TY  - JOUR
AU  - Božinović, Nevena
AU  - Savva, Kyriaki
AU  - Rajić, Vladimir
AU  - Popović, Maja
AU  - Tošić, Dragana
AU  - Janjetović, Kristina
AU  - Despotović, Ana
AU  - Zogović, Nevena
AU  - Stratakis, Emmanuel
AU  - Petrović, Suzana
PY  - 2023-10
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11547
AB  - The creation of novel biocompatible Ti-based thin films with a Zr or Cu sub-layer modified by ultrafast laser processing is studied. To prepare bioactive surfaces, ultrafast laser processing is focused on the formation of laser-induced periodic surface structures (LIPSS) with the production of oxide phases at the surfaces. Two differently designed multilayer thin films Ti/Cu/Ti and Ti/Zr/Ti were deposited on the silicon using the ion sputtering method. The Ti thin film contains Cu or Zr sub-layer (thickness of 10 nm) at the 10 nm below the surface. The composition and surface morphology variations for these systems, deposited and laser-processed under the same experimental conditions, were caused only by different thermo-physical properties of the sub-layer (Cu or Zr). The surface morphology in the form of LIPSS, led to improved cell adhesion and stable cells/thin films interface compared to as-deposited samples. Field-emission scanning electron microscopy and MTT analysis revealed that laser processing of both systems increased cell adhesion, proliferation, and metabolical activity of L929 mouse fibroblast cells compared to non-modified flat surfaces. Overall, the biocompatibility of Zrcontaining thin films is better than Ti/Cu/Ti system. Further, laser processing and formation of LIPSS makes Ti/Zr/Ti thin films excellent candidate for biomedical
T2  - Materials Chemistry and Physics
T1  - Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films
VL  - 308
SP  - 128286
DO  - 10.1016/j.matchemphys.2023.128286
ER  - 

@article{
author = "Božinović, Nevena and Savva, Kyriaki and Rajić, Vladimir and Popović, Maja and Tošić, Dragana and Janjetović, Kristina and Despotović, Ana and Zogović, Nevena and Stratakis, Emmanuel and Petrović, Suzana",
year = "2023-10",
abstract = "The creation of novel biocompatible Ti-based thin films with a Zr or Cu sub-layer modified by ultrafast laser processing is studied. To prepare bioactive surfaces, ultrafast laser processing is focused on the formation of laser-induced periodic surface structures (LIPSS) with the production of oxide phases at the surfaces. Two differently designed multilayer thin films Ti/Cu/Ti and Ti/Zr/Ti were deposited on the silicon using the ion sputtering method. The Ti thin film contains Cu or Zr sub-layer (thickness of 10 nm) at the 10 nm below the surface. The composition and surface morphology variations for these systems, deposited and laser-processed under the same experimental conditions, were caused only by different thermo-physical properties of the sub-layer (Cu or Zr). The surface morphology in the form of LIPSS, led to improved cell adhesion and stable cells/thin films interface compared to as-deposited samples. Field-emission scanning electron microscopy and MTT analysis revealed that laser processing of both systems increased cell adhesion, proliferation, and metabolical activity of L929 mouse fibroblast cells compared to non-modified flat surfaces. Overall, the biocompatibility of Zrcontaining thin films is better than Ti/Cu/Ti system. Further, laser processing and formation of LIPSS makes Ti/Zr/Ti thin films excellent candidate for biomedical",
journal = "Materials Chemistry and Physics",
title = "Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films",
volume = "308",
pages = "128286",
doi = "10.1016/j.matchemphys.2023.128286"
}

Božinović, N., Savva, K., Rajić, V., Popović, M., Tošić, D., Janjetović, K., Despotović, A., Zogović, N., Stratakis, E.,& Petrović, S.. (2023-10). Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films. in Materials Chemistry and Physics, 308, 128286.
https://doi.org/10.1016/j.matchemphys.2023.128286

Božinović N, Savva K, Rajić V, Popović M, Tošić D, Janjetović K, Despotović A, Zogović N, Stratakis E, Petrović S. Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films. in Materials Chemistry and Physics. 2023;308:128286.
doi:10.1016/j.matchemphys.2023.128286 .

Božinović, Nevena, Savva, Kyriaki, Rajić, Vladimir, Popović, Maja, Tošić, Dragana, Janjetović, Kristina, Despotović, Ana, Zogović, Nevena, Stratakis, Emmanuel, Petrović, Suzana, "Influence of zirconium and copper sub-layer in cell integrations on femtosecond laser-processed Ti thin films" in Materials Chemistry and Physics, 308 (2023-10):128286,
https://doi.org/10.1016/j.matchemphys.2023.128286 . .

TY  - JOUR
AU  - Kartalovic, Nenad
AU  - Kovačević, Uroš
AU  - Nikezić, Dušan
AU  - Jusić, Alija
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11578
AB  - The study con sid ers the im pact of the en vi ron men tal con tam i na tion by the elec tro mag netic ra di a tion of elec tron beam gen er a tor and high-en ergy ra dio ac tive source on the mem ory com - po nents. Electron beam gen er a tor can be used for in jecting parti cle en ergy into the plasma of the fusion sys tem based on a Marx gener a tor, while ra dio ac tive source as a sim u la tor of high-en ergy ion iz ing ra di a tion that can be caused by the neu tron-in duced ac ti va tion of plasma sur round ing struc tures or re leased from deu te rium-tri tium fu sion re ac tion. The ef - fects of gamma ra di a tion of high-en ergy radio ac tive source and elec tric field of the electron beam gen er a tor on EPROM and EEPROM semi con ductor com puter mem ory, were in ves ti - gated. An older mem ory types were de lib er ately cho sen for the rea son that their more ro bust con struc tion will better pro tect them from the ef fects of ioniz ing and non-ion iz ing ra di a tion. The re sults ob tained un der well-con trolled condi tions show a high de gree of non-re sis tance of the semi con duc tor tech nol ogy to the ex pected elec tro mag netic pol lu tion of the elec tron beam gen er a tor and high-en ergy radio ac tive source. This con clu sion raises doubts on the pos - si bil ity of si mul ta neous ap pli ca tion of elec tron beam gen er a tor, con se quently fu sion sys tem and nanotechnologies with the in creas ing need for min ia turiza tion of electronic com po nents
T2  - Nuclear Technology and Radiation Protection
T1  - Influence of electromagnetic pollution of the electron beam generator and high-energy radioactive source on the memory components
VL  - 38
IS  - 1
SP  - 10
EP  - 17
DO  - 10.2298/NTRP2301010K
ER  - 

@article{
author = "Kartalovic, Nenad and Kovačević, Uroš and Nikezić, Dušan and Jusić, Alija",
year = "2023",
abstract = "The study con sid ers the im pact of the en vi ron men tal con tam i na tion by the elec tro mag netic ra di a tion of elec tron beam gen er a tor and high-en ergy ra dio ac tive source on the mem ory com - po nents. Electron beam gen er a tor can be used for in jecting parti cle en ergy into the plasma of the fusion sys tem based on a Marx gener a tor, while ra dio ac tive source as a sim u la tor of high-en ergy ion iz ing ra di a tion that can be caused by the neu tron-in duced ac ti va tion of plasma sur round ing struc tures or re leased from deu te rium-tri tium fu sion re ac tion. The ef - fects of gamma ra di a tion of high-en ergy radio ac tive source and elec tric field of the electron beam gen er a tor on EPROM and EEPROM semi con ductor com puter mem ory, were in ves ti - gated. An older mem ory types were de lib er ately cho sen for the rea son that their more ro bust con struc tion will better pro tect them from the ef fects of ioniz ing and non-ion iz ing ra di a tion. The re sults ob tained un der well-con trolled condi tions show a high de gree of non-re sis tance of the semi con duc tor tech nol ogy to the ex pected elec tro mag netic pol lu tion of the elec tron beam gen er a tor and high-en ergy radio ac tive source. This con clu sion raises doubts on the pos - si bil ity of si mul ta neous ap pli ca tion of elec tron beam gen er a tor, con se quently fu sion sys tem and nanotechnologies with the in creas ing need for min ia turiza tion of electronic com po nents",
journal = "Nuclear Technology and Radiation Protection",
title = "Influence of electromagnetic pollution of the electron beam generator and high-energy radioactive source on the memory components",
volume = "38",
number = "1",
pages = "10-17",
doi = "10.2298/NTRP2301010K"
}

Kartalovic, N., Kovačević, U., Nikezić, D.,& Jusić, A.. (2023). Influence of electromagnetic pollution of the electron beam generator and high-energy radioactive source on the memory components. in Nuclear Technology and Radiation Protection, 38(1), 10-17.
https://doi.org/10.2298/NTRP2301010K

Kartalovic N, Kovačević U, Nikezić D, Jusić A. Influence of electromagnetic pollution of the electron beam generator and high-energy radioactive source on the memory components. in Nuclear Technology and Radiation Protection. 2023;38(1):10-17.
doi:10.2298/NTRP2301010K .

