VVNPB, Sharmin D, Rashid F, Stanojević B, Cook JM, Savić MM. Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease. in CNS Neuroscience & Therapeutics..
doi:10.1111/cns.13914 .
Aranđelović, Jovana, Santrač, Anja, Batinić, Bojan, Todorović, Lidija, Stevanović, Vladimir, Tiruveedhula, Veera Venkata Naga Phani Babu, Sharmin, Dishary, Rashid, Farjana, Stanojević, Boban, Cook, James M., Savić, Miroslav M., "Effects of α5 GABAA receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease" in CNS Neuroscience & Therapeutics,
https://doi.org/10.1111/cns.13914 . .
10
1

Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides

Batalovic, Katarina; Radaković, Jana; Paskaš Mamula, Bojana; Kuzmanović, Bojana; Medić-Ilić, Mirjana

TY  - JOUR
AU  - Batalovic, Katarina
AU  - Radaković, Jana
AU  - Paskaš Mamula, Bojana
AU  - Kuzmanović, Bojana
AU  - Medić-Ilić, Mirjana
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10348
AB  - Theoretical tools or structure-property relations that enable the prediction of metal hydrides are of enormous interest in developing new hydrogen storage materials. Density functional theory (DFT) is one such approach that provides accurate hydride formation energies, which, if complemented with vibrational zero-point energy and other contributions, provides accurate hydride formation enthalpies. However, this approach is time consuming and, therefore, often avoided, hindering the modeling of experimental behavior. The recent implementation of graph neural networks (GNN) in materials science enables fast prediction of crystal formation energy with a DFT accuracy. Starting from the MatErials Graph Network (MEGNet), transfer learning is applied to develop a model for predicting hydride formation enthalpy based on the crystal structure of the starting intermetallic. Excellent accuracy is achieved for Mg-containing alloys, allowing the screening of the Mg-Ni-M ternary intermetallics. In addition, data containing matching experimental properties and crystal structure of metal hydrides are provided, enabling future development.
T2  - Advanced Theory and Simulations
T1  - Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides
SP  - 2200293
DO  - 10.1002/adts.202200293
ER  - 
@article{
author = "Batalovic, Katarina and Radaković, Jana and Paskaš Mamula, Bojana and Kuzmanović, Bojana and Medić-Ilić, Mirjana",
abstract = "Theoretical tools or structure-property relations that enable the prediction of metal hydrides are of enormous interest in developing new hydrogen storage materials. Density functional theory (DFT) is one such approach that provides accurate hydride formation energies, which, if complemented with vibrational zero-point energy and other contributions, provides accurate hydride formation enthalpies. However, this approach is time consuming and, therefore, often avoided, hindering the modeling of experimental behavior. The recent implementation of graph neural networks (GNN) in materials science enables fast prediction of crystal formation energy with a DFT accuracy. Starting from the MatErials Graph Network (MEGNet), transfer learning is applied to develop a model for predicting hydride formation enthalpy based on the crystal structure of the starting intermetallic. Excellent accuracy is achieved for Mg-containing alloys, allowing the screening of the Mg-Ni-M ternary intermetallics. In addition, data containing matching experimental properties and crystal structure of metal hydrides are provided, enabling future development.",
journal = "Advanced Theory and Simulations",
title = "Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides",
pages = "2200293",
doi = "10.1002/adts.202200293"
}
Batalovic, K., Radaković, J., Paskaš Mamula, B., Kuzmanović, B.,& Medić-Ilić, M..Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides. in Advanced Theory and Simulations, 2200293.
https://doi.org/10.1002/adts.202200293
Batalovic K, Radaković J, Paskaš Mamula B, Kuzmanović B, Medić-Ilić M. Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides. in Advanced Theory and Simulations.:2200293.
doi:10.1002/adts.202200293 .
Batalovic, Katarina, Radaković, Jana, Paskaš Mamula, Bojana, Kuzmanović, Bojana, Medić-Ilić, Mirjana, "Predicting the Heat of Hydride Formation by Graph Neural Network - Exploring the Structure-Property Relation for Metal Hydrides" in Advanced Theory and Simulations:2200293,
https://doi.org/10.1002/adts.202200293 . .
1
1

Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production

Manić, Nebojša G.; Janković, Bojan; Stojiljković, Dragoslava; Popović, Mina; Cvetković, Slobodan; Mikulčić, Hrvoje

