TY  - JOUR
AU  - Algarra, Manuel
AU  - Carrillo, Celia
AU  - Nešić, Maja D.
AU  - Filipović Tričković, Jelena
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Jiménez-Jiménez, José
AU  - Rodriguez-Castellón, Enrique
AU  - Bandosz, Teresa J.
AU  - Petković, Marijana
AU  - Soto, Juan
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12247
AB  - This paper explains the basis for the excitation energy-independent fluorescence emission of biomass-derived carbon dots (CDs) and shows that these CDs have excellent anti-melanoma and anti-metastatic potential. Additionally, we demonstrate that the black carrots´-derived CDs can be exploited as cell cycle-sensing agents, because of the interaction with chromatin material. Besides their optical properties, fluorescent CDs have gained increased attention for image-guided cancer treatment due to their water solubility, environmental friendliness, affordability, ease of synthesis, and primary biocompatibility. CDs have excellent photostability, determined by their precursors and synthesis pathways. In this study, CDs with chemically homogenous surface functional groups were made using a hydrothermal technique from black carrot extract, an anthocyanin-rich substance derived from biomass. The anti-cancer and anti-metastatic properties of black carrot-derived CDs can be attributed to flavylium cations on the surface, spherical forms, and high water dispersibility. Most importantly, these CDs demonstrate a stable emission at a single wavelength, 612 nm, independent of the excitation energy, which we have explained theoretically for the first time.
T2  - Journal of Molecular Structure
T1  - Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential
VL  - 1300
SP  - 137245
DO  - 10.1016/j.molstruc.2023.137245
ER  - 

@article{
author = "Algarra, Manuel and Carrillo, Celia and Nešić, Maja D. and Filipović Tričković, Jelena and Žakula, Jelena and Korićanac, Lela and Jiménez-Jiménez, José and Rodriguez-Castellón, Enrique and Bandosz, Teresa J. and Petković, Marijana and Soto, Juan",
year = "2024",
abstract = "This paper explains the basis for the excitation energy-independent fluorescence emission of biomass-derived carbon dots (CDs) and shows that these CDs have excellent anti-melanoma and anti-metastatic potential. Additionally, we demonstrate that the black carrots´-derived CDs can be exploited as cell cycle-sensing agents, because of the interaction with chromatin material. Besides their optical properties, fluorescent CDs have gained increased attention for image-guided cancer treatment due to their water solubility, environmental friendliness, affordability, ease of synthesis, and primary biocompatibility. CDs have excellent photostability, determined by their precursors and synthesis pathways. In this study, CDs with chemically homogenous surface functional groups were made using a hydrothermal technique from black carrot extract, an anthocyanin-rich substance derived from biomass. The anti-cancer and anti-metastatic properties of black carrot-derived CDs can be attributed to flavylium cations on the surface, spherical forms, and high water dispersibility. Most importantly, these CDs demonstrate a stable emission at a single wavelength, 612 nm, independent of the excitation energy, which we have explained theoretically for the first time.",
journal = "Journal of Molecular Structure",
title = "Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential",
volume = "1300",
pages = "137245",
doi = "10.1016/j.molstruc.2023.137245"
}

Algarra, M., Carrillo, C., Nešić, M. D., Filipović Tričković, J., Žakula, J., Korićanac, L., Jiménez-Jiménez, J., Rodriguez-Castellón, E., Bandosz, T. J., Petković, M.,& Soto, J.. (2024). Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential. in Journal of Molecular Structure, 1300, 137245.
https://doi.org/10.1016/j.molstruc.2023.137245

Algarra M, Carrillo C, Nešić MD, Filipović Tričković J, Žakula J, Korićanac L, Jiménez-Jiménez J, Rodriguez-Castellón E, Bandosz TJ, Petković M, Soto J. Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential. in Journal of Molecular Structure. 2024;1300:137245.
doi:10.1016/j.molstruc.2023.137245 .

Algarra, Manuel, Carrillo, Celia, Nešić, Maja D., Filipović Tričković, Jelena, Žakula, Jelena, Korićanac, Lela, Jiménez-Jiménez, José, Rodriguez-Castellón, Enrique, Bandosz, Teresa J., Petković, Marijana, Soto, Juan, "Testing of black-carrots-derived fluorescence imaging and anti-metastatic potential" in Journal of Molecular Structure, 1300 (2024):137245,
https://doi.org/10.1016/j.molstruc.2023.137245 . .

TY  - JOUR
AU  - Abu el Rub, Anamarija
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Radoičić, Marija
AU  - Novaković, Mirjana
AU  - Žakula, Jelena
AU  - Ralić, Vanja
AU  - Petković, Marijana
AU  - Stepić, Milutin
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13214
AB  - The increasing incidence rate of pancreatic cancer worldwide, along with high resistance to existing chemotherapies and radiotherapy, demand new approaches for its treatment. Nanoparticle-guided cancer treatment modalities are promising in their anti-cancer efficiency and upgrading potential. We have synthesized and characterized Gd-doped titanium-dioxide nanoparticles (Gd-TiO 2 NPs), which showed good biocompatibility with MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. To assess the effect that these NPs have on tumor cells, we used synchrotron radiation Fourier transform infrared spectroscopy and principal component analysis. We elucidated the biochemical changes in the two cell lines induced after their interaction with these NPs. Results demonstrated changes in nucleic acids and carbohydrate metabolism and alterations in the protein conformation in both cell lines. In addition, considerable changes in lipid area were observed in PANC-1 cell line, suggesting that Gd-TiO 2 NPs have a prospective to be further studied as systems for pancreatic cancer treatment.
T2  - Journal of Molecular Structure
T1  - Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles
VL  - 1309
SP  - 138167
DO  - 10.1016/j.molstruc.2024.138167
ER  - 

@article{
author = "Abu el Rub, Anamarija and Nešić, Maja D. and Dučić, Tanja and Radoičić, Marija and Novaković, Mirjana and Žakula, Jelena and Ralić, Vanja and Petković, Marijana and Stepić, Milutin",
year = "2024",
abstract = "The increasing incidence rate of pancreatic cancer worldwide, along with high resistance to existing chemotherapies and radiotherapy, demand new approaches for its treatment. Nanoparticle-guided cancer treatment modalities are promising in their anti-cancer efficiency and upgrading potential. We have synthesized and characterized Gd-doped titanium-dioxide nanoparticles (Gd-TiO 2 NPs), which showed good biocompatibility with MIA PaCa-2 and PANC-1 pancreatic cancer cell lines. To assess the effect that these NPs have on tumor cells, we used synchrotron radiation Fourier transform infrared spectroscopy and principal component analysis. We elucidated the biochemical changes in the two cell lines induced after their interaction with these NPs. Results demonstrated changes in nucleic acids and carbohydrate metabolism and alterations in the protein conformation in both cell lines. In addition, considerable changes in lipid area were observed in PANC-1 cell line, suggesting that Gd-TiO 2 NPs have a prospective to be further studied as systems for pancreatic cancer treatment.",
journal = "Journal of Molecular Structure",
title = "Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles",
volume = "1309",
pages = "138167",
doi = "10.1016/j.molstruc.2024.138167"
}

Abu el Rub, A., Nešić, M. D., Dučić, T., Radoičić, M., Novaković, M., Žakula, J., Ralić, V., Petković, M.,& Stepić, M.. (2024). Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles. in Journal of Molecular Structure, 1309, 138167.
https://doi.org/10.1016/j.molstruc.2024.138167

Abu el Rub A, Nešić MD, Dučić T, Radoičić M, Novaković M, Žakula J, Ralić V, Petković M, Stepić M. Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles. in Journal of Molecular Structure. 2024;1309:138167.
doi:10.1016/j.molstruc.2024.138167 .

Abu el Rub, Anamarija, Nešić, Maja D., Dučić, Tanja, Radoičić, Marija, Novaković, Mirjana, Žakula, Jelena, Ralić, Vanja, Petković, Marijana, Stepić, Milutin, "Synchrotron radiation-FTIR biomolecular assessment in PANC-1 and MIA PaCa-2 pancreatic cancer cells after treatment with Gd-TiO2 nanoparticles" in Journal of Molecular Structure, 1309 (2024):138167,
https://doi.org/10.1016/j.molstruc.2024.138167 . .

TY  - JOUR
AU  - Carević, Milica
AU  - Vulić, Tatjana
AU  - Šaponjić, Zoran
AU  - Mojović, Zorica D.
AU  - Abazović, Nadica
AU  - Čomor, Mirjana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13240
AB  - Textile dye effluents and textile waste disposal represent two significant environmental challenges. Here, we present possible combined solution for both. Urea-derived graphitic carbon nitride g-C3N4 is thermally exfoliated to nano n-C3N4. Both obtained materials are characterized in detail, and their photocatalytic efficacies in photodegradation of three textile azo dyes under simulated solar light irradiation are compared. n-C3N4 exhibited superior performance over g-C3N4 under given experimental conditions. Novelty of the work is the subsequent usage of the non-woven jute post-industrial waste as a photocatalyst support. It was shown that NW jute impregnated with n-C3N4 can be successfully used in three consecutive photocatalytic cycles, keeping high photodegradation efficacy (~ 90% in the case of Acid Orange 7, and 55% in the case of Acid Blue 113). Additionally, possibility of usage of NW jute post-industrial waste as textile dye sorbent is presented in the case of Basic Yellow 28.
T2  - Cellulose
T1  - Carbon nitride impregnated non-woven jute post-industrial waste in photocatalytic degradation of textile dyes
DO  - 10.1007/s10570-024-05908-7
ER  - 

@article{
author = "Carević, Milica and Vulić, Tatjana and Šaponjić, Zoran and Mojović, Zorica D. and Abazović, Nadica and Čomor, Mirjana",
year = "2024",
abstract = "Textile dye effluents and textile waste disposal represent two significant environmental challenges. Here, we present possible combined solution for both. Urea-derived graphitic carbon nitride g-C3N4 is thermally exfoliated to nano n-C3N4. Both obtained materials are characterized in detail, and their photocatalytic efficacies in photodegradation of three textile azo dyes under simulated solar light irradiation are compared. n-C3N4 exhibited superior performance over g-C3N4 under given experimental conditions. Novelty of the work is the subsequent usage of the non-woven jute post-industrial waste as a photocatalyst support. It was shown that NW jute impregnated with n-C3N4 can be successfully used in three consecutive photocatalytic cycles, keeping high photodegradation efficacy (~ 90% in the case of Acid Orange 7, and 55% in the case of Acid Blue 113). Additionally, possibility of usage of NW jute post-industrial waste as textile dye sorbent is presented in the case of Basic Yellow 28.",
journal = "Cellulose",
title = "Carbon nitride impregnated non-woven jute post-industrial waste in photocatalytic degradation of textile dyes",
doi = "10.1007/s10570-024-05908-7"
}

Carević, M., Vulić, T., Šaponjić, Z., Mojović, Z. D., Abazović, N.,& Čomor, M.. (2024). Carbon nitride impregnated non-woven jute post-industrial waste in photocatalytic degradation of textile dyes. in Cellulose.
https://doi.org/10.1007/s10570-024-05908-7

Carević M, Vulić T, Šaponjić Z, Mojović ZD, Abazović N, Čomor M. Carbon nitride impregnated non-woven jute post-industrial waste in photocatalytic degradation of textile dyes. in Cellulose. 2024;.
doi:10.1007/s10570-024-05908-7 .

Carević, Milica, Vulić, Tatjana, Šaponjić, Zoran, Mojović, Zorica D., Abazović, Nadica, Čomor, Mirjana, "Carbon nitride impregnated non-woven jute post-industrial waste in photocatalytic degradation of textile dyes" in Cellulose (2024),
https://doi.org/10.1007/s10570-024-05908-7 . .