Kartalovic, Nenad, Kovačević, Uroš, Nikezić, Dušan, Jusić, Alija, "Influence of electromagnetic pollution of the electron beam generator and high-energy radioactive source on the memory components" in Nuclear Technology and Radiation Protection, 38, no. 1 (2023):10-17,
https://doi.org/10.2298/NTRP2301010K . .

TY  - JOUR
AU  - Ergün, Sercan
AU  - Sankaranarayanan, Ramamoorthy
AU  - Petrović, Nina
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11577
AB  - COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene's transcriptional activity. The interaction between miRNAs and their target molecules is responsible for homeostasis. Virus-derived and host-derived miRNAs are involved in the activity of hiding from immune system cells, inducing the inflammatory reaction through interplay with associated genes, during SARS-COV-2 infection. Interest in miRNAs has raised the comprehension of the machinery and pathophysiology of SARS-COV-2 infection. In this review, the effects and biological roles of miRNAs on SARS-CoV-2 pathogenicity and life cycle are described. The therapeutic potential of miRNAs against SARS-CoV-2 infection are also mentioned.
T2  - Epigenomics
T1  - Clinically informative microRNAs for SARS-CoV-2 infection
VL  - 15
IS  - 13
SP  - 705
EP  - 716
DO  - 10.2217/epi-2023-0179
ER  - 

@article{
author = "Ergün, Sercan and Sankaranarayanan, Ramamoorthy and Petrović, Nina",
year = "2023",
abstract = "COVID-19 is a viral respiratory infection induced by the newly discovered coronavirus SARS-CoV-2. miRNA is an example of a strong and direct regulator of a gene's transcriptional activity. The interaction between miRNAs and their target molecules is responsible for homeostasis. Virus-derived and host-derived miRNAs are involved in the activity of hiding from immune system cells, inducing the inflammatory reaction through interplay with associated genes, during SARS-COV-2 infection. Interest in miRNAs has raised the comprehension of the machinery and pathophysiology of SARS-COV-2 infection. In this review, the effects and biological roles of miRNAs on SARS-CoV-2 pathogenicity and life cycle are described. The therapeutic potential of miRNAs against SARS-CoV-2 infection are also mentioned.",
journal = "Epigenomics",
title = "Clinically informative microRNAs for SARS-CoV-2 infection",
volume = "15",
number = "13",
pages = "705-716",
doi = "10.2217/epi-2023-0179"
}

Ergün, S., Sankaranarayanan, R.,& Petrović, N.. (2023). Clinically informative microRNAs for SARS-CoV-2 infection. in Epigenomics, 15(13), 705-716.
https://doi.org/10.2217/epi-2023-0179

Ergün S, Sankaranarayanan R, Petrović N. Clinically informative microRNAs for SARS-CoV-2 infection. in Epigenomics. 2023;15(13):705-716.
doi:10.2217/epi-2023-0179 .

Ergün, Sercan, Sankaranarayanan, Ramamoorthy, Petrović, Nina, "Clinically informative microRNAs for SARS-CoV-2 infection" in Epigenomics, 15, no. 13 (2023):705-716,
https://doi.org/10.2217/epi-2023-0179 . .

TY  - JOUR
AU  - Mačvanin, Mirjana T.
AU  - Gluvić, Zoran
AU  - Bajić, Vladan
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11574
AB  - Diabetes mellitus (DM) is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance, inadequate insulin secretion, or excessive glucagon secretion. In 2021, the global prevalence of diabetes is anticipated to be 10.7% (537 million people). Noncoding RNAs (ncRNAs) appear to have an important role in the initiation and progression of DM, according to a growing body of research. The two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding RNAs. miRNAs are singlestranded, short (17–25 nucleotides), ncRNAs that influence gene expression at the post-transcriptional level. Because DM has reached epidemic proportions worldwide, it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases efficiently. miRNAs are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression regulation. In this review, we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these disorders. We hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for DM. We examine and synthesize recent research that used novel, high-throughput technologies to uncover ncRNAs involved in DM, necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.
T2  - World Journal of Diabetes
T1  - Novel insights regarding the role of noncoding RNAs in diabetes
VL  - 14
IS  - 7
SP  - 958
EP  - 976
DO  - 10.4239/wjd.v14.i7.958
ER  - 

@article{
author = "Mačvanin, Mirjana T. and Gluvić, Zoran and Bajić, Vladan and Isenović, Esma R.",
year = "2023",
abstract = "Diabetes mellitus (DM) is a group of metabolic disorders defined by hyperglycemia induced by insulin resistance, inadequate insulin secretion, or excessive glucagon secretion. In 2021, the global prevalence of diabetes is anticipated to be 10.7% (537 million people). Noncoding RNAs (ncRNAs) appear to have an important role in the initiation and progression of DM, according to a growing body of research. The two major groups of ncRNAs implicated in diabetic disorders are miRNAs and long noncoding RNAs. miRNAs are singlestranded, short (17–25 nucleotides), ncRNAs that influence gene expression at the post-transcriptional level. Because DM has reached epidemic proportions worldwide, it appears that novel diagnostic and therapeutic strategies are required to identify and treat complications associated with these diseases efficiently. miRNAs are gaining attention as biomarkers for DM diagnosis and potential treatment due to their function in maintaining physiological homeostasis via gene expression regulation. In this review, we address the issue of the gradually expanding global prevalence of DM by presenting a complete and upto-date synopsis of various regulatory miRNAs involved in these disorders. We hope this review will spark discussion about ncRNAs as prognostic biomarkers and therapeutic tools for DM. We examine and synthesize recent research that used novel, high-throughput technologies to uncover ncRNAs involved in DM, necessitating a systematic approach to examining and summarizing their roles and possible diagnostic and therapeutic uses.",
journal = "World Journal of Diabetes",
title = "Novel insights regarding the role of noncoding RNAs in diabetes",
volume = "14",
number = "7",
pages = "958-976",
doi = "10.4239/wjd.v14.i7.958"
}

Mačvanin, M. T., Gluvić, Z., Bajić, V.,& Isenović, E. R.. (2023). Novel insights regarding the role of noncoding RNAs in diabetes. in World Journal of Diabetes, 14(7), 958-976.
https://doi.org/10.4239/wjd.v14.i7.958

Mačvanin MT, Gluvić Z, Bajić V, Isenović ER. Novel insights regarding the role of noncoding RNAs in diabetes. in World Journal of Diabetes. 2023;14(7):958-976.
doi:10.4239/wjd.v14.i7.958 .

Mačvanin, Mirjana T., Gluvić, Zoran, Bajić, Vladan, Isenović, Esma R., "Novel insights regarding the role of noncoding RNAs in diabetes" in World Journal of Diabetes, 14, no. 7 (2023):958-976,
https://doi.org/10.4239/wjd.v14.i7.958 . .