(2023)

TY  - JOUR
AU  - Manić, Nebojša G.
AU  - Janković, Bojan
AU  - Stojiljković, Dragoslava
AU  - Popović, Mina
AU  - Cvetković, Slobodan
AU  - Mikulčić, Hrvoje
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10595
AB  - The actual paper analyses the performance of different energy crop biomasses, Miscanthus x giganteus Greef et Deu (EC-1) and Arundo donax L. (EC-2) stems, during slow pyrolysis process monitored by simultaneous TG-DTG-MS techniques, through chemical exergy analysis. In addition to considering the physical and chemical characteristics of given feedstocks for their efficient thermo-chemical conversion into pyrolytic gas, in this study, a theoretical simulation for their implementation use in the gasification process was also performed. The performed thermodynamic study with detailed exergy analysis showed that the large contribution of exergy in syngas components such as CO and H2 originates primarily from cellulose pyrolysis of EC-1, while large exergy contribution in syngas component as CH4 originates from lignin pyrolysis of EC-2. It was founded that the exergy efficiency of syngas for EC-1 equals 19.04%, which is lower than the exergy efficiency of syngas for EC-2 (20.46%), as a result of higher ash content in EC-1. Also, it was reported that higher carbon (C) and hydrogen (H) contents present in the EC-2 sample generate higher gaseous energy and exergy values, i.e. the increment of exergy efficiency of syngas, by both approaches (pyrolysis and gasification exergy analysis), but results in a lower biomass chemical exergy (18.28 MJ kg−1). The methodology applied to the gasification process was shown a higher exergy efficiency for EC-2 (∼36 – 42%) than for EC-1 (∼33 – 39%), dependant on the equivalence ratio (ER).
T2  - Thermochimica Acta
T1  - Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production
VL  - 719
SP  - 179408
DO  - 10.1016/j.tca.2022.179408
ER  - 
@article{
author = "Manić, Nebojša G. and Janković, Bojan and Stojiljković, Dragoslava and Popović, Mina and Cvetković, Slobodan and Mikulčić, Hrvoje",
year = "2023",
abstract = "The actual paper analyses the performance of different energy crop biomasses, Miscanthus x giganteus Greef et Deu (EC-1) and Arundo donax L. (EC-2) stems, during slow pyrolysis process monitored by simultaneous TG-DTG-MS techniques, through chemical exergy analysis. In addition to considering the physical and chemical characteristics of given feedstocks for their efficient thermo-chemical conversion into pyrolytic gas, in this study, a theoretical simulation for their implementation use in the gasification process was also performed. The performed thermodynamic study with detailed exergy analysis showed that the large contribution of exergy in syngas components such as CO and H2 originates primarily from cellulose pyrolysis of EC-1, while large exergy contribution in syngas component as CH4 originates from lignin pyrolysis of EC-2. It was founded that the exergy efficiency of syngas for EC-1 equals 19.04%, which is lower than the exergy efficiency of syngas for EC-2 (20.46%), as a result of higher ash content in EC-1. Also, it was reported that higher carbon (C) and hydrogen (H) contents present in the EC-2 sample generate higher gaseous energy and exergy values, i.e. the increment of exergy efficiency of syngas, by both approaches (pyrolysis and gasification exergy analysis), but results in a lower biomass chemical exergy (18.28 MJ kg−1). The methodology applied to the gasification process was shown a higher exergy efficiency for EC-2 (∼36 – 42%) than for EC-1 (∼33 – 39%), dependant on the equivalence ratio (ER).",
journal = "Thermochimica Acta",
title = "Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production",
volume = "719",
pages = "179408",
doi = "10.1016/j.tca.2022.179408"
}
Manić, N. G., Janković, B., Stojiljković, D., Popović, M., Cvetković, S.,& Mikulčić, H.. (2023). Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production. in Thermochimica Acta, 719, 179408.
https://doi.org/10.1016/j.tca.2022.179408
Manić NG, Janković B, Stojiljković D, Popović M, Cvetković S, Mikulčić H. Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production. in Thermochimica Acta. 2023;719:179408.
doi:10.1016/j.tca.2022.179408 .
Manić, Nebojša G., Janković, Bojan, Stojiljković, Dragoslava, Popović, Mina, Cvetković, Slobodan, Mikulčić, Hrvoje, "Thermodynamic study on energy crops thermochemical conversion to increase the efficiency of energy production" in Thermochimica Acta, 719 (2023):179408,
https://doi.org/10.1016/j.tca.2022.179408 . .

Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions

Janković, Bojan; Manić, Nebojša; Popović, Mina; Cvetković, Slobodan; Dželetović, Željko; Stojiljković, Dragoslava

(2023)

TY  - JOUR
AU  - Janković, Bojan
AU  - Manić, Nebojša
AU  - Popović, Mina
AU  - Cvetković, Slobodan
AU  - Dželetović, Željko
AU  - Stojiljković, Dragoslava
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10611
AB  - This work provides insight into possibilities of maximum utilization of C3-C4 energy crops for thermo-chemical conversion (slow pyrolysis) into high value biochemicals, platform chemicals, drop-in fuels and combustible gases, using coupled kinetic and thermodynamic analyses. In order to examine the kinetics of decomposition of lignocellulosic components, model-free and model-based methods faded from thermal analysis data were used. Thermodynamic compensation was used for explicatory of entropy controlled process, where conformational changes and chemical exchange directly affect the type and distribution of obtained pyrolytic products. It was shown that external variable (i.e. the heating rate/temperature) does not change either an entire reaction mechanism (mechanistic nature of MG and AD pyrolyses) or transition state, but it changes activation enthalpy and activation entropy which lead to differences in terms of heat energy consumption, pyrolysis favorability and thus rates of generation of activated complex among feedstocks. To investigate the interplay of catalysts (present in feedstocks as minerals) and reactants, selective energy transfer (SET) model was applied. The model showed an activity of catalyst with different outputs towards two reactants, lignin part of the structure in MG and 1,8-cineole in AD. It was shown that AD is more convenient for thermal conversion than MG, regarding to lower transformation energy requirement, higher reactivity, as well as much faster accumulation of products. © 2023 Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions
VL  - 194
DO  - 10.1016/j.indcrop.2023.116275
ER  - 
@article{
author = "Janković, Bojan and Manić, Nebojša and Popović, Mina and Cvetković, Slobodan and Dželetović, Željko and Stojiljković, Dragoslava",
year = "2023",
abstract = "This work provides insight into possibilities of maximum utilization of C3-C4 energy crops for thermo-chemical conversion (slow pyrolysis) into high value biochemicals, platform chemicals, drop-in fuels and combustible gases, using coupled kinetic and thermodynamic analyses. In order to examine the kinetics of decomposition of lignocellulosic components, model-free and model-based methods faded from thermal analysis data were used. Thermodynamic compensation was used for explicatory of entropy controlled process, where conformational changes and chemical exchange directly affect the type and distribution of obtained pyrolytic products. It was shown that external variable (i.e. the heating rate/temperature) does not change either an entire reaction mechanism (mechanistic nature of MG and AD pyrolyses) or transition state, but it changes activation enthalpy and activation entropy which lead to differences in terms of heat energy consumption, pyrolysis favorability and thus rates of generation of activated complex among feedstocks. To investigate the interplay of catalysts (present in feedstocks as minerals) and reactants, selective energy transfer (SET) model was applied. The model showed an activity of catalyst with different outputs towards two reactants, lignin part of the structure in MG and 1,8-cineole in AD. It was shown that AD is more convenient for thermal conversion than MG, regarding to lower transformation energy requirement, higher reactivity, as well as much faster accumulation of products. © 2023 Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions",
volume = "194",
doi = "10.1016/j.indcrop.2023.116275"
}
Janković, B., Manić, N., Popović, M., Cvetković, S., Dželetović, Ž.,& Stojiljković, D.. (2023). Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions. in Industrial Crops and Products, 194.
https://doi.org/10.1016/j.indcrop.2023.116275
Janković B, Manić N, Popović M, Cvetković S, Dželetović Ž, Stojiljković D. Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions. in Industrial Crops and Products. 2023;194.
doi:10.1016/j.indcrop.2023.116275 .
Janković, Bojan, Manić, Nebojša, Popović, Mina, Cvetković, Slobodan, Dželetović, Željko, Stojiljković, Dragoslava, "Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions" in Industrial Crops and Products, 194 (2023),
https://doi.org/10.1016/j.indcrop.2023.116275 . .