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Popović, Iva A.
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Filipović Tričković, Jelena
AU  - Valenta Šobot, Ana
AU  - Jiménez, Maria Victoria
AU  - Algarra, Manuel
AU  - Dučić, Tanja
AU  - Stepić, Milutin
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13296
AB  - The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging. Our findings reveal that the combined treatment of AgMOFsN-CDs and NIR light significantly increases cell viability to nearly 150% and promotes cell proliferation, with reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR spectroscopy shows this combined treatment results in unique protein alterations, including increased α-helix structures and reduced cross-β. Additionally, protein synthesis was enhanced upon the combined treatment. The likely mechanism behind the observed changes is the charge-specific interaction of N-CDs from the AgMOFsN-CDs with proteins, enhanced by NIR light due to the nanocomposite’s optical characteristics. Remarkably, the complete wound closure in the in vitro scratch assay was achieved exclusively with the combined NIR and AgMOFsN-CDs treatment, demonstrating the promising application of combined AgMOFsN-CDs with NIR light photodynamic therapy in regenerative nanomedicine and tissue engineering.
T2  - Pharmaceutics
T1  - Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots
VL  - 16
IS  - 5
SP  - 671
DO  - 10.3390/pharmaceutics16050671
ER  - 

@article{
author = "Nešić, Maja D. and Popović, Iva A. and Žakula, Jelena and Korićanac, Lela and Filipović Tričković, Jelena and Valenta Šobot, Ana and Jiménez, Maria Victoria and Algarra, Manuel and Dučić, Tanja and Stepić, Milutin",
year = "2024",
abstract = "The literature data emphasize that nanoparticles might improve the beneficial effects of near-infrared light (NIR) on wound healing. This study investigates the mechanisms of the synergistic wound healing potential of NIR light and silver metal–organic frameworks combined with nitrogen- and sulfur-doped carbon dots (AgMOFsN-CDs and AgMOFsS-CDs, respectively), which was conducted by testing the fibroblasts viability, scratch assays, biochemical analysis, and synchrotron-based Fourier transform infrared (SR-FTIR) cell spectroscopy and imaging. Our findings reveal that the combined treatment of AgMOFsN-CDs and NIR light significantly increases cell viability to nearly 150% and promotes cell proliferation, with reduced interleukin-1 levels, suggesting an anti-inflammatory response. SR-FTIR spectroscopy shows this combined treatment results in unique protein alterations, including increased α-helix structures and reduced cross-β. Additionally, protein synthesis was enhanced upon the combined treatment. The likely mechanism behind the observed changes is the charge-specific interaction of N-CDs from the AgMOFsN-CDs with proteins, enhanced by NIR light due to the nanocomposite’s optical characteristics. Remarkably, the complete wound closure in the in vitro scratch assay was achieved exclusively with the combined NIR and AgMOFsN-CDs treatment, demonstrating the promising application of combined AgMOFsN-CDs with NIR light photodynamic therapy in regenerative nanomedicine and tissue engineering.",
journal = "Pharmaceutics",
title = "Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots",
volume = "16",
number = "5",
pages = "671",
doi = "10.3390/pharmaceutics16050671"
}

Nešić, M. D., Popović, I. A., Žakula, J., Korićanac, L., Filipović Tričković, J., Valenta Šobot, A., Jiménez, M. V., Algarra, M., Dučić, T.,& Stepić, M.. (2024). Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots. in Pharmaceutics, 16(5), 671.
https://doi.org/10.3390/pharmaceutics16050671

Nešić MD, Popović IA, Žakula J, Korićanac L, Filipović Tričković J, Valenta Šobot A, Jiménez MV, Algarra M, Dučić T, Stepić M. Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots. in Pharmaceutics. 2024;16(5):671.
doi:10.3390/pharmaceutics16050671 .

Nešić, Maja D., Popović, Iva A., Žakula, Jelena, Korićanac, Lela, Filipović Tričković, Jelena, Valenta Šobot, Ana, Jiménez, Maria Victoria, Algarra, Manuel, Dučić, Tanja, Stepić, Milutin, "Synergistic Enhancement of Targeted Wound Healing by Near-Infrared Photodynamic Therapy and Silver Metal–Organic Frameworks Combined with S- or N-Doped Carbon Dots" in Pharmaceutics, 16, no. 5 (2024):671,
https://doi.org/10.3390/pharmaceutics16050671 . .

TY  - JOUR
AU  - Blagojević, Jovan
AU  - Đurđić-Mijin, Sanja
AU  - Bekaert, J.
AU  - Opačić, Marko
AU  - Liu, Y.
AU  - Milošević, Milorad V.
AU  - Petrović, Čedomir
AU  - Popović, Zoran V.
AU  - Lazarević, Nenad
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13344
AB  - The vibrational properties of 2⁢𝐻−TaSe2−𝑥⁢S𝑥 (0≤𝑥≤2) single crystals were probed using Raman spectroscopy and density functional theory calculations. The end members revealed two out of four symmetry-predicted Raman active modes, together with the pronounced two-phonon structure, attributable to the enhanced electron-phonon coupling. Additional peaks become observable due to crystallographic disorder for the doped samples. The evolution of the 𝐸2 2⁢𝑔 mode Fano parameter reveals that the disorder has a weak impact on electron-phonon coupling, which is also supported by the persistence of two-phonon structure in doped samples. As such, this research provides thorough insights into the lattice properties, the effects of crystallographic disorder on Raman spectra, and the interplay of this disorder with the electron-phonon coupling in 2⁢𝐻−TaSe2−𝑥⁢S𝑥 compounds.
T2  - Physical Review Materials
T1  - Competition of disorder and electron-phonon coupling in                                                                  2                        H                        −                                                  TaSe                                                      2                            −                            x                                                                                                    S                          x                                                                                                                  (                        0                        ≤                        x                        ≤                        2                        )                                                              as evidenced by Raman spectroscopy
VL  - 8
IS  - 2
SP  - 024004
DO  - 10.1103/PhysRevMaterials.8.024004
ER  - 

@article{
author = "Blagojević, Jovan and Đurđić-Mijin, Sanja and Bekaert, J. and Opačić, Marko and Liu, Y. and Milošević, Milorad V. and Petrović, Čedomir and Popović, Zoran V. and Lazarević, Nenad",
year = "2024",
abstract = "The vibrational properties of 2⁢𝐻−TaSe2−𝑥⁢S𝑥 (0≤𝑥≤2) single crystals were probed using Raman spectroscopy and density functional theory calculations. The end members revealed two out of four symmetry-predicted Raman active modes, together with the pronounced two-phonon structure, attributable to the enhanced electron-phonon coupling. Additional peaks become observable due to crystallographic disorder for the doped samples. The evolution of the 𝐸2 2⁢𝑔 mode Fano parameter reveals that the disorder has a weak impact on electron-phonon coupling, which is also supported by the persistence of two-phonon structure in doped samples. As such, this research provides thorough insights into the lattice properties, the effects of crystallographic disorder on Raman spectra, and the interplay of this disorder with the electron-phonon coupling in 2⁢𝐻−TaSe2−𝑥⁢S𝑥 compounds.",
journal = "Physical Review Materials",
title = "Competition of disorder and electron-phonon coupling in                                                                  2                        H                        −                                                  TaSe                                                      2                            −                            x                                                                                                    S                          x                                                                                                                  (                        0                        ≤                        x                        ≤                        2                        )                                                              as evidenced by Raman spectroscopy",
volume = "8",
number = "2",
pages = "024004",
doi = "10.1103/PhysRevMaterials.8.024004"
}

Blagojević, J., Đurđić-Mijin, S., Bekaert, J., Opačić, M., Liu, Y., Milošević, M. V., Petrović, Č., Popović, Z. V.,& Lazarević, N.. (2024). Competition of disorder and electron-phonon coupling in                                                                  2                        H                        −                                                  TaSe                                                      2                            −                            x                                                                                                    S                          x                                                                                                                  (                        0                        ≤                        x                        ≤                        2                        )                                                              as evidenced by Raman spectroscopy. in Physical Review Materials, 8(2), 024004.
https://doi.org/10.1103/PhysRevMaterials.8.024004

Blagojević J, Đurđić-Mijin S, Bekaert J, Opačić M, Liu Y, Milošević MV, Petrović Č, Popović ZV, Lazarević N. Competition of disorder and electron-phonon coupling in                                                                  2                        H                        −                                                  TaSe                                                      2                            −                            x                                                                                                    S                          x                                                                                                                  (                        0                        ≤                        x                        ≤                        2                        )                                                              as evidenced by Raman spectroscopy. in Physical Review Materials. 2024;8(2):024004.
doi:10.1103/PhysRevMaterials.8.024004 .

Blagojević, Jovan, Đurđić-Mijin, Sanja, Bekaert, J., Opačić, Marko, Liu, Y., Milošević, Milorad V., Petrović, Čedomir, Popović, Zoran V., Lazarević, Nenad, "Competition of disorder and electron-phonon coupling in                                                                  2                        H                        −                                                  TaSe                                                      2                            −                            x                                                                                                    S                          x                                                                                                                  (                        0                        ≤                        x                        ≤                        2                        )                                                              as evidenced by Raman spectroscopy" in Physical Review Materials, 8, no. 2 (2024):024004,
https://doi.org/10.1103/PhysRevMaterials.8.024004 . .

TY  - JOUR
AU  - Vujnović, Sanja
AU  - Cvetinović, Dejan
AU  - Bakić, Vukman
AU  - Đurović, Željko
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13343
AB  - Several recently signed environmental agreements and protocols emphasize the global need to reduce greenhouse gas emissions, with a focus on limiting coal consumption due to high NOX and CO2 emissions. However, many countries, including those in the Western Balkans, rely heavily on coal for electricity generation. The outdated thermal power plant infrastructure in these regions poses a major challenge when it comes to meeting modern environmental standards while maintaining efficiency. This study is part of the more comprehensive research which aims to develop an expert system that utilizes existing measurements to estimate key parameters crucial for both energy production and pollution reduction. The focus is on Serbian thermal power plants, particularly plant "Nikola Tesla" unit B1. One of the critical parameters for optimizing thermal power plant control loops is the heating value of coal, which is challenging to measure in real time due to the coal's varying chemical compositions and caloric values. This paper examines 74 different parameters measured in 59 instances to estimate the hating value of coal at unit B1. Through detailed analysis and feature selection methods, including linear regression, this research aims to identify the most informative parameters for estimating the heating value of coal, which will improve the control system that enables more efficient and environmentally friendly power generation in coal fired thermal power plants.
T2  - Thermal Science
T1  - Feature selection for coal heating level estimation in thermal power plants
IS  - InPress
DO  - 10.2298/TSCI240124124V
ER  - 

@article{
author = "Vujnović, Sanja and Cvetinović, Dejan and Bakić, Vukman and Đurović, Željko",
year = "2024",
abstract = "Several recently signed environmental agreements and protocols emphasize the global need to reduce greenhouse gas emissions, with a focus on limiting coal consumption due to high NOX and CO2 emissions. However, many countries, including those in the Western Balkans, rely heavily on coal for electricity generation. The outdated thermal power plant infrastructure in these regions poses a major challenge when it comes to meeting modern environmental standards while maintaining efficiency. This study is part of the more comprehensive research which aims to develop an expert system that utilizes existing measurements to estimate key parameters crucial for both energy production and pollution reduction. The focus is on Serbian thermal power plants, particularly plant "Nikola Tesla" unit B1. One of the critical parameters for optimizing thermal power plant control loops is the heating value of coal, which is challenging to measure in real time due to the coal's varying chemical compositions and caloric values. This paper examines 74 different parameters measured in 59 instances to estimate the hating value of coal at unit B1. Through detailed analysis and feature selection methods, including linear regression, this research aims to identify the most informative parameters for estimating the heating value of coal, which will improve the control system that enables more efficient and environmentally friendly power generation in coal fired thermal power plants.",
journal = "Thermal Science",
title = "Feature selection for coal heating level estimation in thermal power plants",
number = "InPress",
doi = "10.2298/TSCI240124124V"
}

Vujnović, S., Cvetinović, D., Bakić, V.,& Đurović, Ž.. (2024). Feature selection for coal heating level estimation in thermal power plants. in Thermal Science(InPress).
https://doi.org/10.2298/TSCI240124124V

Vujnović S, Cvetinović D, Bakić V, Đurović Ž. Feature selection for coal heating level estimation in thermal power plants. in Thermal Science. 2024;(InPress).
doi:10.2298/TSCI240124124V .

Vujnović, Sanja, Cvetinović, Dejan, Bakić, Vukman, Đurović, Željko, "Feature selection for coal heating level estimation in thermal power plants" in Thermal Science, no. InPress (2024),
https://doi.org/10.2298/TSCI240124124V . .

TY  - JOUR
AU  - Stamenković, Tijana
AU  - Zdolšek, Nikola
AU  - Vujković, Milica
AU  - Brković, Snežana
AU  - Perović, Ivana
AU  - Lojpur, Vesna
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13293
AB  - Electrochemical supercapacitors represent advanced energy storage devices that excel in the swift storage and delivery of electrical energy, effectively bridging the gap between conventional capacitors and batteries. The present work, aimed to investigate charge storage properties of SrGd2O4 and rare earth ions Yb3+and Tm3+ doped in SrGd2O4. Both materials were prepared via simple sol-gel synthesis and characterized by XRD, XPS, and FE-SEM with EDS. Characterization confirmed the presence of Tm3+and Yb3+ in the SrGd2O4 matrix with a uniform distribution of elements. The charge storage behavior of pure SrGd2O4 and SrGd2O4:Yb4Tm1 in various electrolytes was thoroughly explored. Large electrochemical potential windows were shown by both electrode materials in aqueous 6 M KOH (1.7 V), which is essential for supercapacitors to achieve high specific energy. Furthermore, SrGd2O4:Yb4Tm1 demonstrated a substantially more pronounced charge storage effect in 6 M KOH electrolyte, with almost double times higher specific capacitance values compared with an un-doped SrGd2O4 sample. The main impact on the electrochemical window had matrix SrGd2O4, while the main impact on specific capacitance had rear earth dopants (Yb3+and Tm3+). Improved charge storage characteristics of SrGd2O4: Yb4Tm1 were also evident through a notable reduction in overall resistance observed in electrochemical impedance spectroscopy experiments. Concerning the two-electrode GCD measurements, the SrGd2O4:Yb4Tm1 electrode in 6 M KOH showed a specific capacitance of 143 F g 1, with the specific energy of 12.5 Wh kg 1 at 0.6 A g 1. These findings demonstrate the potential of rare earth ion doping in enhancing the energy storage properties of SrGd2O4, offering promising avenues for the development of high-performance supercapacitors.
T2  - Electrochimica Acta
T1  - Boosting electrochemical energy storage properties of SrGd2O4 through Yb3+ and Tm3+ rare earth ion doping
VL  - 495
SP  - 144489
DO  - 10.1016/j.electacta.2024.144489
ER  - 