TY  - JOUR
AU  - Milutinović, Slobodan
AU  - Pandurović, Mila
AU  - Vujisić, Miloš
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11573
AB  - Gold nanoparticles (AuNPs) have been investigated extensively in the past twenty years as a sensitizing agent in photon radiotherapy. Targeted delivery of AuNPs to specifc sites in cells and tissues contributes to highly localized radiation dose enhancement, whereby the surrounding healthy structures can be largely spared from the unwanted radiation efects. Te efciency of introduced AuNPs with regard to dose enhancement depends on the properties of the nanoparticles since not all of deposited radiation energy reaches the intended biological target but is partially absorbed within the nanoparticles themselves or distributed elsewhere. Te present paper investigates the infuence of AuNP shape and localization on the enhancement and intracellular distribution of deposited energy in radiation therapy with photons. Energy deposition patterns are calculated with nanoscale accuracy through Monte Carlo simulations of radiation transport, which are optimized to accommodate a structured geometrical representation of the region loaded with AuNPs, i.e., to allow discrete modeling of individual nanoparticles. Same-volume nanoparticles of three commonly encountered shapes—nanospheres, nanorods, and square nanoplates—are examined, in order to inspect the diferences in the propagation and absorption of secondary charged particles produced by the incident photons. Five diferent spatial distributions of spherical AuNPs at the single-cell level are studied in the simulations and compared according to the energy deposited in the cell nucleus. Photon energy, nanoparticle size, and concentration are also varied across simulation runs, and their infuence is analyzed in connection to nanoparticle shape and localization. Te obtained results reveal how the investigated nanoparticle properties afect their dose-enhancing ability and irradiation specifcity in AuNP-augmented radiotherapy.
T2  - Nanomaterials and Nanotechnology
T1  - Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy
VL  - 2023
SP  - 1
EP  - 18
DO  - 10.1155/2023/9841614
ER  - 

@article{
editor = "Cleri, Fabrizio",
author = "Milutinović, Slobodan and Pandurović, Mila and Vujisić, Miloš",
year = "2023",
abstract = "Gold nanoparticles (AuNPs) have been investigated extensively in the past twenty years as a sensitizing agent in photon radiotherapy. Targeted delivery of AuNPs to specifc sites in cells and tissues contributes to highly localized radiation dose enhancement, whereby the surrounding healthy structures can be largely spared from the unwanted radiation efects. Te efciency of introduced AuNPs with regard to dose enhancement depends on the properties of the nanoparticles since not all of deposited radiation energy reaches the intended biological target but is partially absorbed within the nanoparticles themselves or distributed elsewhere. Te present paper investigates the infuence of AuNP shape and localization on the enhancement and intracellular distribution of deposited energy in radiation therapy with photons. Energy deposition patterns are calculated with nanoscale accuracy through Monte Carlo simulations of radiation transport, which are optimized to accommodate a structured geometrical representation of the region loaded with AuNPs, i.e., to allow discrete modeling of individual nanoparticles. Same-volume nanoparticles of three commonly encountered shapes—nanospheres, nanorods, and square nanoplates—are examined, in order to inspect the diferences in the propagation and absorption of secondary charged particles produced by the incident photons. Five diferent spatial distributions of spherical AuNPs at the single-cell level are studied in the simulations and compared according to the energy deposited in the cell nucleus. Photon energy, nanoparticle size, and concentration are also varied across simulation runs, and their infuence is analyzed in connection to nanoparticle shape and localization. Te obtained results reveal how the investigated nanoparticle properties afect their dose-enhancing ability and irradiation specifcity in AuNP-augmented radiotherapy.",
journal = "Nanomaterials and Nanotechnology",
title = "Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy",
volume = "2023",
pages = "1-18",
doi = "10.1155/2023/9841614"
}

Cleri, F., Milutinović, S., Pandurović, M.,& Vujisić, M.. (2023). Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy. in Nanomaterials and Nanotechnology, 2023, 1-18.
https://doi.org/10.1155/2023/9841614

Cleri F, Milutinović S, Pandurović M, Vujisić M. Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy. in Nanomaterials and Nanotechnology. 2023;2023:1-18.
doi:10.1155/2023/9841614 .

Cleri, Fabrizio, Milutinović, Slobodan, Pandurović, Mila, Vujisić, Miloš, "Influence of Gold Nanoparticle Shape and Single-Cell Localization on Energy Deposition Efficiency and Irradiation Specificity in Photon Radiotherapy" in Nanomaterials and Nanotechnology, 2023 (2023):1-18,
https://doi.org/10.1155/2023/9841614 . .

TY  - JOUR
AU  - Tasić, Danijela
AU  - Đorđević, Katarina
AU  - Galović, Slobodanka
AU  - Furundžić, Draško
AU  - Dimitrijević, Zorica
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11572
AB  - Acute kidney injury is a syndrome that occurs in different clinical situations, under the influence of different risk factors, in patients of all ages, especially those in the intensive care unit. The problem of acute kidney damage refers to numerous clinical situations, different disease mechanisms and poor outcomes. In addition, with the current definition of acute kidney injury, only one conventional marker is available for diagnosis in daily clinical practice. To recognize the disease promptly and start treatment, and thereby improving the outcome, the paper presents a model for recognizing acute kidney damage in the stage that requires hemodialysis treatment.The study included 86 hospitalized patients with acute renal impairment who were divided according to the stage of renal impairment at admission to hospital treatment into three groups. The assessment of acute renal impairment and the classification of disease stages were based on the diagnostic stages by the K / DIGO group. All examined patients were over 18 years of age. In the first stage of the disease it was 12.79%, in the second stage it was 15.12%, and in the third 72.09% of patients. Test methods included clinical processing, laboratory evaluation, functional tests, and echosonographic examination. Clinical data included demographic, comorbidity and vital parameters, baseline full blood count, biochemistry and renal function tests. Further laboratory investigations were performed as indicated clinically thereafter. Spot blood and urine samples were collected from all patients in the morning after overnight fasting. The neural network was created in feed forward back propagation of the connection between the data of 69 patients with 31 parameters. In pattern recognition, the neural network learns to recognize the conditions in which it was decided to send the patient to dialysis 10 or to send to classical treatment 01. The training function analyzed the patients separated in three special categories 80% training, 10% test and 10% validation. The algorithm of the learning function is a scaling gradient that adapts the input data to the output data.The neural network achieved a performance of 0.14322 in 6 epochs. In a test with the data of 17 patients, it was shown that the neural network indicates for which patients dialysis treatment is a better option that fits with AKI stage 3. For patients with the first and second stages of the disease, conservative treatment is a better therapeutic choice.This paper deals with a current topic by analyzing data using a neural network algorithm to help assess the stage of the disease in high-risk hospitalized patients with acute kidney injury and select treatment modalities. The conclusions derived from this analysis should help with stage recognition and the selection of treatment modalities for patients with acute kidney injury.
T2  - Nephrology Dialysis Transplantation
T2  - Nephrology Dialysis TransplantationNephrology Dialysis Transplantation
T1  - Application of the neural network algorithm in the assessment of the stage of acute kidney damage and the selection of treatment
VL  - 38
IS  - Supplement_1
SP  - #6830
DO  - 10.1093/ndt/gfad063c_6830
ER  - 

@article{
author = "Tasić, Danijela and Đorđević, Katarina and Galović, Slobodanka and Furundžić, Draško and Dimitrijević, Zorica",
year = "2023",
abstract = "Acute kidney injury is a syndrome that occurs in different clinical situations, under the influence of different risk factors, in patients of all ages, especially those in the intensive care unit. The problem of acute kidney damage refers to numerous clinical situations, different disease mechanisms and poor outcomes. In addition, with the current definition of acute kidney injury, only one conventional marker is available for diagnosis in daily clinical practice. To recognize the disease promptly and start treatment, and thereby improving the outcome, the paper presents a model for recognizing acute kidney damage in the stage that requires hemodialysis treatment.The study included 86 hospitalized patients with acute renal impairment who were divided according to the stage of renal impairment at admission to hospital treatment into three groups. The assessment of acute renal impairment and the classification of disease stages were based on the diagnostic stages by the K / DIGO group. All examined patients were over 18 years of age. In the first stage of the disease it was 12.79%, in the second stage it was 15.12%, and in the third 72.09% of patients. Test methods included clinical processing, laboratory evaluation, functional tests, and echosonographic examination. Clinical data included demographic, comorbidity and vital parameters, baseline full blood count, biochemistry and renal function tests. Further laboratory investigations were performed as indicated clinically thereafter. Spot blood and urine samples were collected from all patients in the morning after overnight fasting. The neural network was created in feed forward back propagation of the connection between the data of 69 patients with 31 parameters. In pattern recognition, the neural network learns to recognize the conditions in which it was decided to send the patient to dialysis 10 or to send to classical treatment 01. The training function analyzed the patients separated in three special categories 80% training, 10% test and 10% validation. The algorithm of the learning function is a scaling gradient that adapts the input data to the output data.The neural network achieved a performance of 0.14322 in 6 epochs. In a test with the data of 17 patients, it was shown that the neural network indicates for which patients dialysis treatment is a better option that fits with AKI stage 3. For patients with the first and second stages of the disease, conservative treatment is a better therapeutic choice.This paper deals with a current topic by analyzing data using a neural network algorithm to help assess the stage of the disease in high-risk hospitalized patients with acute kidney injury and select treatment modalities. The conclusions derived from this analysis should help with stage recognition and the selection of treatment modalities for patients with acute kidney injury.",
journal = "Nephrology Dialysis Transplantation, Nephrology Dialysis TransplantationNephrology Dialysis Transplantation",
title = "Application of the neural network algorithm in the assessment of the stage of acute kidney damage and the selection of treatment",
volume = "38",
number = "Supplement_1",
pages = "#6830",
doi = "10.1093/ndt/gfad063c_6830"
}