Erosion Wear Behavior of High Chromium Cast Irons

Rajičić, Bratislav M.; Maslarević, Aleksandar; Bakić, Gordana; Maksimović, Vesna; Đukić, Miloš B.

(2023)

TY  - JOUR
AU  - Rajičić, Bratislav M.
AU  - Maslarević, Aleksandar
AU  - Bakić, Gordana
AU  - Maksimović, Vesna
AU  - Đukić, Miloš B.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10614
AB  - In this study, two high chromium cast irons (HCCI) with different chromium content (15%Cr and 25%Cr), in as-cast and annealed conditions (heat-treated, HT), were tested to determine the erosion wear behavior of these alloys. Erosion tests were done using a gas blast sand facility with high erodent particle velocity (90 m/s) and high erodent feed rate, at an impact angle of 45°, which represents conditions similar to service conditions of some components of thermal power plants using pulverized high mineral content coals. To identify erosion mechanisms, microstructural characterization was done by a scanning electron microscope on samples before and after erosion tests. Identification of microstructural phases was done by X-ray diffraction analysis. The main results of the tests shown in this paper indicate that matrix plastic deformation and distribution of carbide phase have a significant contribution to erosion resistance of HCCI alloys in severe erosion service conditions.
T2  - Transactions of the Indian Institute of Metals
T1  - Erosion Wear Behavior of High Chromium Cast Irons
DO  - 10.1007/s12666-022-02860-7
ER  - 
@article{
author = "Rajičić, Bratislav M. and Maslarević, Aleksandar and Bakić, Gordana and Maksimović, Vesna and Đukić, Miloš B.",
year = "2023",
abstract = "In this study, two high chromium cast irons (HCCI) with different chromium content (15%Cr and 25%Cr), in as-cast and annealed conditions (heat-treated, HT), were tested to determine the erosion wear behavior of these alloys. Erosion tests were done using a gas blast sand facility with high erodent particle velocity (90 m/s) and high erodent feed rate, at an impact angle of 45°, which represents conditions similar to service conditions of some components of thermal power plants using pulverized high mineral content coals. To identify erosion mechanisms, microstructural characterization was done by a scanning electron microscope on samples before and after erosion tests. Identification of microstructural phases was done by X-ray diffraction analysis. The main results of the tests shown in this paper indicate that matrix plastic deformation and distribution of carbide phase have a significant contribution to erosion resistance of HCCI alloys in severe erosion service conditions.",
journal = "Transactions of the Indian Institute of Metals",
title = "Erosion Wear Behavior of High Chromium Cast Irons",
doi = "10.1007/s12666-022-02860-7"
}
Rajičić, B. M., Maslarević, A., Bakić, G., Maksimović, V.,& Đukić, M. B.. (2023). Erosion Wear Behavior of High Chromium Cast Irons. in Transactions of the Indian Institute of Metals.
https://doi.org/10.1007/s12666-022-02860-7
Rajičić BM, Maslarević A, Bakić G, Maksimović V, Đukić MB. Erosion Wear Behavior of High Chromium Cast Irons. in Transactions of the Indian Institute of Metals. 2023;.
doi:10.1007/s12666-022-02860-7 .
Rajičić, Bratislav M., Maslarević, Aleksandar, Bakić, Gordana, Maksimović, Vesna, Đukić, Miloš B., "Erosion Wear Behavior of High Chromium Cast Irons" in Transactions of the Indian Institute of Metals (2023),
https://doi.org/10.1007/s12666-022-02860-7 . .

The protective role of nutritional antioxidants against oxidative stress in thyroid disorders

Mačvanin, Milena; Gluvić, Zoran; Zafirović, Sonja; Gao, Xin; Essack, Magbubah; Isenović, Esma R.

(2023)