@article{
author = "Stamenković, Tijana and Zdolšek, Nikola and Vujković, Milica and Brković, Snežana and Perović, Ivana and Lojpur, Vesna",
year = "2024",
abstract = "Electrochemical supercapacitors represent advanced energy storage devices that excel in the swift storage and delivery of electrical energy, effectively bridging the gap between conventional capacitors and batteries. The present work, aimed to investigate charge storage properties of SrGd2O4 and rare earth ions Yb3+and Tm3+ doped in SrGd2O4. Both materials were prepared via simple sol-gel synthesis and characterized by XRD, XPS, and FE-SEM with EDS. Characterization confirmed the presence of Tm3+and Yb3+ in the SrGd2O4 matrix with a uniform distribution of elements. The charge storage behavior of pure SrGd2O4 and SrGd2O4:Yb4Tm1 in various electrolytes was thoroughly explored. Large electrochemical potential windows were shown by both electrode materials in aqueous 6 M KOH (1.7 V), which is essential for supercapacitors to achieve high specific energy. Furthermore, SrGd2O4:Yb4Tm1 demonstrated a substantially more pronounced charge storage effect in 6 M KOH electrolyte, with almost double times higher specific capacitance values compared with an un-doped SrGd2O4 sample. The main impact on the electrochemical window had matrix SrGd2O4, while the main impact on specific capacitance had rear earth dopants (Yb3+and Tm3+). Improved charge storage characteristics of SrGd2O4: Yb4Tm1 were also evident through a notable reduction in overall resistance observed in electrochemical impedance spectroscopy experiments. Concerning the two-electrode GCD measurements, the SrGd2O4:Yb4Tm1 electrode in 6 M KOH showed a specific capacitance of 143 F g 1, with the specific energy of 12.5 Wh kg 1 at 0.6 A g 1. These findings demonstrate the potential of rare earth ion doping in enhancing the energy storage properties of SrGd2O4, offering promising avenues for the development of high-performance supercapacitors.",
journal = "Electrochimica Acta",
title = "Boosting electrochemical energy storage properties of SrGd2O4 through Yb3+ and Tm3+ rare earth ion doping",
volume = "495",
pages = "144489",
doi = "10.1016/j.electacta.2024.144489"
}

Stamenković, T., Zdolšek, N., Vujković, M., Brković, S., Perović, I.,& Lojpur, V.. (2024). Boosting electrochemical energy storage properties of SrGd2O4 through Yb3+ and Tm3+ rare earth ion doping. in Electrochimica Acta, 495, 144489.
https://doi.org/10.1016/j.electacta.2024.144489

Stamenković T, Zdolšek N, Vujković M, Brković S, Perović I, Lojpur V. Boosting electrochemical energy storage properties of SrGd2O4 through Yb3+ and Tm3+ rare earth ion doping. in Electrochimica Acta. 2024;495:144489.
doi:10.1016/j.electacta.2024.144489 .

Stamenković, Tijana, Zdolšek, Nikola, Vujković, Milica, Brković, Snežana, Perović, Ivana, Lojpur, Vesna, "Boosting electrochemical energy storage properties of SrGd2O4 through Yb3+ and Tm3+ rare earth ion doping" in Electrochimica Acta, 495 (2024):144489,
https://doi.org/10.1016/j.electacta.2024.144489 . .

TY  - JOUR
AU  - Filipović, Suzana
AU  - Obradović, Nina
AU  - Fahrenholtz, William G.
AU  - Smith, Steven
AU  - Mirković, Miljana M.
AU  - Peleš Tadić, Adriana
AU  - Petrović, Jovana
AU  - Đorđević, Antonije
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12795
AB  - Magnesium titanate ceramics were prepared by reactive spark plasma sintering (SPS) at 1200 °C for 5 min. Prior to sintering, MgO and TiO2 powders were mixed by high energy ball milling (HEBM) for 15, 30, or 60 min. The effect of milling time on phase composition was analyzed by X-ray diffraction (XRD) for milled powders and sintered specimens. The morphology of the sintered ceramics was investigated by scanning electron microscopy (SEM), while elemental distribution was determined by energy dispersive spectroscopy (EDS). The presence of the MgTi2O5 phase was detected in XRD and was confirmed by EDS analysis. Microcracking was observed for specimens prepared with longer milling times and attributed to the coefficient of thermal expansion (CTE) mismatch dominantly due to the anisotropic crystal structure of MgTiO3 phase. The sample milled for 15 min showed the highest Vickers hardness due to less or no microcracking and nearly full density. The dielectric measurements in the range of 10 Hz–250 MHz demonstrated extremely high dielectric permittivity, as high as 104 at 1 kHz. An increase in loss tangents was observed due to oxygen vacancy formation, which was promoted by the vacuum environment during SPS. Oxygen vacancy-related dielectric relaxation was also detected and explained.
T2  - Ceramics International
T1  - Spark plasma sintering of magnesium titanate ceramics
IS  - InPress
DO  - 10.1016/j.ceramint.2024.02.004
ER  - 

@article{
author = "Filipović, Suzana and Obradović, Nina and Fahrenholtz, William G. and Smith, Steven and Mirković, Miljana M. and Peleš Tadić, Adriana and Petrović, Jovana and Đorđević, Antonije",
year = "2024",
abstract = "Magnesium titanate ceramics were prepared by reactive spark plasma sintering (SPS) at 1200 °C for 5 min. Prior to sintering, MgO and TiO2 powders were mixed by high energy ball milling (HEBM) for 15, 30, or 60 min. The effect of milling time on phase composition was analyzed by X-ray diffraction (XRD) for milled powders and sintered specimens. The morphology of the sintered ceramics was investigated by scanning electron microscopy (SEM), while elemental distribution was determined by energy dispersive spectroscopy (EDS). The presence of the MgTi2O5 phase was detected in XRD and was confirmed by EDS analysis. Microcracking was observed for specimens prepared with longer milling times and attributed to the coefficient of thermal expansion (CTE) mismatch dominantly due to the anisotropic crystal structure of MgTiO3 phase. The sample milled for 15 min showed the highest Vickers hardness due to less or no microcracking and nearly full density. The dielectric measurements in the range of 10 Hz–250 MHz demonstrated extremely high dielectric permittivity, as high as 104 at 1 kHz. An increase in loss tangents was observed due to oxygen vacancy formation, which was promoted by the vacuum environment during SPS. Oxygen vacancy-related dielectric relaxation was also detected and explained.",
journal = "Ceramics International",
title = "Spark plasma sintering of magnesium titanate ceramics",
number = "InPress",
doi = "10.1016/j.ceramint.2024.02.004"
}

Filipović, S., Obradović, N., Fahrenholtz, W. G., Smith, S., Mirković, M. M., Peleš Tadić, A., Petrović, J.,& Đorđević, A.. (2024). Spark plasma sintering of magnesium titanate ceramics. in Ceramics International(InPress).
https://doi.org/10.1016/j.ceramint.2024.02.004

Filipović S, Obradović N, Fahrenholtz WG, Smith S, Mirković MM, Peleš Tadić A, Petrović J, Đorđević A. Spark plasma sintering of magnesium titanate ceramics. in Ceramics International. 2024;(InPress).
doi:10.1016/j.ceramint.2024.02.004 .

Filipović, Suzana, Obradović, Nina, Fahrenholtz, William G., Smith, Steven, Mirković, Miljana M., Peleš Tadić, Adriana, Petrović, Jovana, Đorđević, Antonije, "Spark plasma sintering of magnesium titanate ceramics" in Ceramics International, no. InPress (2024),
https://doi.org/10.1016/j.ceramint.2024.02.004 . .

TY  - JOUR
AU  - Atanasoski, Vladimir
AU  - Petrović, Jovana S.
AU  - Popović Maneski, Lana
AU  - Miletić, Marjan
AU  - Babić, Miloš
AU  - Nikolić, Aleksandra
AU  - Panescu, Dorin
AU  - Ivanović, Marija D.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13128
AB  - Clinical interpretation of an electrocardiogram (ECG) can be detrimentally affected by noise. Removal of the electromyographic (EMG) noise is particularly challenging due to its spectral overlap with the QRS complex. The existing EMG-denoising algorithms often distort signal morphology, thus obscuring diagnostically relevant information. Here, a new iterative regeneration method (IRM) for efficient EMG-noise suppression is proposed. The main hypothesis is that the temporary removal of the dominant ECG components enables extraction of the noise with the minimum alteration to the signal. The method is validated on SimEMG database of simultaneously recorded reference and noisy signals, MIT-BIH arrhythmia database and synthesized ECG signals, both with the noise from MIT Noise Stress Test Database. IRM denoising and morphology-preserving performance is superior to the wavelet- and FIR-based benchmark methods. : IRM is reliable, computationally non-intensive, fast and applicable to any number of ECG channels recorded by mobile or standard ECG devices.
T2  - IEEE Open Journal of Engineering in Medicine and Biology
T1  - A morphology-preserving algorithm for denoising of EMG-contaminated ECG signals
SP  - 1
EP  - 10
DO  - 10.1109/OJEMB.2024.3380352
ER  - 

@article{
author = "Atanasoski, Vladimir and Petrović, Jovana S. and Popović Maneski, Lana and Miletić, Marjan and Babić, Miloš and Nikolić, Aleksandra and Panescu, Dorin and Ivanović, Marija D.",
year = "2024",
abstract = "Clinical interpretation of an electrocardiogram (ECG) can be detrimentally affected by noise. Removal of the electromyographic (EMG) noise is particularly challenging due to its spectral overlap with the QRS complex. The existing EMG-denoising algorithms often distort signal morphology, thus obscuring diagnostically relevant information. Here, a new iterative regeneration method (IRM) for efficient EMG-noise suppression is proposed. The main hypothesis is that the temporary removal of the dominant ECG components enables extraction of the noise with the minimum alteration to the signal. The method is validated on SimEMG database of simultaneously recorded reference and noisy signals, MIT-BIH arrhythmia database and synthesized ECG signals, both with the noise from MIT Noise Stress Test Database. IRM denoising and morphology-preserving performance is superior to the wavelet- and FIR-based benchmark methods. : IRM is reliable, computationally non-intensive, fast and applicable to any number of ECG channels recorded by mobile or standard ECG devices.",
journal = "IEEE Open Journal of Engineering in Medicine and Biology",
title = "A morphology-preserving algorithm for denoising of EMG-contaminated ECG signals",
pages = "1-10",
doi = "10.1109/OJEMB.2024.3380352"
}

Atanasoski, V., Petrović, J. S., Popović Maneski, L., Miletić, M., Babić, M., Nikolić, A., Panescu, D.,& Ivanović, M. D.. (2024). A morphology-preserving algorithm for denoising of EMG-contaminated ECG signals. in IEEE Open Journal of Engineering in Medicine and Biology, 1-10.
https://doi.org/10.1109/OJEMB.2024.3380352

Atanasoski V, Petrović JS, Popović Maneski L, Miletić M, Babić M, Nikolić A, Panescu D, Ivanović MD. A morphology-preserving algorithm for denoising of EMG-contaminated ECG signals. in IEEE Open Journal of Engineering in Medicine and Biology. 2024;:1-10.
doi:10.1109/OJEMB.2024.3380352 .

Atanasoski, Vladimir, Petrović, Jovana S., Popović Maneski, Lana, Miletić, Marjan, Babić, Miloš, Nikolić, Aleksandra, Panescu, Dorin, Ivanović, Marija D., "A morphology-preserving algorithm for denoising of EMG-contaminated ECG signals" in IEEE Open Journal of Engineering in Medicine and Biology (2024):1-10,
https://doi.org/10.1109/OJEMB.2024.3380352 . .

TY  - CONF
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13138
PB  - Belgrade : Vinča Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade
PB  - Belgrade : Serbian Society for Innovative Materials in Extreme Conditions (SIM-EXTREME)
T1  - Program and Book of Abstracts of the 2nd International Conference on Innovative Materials in Extreme Conditions (IMEC2024)
SP  - 82
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13138
ER  - 

@conference{
editor = "Matović, Branko, Cvijović-Alagić, Ivana, Maksimović, Vesna, Zagorac, Dejan",
year = "2024",
publisher = "Belgrade : Vinča Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Belgrade : Serbian Society for Innovative Materials in Extreme Conditions (SIM-EXTREME)",
title = "Program and Book of Abstracts of the 2nd International Conference on Innovative Materials in Extreme Conditions (IMEC2024)",
pages = "82",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13138"
}

Matović, B., Cvijović-Alagić, I., Maksimović, V.,& Zagorac, D.. (2024). Program and Book of Abstracts of the 2nd International Conference on Innovative Materials in Extreme Conditions (IMEC2024). 
Belgrade : Vinča Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade., 82.
https://hdl.handle.net/21.15107/rcub_vinar_13138

Matović B, Cvijović-Alagić I, Maksimović V, Zagorac D. Program and Book of Abstracts of the 2nd International Conference on Innovative Materials in Extreme Conditions (IMEC2024). 2024;:82.
https://hdl.handle.net/21.15107/rcub_vinar_13138 .

Matović, Branko, Cvijović-Alagić, Ivana, Maksimović, Vesna, Zagorac, Dejan, "Program and Book of Abstracts of the 2nd International Conference on Innovative Materials in Extreme Conditions (IMEC2024)" (2024):82,
https://hdl.handle.net/21.15107/rcub_vinar_13138 .