Tasić, D., Đorđević, K., Galović, S., Furundžić, D.,& Dimitrijević, Z.. (2023). Application of the neural network algorithm in the assessment of the stage of acute kidney damage and the selection of treatment. in Nephrology Dialysis Transplantation, 38(Supplement_1), #6830.
https://doi.org/10.1093/ndt/gfad063c_6830

Tasić D, Đorđević K, Galović S, Furundžić D, Dimitrijević Z. Application of the neural network algorithm in the assessment of the stage of acute kidney damage and the selection of treatment. in Nephrology Dialysis Transplantation. 2023;38(Supplement_1):#6830.
doi:10.1093/ndt/gfad063c_6830 .

Tasić, Danijela, Đorđević, Katarina, Galović, Slobodanka, Furundžić, Draško, Dimitrijević, Zorica, "Application of the neural network algorithm in the assessment of the stage of acute kidney damage and the selection of treatment" in Nephrology Dialysis Transplantation, 38, no. Supplement_1 (2023):#6830,
https://doi.org/10.1093/ndt/gfad063c_6830 . .

TY  - JOUR
AU  - Bektashi, Nora Limani
AU  - Mladenoska, Irina
AU  - Popovska, Olga
AU  - Dimitrovski, Darko
AU  - Spasevska, Hristina
AU  - Reka, Arianit A.
AU  - Mašić, Slobodan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11571
PB  - Walter de Gruyter GmbH
T2  - Open Chemistry
T1  - Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper
VL  - 21
IS  - 1
DO  - 10.1515/chem-2022-0356
ER  - 

@article{
author = "Bektashi, Nora Limani and Mladenoska, Irina and Popovska, Olga and Dimitrovski, Darko and Spasevska, Hristina and Reka, Arianit A. and Mašić, Slobodan",
year = "2023",
publisher = "Walter de Gruyter GmbH",
journal = "Open Chemistry",
title = "Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper",
volume = "21",
number = "1",
doi = "10.1515/chem-2022-0356"
}

Bektashi, N. L., Mladenoska, I., Popovska, O., Dimitrovski, D., Spasevska, H., Reka, A. A.,& Mašić, S.. (2023). Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper. in Open Chemistry
Walter de Gruyter GmbH., 21(1).
https://doi.org/10.1515/chem-2022-0356

Bektashi NL, Mladenoska I, Popovska O, Dimitrovski D, Spasevska H, Reka AA, Mašić S. Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper. in Open Chemistry. 2023;21(1).
doi:10.1515/chem-2022-0356 .

Bektashi, Nora Limani, Mladenoska, Irina, Popovska, Olga, Dimitrovski, Darko, Spasevska, Hristina, Reka, Arianit A., Mašić, Slobodan, "Assessment of the impact of γ-irradiation on the piperine content and microbial quality of black pepper" in Open Chemistry, 21, no. 1 (2023),
https://doi.org/10.1515/chem-2022-0356 . .

TY  - JOUR
AU  - Ilinčić, B.
AU  - Naglić, D. T.
AU  - Čabarkapa, V.
AU  - Bajkin, I.
AU  - Đurić, A. P.
AU  - Kolarski, I.
AU  - Bojović, M.
AU  - Urošević, I.
AU  - Stokić, E.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11569
AB  - Objective: Hypovitaminosis D may be associated with an increased susceptibility to infection, more severe COVID-19 forms, and a higher risk of death. The objective of this study was to investigate any possible connections between vitamin D status [as measured by serum 25-hydroxyvitamin D (25(OH)D) levels] and COVID-19 severity.  Patients and methods: In 2021, a cross-sectional study of consecutive adult COVID-19 patients was conducted. Anthropometric data, comorbidities, hospital setting, length of stay, respiratory support, outcome data, and vitamin D status were all evaluated.  Results: The length of hospitalization among participants (n = 74; mean age 57.64 ± 17.83 years, 55.4% male) was 18.58 ± 10 days, the majority of the hospital setting was a medical ward (67.6%), and the respiratory support in the form of mechanical ventilation was represented by 12.2%. Hypertension (54.1%), obesity (64.9%), and overweight (64.9%) were the most common cardiometabolic risk factors. In the study group, 44.6% of participants had severe vitamin D deficiency (< 30 nmol/l), while 8.1% had vitamin D insufficiency (50 - 74.9 nmol/l). Furthermore, patients with severe COVID-19 (semi-intensive care unit, intensive care unit) had significantly lower serum 25(OH)D levels (32.9 vs. 20.5 nmol/l; p = 0.007). Participants with severe vitamin D deficiency were older and had more prevalent hypertension, requiring mechanical ventilation; 24.2% experienced a fatal outcome.  Conclusions: Severe vitamin D deficiency may contribute significantly to the influence of other cardiometabolic risk factors in COVID-19.
T2  - European review for medical and pharmacological sciences
T1  - Association between vitamin D hypovitaminosis and severe forms of COVID-19
VL  - 27
IS  - 11
SP  - 5318
EP  - 5326
DO  - 10.26355/eurrev_202306_32651
ER  - 

@article{
author = "Ilinčić, B. and Naglić, D. T. and Čabarkapa, V. and Bajkin, I. and Đurić, A. P. and Kolarski, I. and Bojović, M. and Urošević, I. and Stokić, E. and Isenović, Esma R.",
year = "2023",
abstract = "Objective: Hypovitaminosis D may be associated with an increased susceptibility to infection, more severe COVID-19 forms, and a higher risk of death. The objective of this study was to investigate any possible connections between vitamin D status [as measured by serum 25-hydroxyvitamin D (25(OH)D) levels] and COVID-19 severity.  Patients and methods: In 2021, a cross-sectional study of consecutive adult COVID-19 patients was conducted. Anthropometric data, comorbidities, hospital setting, length of stay, respiratory support, outcome data, and vitamin D status were all evaluated.  Results: The length of hospitalization among participants (n = 74; mean age 57.64 ± 17.83 years, 55.4% male) was 18.58 ± 10 days, the majority of the hospital setting was a medical ward (67.6%), and the respiratory support in the form of mechanical ventilation was represented by 12.2%. Hypertension (54.1%), obesity (64.9%), and overweight (64.9%) were the most common cardiometabolic risk factors. In the study group, 44.6% of participants had severe vitamin D deficiency (< 30 nmol/l), while 8.1% had vitamin D insufficiency (50 - 74.9 nmol/l). Furthermore, patients with severe COVID-19 (semi-intensive care unit, intensive care unit) had significantly lower serum 25(OH)D levels (32.9 vs. 20.5 nmol/l; p = 0.007). Participants with severe vitamin D deficiency were older and had more prevalent hypertension, requiring mechanical ventilation; 24.2% experienced a fatal outcome.  Conclusions: Severe vitamin D deficiency may contribute significantly to the influence of other cardiometabolic risk factors in COVID-19.",
journal = "European review for medical and pharmacological sciences",
title = "Association between vitamin D hypovitaminosis and severe forms of COVID-19",
volume = "27",
number = "11",
pages = "5318-5326",
doi = "10.26355/eurrev_202306_32651"
}

Ilinčić, B., Naglić, D. T., Čabarkapa, V., Bajkin, I., Đurić, A. P., Kolarski, I., Bojović, M., Urošević, I., Stokić, E.,& Isenović, E. R.. (2023). Association between vitamin D hypovitaminosis and severe forms of COVID-19. in European review for medical and pharmacological sciences, 27(11), 5318-5326.
https://doi.org/10.26355/eurrev_202306_32651

Ilinčić B, Naglić DT, Čabarkapa V, Bajkin I, Đurić AP, Kolarski I, Bojović M, Urošević I, Stokić E, Isenović ER. Association between vitamin D hypovitaminosis and severe forms of COVID-19. in European review for medical and pharmacological sciences. 2023;27(11):5318-5326.
doi:10.26355/eurrev_202306_32651 .