TY  - JOUR
AU  - Mačvanin, Milena
AU  - Gluvić, Zoran
AU  - Zafirović, Sonja
AU  - Gao, Xin
AU  - Essack, Magbubah
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10613
AB  - An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.
T2  - Frontiers in Endocrinology
T1  - The protective role of nutritional antioxidants against oxidative stress in thyroid disorders
VL  - 13
DO  - 10.3389/fendo.2022.1092837
ER  - 
@article{
author = "Mačvanin, Milena and Gluvić, Zoran and Zafirović, Sonja and Gao, Xin and Essack, Magbubah and Isenović, Esma R.",
year = "2023",
abstract = "An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.",
journal = "Frontiers in Endocrinology",
title = "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders",
volume = "13",
doi = "10.3389/fendo.2022.1092837"
}
Mačvanin, M., Gluvić, Z., Zafirović, S., Gao, X., Essack, M.,& Isenović, E. R.. (2023). The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology, 13.
https://doi.org/10.3389/fendo.2022.1092837
Mačvanin M, Gluvić Z, Zafirović S, Gao X, Essack M, Isenović ER. The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology. 2023;13.
doi:10.3389/fendo.2022.1092837 .
Mačvanin, Milena, Gluvić, Zoran, Zafirović, Sonja, Gao, Xin, Essack, Magbubah, Isenović, Esma R., "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders" in Frontiers in Endocrinology, 13 (2023),
https://doi.org/10.3389/fendo.2022.1092837 . .

Free radicals: Relationship to Human Diseases and Potential Therapeutic applications

Zarić, Božidarka; Mačvanin, Mirjana T.; Isenović, Esma R.

(2023)

TY  - JOUR
AU  - Zarić, Božidarka
AU  - Mačvanin, Mirjana T.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10562
AB  - Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.
T2  - The International Journal of Biochemistry & Cell Biology
T1  - Free radicals: Relationship to Human Diseases and Potential Therapeutic applications
VL  - 154
SP  - 106346
DO  - 10.1016/j.biocel.2022.106346
ER  - 
@article{
author = "Zarić, Božidarka and Mačvanin, Mirjana T. and Isenović, Esma R.",
year = "2023",
abstract = "Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.",
journal = "The International Journal of Biochemistry & Cell Biology",
title = "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications",
volume = "154",
pages = "106346",
doi = "10.1016/j.biocel.2022.106346"
}
Zarić, B., Mačvanin, M. T.,& Isenović, E. R.. (2023). Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry & Cell Biology, 154, 106346.
https://doi.org/10.1016/j.biocel.2022.106346
Zarić B, Mačvanin MT, Isenović ER. Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry & Cell Biology. 2023;154:106346.
doi:10.1016/j.biocel.2022.106346 .
Zarić, Božidarka, Mačvanin, Mirjana T., Isenović, Esma R., "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications" in The International Journal of Biochemistry & Cell Biology, 154 (2023):106346,
https://doi.org/10.1016/j.biocel.2022.106346 . .

Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents

Milojkov, Dušan V.; Radosavljević-Mihajlović, Ana S.; Stanić, Vojislav Đ.; Nastasijević, Branislav J.; Radotić, Ksenija; Janković-Častvan, Ivona; Živković-Radovanović, Vukosava

(2023)