TY  - JOUR
AU  - Valenta Šobot, Ana
AU  - Janić, Marijana
AU  - Popović, Iva
AU  - Lazarević-Pašti, Tamara
AU  - Momić, Tatjana
AU  - Krstić, Aleksandar D.
AU  - Filipović Tričković, Jelena
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13334
AB  - Traditional medicine has used sage (Salvia officinalis L.) preparations for centuries to prevent and treat various inflammatory and oxidative stress-induced conditions. The aim of this in vitro study was to determine the bioactive properties of a sage leave extract obtained with environmentally friendly aqueous extraction and lyophilisation in primary human peripheral blood cells. To that end we measured the total phenolic and flavonoid content (TPC and TFC, respectively) with gas chromatography-mass spectrometry (GC-MS). Non-cytotoxic concentrations determined with the trypan blue assay were used to assess the antioxidant (DPPH, ABTS, and PAB assay), antigenotoxic (CBMN assay), immunomodulatory (IL-1β and TNF-α), and neuroprotective effects (AChE inhibition). The extract contained high TPC (162 mg GAE/g of dry extract) and TFC (39.47 mg QE/g of dry extract) concentrations, while β-thujone content was unexpectedly low (below 0.9 %). Strong radical-scavenging activity combined with glutathione reductase activation led to a decrease in basal and H2 O 2 - induced oxidative stress and DNA damage. A decrease in TNF-α and increase in IL-1β levels suggest complex immunomodulatory response that could contribute to antioxidant and, together with mild AChE inhibition, neuroprotective effects. Overall, this study has demonstrated that aqueous sage leave extract reduces the levels of thujone, 1,8-cineole, pinene, and terpene ketones that could be toxic in high concentrations, while maintaining high concentrations of biologically active protective compounds which have a potential to prevent and/ or treat inflammatory and oxidative stress-related conditions.
AB  - Salvia officinalis L. stoljećima se koristi u tradicionalnoj medicini za prevenciju i liječenje raznih upalnih i oksidacijskim stresom izazvanih poremećaja. U ovoj studiji željeli smo ekstrahirati kaduljino lišće korištenjem ekološki prihvatljivog, “zelenog” pristupa vodenom ekstrakcijom i liofilizacijom te odrediti njegova bioaktivna svojstva u primarnim ljudskim perifernim krvnim stanicama. Ukupni sadržaj fenola i flavonoida i GC-MS korišteni su za karakterizaciju ekstrakta. Necitotoksične koncentracije, određene tripan plavim testom, analizirane su za procjenu antioksidacijskih (DPPH, ABTS i PAB test), antigenotoksičnih (CBMN test), imunomodulacijskih (IL-1β i TNF-α) i neuroprotektivnih učinaka (AChE inhibicija). Ekstrakt je sadržavao visoku koncentraciju ukupnih fenola (162 mg GAE/g liofilizata) i flavonoida (39,47 mg QE/g liofilizata), dok je sadržaj β-tujona bio neočekivano nizak (niži od 0,9 %). Snažna aktivnost hvatanja radikala u kombinaciji s aktivacijom glutation reduktaze dovela je do smanjenja bazalnog i H2 O 2 induciranog oksidacijskog stresa i oštećenja DNA. Smanjenje TNF-α i povišenje razine IL-1β sugeriraju kompleksan imunomodulatorni odgovor koji bi mogao pridonijeti antioksidacijskim i, zajedno s blagom inhibicijom AChE, neuroprotektivnim učincima. Sveukupno, ova je studija pokazala da vodena ekstrakcija kaduljina lišća smanjuje toksične spojeve kao što su tujon, 1,8-cineol, pinen i terpenski ketoni, a održava visoku koncentraciju biološki aktivnih zaštitnih spojeva u ekstraktu, što bi moglo imati potencijal za prevenciju i/ili liječenje oksidacijskih i upalnih poremećaja.
T2  - Arhiv za higijenu rada i toksikologiju
T1  - Aqueous sage leave extract attenuates inflammation and oxidant-induced genotoxicity in human peripheral blood mononuclear cells
T1  - Vodeni ekstrakt kaduljina lišća umanjuje upalu i oksidacijsku genotoksičnost u ljudskim mononuklearnim stanicama periferne krvi
VL  - 75
IS  - InPress
SP  - 105
EP  - 114
DO  - 10.2478/aiht-2024-75-3836
ER  - 

@article{
author = "Valenta Šobot, Ana and Janić, Marijana and Popović, Iva and Lazarević-Pašti, Tamara and Momić, Tatjana and Krstić, Aleksandar D. and Filipović Tričković, Jelena",
year = "2024",
abstract = "Traditional medicine has used sage (Salvia officinalis L.) preparations for centuries to prevent and treat various inflammatory and oxidative stress-induced conditions. The aim of this in vitro study was to determine the bioactive properties of a sage leave extract obtained with environmentally friendly aqueous extraction and lyophilisation in primary human peripheral blood cells. To that end we measured the total phenolic and flavonoid content (TPC and TFC, respectively) with gas chromatography-mass spectrometry (GC-MS). Non-cytotoxic concentrations determined with the trypan blue assay were used to assess the antioxidant (DPPH, ABTS, and PAB assay), antigenotoxic (CBMN assay), immunomodulatory (IL-1β and TNF-α), and neuroprotective effects (AChE inhibition). The extract contained high TPC (162 mg GAE/g of dry extract) and TFC (39.47 mg QE/g of dry extract) concentrations, while β-thujone content was unexpectedly low (below 0.9 %). Strong radical-scavenging activity combined with glutathione reductase activation led to a decrease in basal and H2 O 2 - induced oxidative stress and DNA damage. A decrease in TNF-α and increase in IL-1β levels suggest complex immunomodulatory response that could contribute to antioxidant and, together with mild AChE inhibition, neuroprotective effects. Overall, this study has demonstrated that aqueous sage leave extract reduces the levels of thujone, 1,8-cineole, pinene, and terpene ketones that could be toxic in high concentrations, while maintaining high concentrations of biologically active protective compounds which have a potential to prevent and/ or treat inflammatory and oxidative stress-related conditions., Salvia officinalis L. stoljećima se koristi u tradicionalnoj medicini za prevenciju i liječenje raznih upalnih i oksidacijskim stresom izazvanih poremećaja. U ovoj studiji željeli smo ekstrahirati kaduljino lišće korištenjem ekološki prihvatljivog, “zelenog” pristupa vodenom ekstrakcijom i liofilizacijom te odrediti njegova bioaktivna svojstva u primarnim ljudskim perifernim krvnim stanicama. Ukupni sadržaj fenola i flavonoida i GC-MS korišteni su za karakterizaciju ekstrakta. Necitotoksične koncentracije, određene tripan plavim testom, analizirane su za procjenu antioksidacijskih (DPPH, ABTS i PAB test), antigenotoksičnih (CBMN test), imunomodulacijskih (IL-1β i TNF-α) i neuroprotektivnih učinaka (AChE inhibicija). Ekstrakt je sadržavao visoku koncentraciju ukupnih fenola (162 mg GAE/g liofilizata) i flavonoida (39,47 mg QE/g liofilizata), dok je sadržaj β-tujona bio neočekivano nizak (niži od 0,9 %). Snažna aktivnost hvatanja radikala u kombinaciji s aktivacijom glutation reduktaze dovela je do smanjenja bazalnog i H2 O 2 induciranog oksidacijskog stresa i oštećenja DNA. Smanjenje TNF-α i povišenje razine IL-1β sugeriraju kompleksan imunomodulatorni odgovor koji bi mogao pridonijeti antioksidacijskim i, zajedno s blagom inhibicijom AChE, neuroprotektivnim učincima. Sveukupno, ova je studija pokazala da vodena ekstrakcija kaduljina lišća smanjuje toksične spojeve kao što su tujon, 1,8-cineol, pinen i terpenski ketoni, a održava visoku koncentraciju biološki aktivnih zaštitnih spojeva u ekstraktu, što bi moglo imati potencijal za prevenciju i/ili liječenje oksidacijskih i upalnih poremećaja.",
journal = "Arhiv za higijenu rada i toksikologiju",
title = "Aqueous sage leave extract attenuates inflammation and oxidant-induced genotoxicity in human peripheral blood mononuclear cells, Vodeni ekstrakt kaduljina lišća umanjuje upalu i oksidacijsku genotoksičnost u ljudskim mononuklearnim stanicama periferne krvi",
volume = "75",
number = "InPress",
pages = "105-114",
doi = "10.2478/aiht-2024-75-3836"
}

Valenta Šobot, A., Janić, M., Popović, I., Lazarević-Pašti, T., Momić, T., Krstić, A. D.,& Filipović Tričković, J.. (2024). Aqueous sage leave extract attenuates inflammation and oxidant-induced genotoxicity in human peripheral blood mononuclear cells. in Arhiv za higijenu rada i toksikologiju, 75(InPress), 105-114.
https://doi.org/10.2478/aiht-2024-75-3836

Valenta Šobot A, Janić M, Popović I, Lazarević-Pašti T, Momić T, Krstić AD, Filipović Tričković J. Aqueous sage leave extract attenuates inflammation and oxidant-induced genotoxicity in human peripheral blood mononuclear cells. in Arhiv za higijenu rada i toksikologiju. 2024;75(InPress):105-114.
doi:10.2478/aiht-2024-75-3836 .

Valenta Šobot, Ana, Janić, Marijana, Popović, Iva, Lazarević-Pašti, Tamara, Momić, Tatjana, Krstić, Aleksandar D., Filipović Tričković, Jelena, "Aqueous sage leave extract attenuates inflammation and oxidant-induced genotoxicity in human peripheral blood mononuclear cells" in Arhiv za higijenu rada i toksikologiju, 75, no. InPress (2024):105-114,
https://doi.org/10.2478/aiht-2024-75-3836 . .

TY  - JOUR
AU  - Valenta Šobot, Ana
AU  - Drakulić, Dunja
AU  - Todorović, Ana
AU  - Janić, Marijana
AU  - Božović, Ana
AU  - Todorović, Lidija
AU  - Filipović Tričković, Jelena
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13330
AB  - Gentiopicroside (Gp) and swertiamarin (Sm), secoiridoid glycosides commonly found in plants of the Gentianaceae family, differ in one functional group. They exhibit promising cytotoxic effects in cancer cell lines and overall protective outcomes, marking them as promising molecules for developing novel pharmaceuticals. To investigate potential variations in cellular sensitivity to compounds of similar molecular structures, we analyzed the mode of Gp and Sm induced cell death in human peripheral blood mononuclear cells (PBMCs) after 48 h of treatment. The lowest tested concentration that significantly reduces cell viability, 50 μ M, was applied. Oxidative stress parameters were estimated by measuring the levels of prooxidative/antioxidative balance, lipid peroxidation products, and 8-oxo-7,8-dihydro-2-deoxyguanosine, while gene expression of DNA repair enzymes was evaluated by employing quantitative real-time PCR. Cellular morphology was analyzed by fluorescent microscopy, and immunoblot analysis of apoptosis and necroptosis-related proteins was used to assess the type of cell death induced by the treatments. The discriminatory impact of Gp/Sm treatments on apoptosis and necroptosis- induced cell death was evaluated by monitoring the cell survival in co-treatment with specific cell death inhibitors. Obtained results show greater cytotoxicity of Gp than Sm suggesting that variations in the molecular structures of the tested compounds can substantially affect their biological effects. Gp/Sm co-treatment with apoptosis and necroptosis inhibitors revealed a distinct, albeit non-specific mechanism of PBMCs cell death. Although the therapeutic may not directly cause a specific type of cell death, its extent can be pivotal in assessing the safety of therapeutic application and developing phytopharmaceuticals with improved features. Since phytopharmaceuticals affect all exposed cells, identification of cytotoxic mechanisms on PBMCs after Gp and Sm treatment is important for addressing the formulation and dosage of potential phytopharmaceuticals.
T2  - Chemico-Biological Interactions
T1  - Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells
VL  - 398
SP  - 111103
DO  - 10.1016/j.cbi.2024.111103
ER  - 

@article{
author = "Valenta Šobot, Ana and Drakulić, Dunja and Todorović, Ana and Janić, Marijana and Božović, Ana and Todorović, Lidija and Filipović Tričković, Jelena",
year = "2024",
abstract = "Gentiopicroside (Gp) and swertiamarin (Sm), secoiridoid glycosides commonly found in plants of the Gentianaceae family, differ in one functional group. They exhibit promising cytotoxic effects in cancer cell lines and overall protective outcomes, marking them as promising molecules for developing novel pharmaceuticals. To investigate potential variations in cellular sensitivity to compounds of similar molecular structures, we analyzed the mode of Gp and Sm induced cell death in human peripheral blood mononuclear cells (PBMCs) after 48 h of treatment. The lowest tested concentration that significantly reduces cell viability, 50 μ M, was applied. Oxidative stress parameters were estimated by measuring the levels of prooxidative/antioxidative balance, lipid peroxidation products, and 8-oxo-7,8-dihydro-2-deoxyguanosine, while gene expression of DNA repair enzymes was evaluated by employing quantitative real-time PCR. Cellular morphology was analyzed by fluorescent microscopy, and immunoblot analysis of apoptosis and necroptosis-related proteins was used to assess the type of cell death induced by the treatments. The discriminatory impact of Gp/Sm treatments on apoptosis and necroptosis- induced cell death was evaluated by monitoring the cell survival in co-treatment with specific cell death inhibitors. Obtained results show greater cytotoxicity of Gp than Sm suggesting that variations in the molecular structures of the tested compounds can substantially affect their biological effects. Gp/Sm co-treatment with apoptosis and necroptosis inhibitors revealed a distinct, albeit non-specific mechanism of PBMCs cell death. Although the therapeutic may not directly cause a specific type of cell death, its extent can be pivotal in assessing the safety of therapeutic application and developing phytopharmaceuticals with improved features. Since phytopharmaceuticals affect all exposed cells, identification of cytotoxic mechanisms on PBMCs after Gp and Sm treatment is important for addressing the formulation and dosage of potential phytopharmaceuticals.",
journal = "Chemico-Biological Interactions",
title = "Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells",
volume = "398",
pages = "111103",
doi = "10.1016/j.cbi.2024.111103"
}

Valenta Šobot, A., Drakulić, D., Todorović, A., Janić, M., Božović, A., Todorović, L.,& Filipović Tričković, J.. (2024). Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells. in Chemico-Biological Interactions, 398, 111103.
https://doi.org/10.1016/j.cbi.2024.111103

Valenta Šobot A, Drakulić D, Todorović A, Janić M, Božović A, Todorović L, Filipović Tričković J. Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells. in Chemico-Biological Interactions. 2024;398:111103.
doi:10.1016/j.cbi.2024.111103 .