Ilinčić, B., Naglić, D. T., Čabarkapa, V., Bajkin, I., Đurić, A. P., Kolarski, I., Bojović, M., Urošević, I., Stokić, E., Isenović, Esma R., "Association between vitamin D hypovitaminosis and severe forms of COVID-19" in European review for medical and pharmacological sciences, 27, no. 11 (2023):5318-5326,
https://doi.org/10.26355/eurrev_202306_32651 . .

TY  - JOUR
AU  - Stamenković, Tijana
AU  - Dinić, Ivana
AU  - Vuković, Marina
AU  - Radmilović, Nadežda
AU  - Barudžija, Tanja
AU  - Tomić, Miloš
AU  - Mančić, Lidija
AU  - Lojpur, Vesna
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11579
AB  - In this investigation, samples of strontium-gadolinium-oxide (SrGd2O4) doped with different Yb3+ (2, 4 and 6 at%) and constant Ho3+ (1 at%) contents and co-doped with Bi3+ (2 at%) were prepared using the glycine-assisted sol–gel method. The pure orthorhombic SrGd2O4 phase, space group Pnma, was revealed using X-ray diffraction in all samples. Transmission electron microscopy discovered agglomerated clusters of spherical particles measuring approximately 150 nm in size. The inclusion of Bi3+ ions into the structure influenced the morphology since the formation of larger grains was observed, with sizes reaching up to ∼1.7 μm. The uniform distribution of all constitutive elements was confirmed by energy-dispersive X-ray spectroscopy. In all samples, up-conversion emission spectra revealed two dominant green (540 and 550 nm), red (671 nm), and infrared (758 nm) emission lines, due to the 5F4,5S2→5I8, 5F5→5I8, and 5F4,5S2 → 5I7 transitions, respectively. The sample co-doped with Bi3+ showed the most intense photoluminescent emissions, shorter luminescence decay, and the highest quantum yield. Additionally, a significant decrease in the energy band gap value was detected using diffuse reflectance spectroscopy for this sample. Methylene blue was used as a test pollutant to investigate its photocatalytic efficiency under simulated sunlight irradiation. The results show that Bi3+ co-doping deteriorates the photocatalytic efficiency of the SrGd2O4:Yb3+/Ho3+ phase by reducing hydroxyl radical formation.
T2  - Ceramics International
T1  - Effect of Bi3+co-doping on the up-converting and photocatalytic properties of SrGd2O4:Yb3+/Ho3+ phase
DO  - 10.1016/j.ceramint.2023.09.103
ER  - 

@article{
author = "Stamenković, Tijana and Dinić, Ivana and Vuković, Marina and Radmilović, Nadežda and Barudžija, Tanja and Tomić, Miloš and Mančić, Lidija and Lojpur, Vesna",
year = "2023",
abstract = "In this investigation, samples of strontium-gadolinium-oxide (SrGd2O4) doped with different Yb3+ (2, 4 and 6 at%) and constant Ho3+ (1 at%) contents and co-doped with Bi3+ (2 at%) were prepared using the glycine-assisted sol–gel method. The pure orthorhombic SrGd2O4 phase, space group Pnma, was revealed using X-ray diffraction in all samples. Transmission electron microscopy discovered agglomerated clusters of spherical particles measuring approximately 150 nm in size. The inclusion of Bi3+ ions into the structure influenced the morphology since the formation of larger grains was observed, with sizes reaching up to ∼1.7 μm. The uniform distribution of all constitutive elements was confirmed by energy-dispersive X-ray spectroscopy. In all samples, up-conversion emission spectra revealed two dominant green (540 and 550 nm), red (671 nm), and infrared (758 nm) emission lines, due to the 5F4,5S2→5I8, 5F5→5I8, and 5F4,5S2 → 5I7 transitions, respectively. The sample co-doped with Bi3+ showed the most intense photoluminescent emissions, shorter luminescence decay, and the highest quantum yield. Additionally, a significant decrease in the energy band gap value was detected using diffuse reflectance spectroscopy for this sample. Methylene blue was used as a test pollutant to investigate its photocatalytic efficiency under simulated sunlight irradiation. The results show that Bi3+ co-doping deteriorates the photocatalytic efficiency of the SrGd2O4:Yb3+/Ho3+ phase by reducing hydroxyl radical formation.",
journal = "Ceramics International",
title = "Effect of Bi3+co-doping on the up-converting and photocatalytic properties of SrGd2O4:Yb3+/Ho3+ phase",
doi = "10.1016/j.ceramint.2023.09.103"
}

Stamenković, T., Dinić, I., Vuković, M., Radmilović, N., Barudžija, T., Tomić, M., Mančić, L.,& Lojpur, V.. (2023). Effect of Bi3+co-doping on the up-converting and photocatalytic properties of SrGd2O4:Yb3+/Ho3+ phase. in Ceramics International.
https://doi.org/10.1016/j.ceramint.2023.09.103

Stamenković T, Dinić I, Vuković M, Radmilović N, Barudžija T, Tomić M, Mančić L, Lojpur V. Effect of Bi3+co-doping on the up-converting and photocatalytic properties of SrGd2O4:Yb3+/Ho3+ phase. in Ceramics International. 2023;.
doi:10.1016/j.ceramint.2023.09.103 .

Stamenković, Tijana, Dinić, Ivana, Vuković, Marina, Radmilović, Nadežda, Barudžija, Tanja, Tomić, Miloš, Mančić, Lidija, Lojpur, Vesna, "Effect of Bi3+co-doping on the up-converting and photocatalytic properties of SrGd2O4:Yb3+/Ho3+ phase" in Ceramics International (2023),
https://doi.org/10.1016/j.ceramint.2023.09.103 . .

TY  - JOUR
AU  - Kartalović, Nenad M.
AU  - Jusić, Alija
AU  - Nikezić, Dušan P.
AU  - Stanković, Koviljka
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10508
AB  - The study discusses the validity of the law of similarity for the impulse breakdown of gases at low pressure and small inter-electrode distances. The research has been done theoretically, experimentally and numerically. The experiments were conducted under well-controlled laboratory conditions. The combined measurement uncertainty was less than 5%. The experiments were carried out with gases SF6, N2 and He. The electrodes were made of copper, but also of metals with different values of the work function. The obtained results are presented through the impulse characteristics for similar systems. Such a presentation only provided qualitative information. In order to obtain quantitative information, a modified Wilcoxon Rank Sum Test (U test) was performed. The obtained results show that the law of similarity is valid for the DC breakdown of gases, but it is not valid for the impulse breakdown of gases. It can be concluded that the law of similarity is inapplicable for the design of gas-insulated systems under low pressure at small values of the inter-electrode distance.
T2  - Vacuum
T1  - Validity of the law of similarity for impulse and DC breakdown of gases in the vicinity of the Paschen’s minimum
VL  - 207
SP  - 111683
DO  - 10.1016/j.vacuum.2022.111683
ER  - 