TY  - JOUR
AU  - Milojkov, Dušan V.
AU  - Radosavljević-Mihajlović, Ana S.
AU  - Stanić, Vojislav Đ.
AU  - Nastasijević, Branislav J.
AU  - Radotić, Ksenija
AU  - Janković-Častvan, Ivona
AU  - Živković-Radovanović, Vukosava
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10612
AB  - Nanomaterials based on metal–doped fluorapatite (FAP) have attracted considerable interest as potential next–generation antimicrobial agents. In this study, Cu2+–doped FAP nanocrystals have been successfully synthesized by a neutralization method at room temperature. Their structural, optical, antimicrobial, and hemcompatible properties have been investigated. XRD, FTIR, FESEM, and N2 adsorption–desorption studies indicate the formation of single–phase FAP mesoporous nanopowders, composed of rod–like particles. TEM images confirmed the formation of nanorodes with a length of 60 nm and a width of about 18 nm. Rietveld analysis shows that the Cu2+ ions preferentially substitute Ca2 (6 h) sites in the hexagonal fluorapatite crystal structure. Fluorescence spectroscopy accompanied by MCR–ALS method confirms substitution of Cu2+ ions in FAP crystal lattice with extracting additional d–d band transition at green color from FAP broadband self–activated luminescence in violet–blue color. Antimicrobial studies conducted on Staphylococcus aureus, Escherichia coli and Micrococcus lysodeikticus showed that FAP nanopowder with the highest Cu2+ content have strong bacteriostatic action on Staphylococcus aureus bacterial strain in mediums containing nutrition matters. In addition, this sample in comparison to pure FAP achieved a high percentage of relative reduction of bacterial population for all three species, being >90% in most cases. Fungistatic action is noticed too, throwgh the slowing down mycelium growth of fungus Aspergillus niger, Aspergillus flavus and Penicillium roqueforti and reduction of sporulation of Aspergillus niger species. Cu2+–doped FAP nanocrystals shows a synergistic antimicrobial effect with Cu2+ and F− ions. Concerning the potential biomedical applications, the hemolysis ratios of the Cu2+–doped FAP samples were below 5%. The obtained results pointed out the possible use of the synthesized nanocrystals as broad–spectrum antimicrobial agents for various biomedical and health care preparations.
T2  - Journal of Photochemistry and Photobiology B: Biology
T1  - Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents
VL  - 239
SP  - 112649
DO  - 10.1016/j.jphotobiol.2023.112649
ER  - 
@article{
author = "Milojkov, Dušan V. and Radosavljević-Mihajlović, Ana S. and Stanić, Vojislav Đ. and Nastasijević, Branislav J. and Radotić, Ksenija and Janković-Častvan, Ivona and Živković-Radovanović, Vukosava",
year = "2023",
abstract = "Nanomaterials based on metal–doped fluorapatite (FAP) have attracted considerable interest as potential next–generation antimicrobial agents. In this study, Cu2+–doped FAP nanocrystals have been successfully synthesized by a neutralization method at room temperature. Their structural, optical, antimicrobial, and hemcompatible properties have been investigated. XRD, FTIR, FESEM, and N2 adsorption–desorption studies indicate the formation of single–phase FAP mesoporous nanopowders, composed of rod–like particles. TEM images confirmed the formation of nanorodes with a length of 60 nm and a width of about 18 nm. Rietveld analysis shows that the Cu2+ ions preferentially substitute Ca2 (6 h) sites in the hexagonal fluorapatite crystal structure. Fluorescence spectroscopy accompanied by MCR–ALS method confirms substitution of Cu2+ ions in FAP crystal lattice with extracting additional d–d band transition at green color from FAP broadband self–activated luminescence in violet–blue color. Antimicrobial studies conducted on Staphylococcus aureus, Escherichia coli and Micrococcus lysodeikticus showed that FAP nanopowder with the highest Cu2+ content have strong bacteriostatic action on Staphylococcus aureus bacterial strain in mediums containing nutrition matters. In addition, this sample in comparison to pure FAP achieved a high percentage of relative reduction of bacterial population for all three species, being >90% in most cases. Fungistatic action is noticed too, throwgh the slowing down mycelium growth of fungus Aspergillus niger, Aspergillus flavus and Penicillium roqueforti and reduction of sporulation of Aspergillus niger species. Cu2+–doped FAP nanocrystals shows a synergistic antimicrobial effect with Cu2+ and F− ions. Concerning the potential biomedical applications, the hemolysis ratios of the Cu2+–doped FAP samples were below 5%. The obtained results pointed out the possible use of the synthesized nanocrystals as broad–spectrum antimicrobial agents for various biomedical and health care preparations.",
journal = "Journal of Photochemistry and Photobiology B: Biology",
title = "Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents",
volume = "239",
pages = "112649",
doi = "10.1016/j.jphotobiol.2023.112649"
}
Milojkov, D. V., Radosavljević-Mihajlović, A. S., Stanić, V. Đ., Nastasijević, B. J., Radotić, K., Janković-Častvan, I.,& Živković-Radovanović, V.. (2023). Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents. in Journal of Photochemistry and Photobiology B: Biology, 239, 112649.
https://doi.org/10.1016/j.jphotobiol.2023.112649
Milojkov DV, Radosavljević-Mihajlović AS, Stanić VĐ, Nastasijević BJ, Radotić K, Janković-Častvan I, Živković-Radovanović V. Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents. in Journal of Photochemistry and Photobiology B: Biology. 2023;239:112649.
doi:10.1016/j.jphotobiol.2023.112649 .
Milojkov, Dušan V., Radosavljević-Mihajlović, Ana S., Stanić, Vojislav Đ., Nastasijević, Branislav J., Radotić, Ksenija, Janković-Častvan, Ivona, Živković-Radovanović, Vukosava, "Synthesis and characterization of luminescent Cu2+–doped fluorapatite nanocrystals as potential broad–spectrum antimicrobial agents" in Journal of Photochemistry and Photobiology B: Biology, 239 (2023):112649,
https://doi.org/10.1016/j.jphotobiol.2023.112649 . .