Valenta Šobot, Ana, Drakulić, Dunja, Todorović, Ana, Janić, Marijana, Božović, Ana, Todorović, Lidija, Filipović Tričković, Jelena, "Gentiopicroside and swertiamarin induce non-selective oxidative stress-mediated cytotoxic effects in human peripheral blood mononuclear cells" in Chemico-Biological Interactions, 398 (2024):111103,
https://doi.org/10.1016/j.cbi.2024.111103 . .

TY  - JOUR
AU  - Jocić, Ana
AU  - Marić, Slađana
AU  - Tekić, Danijela
AU  - Lazarević-Pašti, Tamara
AU  - Mušović, Jasmina
AU  - Filipović Tričković, Jelena
AU  - Dimitrijević, Aleksandra
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13329
AB  - Due to extensive food production, organophosphate pesticides (OPs) are widely utilized for crop protection, leading to their presence in the environment. The focus of this study was the design of an efficient aqueous biphasic system (ABS) strategy for OP removal, namely, malathion (MAL), azinphos-methyl (AZM), and chlorpyrifos (CHP) from water. Different ionic liquids (ILs) with symmetrical cations were selected as ABS phase- formers (tetrabutylphosphonium salicylate, tetrabutylammonium salicylate, 1,3-dibutylimidazolium dicyanamide, 1,3-dibutylimidazolium salicylate and 1,3-dibutylimidazolium bromide) with citrate salt as a salting-out agent. Initially, phase diagrams were determined, followed by partition studies revealing that the partition of MAL and CHP aligns with the IL- ABS formation trend, while the AZM partition is governed by specific interactions with ILs. For optimization studies, tetrabutylphosphonium-salicylate i.e. [TBP][Sal]-based ABS was chosen, due to obtained high extraction efficiencies of over 99.3 %. After establishing the effects of pH, temperature, tie-line length, and phase ratio on extraction performance, extraction of OPs from a real wastewater sample further confirmed the effectiveness of the designed method achieving complete removal of each pesticide. Furthermore, recovery of IL was achieved using an antisolvent method to precipitate CHP followed by IL-reuse in three consecutive cycles without efficiency decreased. Finally, it was demonstrated that [TBP][Sal] exhibits low cytotoxic potential, indicating that the presence of low amounts of this IL in aqueous media could be acceptable from ecotoxicological standpoint. This study showcased the exceptional potential of the proposed technology for the efficient and sustainable treatment of wastewater contaminated with OPs, affirming its capability to treat significant wastewater volumes.
T2  - Journal of Water Process Engineering
T1  - Complete removal of organophosphate pesticides from wastewaters with sustainable ionic liquid-based aqueous two-phase strategy
VL  - 64
SP  - 105621
DO  - 10.1016/j.jwpe.2024.105621
ER  - 

@article{
author = "Jocić, Ana and Marić, Slađana and Tekić, Danijela and Lazarević-Pašti, Tamara and Mušović, Jasmina and Filipović Tričković, Jelena and Dimitrijević, Aleksandra",
year = "2024",
abstract = "Due to extensive food production, organophosphate pesticides (OPs) are widely utilized for crop protection, leading to their presence in the environment. The focus of this study was the design of an efficient aqueous biphasic system (ABS) strategy for OP removal, namely, malathion (MAL), azinphos-methyl (AZM), and chlorpyrifos (CHP) from water. Different ionic liquids (ILs) with symmetrical cations were selected as ABS phase- formers (tetrabutylphosphonium salicylate, tetrabutylammonium salicylate, 1,3-dibutylimidazolium dicyanamide, 1,3-dibutylimidazolium salicylate and 1,3-dibutylimidazolium bromide) with citrate salt as a salting-out agent. Initially, phase diagrams were determined, followed by partition studies revealing that the partition of MAL and CHP aligns with the IL- ABS formation trend, while the AZM partition is governed by specific interactions with ILs. For optimization studies, tetrabutylphosphonium-salicylate i.e. [TBP][Sal]-based ABS was chosen, due to obtained high extraction efficiencies of over 99.3 %. After establishing the effects of pH, temperature, tie-line length, and phase ratio on extraction performance, extraction of OPs from a real wastewater sample further confirmed the effectiveness of the designed method achieving complete removal of each pesticide. Furthermore, recovery of IL was achieved using an antisolvent method to precipitate CHP followed by IL-reuse in three consecutive cycles without efficiency decreased. Finally, it was demonstrated that [TBP][Sal] exhibits low cytotoxic potential, indicating that the presence of low amounts of this IL in aqueous media could be acceptable from ecotoxicological standpoint. This study showcased the exceptional potential of the proposed technology for the efficient and sustainable treatment of wastewater contaminated with OPs, affirming its capability to treat significant wastewater volumes.",
journal = "Journal of Water Process Engineering",
title = "Complete removal of organophosphate pesticides from wastewaters with sustainable ionic liquid-based aqueous two-phase strategy",
volume = "64",
pages = "105621",
doi = "10.1016/j.jwpe.2024.105621"
}

Jocić, A., Marić, S., Tekić, D., Lazarević-Pašti, T., Mušović, J., Filipović Tričković, J.,& Dimitrijević, A.. (2024). Complete removal of organophosphate pesticides from wastewaters with sustainable ionic liquid-based aqueous two-phase strategy. in Journal of Water Process Engineering, 64, 105621.
https://doi.org/10.1016/j.jwpe.2024.105621

Jocić A, Marić S, Tekić D, Lazarević-Pašti T, Mušović J, Filipović Tričković J, Dimitrijević A. Complete removal of organophosphate pesticides from wastewaters with sustainable ionic liquid-based aqueous two-phase strategy. in Journal of Water Process Engineering. 2024;64:105621.
doi:10.1016/j.jwpe.2024.105621 .

Jocić, Ana, Marić, Slađana, Tekić, Danijela, Lazarević-Pašti, Tamara, Mušović, Jasmina, Filipović Tričković, Jelena, Dimitrijević, Aleksandra, "Complete removal of organophosphate pesticides from wastewaters with sustainable ionic liquid-based aqueous two-phase strategy" in Journal of Water Process Engineering, 64 (2024):105621,
https://doi.org/10.1016/j.jwpe.2024.105621 . .

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Sredojević, Dušan
AU  - Ciasca, Gabriele
AU  - Di Santo, Riccardo
AU  - Mead, James L.
AU  - Budimir, Milica
AU  - Bajuk-Bogdanović, Danica
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena
AU  - Jovanović, Svetlana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13322
AB  - The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocompatibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. The high coefficient of determination (R-squared (R2) = 0.99) and very low limit of detection (3.02 μmol L-1) reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an air medium can be potentially applied for glyphosate detection.
T2  - Journal of Environmental Chemical Engineering
T1  - High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights
VL  - 12
IS  - 4
SP  - 113193
DO  - 10.1016/j.jece.2024.113193
ER  - 

@article{
author = "Dorontić, Slađana and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Sredojević, Dušan and Ciasca, Gabriele and Di Santo, Riccardo and Mead, James L. and Budimir, Milica and Bajuk-Bogdanović, Danica and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocompatibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. The high coefficient of determination (R-squared (R2) = 0.99) and very low limit of detection (3.02 μmol L-1) reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an air medium can be potentially applied for glyphosate detection.",
journal = "Journal of Environmental Chemical Engineering",
title = "High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights",
volume = "12",
number = "4",
pages = "113193",
doi = "10.1016/j.jece.2024.113193"
}

Dorontić, S., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Sredojević, D., Ciasca, G., Di Santo, R., Mead, J. L., Budimir, M., Bajuk-Bogdanović, D., Mojsin, M., Pejić, J., Stevanović, M.,& Jovanović, S.. (2024). High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights. in Journal of Environmental Chemical Engineering, 12(4), 113193.
https://doi.org/10.1016/j.jece.2024.113193

Dorontić S, Bonasera A, Scopelliti M, Marković O, Verbić T, Sredojević D, Ciasca G, Di Santo R, Mead JL, Budimir M, Bajuk-Bogdanović D, Mojsin M, Pejić J, Stevanović M, Jovanović S. High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights. in Journal of Environmental Chemical Engineering. 2024;12(4):113193.
doi:10.1016/j.jece.2024.113193 .

Dorontić, Slađana, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Sredojević, Dušan, Ciasca, Gabriele, Di Santo, Riccardo, Mead, James L., Budimir, Milica, Bajuk-Bogdanović, Danica, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena, Jovanović, Svetlana, "High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights" in Journal of Environmental Chemical Engineering, 12, no. 4 (2024):113193,
https://doi.org/10.1016/j.jece.2024.113193 . .

TY  - CHAP
AU  - Jovanović, Svetlana
AU  - Dorontić, Slađana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13323
AB  - Graphene quantum dots (GQDs) show exceptional optical, photoluminescent, chemiluminescent, and electroluminescent properties that made them excellent materials for sensing. In this chapter, we summarized the knowledge about GQDs and explored their applications in the detection of inorganic cations and anions, organic molecules, such as pesticides, cancer biomarkers, metabolites like glucose, L-glutamine, and in the detection of enzymes, microorganisms, etc. The methods for detection as well as mechanisms involved in the monitoring of analytes are explained in depth.
PB  - Nova Science Publishers
T2  - Graphene Quantum Dots (GQDs): Advances in Research and Applications
T1  - Graphene quantum dots for detection - from inorganic ions via biomolecules to pathogenic microorganisms
SP  - 31
EP  - 78
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13323
ER  - 

@inbook{
author = "Jovanović, Svetlana and Dorontić, Slađana",
year = "2024",
abstract = "Graphene quantum dots (GQDs) show exceptional optical, photoluminescent, chemiluminescent, and electroluminescent properties that made them excellent materials for sensing. In this chapter, we summarized the knowledge about GQDs and explored their applications in the detection of inorganic cations and anions, organic molecules, such as pesticides, cancer biomarkers, metabolites like glucose, L-glutamine, and in the detection of enzymes, microorganisms, etc. The methods for detection as well as mechanisms involved in the monitoring of analytes are explained in depth.",
publisher = "Nova Science Publishers",
journal = "Graphene Quantum Dots (GQDs): Advances in Research and Applications",
booktitle = "Graphene quantum dots for detection - from inorganic ions via biomolecules to pathogenic microorganisms",
pages = "31-78",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13323"
}

Jovanović, S.,& Dorontić, S.. (2024). Graphene quantum dots for detection - from inorganic ions via biomolecules to pathogenic microorganisms. in Graphene Quantum Dots (GQDs): Advances in Research and Applications
Nova Science Publishers., 31-78.
https://hdl.handle.net/21.15107/rcub_vinar_13323

Jovanović S, Dorontić S. Graphene quantum dots for detection - from inorganic ions via biomolecules to pathogenic microorganisms. in Graphene Quantum Dots (GQDs): Advances in Research and Applications. 2024;:31-78.
https://hdl.handle.net/21.15107/rcub_vinar_13323 .

Jovanović, Svetlana, Dorontić, Slađana, "Graphene quantum dots for detection - from inorganic ions via biomolecules to pathogenic microorganisms" in Graphene Quantum Dots (GQDs): Advances in Research and Applications (2024):31-78,
https://hdl.handle.net/21.15107/rcub_vinar_13323 .