@article{
author = "Kartalović, Nenad M. and Jusić, Alija and Nikezić, Dušan P. and Stanković, Koviljka",
year = "2023",
abstract = "The study discusses the validity of the law of similarity for the impulse breakdown of gases at low pressure and small inter-electrode distances. The research has been done theoretically, experimentally and numerically. The experiments were conducted under well-controlled laboratory conditions. The combined measurement uncertainty was less than 5%. The experiments were carried out with gases SF6, N2 and He. The electrodes were made of copper, but also of metals with different values of the work function. The obtained results are presented through the impulse characteristics for similar systems. Such a presentation only provided qualitative information. In order to obtain quantitative information, a modified Wilcoxon Rank Sum Test (U test) was performed. The obtained results show that the law of similarity is valid for the DC breakdown of gases, but it is not valid for the impulse breakdown of gases. It can be concluded that the law of similarity is inapplicable for the design of gas-insulated systems under low pressure at small values of the inter-electrode distance.",
journal = "Vacuum",
title = "Validity of the law of similarity for impulse and DC breakdown of gases in the vicinity of the Paschen’s minimum",
volume = "207",
pages = "111683",
doi = "10.1016/j.vacuum.2022.111683"
}

Kartalović, N. M., Jusić, A., Nikezić, D. P.,& Stanković, K.. (2023). Validity of the law of similarity for impulse and DC breakdown of gases in the vicinity of the Paschen’s minimum. in Vacuum, 207, 111683.
https://doi.org/10.1016/j.vacuum.2022.111683

Kartalović NM, Jusić A, Nikezić DP, Stanković K. Validity of the law of similarity for impulse and DC breakdown of gases in the vicinity of the Paschen’s minimum. in Vacuum. 2023;207:111683.
doi:10.1016/j.vacuum.2022.111683 .

Kartalović, Nenad M., Jusić, Alija, Nikezić, Dušan P., Stanković, Koviljka, "Validity of the law of similarity for impulse and DC breakdown of gases in the vicinity of the Paschen’s minimum" in Vacuum, 207 (2023):111683,
https://doi.org/10.1016/j.vacuum.2022.111683 . .

TY  - JOUR
AU  - Brajović, Dragan
AU  - Jokanović, Bojan
AU  - Bebić, Milan
AU  - Kartalović, Nenad
AU  - Nikezić, Dušan P.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10642
AB  - The study aims to achieve a simple, reliable, and significant lifetime extension of the high-voltage asynchronous machine in relation to the voltage endurance test. To achieve this goal, the focus was on achieving longer-lasting and more stable insulation of the stator package of an asynchronous machine. Longer-lasting and more stable insulation of a stator is achieved by reinforcing the weak points on its prefabricated multiturn coils. These reinforcements were performed with standard insulating materials that are used for the production of the prefabricated multiturn coils (because there is no data regarding the long-term behavior of new materials that show some better properties in laboratories, but only during short-term tests). With such reinforced weak spots based on prefabricated models, they were made by the classical procedure with the use of standardized tools. To track the effects of the improvement of the insulation characteristics of a stator, an algorithm was developed based on the law of increasing probability and the determination of lifetime curves to the voltage endurance test. The lifetime curves were determined by the method of increasing voltage with the transformation of the obtained results to the corresponding results by the constant voltage method. The applied algorithm that was formed for this study, had been verified with statistical reliability of 95%. The combined measurement uncertainty of the measurement procedure was about 5%.
T2  - Electrical Engineering
T1  - Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test
IS  - InPress
DO  - 10.1007/s00202-023-01767-w
ER  - 

@article{
author = "Brajović, Dragan and Jokanović, Bojan and Bebić, Milan and Kartalović, Nenad and Nikezić, Dušan P.",
year = "2023",
abstract = "The study aims to achieve a simple, reliable, and significant lifetime extension of the high-voltage asynchronous machine in relation to the voltage endurance test. To achieve this goal, the focus was on achieving longer-lasting and more stable insulation of the stator package of an asynchronous machine. Longer-lasting and more stable insulation of a stator is achieved by reinforcing the weak points on its prefabricated multiturn coils. These reinforcements were performed with standard insulating materials that are used for the production of the prefabricated multiturn coils (because there is no data regarding the long-term behavior of new materials that show some better properties in laboratories, but only during short-term tests). With such reinforced weak spots based on prefabricated models, they were made by the classical procedure with the use of standardized tools. To track the effects of the improvement of the insulation characteristics of a stator, an algorithm was developed based on the law of increasing probability and the determination of lifetime curves to the voltage endurance test. The lifetime curves were determined by the method of increasing voltage with the transformation of the obtained results to the corresponding results by the constant voltage method. The applied algorithm that was formed for this study, had been verified with statistical reliability of 95%. The combined measurement uncertainty of the measurement procedure was about 5%.",
journal = "Electrical Engineering",
title = "Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test",
number = "InPress",
doi = "10.1007/s00202-023-01767-w"
}

Brajović, D., Jokanović, B., Bebić, M., Kartalović, N.,& Nikezić, D. P.. (2023). Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test. in Electrical Engineering(InPress).
https://doi.org/10.1007/s00202-023-01767-w

Brajović D, Jokanović B, Bebić M, Kartalović N, Nikezić DP. Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test. in Electrical Engineering. 2023;(InPress).
doi:10.1007/s00202-023-01767-w .

Brajović, Dragan, Jokanović, Bojan, Bebić, Milan, Kartalović, Nenad, Nikezić, Dušan P., "Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test" in Electrical Engineering, no. InPress (2023),
https://doi.org/10.1007/s00202-023-01767-w . .

TY  - JOUR
AU  - Brajović, Dragan
AU  - Jokanović, Bojan
AU  - Bebić, Milan
AU  - Kartalović, Nenad
AU  - Nikezić, Dušan P.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10648
AB  - The study aims to achieve a simple, reliable, and significant lifetime extension of the high-voltage asynchronous machine in relation to the voltage endurance test. To achieve this goal, the focus was on achieving longer-lasting and more stable insulation of the stator package of an asynchronous machine. Longer-lasting and more stable insulation of a stator is achieved by reinforcing the weak points on its prefabricated multiturn coils. These reinforcements were performed with standard insulating materials that are used for the production of the prefabricated multiturn coils (because there is no data regarding the long-term behavior of new materials that show some better properties in laboratories, but only during short-term tests). With such reinforced weak spots based on prefabricated models, they were made by the classical procedure with the use of standardized tools. To track the effects of the improvement of the insulation characteristics of a stator, an algorithm was developed based on the law of increasing probability and the determination of lifetime curves to the voltage endurance test. The lifetime curves were determined by the method of increasing voltage with the transformation of the obtained results to the corresponding results by the constant voltage method. The applied algorithm that was formed for this study, had been verified with statistical reliability of 95%. The combined measurement uncertainty of the measurement procedure was about 5%.
T2  - Electrical Engineering
T1  - Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test
IS  - InPress
DO  - 10.21203/rs.3.rs-2254547/v1
ER  - 

@article{
author = "Brajović, Dragan and Jokanović, Bojan and Bebić, Milan and Kartalović, Nenad and Nikezić, Dušan P.",
year = "2023",
abstract = "The study aims to achieve a simple, reliable, and significant lifetime extension of the high-voltage asynchronous machine in relation to the voltage endurance test. To achieve this goal, the focus was on achieving longer-lasting and more stable insulation of the stator package of an asynchronous machine. Longer-lasting and more stable insulation of a stator is achieved by reinforcing the weak points on its prefabricated multiturn coils. These reinforcements were performed with standard insulating materials that are used for the production of the prefabricated multiturn coils (because there is no data regarding the long-term behavior of new materials that show some better properties in laboratories, but only during short-term tests). With such reinforced weak spots based on prefabricated models, they were made by the classical procedure with the use of standardized tools. To track the effects of the improvement of the insulation characteristics of a stator, an algorithm was developed based on the law of increasing probability and the determination of lifetime curves to the voltage endurance test. The lifetime curves were determined by the method of increasing voltage with the transformation of the obtained results to the corresponding results by the constant voltage method. The applied algorithm that was formed for this study, had been verified with statistical reliability of 95%. The combined measurement uncertainty of the measurement procedure was about 5%.",
journal = "Electrical Engineering",
title = "Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test",
number = "InPress",
doi = "10.21203/rs.3.rs-2254547/v1"
}

Brajović, D., Jokanović, B., Bebić, M., Kartalović, N.,& Nikezić, D. P.. (2023). Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test. in Electrical Engineering(InPress).
https://doi.org/10.21203/rs.3.rs-2254547/v1

Brajović D, Jokanović B, Bebić M, Kartalović N, Nikezić DP. Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test. in Electrical Engineering. 2023;(InPress).
doi:10.21203/rs.3.rs-2254547/v1 .

Brajović, Dragan, Jokanović, Bojan, Bebić, Milan, Kartalović, Nenad, Nikezić, Dušan P., "Lifetime extension of the high voltage asynchronous machine in relation to the voltage endurance test" in Electrical Engineering, no. InPress (2023),
https://doi.org/10.21203/rs.3.rs-2254547/v1 . .

TY  - JOUR
AU  - Antić, Željka M.
AU  - Đorđević, V.
AU  - Ristić, Z.
AU  - Srivastava, A.M.
AU  - Beers, W.W.
AU  - Dramićanin, Miroslav
AU  - Brik, Mikhail G.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11576
AB  - The importance of structural disorder of crystal lattice for the formation of the optical properties of impurity ions is studied by evaluating the optical properties of Cr3+ impurity ions in Mg1-xZnxAl2O4:Cr3+ (x = 0; 0.25; 0.50; 0.75; 1.0) spinel solid solutions. It is demonstrated that the gradual replacement of Zn by Mg, which transforms the normal spinel ZnAl2O4 into the inverse spinel MgAl2O4, leads to an enhancement of the Cr3+ red emission. In addition, the Cr3+ decay rate (inverse to the emitting excited state lifetime) increases linearly when Zn is gradually replaced by Mg. These observations are explained by the lifting of the parity selection rule due to the random distribution of the Zn and Mg cations in the second coordination sphere around the emitting ion, which lowers the local symmetry at the impurity ion site. The strategy of deliberately creating disorder in the crystalline lattice is a successful way of increasing brightness and decreasing the excited state lifetime of the impurity ions, which can be applied for improving emission properties of the phosphor materials used in solid state lighting.
T2  - Journal of Luminescence
T1  - Influence of composition on the emission properties of impurities in solids: Case study of Mg1-xZnxAl2O4:Cr3+ with the spinel structure
VL  - 264
SP  - 120190
DO  - 10.1016/j.jlumin.2023.120190
ER  - 

@article{
author = "Antić, Željka M. and Đorđević, V. and Ristić, Z. and Srivastava, A.M. and Beers, W.W. and Dramićanin, Miroslav and Brik, Mikhail G.",
year = "2023",
abstract = "The importance of structural disorder of crystal lattice for the formation of the optical properties of impurity ions is studied by evaluating the optical properties of Cr3+ impurity ions in Mg1-xZnxAl2O4:Cr3+ (x = 0; 0.25; 0.50; 0.75; 1.0) spinel solid solutions. It is demonstrated that the gradual replacement of Zn by Mg, which transforms the normal spinel ZnAl2O4 into the inverse spinel MgAl2O4, leads to an enhancement of the Cr3+ red emission. In addition, the Cr3+ decay rate (inverse to the emitting excited state lifetime) increases linearly when Zn is gradually replaced by Mg. These observations are explained by the lifting of the parity selection rule due to the random distribution of the Zn and Mg cations in the second coordination sphere around the emitting ion, which lowers the local symmetry at the impurity ion site. The strategy of deliberately creating disorder in the crystalline lattice is a successful way of increasing brightness and decreasing the excited state lifetime of the impurity ions, which can be applied for improving emission properties of the phosphor materials used in solid state lighting.",
journal = "Journal of Luminescence",
title = "Influence of composition on the emission properties of impurities in solids: Case study of Mg1-xZnxAl2O4:Cr3+ with the spinel structure",
volume = "264",
pages = "120190",
doi = "10.1016/j.jlumin.2023.120190"
}

Antić, Ž. M., Đorđević, V., Ristić, Z., Srivastava, A.M., Beers, W.W., Dramićanin, M.,& Brik, M. G.. (2023). Influence of composition on the emission properties of impurities in solids: Case study of Mg1-xZnxAl2O4:Cr3+ with the spinel structure. in Journal of Luminescence, 264, 120190.
https://doi.org/10.1016/j.jlumin.2023.120190

Antić ŽM, Đorđević V, Ristić Z, Srivastava A, Beers W, Dramićanin M, Brik MG. Influence of composition on the emission properties of impurities in solids: Case study of Mg1-xZnxAl2O4:Cr3+ with the spinel structure. in Journal of Luminescence. 2023;264:120190.
doi:10.1016/j.jlumin.2023.120190 .

Antić, Željka M., Đorđević, V., Ristić, Z., Srivastava, A.M., Beers, W.W., Dramićanin, Miroslav, Brik, Mikhail G., "Influence of composition on the emission properties of impurities in solids: Case study of Mg1-xZnxAl2O4:Cr3+ with the spinel structure" in Journal of Luminescence, 264 (2023):120190,
https://doi.org/10.1016/j.jlumin.2023.120190 . .

TY  - JOUR
AU  - Zarić, Božidarka
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10562
AB  - Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.
T2  - The International Journal of Biochemistry and Cell Biology
T1  - Free radicals: Relationship to Human Diseases and Potential Therapeutic applications
VL  - 154
SP  - 106346
DO  - 10.1016/j.biocel.2022.106346
ER  - 

@article{
author = "Zarić, Božidarka and Mačvanin, Mirjana and Isenović, Esma R.",
year = "2023",
abstract = "Reactive species are highly-reactive enzymatically, or non-enzymatically produced compounds with important roles in physiological and pathophysiological cellular processes. Although reactive species represent an extensively researched topic in biomedical sciences, many aspects of their roles and functions remain unclear. This review aims to systematically summarize findings regarding the biochemical characteristics of various types of reactive species and specify the localization and mechanisms of their production in cells. In addition, we discuss the specific roles of free radicals in cellular physiology, focusing on the current lines of research that aim to identify the reactive oxygen species-initiated cascades of reactions resulting in adaptive or pathological cellular responses. Finally, we present recent findings regarding the therapeutic modulations of intracellular levels of reactive oxygen species, which may have substantial significance in developing novel agents for treating several diseases.",
journal = "The International Journal of Biochemistry and Cell Biology",
title = "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications",
volume = "154",
pages = "106346",
doi = "10.1016/j.biocel.2022.106346"
}

Zarić, B., Mačvanin, M.,& Isenović, E. R.. (2023). Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology, 154, 106346.
https://doi.org/10.1016/j.biocel.2022.106346

Zarić B, Mačvanin M, Isenović ER. Free radicals: Relationship to Human Diseases and Potential Therapeutic applications. in The International Journal of Biochemistry and Cell Biology. 2023;154:106346.
doi:10.1016/j.biocel.2022.106346 .

Zarić, Božidarka, Mačvanin, Mirjana, Isenović, Esma R., "Free radicals: Relationship to Human Diseases and Potential Therapeutic applications" in The International Journal of Biochemistry and Cell Biology, 154 (2023):106346,
https://doi.org/10.1016/j.biocel.2022.106346 . .