TY  - JOUR
AU  - Stijepović, Ivan
AU  - Milanović, Marija
AU  - Novaković, Mirjana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13324
AB  - Double ferrite nanocomposites with NiF2O4 as the core and ZnFe2O4 as the shell, were synthesised through combination of co-precipitation and hydrothermal methods. This two-step process resulted in formation of a cubic structured core of around 100 nm and a shell of zinc ferrite nanoparticles which are below 10 nm in size. The core/shell structures were characterised using various techniques such as XRD, Raman, TEM/EDS and VSM. In addition, Ni leaching out of these structures was tested in the ultra-pure water and saline solution. These analyses demonstrated that the shell of zinc ferrites effectively prevents Ni leaching from the core keeping the concentration of nickel well below the level usually found in drinking water. These core/shell nanocomposites exhibit a ferrimagnetic behaviour.
T2  - Ceramics International
T1  - Cubic structured core/shell NiFe2O4@ZnFe2O4 nanocomposite: Structural, morphological and magnetic properties
IS  - InPress
DO  - 10.1016/j.ceramint.2024.05.436
ER  - 

@article{
author = "Stijepović, Ivan and Milanović, Marija and Novaković, Mirjana",
year = "2024",
abstract = "Double ferrite nanocomposites with NiF2O4 as the core and ZnFe2O4 as the shell, were synthesised through combination of co-precipitation and hydrothermal methods. This two-step process resulted in formation of a cubic structured core of around 100 nm and a shell of zinc ferrite nanoparticles which are below 10 nm in size. The core/shell structures were characterised using various techniques such as XRD, Raman, TEM/EDS and VSM. In addition, Ni leaching out of these structures was tested in the ultra-pure water and saline solution. These analyses demonstrated that the shell of zinc ferrites effectively prevents Ni leaching from the core keeping the concentration of nickel well below the level usually found in drinking water. These core/shell nanocomposites exhibit a ferrimagnetic behaviour.",
journal = "Ceramics International",
title = "Cubic structured core/shell NiFe2O4@ZnFe2O4 nanocomposite: Structural, morphological and magnetic properties",
number = "InPress",
doi = "10.1016/j.ceramint.2024.05.436"
}

Stijepović, I., Milanović, M.,& Novaković, M.. (2024). Cubic structured core/shell NiFe2O4@ZnFe2O4 nanocomposite: Structural, morphological and magnetic properties. in Ceramics International(InPress).
https://doi.org/10.1016/j.ceramint.2024.05.436

Stijepović I, Milanović M, Novaković M. Cubic structured core/shell NiFe2O4@ZnFe2O4 nanocomposite: Structural, morphological and magnetic properties. in Ceramics International. 2024;(InPress).
doi:10.1016/j.ceramint.2024.05.436 .

Stijepović, Ivan, Milanović, Marija, Novaković, Mirjana, "Cubic structured core/shell NiFe2O4@ZnFe2O4 nanocomposite: Structural, morphological and magnetic properties" in Ceramics International, no. InPress (2024),
https://doi.org/10.1016/j.ceramint.2024.05.436 . .

TY  - CHAP
AU  - Jokanović, Vukoman
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13325
AB  - Gaps in data management in healthcare applications are related to the unbalanced distribution of medical resources, especially in rural areas around the world. Cognitive intelligence in data management implies the integration of cognitive computing, mass analytics and artificial intelligence, especially machine learning, which can be used to find the patient’s health status, physiologically and psychologically transforming the current health system. In order to remotely detect the emotional state of patients during disease diagnosis, it is proposed to integrate the tactile Internet with 6G as cognitive intelligence in the evaluation of data and the Internet for health systems. All this aims to form the 6G Cognitive healthcare Internet of Everything (6GCIoHE) system in order to achieve global availability, extremely low latency and high reliability. 6G is a promising communication technology that will soon dominate the healthcare sector. This technology will lead to significant changes in numerous areas thanks to the increasingly widespread form of artificial intelligence whose development will be stimulated by 6G communication technologies, fundamentally changing our understandings and way of life. In addition, various new methodologies that include quality of life (QoL), intelligent wearable devices (IWD), intelligent Internet of Medical Things (IIoMT), 3D holography, hospital to home (H2H) services and new business models. In addition, 6G communication technologies will lead to remarkable progress in tele surgery as well as epidemiology.
PB  - CRC Press
T2  - Deep Learning in Internet of Things for Next Generation Healthcare
T1  - The Extraordinary Importance of 6G Network Development and 3D Holography in Future Healthcare
SP  - 224
EP  - 241
DO  - 10.1201/9781003451846-18
ER  - 

@inbook{
author = "Jokanović, Vukoman",
year = "2024",
abstract = "Gaps in data management in healthcare applications are related to the unbalanced distribution of medical resources, especially in rural areas around the world. Cognitive intelligence in data management implies the integration of cognitive computing, mass analytics and artificial intelligence, especially machine learning, which can be used to find the patient’s health status, physiologically and psychologically transforming the current health system. In order to remotely detect the emotional state of patients during disease diagnosis, it is proposed to integrate the tactile Internet with 6G as cognitive intelligence in the evaluation of data and the Internet for health systems. All this aims to form the 6G Cognitive healthcare Internet of Everything (6GCIoHE) system in order to achieve global availability, extremely low latency and high reliability. 6G is a promising communication technology that will soon dominate the healthcare sector. This technology will lead to significant changes in numerous areas thanks to the increasingly widespread form of artificial intelligence whose development will be stimulated by 6G communication technologies, fundamentally changing our understandings and way of life. In addition, various new methodologies that include quality of life (QoL), intelligent wearable devices (IWD), intelligent Internet of Medical Things (IIoMT), 3D holography, hospital to home (H2H) services and new business models. In addition, 6G communication technologies will lead to remarkable progress in tele surgery as well as epidemiology.",
publisher = "CRC Press",
journal = "Deep Learning in Internet of Things for Next Generation Healthcare",
booktitle = "The Extraordinary Importance of 6G Network Development and 3D Holography in Future Healthcare",
pages = "224-241",
doi = "10.1201/9781003451846-18"
}

Jokanović, V.. (2024). The Extraordinary Importance of 6G Network Development and 3D Holography in Future Healthcare. in Deep Learning in Internet of Things for Next Generation Healthcare
CRC Press., 224-241.
https://doi.org/10.1201/9781003451846-18

Jokanović V. The Extraordinary Importance of 6G Network Development and 3D Holography in Future Healthcare. in Deep Learning in Internet of Things for Next Generation Healthcare. 2024;:224-241.
doi:10.1201/9781003451846-18 .

Jokanović, Vukoman, "The Extraordinary Importance of 6G Network Development and 3D Holography in Future Healthcare" in Deep Learning in Internet of Things for Next Generation Healthcare (2024):224-241,
https://doi.org/10.1201/9781003451846-18 . .

TY  - JOUR
AU  - Лазаров, Ненад Ђ.
AU  - Цуцић, Драгољуб А.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13312
AB  - У овом раду ћемо размотрити микростања дводимензионалног Изинговог модела користећи Монте Карло (Monte Carlo) методу. Да би добили микростања дводимензионалног Изинговог модела, употребићемо добро познати Метрополис алгоритам M(PT)2, који је добио назив по ауторима алгоритма, Nicholas Constantine Metropolis, Arianna Wright Rosenbluth, Marshall Nicholas Rosenbluth, Augusta Maria "Mici" Teller (на мађарском Schutz-Harkanyi), Edward Teller (на мађарском Teller Ede). Метрополис алгоритам је презентован у познатом и често цитираном раду, који је објављен 1953. године. Решетка димензије NxN дводимензионалног Изинговог модела има 2<sup>NxN</sup> микростања. Добијена микростања служе за израду QR дводимензионалног кода.
T2  - Настава физике
T1  - Микростања дводимензионог Изинговог модела као QR код
IS  - 13
SP  - 207
EP  - 214
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13312
ER  - 

@article{
author = "Лазаров, Ненад Ђ. and Цуцић, Драгољуб А.",
year = "2024",
abstract = "У овом раду ћемо размотрити микростања дводимензионалног Изинговог модела користећи Монте Карло (Monte Carlo) методу. Да би добили микростања дводимензионалног Изинговог модела, употребићемо добро познати Метрополис алгоритам M(PT)2, који је добио назив по ауторима алгоритма, Nicholas Constantine Metropolis, Arianna Wright Rosenbluth, Marshall Nicholas Rosenbluth, Augusta Maria "Mici" Teller (на мађарском Schutz-Harkanyi), Edward Teller (на мађарском Teller Ede). Метрополис алгоритам је презентован у познатом и често цитираном раду, који је објављен 1953. године. Решетка димензије NxN дводимензионалног Изинговог модела има 2<sup>NxN</sup> микростања. Добијена микростања служе за израду QR дводимензионалног кода.",
journal = "Настава физике",
title = "Микростања дводимензионог Изинговог модела као QR код",
number = "13",
pages = "207-214",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13312"
}

Лазаров, Н. Ђ.,& Цуцић, Д. А.. (2024). Микростања дводимензионог Изинговог модела као QR код. in Настава физике(13), 207-214.
https://hdl.handle.net/21.15107/rcub_vinar_13312

Лазаров НЂ, Цуцић ДА. Микростања дводимензионог Изинговог модела као QR код. in Настава физике. 2024;(13):207-214.
https://hdl.handle.net/21.15107/rcub_vinar_13312 .

Лазаров, Ненад Ђ., Цуцић, Драгољуб А., "Микростања дводимензионог Изинговог модела као QR код" in Настава физике, no. 13 (2024):207-214,
https://hdl.handle.net/21.15107/rcub_vinar_13312 .

TY  - CONF
AU  - Krajnović, Milena
AU  - Jovanović-Ćupić, Snežana
AU  - Kokanov, Nikola
AU  - Petrović, Nina
AU  - Kožik, Bojana
AU  - Šiljić, Marina
AU  - Ćirković, Valentina
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13314
AB  - Variations in the hepatitis C virus (HCV) core gene are related to the progression of liver fibrosis and therapy response. However, the influence of individual amino acid (aa) substitutions at different positions of HCV Core protein on the response to combined pegylated interferon/ribavirin (PEG-IFN/RBV) therapy and disease progression is not yet fully understood. The HCV Core protein can inactivate various genes in the host genome by affecting the methylation of their promoters, leading to liver damage and carcinogenesis. Two genes whose methylation status is affected by the HCV Core protein are the tumor suppressor genes RASSF1A and p16. We have previously shown that the methylation status of these two genes, together with the single nucleotide polymorphism (SNP) rs12979860 near the interleukin-28 beta subunit (IL-28B) gene, influences the response to combined therapy. Herein, we investigated a possible association between detected aa substitutions in HCV Core protein and response to combined therapy, liver disease progression, IL28B genotype, and the methylation status of the RASSF1A and p16 genes. In 29 examined patients we found no association between individual aa substitutions and therapy response. However, we observed that patients with HCV Core aa substitutions at position 75 and CT/TT IL28B genotypes were non-responders (NR) (p=0.023), which was associated with the presence of unmethylated RASSF1A gene. In contrast, even 75% of patients with aa substitutions at position 91 and CC IL28B genotype achieved a sustained virologic response (SVR) (p=0.030), and 70% of them had methylated RASSF1A gene. There was no significant association between the methylation status of the p16 gene and aa variations in the HCV core region. Our results suggest that combined analysis of aa substitutions in HCV Core protein, IL28B genotype, and methylation status of the RASSF1A gene may help predict response to PEG-IFN/RBV therapy in patients with chronic hepatitis C genotype 1b.xx
C3  - Genetics & Applications
T1  - Sequence variability of HCV core region and host genetic and epigenetic factors can predict the response to combined PEG-IFN/RBV therapy in patients with chronic hepatitis c infection genotype 1B
SP  - 26
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13314
ER  - 

@conference{
author = "Krajnović, Milena and Jovanović-Ćupić, Snežana and Kokanov, Nikola and Petrović, Nina and Kožik, Bojana and Šiljić, Marina and Ćirković, Valentina",
year = "2024",
abstract = "Variations in the hepatitis C virus (HCV) core gene are related to the progression of liver fibrosis and therapy response. However, the influence of individual amino acid (aa) substitutions at different positions of HCV Core protein on the response to combined pegylated interferon/ribavirin (PEG-IFN/RBV) therapy and disease progression is not yet fully understood. The HCV Core protein can inactivate various genes in the host genome by affecting the methylation of their promoters, leading to liver damage and carcinogenesis. Two genes whose methylation status is affected by the HCV Core protein are the tumor suppressor genes RASSF1A and p16. We have previously shown that the methylation status of these two genes, together with the single nucleotide polymorphism (SNP) rs12979860 near the interleukin-28 beta subunit (IL-28B) gene, influences the response to combined therapy. Herein, we investigated a possible association between detected aa substitutions in HCV Core protein and response to combined therapy, liver disease progression, IL28B genotype, and the methylation status of the RASSF1A and p16 genes. In 29 examined patients we found no association between individual aa substitutions and therapy response. However, we observed that patients with HCV Core aa substitutions at position 75 and CT/TT IL28B genotypes were non-responders (NR) (p=0.023), which was associated with the presence of unmethylated RASSF1A gene. In contrast, even 75% of patients with aa substitutions at position 91 and CC IL28B genotype achieved a sustained virologic response (SVR) (p=0.030), and 70% of them had methylated RASSF1A gene. There was no significant association between the methylation status of the p16 gene and aa variations in the HCV core region. Our results suggest that combined analysis of aa substitutions in HCV Core protein, IL28B genotype, and methylation status of the RASSF1A gene may help predict response to PEG-IFN/RBV therapy in patients with chronic hepatitis C genotype 1b.xx",
journal = "Genetics & Applications",
title = "Sequence variability of HCV core region and host genetic and epigenetic factors can predict the response to combined PEG-IFN/RBV therapy in patients with chronic hepatitis c infection genotype 1B",
pages = "26-26",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13314"
}

Krajnović, M., Jovanović-Ćupić, S., Kokanov, N., Petrović, N., Kožik, B., Šiljić, M.,& Ćirković, V.. (2024). Sequence variability of HCV core region and host genetic and epigenetic factors can predict the response to combined PEG-IFN/RBV therapy in patients with chronic hepatitis c infection genotype 1B. in Genetics & Applications, 26-26.
https://hdl.handle.net/21.15107/rcub_vinar_13314

Krajnović M, Jovanović-Ćupić S, Kokanov N, Petrović N, Kožik B, Šiljić M, Ćirković V. Sequence variability of HCV core region and host genetic and epigenetic factors can predict the response to combined PEG-IFN/RBV therapy in patients with chronic hepatitis c infection genotype 1B. in Genetics & Applications. 2024;:26-26.
https://hdl.handle.net/21.15107/rcub_vinar_13314 .

Krajnović, Milena, Jovanović-Ćupić, Snežana, Kokanov, Nikola, Petrović, Nina, Kožik, Bojana, Šiljić, Marina, Ćirković, Valentina, "Sequence variability of HCV core region and host genetic and epigenetic factors can predict the response to combined PEG-IFN/RBV therapy in patients with chronic hepatitis c infection genotype 1B" in Genetics & Applications (2024):26-26,
https://hdl.handle.net/21.15107/rcub_vinar_13314 .

TY  - CONF
AU  - Blagojević, Danijela
AU  - Milanović, Ivana
AU  - Imširović, Mirela
AU  - Lazić, Sanda
AU  - Maksimović, Zlatko
AU  - Tanić, Nasta
AU  - Tanić, Nikola
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13316
AB  - COVID-19 pandemic caused by coronavirus 2 respiratory virus (SARS-CoV-2) required fast and effective diagnostics for the purpose of preventing the spread of the disease and outbreak monitoring and control. Therefore, prompt, accurate and reliable testing was of particular importance. Indubitably, the most representative, the most sensitive and the fastest method for detection of SARS CoV-2 is Real Time RT-PCR (RT-qPCR). During the pandemic there were numerous different assays, reagents, protocols and reporting procedures under the question mark because of lack of certified standards, standardization of RNA extraction and reporting procedures. In practice, the reliability of RT-qPCR results depend on a number of parameters that include sample collection and processing, method of RNA extraction, choice of assay, choice of instrument, analysis method and operator intervention. Here we present the various challenges which we encountered during our work and emphasize comparative analysis by different assays, as well as automated versus manual RNA extraction. Sampling, adequate manipulation load, the quality of the assay and interpretation of the result are extremely important. Our results revealed that manual viral RNA extraction should be a method of choice for high sensitivity. In addition, amplification assays targeting three SARS-CoV-2 genes are much more efficient from those targeting one. Unfortunately, RT-qPCR (originally quantitative method) was exclusively used as qualitative diagnostic test for SARS-CoV-2. We think that the ideal testing regimen would involve not just qualitative detection of SARS-CoV-2 but reliable and meaningful quantitative reporting of viral load. For such a thing, a consensus at the level of the world medical community is necessary regarding the most important thing: defining the cut-off value for a clinically significant viral load. It has never been done and therefore many people, all over the world, were sentenced to house arrest for no reason at all.
C3  - Genetics & Applications
T1  - Challenges in SARS-COV-2 diagnostics by real time RT-PCR
SP  - 33
EP  - 33
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13316
ER  - 

@conference{
author = "Blagojević, Danijela and Milanović, Ivana and Imširović, Mirela and Lazić, Sanda and Maksimović, Zlatko and Tanić, Nasta and Tanić, Nikola",
year = "2024",
abstract = "COVID-19 pandemic caused by coronavirus 2 respiratory virus (SARS-CoV-2) required fast and effective diagnostics for the purpose of preventing the spread of the disease and outbreak monitoring and control. Therefore, prompt, accurate and reliable testing was of particular importance. Indubitably, the most representative, the most sensitive and the fastest method for detection of SARS CoV-2 is Real Time RT-PCR (RT-qPCR). During the pandemic there were numerous different assays, reagents, protocols and reporting procedures under the question mark because of lack of certified standards, standardization of RNA extraction and reporting procedures. In practice, the reliability of RT-qPCR results depend on a number of parameters that include sample collection and processing, method of RNA extraction, choice of assay, choice of instrument, analysis method and operator intervention. Here we present the various challenges which we encountered during our work and emphasize comparative analysis by different assays, as well as automated versus manual RNA extraction. Sampling, adequate manipulation load, the quality of the assay and interpretation of the result are extremely important. Our results revealed that manual viral RNA extraction should be a method of choice for high sensitivity. In addition, amplification assays targeting three SARS-CoV-2 genes are much more efficient from those targeting one. Unfortunately, RT-qPCR (originally quantitative method) was exclusively used as qualitative diagnostic test for SARS-CoV-2. We think that the ideal testing regimen would involve not just qualitative detection of SARS-CoV-2 but reliable and meaningful quantitative reporting of viral load. For such a thing, a consensus at the level of the world medical community is necessary regarding the most important thing: defining the cut-off value for a clinically significant viral load. It has never been done and therefore many people, all over the world, were sentenced to house arrest for no reason at all.",
journal = "Genetics & Applications",
title = "Challenges in SARS-COV-2 diagnostics by real time RT-PCR",
pages = "33-33",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13316"
}

Blagojević, D., Milanović, I., Imširović, M., Lazić, S., Maksimović, Z., Tanić, N.,& Tanić, N.. (2024). Challenges in SARS-COV-2 diagnostics by real time RT-PCR. in Genetics & Applications, 33-33.
https://hdl.handle.net/21.15107/rcub_vinar_13316

Blagojević D, Milanović I, Imširović M, Lazić S, Maksimović Z, Tanić N, Tanić N. Challenges in SARS-COV-2 diagnostics by real time RT-PCR. in Genetics & Applications. 2024;:33-33.
https://hdl.handle.net/21.15107/rcub_vinar_13316 .

Blagojević, Danijela, Milanović, Ivana, Imširović, Mirela, Lazić, Sanda, Maksimović, Zlatko, Tanić, Nasta, Tanić, Nikola, "Challenges in SARS-COV-2 diagnostics by real time RT-PCR" in Genetics & Applications (2024):33-33,
https://hdl.handle.net/21.15107/rcub_vinar_13316 .

TY  - JOUR
AU  - Цуцић, Драгољуб А.
AU  - Лазаров, Ненад Ђ.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13311
AB  - Парадоски су питања постављена на одговоре који немају задовољавајућу сатисфакцију у оквирима формулисаног знања. Као многи други парадокси, и Болцманов парадокс изазивао је пажњу физичарске јавности одмах када је настао. Од како је Болцманов парадокс формулисан физичари су покушавали да пронађу решење са којим би се сагласили сви. Разна су објашњења Болцмановог парадокса, нека потичу и од самог Болцмана. У овом раду ће бити понуђено једно објашњење, које ће проблем овог парадокса сагледати из перспективе статистичког детерминизма.
T2  - Настава физике
T1  - Болцманов парадокс и статистички детерминизам
IS  - 13
SP  - 81
EP  - 86
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13311
ER  - 

@article{
author = "Цуцић, Драгољуб А. and Лазаров, Ненад Ђ.",
year = "2024",
abstract = "Парадоски су питања постављена на одговоре који немају задовољавајућу сатисфакцију у оквирима формулисаног знања. Као многи други парадокси, и Болцманов парадокс изазивао је пажњу физичарске јавности одмах када је настао. Од како је Болцманов парадокс формулисан физичари су покушавали да пронађу решење са којим би се сагласили сви. Разна су објашњења Болцмановог парадокса, нека потичу и од самог Болцмана. У овом раду ће бити понуђено једно објашњење, које ће проблем овог парадокса сагледати из перспективе статистичког детерминизма.",
journal = "Настава физике",
title = "Болцманов парадокс и статистички детерминизам",
number = "13",
pages = "81-86",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13311"
}

Цуцић, Д. А.,& Лазаров, Н. Ђ.. (2024). Болцманов парадокс и статистички детерминизам. in Настава физике(13), 81-86.
https://hdl.handle.net/21.15107/rcub_vinar_13311

Цуцић ДА, Лазаров НЂ. Болцманов парадокс и статистички детерминизам. in Настава физике. 2024;(13):81-86.
https://hdl.handle.net/21.15107/rcub_vinar_13311 .

Цуцић, Драгољуб А., Лазаров, Ненад Ђ., "Болцманов парадокс и статистички детерминизам" in Настава физике, no. 13 (2024):81-86,
https://hdl.handle.net/21.15107/rcub_vinar_13311 .

TY  - CONF
AU  - Kožik, Bojana
AU  - Todorović, Lidija
AU  - Božović, Ana
AU  - Kolaković, Ana
AU  - Vasiljević, Tijana
AU  - Đermanović, Aleksandar
AU  - Đurić, Mladen
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13313
AB  - The prognosis of rectal cancer (RC) can be influenced by various factors, including the location of the tumor. Studies have shown that the position of the tumor within the rectum can impact the recurrence and overall survival rates. Tumor localization in RC is also associated with gene expression alterations. ZEB1 is a transcriptional factor that promotes tumor invasiveness via regulation of the epithelialmesenchymal transition process and plays a significant role in RC by influencing tumor aggressiveness. This study aimed to evaluate the location-specific expression of the ZEB1 gene and its prognostic role in RC patients. This preliminary study included 45 untreated RC patients who underwent curative resection. In 10 patients, the tumor was located in the low rectum (0-5 cm), while 35 tumors were positioned within the mid and upper rectum (5-15 cm). We isolated mRNA from postoperative tumor FFPE samples. TaqMan® gene expression assay was used for quantitative real-time PCR analysis of ZEB1 gene expression. The preliminary analysis revealed that relative ZEB1 gene expression was significantly higher in upper RC locations than among low-positioned tumors (0.00198 vs. 0.000947, p=0.024). We did not find a significant difference in overall survival (OS) and disease-free survival (DFS) among RC patients based on the tumor location and ZEB1 expression (p > 0.05 in both cases). However, among 35 patients with upper-positioned tumors, we noted that patients with elevated ZEB1 expression had shorter DFS than patients with low ZEB1 expression (48.062±6.557 vs. 61.682±6.095 months), although the observed difference was not statistically significant (p=0.270). Our results indicate the importance of evaluating spatial ZEB1 expression in RC and suggest its potential prognostic role, especially in determining the survival time without disease recurrence in RC patients. However, further research on a larger number of samples is needed to confirm these findings.
C3  - Genetics & Applications
T1  - Spatial expression of ZEB1 gene as a potential prognostic marker in rectal cancer
SP  - 25
EP  - 25
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13313
ER  - 

@conference{
author = "Kožik, Bojana and Todorović, Lidija and Božović, Ana and Kolaković, Ana and Vasiljević, Tijana and Đermanović, Aleksandar and Đurić, Mladen",
year = "2024",
abstract = "The prognosis of rectal cancer (RC) can be influenced by various factors, including the location of the tumor. Studies have shown that the position of the tumor within the rectum can impact the recurrence and overall survival rates. Tumor localization in RC is also associated with gene expression alterations. ZEB1 is a transcriptional factor that promotes tumor invasiveness via regulation of the epithelialmesenchymal transition process and plays a significant role in RC by influencing tumor aggressiveness. This study aimed to evaluate the location-specific expression of the ZEB1 gene and its prognostic role in RC patients. This preliminary study included 45 untreated RC patients who underwent curative resection. In 10 patients, the tumor was located in the low rectum (0-5 cm), while 35 tumors were positioned within the mid and upper rectum (5-15 cm). We isolated mRNA from postoperative tumor FFPE samples. TaqMan® gene expression assay was used for quantitative real-time PCR analysis of ZEB1 gene expression. The preliminary analysis revealed that relative ZEB1 gene expression was significantly higher in upper RC locations than among low-positioned tumors (0.00198 vs. 0.000947, p=0.024). We did not find a significant difference in overall survival (OS) and disease-free survival (DFS) among RC patients based on the tumor location and ZEB1 expression (p > 0.05 in both cases). However, among 35 patients with upper-positioned tumors, we noted that patients with elevated ZEB1 expression had shorter DFS than patients with low ZEB1 expression (48.062±6.557 vs. 61.682±6.095 months), although the observed difference was not statistically significant (p=0.270). Our results indicate the importance of evaluating spatial ZEB1 expression in RC and suggest its potential prognostic role, especially in determining the survival time without disease recurrence in RC patients. However, further research on a larger number of samples is needed to confirm these findings.",
journal = "Genetics & Applications",
title = "Spatial expression of ZEB1 gene as a potential prognostic marker in rectal cancer",
pages = "25-25",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13313"
}

Kožik, B., Todorović, L., Božović, A., Kolaković, A., Vasiljević, T., Đermanović, A.,& Đurić, M.. (2024). Spatial expression of ZEB1 gene as a potential prognostic marker in rectal cancer. in Genetics & Applications, 25-25.
https://hdl.handle.net/21.15107/rcub_vinar_13313

Kožik B, Todorović L, Božović A, Kolaković A, Vasiljević T, Đermanović A, Đurić M. Spatial expression of ZEB1 gene as a potential prognostic marker in rectal cancer. in Genetics & Applications. 2024;:25-25.
https://hdl.handle.net/21.15107/rcub_vinar_13313 .

Kožik, Bojana, Todorović, Lidija, Božović, Ana, Kolaković, Ana, Vasiljević, Tijana, Đermanović, Aleksandar, Đurić, Mladen, "Spatial expression of ZEB1 gene as a potential prognostic marker in rectal cancer" in Genetics & Applications (2024):25-25,
https://hdl.handle.net/21.15107/rcub_vinar_13313 .

TY  - CONF
AU  - Božović, Ana
AU  - Nedeljković, Milica
AU  - Kožik, Bojana
AU  - Todorović, Lidija
AU  - Krajnović, Milena
AU  - Jovanović-Ćupić, Snežana
AU  - Kokanov, Nikola
AU  - Mandušić, Vesna
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13315
AB  - Breast cancer (BC) is the most common cancer among women worldwide. The diagnosis and treatment decisions depend on the three biomarkers: oestrogen receptor alfa, progesterone receptor and human epidermal growth factor 2. The foremost treatment line is Nolvadex (tamoxifen). Yet approximately 30% of patients do not respond to tamoxifen treatment. The discovery of oestrogen receptor beta (ERβ) opened the door for another BC biomarker’s introduction. The studies show that the ERβ usually behaves like a tumour suppressor and that its expression is a favourable parameter of the patient survival and treatment response. Our study aimed to assess the prognostic and predictive role of ERβ in BC. It encompassed 118 BC samples from patients operated at the Institute of Oncology and Radiology of Serbia from 2002 to 2004. Overall (OS) and disease-free survival (DFS) data were collected between 2002 and 2022. We used the Western blot method for ERβ1 protein detection. The ERβ1 mRNA and ERβ delta5 mRNA isoforms were detected by quantitative PCR method with TaqMan Assays. The extracted DNA was subjected to a two-step MSP MethEvaGreen procedure, using primers we designed to detect specific ERβ gene promoter ON methylation. Patient groups were divided into low and high-expression groups based on median values. Our results showed that in the high methylation index group, OS and DFS of patients who received adjuvant Nolvadex treatment were significantly longer than those who did not (p=0.001, p=0.033, respectively). In the low methylation index group, the DFS of patients who received radiotherapy was significantly shorter than those who did not (p=0.037). However, in the low ERβ mRNA expression group, the DFS of patients who received radiotherapy was significantly shorter than those who did not (p=0.028). Our results show that ERβ could be a significant additional parameter in the BC prognosis and treatment decisions. Further analyses are needed.
C3  - Genetics & Applications
T1  - ERΒ is a possible biomarker of breast cancer
SP  - 28
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_vinar_13315
ER  - 

@conference{
author = "Božović, Ana and Nedeljković, Milica and Kožik, Bojana and Todorović, Lidija and Krajnović, Milena and Jovanović-Ćupić, Snežana and Kokanov, Nikola and Mandušić, Vesna",
year = "2024",
abstract = "Breast cancer (BC) is the most common cancer among women worldwide. The diagnosis and treatment decisions depend on the three biomarkers: oestrogen receptor alfa, progesterone receptor and human epidermal growth factor 2. The foremost treatment line is Nolvadex (tamoxifen). Yet approximately 30% of patients do not respond to tamoxifen treatment. The discovery of oestrogen receptor beta (ERβ) opened the door for another BC biomarker’s introduction. The studies show that the ERβ usually behaves like a tumour suppressor and that its expression is a favourable parameter of the patient survival and treatment response. Our study aimed to assess the prognostic and predictive role of ERβ in BC. It encompassed 118 BC samples from patients operated at the Institute of Oncology and Radiology of Serbia from 2002 to 2004. Overall (OS) and disease-free survival (DFS) data were collected between 2002 and 2022. We used the Western blot method for ERβ1 protein detection. The ERβ1 mRNA and ERβ delta5 mRNA isoforms were detected by quantitative PCR method with TaqMan Assays. The extracted DNA was subjected to a two-step MSP MethEvaGreen procedure, using primers we designed to detect specific ERβ gene promoter ON methylation. Patient groups were divided into low and high-expression groups based on median values. Our results showed that in the high methylation index group, OS and DFS of patients who received adjuvant Nolvadex treatment were significantly longer than those who did not (p=0.001, p=0.033, respectively). In the low methylation index group, the DFS of patients who received radiotherapy was significantly shorter than those who did not (p=0.037). However, in the low ERβ mRNA expression group, the DFS of patients who received radiotherapy was significantly shorter than those who did not (p=0.028). Our results show that ERβ could be a significant additional parameter in the BC prognosis and treatment decisions. Further analyses are needed.",
journal = "Genetics & Applications",
title = "ERΒ is a possible biomarker of breast cancer",
pages = "28-28",
url = "https://hdl.handle.net/21.15107/rcub_vinar_13315"
}

Božović, A., Nedeljković, M., Kožik, B., Todorović, L., Krajnović, M., Jovanović-Ćupić, S., Kokanov, N.,& Mandušić, V.. (2024). ERΒ is a possible biomarker of breast cancer. in Genetics & Applications, 28-28.
https://hdl.handle.net/21.15107/rcub_vinar_13315

Božović A, Nedeljković M, Kožik B, Todorović L, Krajnović M, Jovanović-Ćupić S, Kokanov N, Mandušić V. ERΒ is a possible biomarker of breast cancer. in Genetics & Applications. 2024;:28-28.
https://hdl.handle.net/21.15107/rcub_vinar_13315 .

Božović, Ana, Nedeljković, Milica, Kožik, Bojana, Todorović, Lidija, Krajnović, Milena, Jovanović-Ćupić, Snežana, Kokanov, Nikola, Mandušić, Vesna, "ERΒ is a possible biomarker of breast cancer" in Genetics & Applications (2024):28-28,
https://hdl.handle.net/21.15107/rcub_vinar_13315 .

TY  - JOUR
AU  - Vranješ-Đurić, Sanja
AU  - Milanović, Zorana
AU  - Mirković, Marija D.
AU  - Radović, Magdalena
AU  - Perić, Marko R.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13264
AB  - The use of vanadium complexes for potential applications in medicine largely depends on the structural properties of the complex itself, as well as on the electronic configuration of the metal and its oxidation state. When the vanadium complex binds to biomolecules or by binding solvent molecules to the complex, there is a change in the structure but also a change in the redox properties of the complex. Using theoretical methods, especially Density Functional theory (DFT), it is possible to determine which factors influence changes in the redox properties of the complex. Furthermore, by calculating the Electron Paramagnetic Resonance (EPR) constants of hyperfine coupling, it is possible to obtain not only data on the electronic configuration, but also to predict changes in redox properties upon changes in the structure of the complex. DFT results show that the binding of pyridine or imidazole to the VO(acac)2 complex leads to a lowering of the redox potential. The largest changes in the redox potential were observed in the case when the incoming ligand binds in a cis position relative to the V==O bond.
T2  - Polyhedron
T1  - On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO(acac)2pyr and VO(acac)2 imidazole complexes. A DFT study
VL  - 259
SP  - 117049
SP  - 117049
DO  - 10.1016/j.poly.2024.117049
ER  - 

@article{
author = "Vranješ-Đurić, Sanja and Milanović, Zorana and Mirković, Marija D. and Radović, Magdalena and Perić, Marko R.",
year = "2024",
abstract = "The use of vanadium complexes for potential applications in medicine largely depends on the structural properties of the complex itself, as well as on the electronic configuration of the metal and its oxidation state. When the vanadium complex binds to biomolecules or by binding solvent molecules to the complex, there is a change in the structure but also a change in the redox properties of the complex. Using theoretical methods, especially Density Functional theory (DFT), it is possible to determine which factors influence changes in the redox properties of the complex. Furthermore, by calculating the Electron Paramagnetic Resonance (EPR) constants of hyperfine coupling, it is possible to obtain not only data on the electronic configuration, but also to predict changes in redox properties upon changes in the structure of the complex. DFT results show that the binding of pyridine or imidazole to the VO(acac)2 complex leads to a lowering of the redox potential. The largest changes in the redox potential were observed in the case when the incoming ligand binds in a cis position relative to the V==O bond.",
journal = "Polyhedron",
title = "On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO(acac)2pyr and VO(acac)2 imidazole complexes. A DFT study",
volume = "259",
pages = "117049-117049",
doi = "10.1016/j.poly.2024.117049"
}

Vranješ-Đurić, S., Milanović, Z., Mirković, M. D., Radović, M.,& Perić, M. R.. (2024). On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO(acac)2pyr and VO(acac)2 imidazole complexes. A DFT study. in Polyhedron, 259, 117049.
https://doi.org/10.1016/j.poly.2024.117049

Vranješ-Đurić S, Milanović Z, Mirković MD, Radović M, Perić MR. On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO(acac)2pyr and VO(acac)2 imidazole complexes. A DFT study. in Polyhedron. 2024;259:117049.
doi:10.1016/j.poly.2024.117049 .

Vranješ-Đurić, Sanja, Milanović, Zorana, Mirković, Marija D., Radović, Magdalena, Perić, Marko R., "On the driving forces behind the change of reduction potentials and the prediction of redox properties through analysis of EPR hyperfine couplings in VO(acac)2pyr and VO(acac)2 imidazole complexes. A DFT study" in Polyhedron, 259 (2024):117049,
https://doi.org/10.1016/j.poly.2024.117049 . .

TY  - JOUR
AU  - Leovac, Vukadin M.
AU  - Novaković, Slađana B.
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13319
AB  - Very rich coordination chemistry of thiosemicarbazide based ligands is mainly associated with the diversity of their Schiff base derivatives, known as thiosemicarbazones. The significant interest in thiosemicarbazones and their metal complexes arises from a wide range of valuable biological, chemical and physico-chemical features, as documented by numerous review papers in medicinal, structural, analytical chemistry, catalysis and other. The thiosemicarbazide based ligands other than Schiff bases did not draw the same attention. A literature survey, however, shows considerable number of non-Schiff base derivatives with interesting coordination chemistry, giving rise to metal complexes with pronounced structural diversity and useful properties. Considering the polydentate thiosemicarbazide scaffold [N–N–C(=S)–N] it is not surprising that its other derivatives can offer versatile coordination modes and stable complexes with variety of metal ions. This article attempts to bring together the thiosemicarbazide derived ligands other than Schiff bases, and to explore their coordination tendencies as well as the structural aspects of their metal complexes. The first papers in coordination chemistry of thiosemicarbazide were reported exactly 90 years ago. Therefore, it is also our aim to gain better overview of various types of thiosemicarbazide ligands that have emerged since, and to understand different possibilities of thiosemicarbazide modification. In order to present and compare the molecular and supramolecular properties the review primary relies on structurally characterized coordination compounds. It also includes some experimental charge density findings in an effort to explain behaviour of thiosemicarbazide ligands at subatomic level.
T2  - Journal of Molecular Structure
T1  - Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives
VL  - 1314
SP  - 138721
DO  - 10.1016/j.molstruc.2024.138721
ER  - 

@article{
author = "Leovac, Vukadin M. and Novaković, Slađana B.",
year = "2024",
abstract = "Very rich coordination chemistry of thiosemicarbazide based ligands is mainly associated with the diversity of their Schiff base derivatives, known as thiosemicarbazones. The significant interest in thiosemicarbazones and their metal complexes arises from a wide range of valuable biological, chemical and physico-chemical features, as documented by numerous review papers in medicinal, structural, analytical chemistry, catalysis and other. The thiosemicarbazide based ligands other than Schiff bases did not draw the same attention. A literature survey, however, shows considerable number of non-Schiff base derivatives with interesting coordination chemistry, giving rise to metal complexes with pronounced structural diversity and useful properties. Considering the polydentate thiosemicarbazide scaffold [N–N–C(=S)–N] it is not surprising that its other derivatives can offer versatile coordination modes and stable complexes with variety of metal ions. This article attempts to bring together the thiosemicarbazide derived ligands other than Schiff bases, and to explore their coordination tendencies as well as the structural aspects of their metal complexes. The first papers in coordination chemistry of thiosemicarbazide were reported exactly 90 years ago. Therefore, it is also our aim to gain better overview of various types of thiosemicarbazide ligands that have emerged since, and to understand different possibilities of thiosemicarbazide modification. In order to present and compare the molecular and supramolecular properties the review primary relies on structurally characterized coordination compounds. It also includes some experimental charge density findings in an effort to explain behaviour of thiosemicarbazide ligands at subatomic level.",
journal = "Journal of Molecular Structure",
title = "Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives",
volume = "1314",
pages = "138721",
doi = "10.1016/j.molstruc.2024.138721"
}

Leovac, V. M.,& Novaković, S. B.. (2024). Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives. in Journal of Molecular Structure, 1314, 138721.
https://doi.org/10.1016/j.molstruc.2024.138721

Leovac VM, Novaković SB. Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives. in Journal of Molecular Structure. 2024;1314:138721.
doi:10.1016/j.molstruc.2024.138721 .

Leovac, Vukadin M., Novaković, Slađana B., "Versatile coordination chemistry of thiosemicarbazide and its non-Schiff base derivatives" in Journal of Molecular Structure, 1314 (2024):138721,
https://doi.org/10.1016/j.molstruc.2024.138721 . .