TY  - JOUR
AU  - Alamro, Hind
AU  - Bajić, Vladan
AU  - Mačvanin, Mirjana
AU  - Isenović, Esma R.
AU  - Gojobori, Takashi
AU  - Essack, Magbubah
AU  - Gao, Xin
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10628
AB  - MicroRNAs (miRNAs) are critical regulators of gene expression in healthy and diseased states, and numerous studies have established their tremendous potential as a tool for improving the diagnosis of Type 2 Diabetes Mellitus (T2D) and its comorbidities. In this regard, we computationally identify novel top-ranked hub miRNAs that might be involved in T2D. We accomplish this via two strategies: 1) by ranking miRNAs based on the number of T2D differentially expressed genes (DEGs) they target, and 2) using only the common DEGs between T2D and its comorbidity, Alzheimer’s disease (AD) to predict and rank miRNA. Then classifier models are built using the DEGs targeted by each miRNA as features. Here, we show the T2D DEGs targeted by hsa-mir-1-3p, hsa-mir-16-5p, hsa-mir-124-3p, hsa-mir-34a-5p, hsa-let-7b-5p, hsa-mir-155-5p, hsa-mir-107, hsa-mir-27a-3p, hsa-mir-129-2-3p, and hsa-mir-146a-5p are capable of distinguishing T2D samples from the controls, which serves as a measure of confidence in the miRNAs’ potential role in T2D progression. Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease’s comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir-124-3p models achieved the best scores for the AD datasets. To the best of our knowledge, this is the first study that used predicted miRNAs to determine the features that can separate the diseased samples (T2D or AD) from the normal ones, instead of using conventional non-biology-based feature selection methods.
T2  - Frontiers in Endocrinology
T1  - Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning
VL  - 13
SP  - 1084656
DO  - 10.3389/fendo.2022.1084656
ER  - 

@article{
author = "Alamro, Hind and Bajić, Vladan and Mačvanin, Mirjana and Isenović, Esma R. and Gojobori, Takashi and Essack, Magbubah and Gao, Xin",
year = "2023",
abstract = "MicroRNAs (miRNAs) are critical regulators of gene expression in healthy and diseased states, and numerous studies have established their tremendous potential as a tool for improving the diagnosis of Type 2 Diabetes Mellitus (T2D) and its comorbidities. In this regard, we computationally identify novel top-ranked hub miRNAs that might be involved in T2D. We accomplish this via two strategies: 1) by ranking miRNAs based on the number of T2D differentially expressed genes (DEGs) they target, and 2) using only the common DEGs between T2D and its comorbidity, Alzheimer’s disease (AD) to predict and rank miRNA. Then classifier models are built using the DEGs targeted by each miRNA as features. Here, we show the T2D DEGs targeted by hsa-mir-1-3p, hsa-mir-16-5p, hsa-mir-124-3p, hsa-mir-34a-5p, hsa-let-7b-5p, hsa-mir-155-5p, hsa-mir-107, hsa-mir-27a-3p, hsa-mir-129-2-3p, and hsa-mir-146a-5p are capable of distinguishing T2D samples from the controls, which serves as a measure of confidence in the miRNAs’ potential role in T2D progression. Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease’s comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir-124-3p models achieved the best scores for the AD datasets. To the best of our knowledge, this is the first study that used predicted miRNAs to determine the features that can separate the diseased samples (T2D or AD) from the normal ones, instead of using conventional non-biology-based feature selection methods.",
journal = "Frontiers in Endocrinology",
title = "Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning",
volume = "13",
pages = "1084656",
doi = "10.3389/fendo.2022.1084656"
}

Alamro, H., Bajić, V., Mačvanin, M., Isenović, E. R., Gojobori, T., Essack, M.,& Gao, X.. (2023). Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning. in Frontiers in Endocrinology, 13, 1084656.
https://doi.org/10.3389/fendo.2022.1084656

Alamro H, Bajić V, Mačvanin M, Isenović ER, Gojobori T, Essack M, Gao X. Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning. in Frontiers in Endocrinology. 2023;13:1084656.
doi:10.3389/fendo.2022.1084656 .

Alamro, Hind, Bajić, Vladan, Mačvanin, Mirjana, Isenović, Esma R., Gojobori, Takashi, Essack, Magbubah, Gao, Xin, "Type 2 Diabetes Mellitus and its comorbidity, Alzheimer’s disease: Identifying critical microRNA using machine learning" in Frontiers in Endocrinology, 13 (2023):1084656,
https://doi.org/10.3389/fendo.2022.1084656 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Radovanović, Jelena
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10686
AB  - Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.
T2  - Frontiers in Endocrinology
T1  - New insights on the cardiovascular effects of IGF-1
VL  - 14
SP  - 1142644
DO  - 10.3389/fendo.2023.1142644
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Radovanović, Jelena and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV healthMethodsWe searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.ResultsIGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.DiscussionWe anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.",
journal = "Frontiers in Endocrinology",
title = "New insights on the cardiovascular effects of IGF-1",
volume = "14",
pages = "1142644",
doi = "10.3389/fendo.2023.1142644"
}

Mačvanin, M., Gluvić, Z., Radovanović, J., Essack, M., Gao, X.,& Isenović, E. R.. (2023). New insights on the cardiovascular effects of IGF-1. in Frontiers in Endocrinology, 14, 1142644.
https://doi.org/10.3389/fendo.2023.1142644

Mačvanin M, Gluvić Z, Radovanović J, Essack M, Gao X, Isenović ER. New insights on the cardiovascular effects of IGF-1. in Frontiers in Endocrinology. 2023;14:1142644.
doi:10.3389/fendo.2023.1142644 .

Mačvanin, Mirjana, Gluvić, Zoran, Radovanović, Jelena, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "New insights on the cardiovascular effects of IGF-1" in Frontiers in Endocrinology, 14 (2023):1142644,
https://doi.org/10.3389/fendo.2023.1142644 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Zafirović, Sonja
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10687
T2  - Frontiers in Endocrinology
T1  - Editorial: Non-coding RNA in diabetes and cardiovascular diseases
VL  - 14
DO  - 10.3389/fendo.2023.1149857
ER  - 

@article{
author = "Mačvanin, Mirjana and Zafirović, Sonja and Obradović, Milan M. and Isenović, Esma R.",
year = "2023",
journal = "Frontiers in Endocrinology",
title = "Editorial: Non-coding RNA in diabetes and cardiovascular diseases",
volume = "14",
doi = "10.3389/fendo.2023.1149857"
}

Mačvanin, M., Zafirović, S., Obradović, M. M.,& Isenović, E. R.. (2023). Editorial: Non-coding RNA in diabetes and cardiovascular diseases. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1149857

Mačvanin M, Zafirović S, Obradović MM, Isenović ER. Editorial: Non-coding RNA in diabetes and cardiovascular diseases. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1149857 .

Mačvanin, Mirjana, Zafirović, Sonja, Obradović, Milan M., Isenović, Esma R., "Editorial: Non-coding RNA in diabetes and cardiovascular diseases" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1149857 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Obradović, Milan M.
AU  - Zafirović, Sonja
AU  - Stanimirović, Julijana
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10757
AB  - Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance are characterized by glucose and lipid metabolism alterations and represent a global health problem. Many studies have established the crucial role of micro-ribonucleic acids (miRNAs) in controlling metabolic processes in various tissues. miRNAs are single-stranded, highly conserved non-coding RNAs containing 20-24 oligonucleotides that are expressed in a tissue-specific manner. miRNAs mainly interact through base pairing with 3' untranslated regions of target gene mRNAs to promote inhibition of their translation. miRNAs regulate the expression of as many as 30% of the human genes and have a role in crucial physiological processes such as human growth and development, cell proliferation, apoptosis, and metabolism. The number of miRNA molecules with a confirmed role in the pathogenesis of metabolic diseases is quickly expanding due to the availability of high-throughput methodologies for their identification. In this review, we present recent findings regarding the role of miRNAs as endocrine signaling molecules involved in the regulation of insulin production and fat metabolism. We discuss the potential of extracellular miRNAs present in biological fluids miRNAs as biomarkers for the prediction of diabetes and MetS. We also give an updated overview of therapeutic interventions based on antisense oligonucleotides and the CRISPR/Cas9 editing platform for manipulating levels of miRNAs involved in metabolic disorders. © 2023 Bentham Science Publishers.
T2  - Current Medicinal Chemistry
T1  - The Role of miRNAs in Metabolic Diseases
VL  - 30
IS  - 17
SP  - 1922
EP  - 1944
DO  - 10.2174/0929867329666220801161536
ER  - 

@article{
author = "Mačvanin, Mirjana and Obradović, Milan M. and Zafirović, Sonja and Stanimirović, Julijana and Isenović, Esma R.",
year = "2023",
abstract = "Metabolic diseases such as obesity, diabetes, dyslipidemia, and insulin resistance are characterized by glucose and lipid metabolism alterations and represent a global health problem. Many studies have established the crucial role of micro-ribonucleic acids (miRNAs) in controlling metabolic processes in various tissues. miRNAs are single-stranded, highly conserved non-coding RNAs containing 20-24 oligonucleotides that are expressed in a tissue-specific manner. miRNAs mainly interact through base pairing with 3' untranslated regions of target gene mRNAs to promote inhibition of their translation. miRNAs regulate the expression of as many as 30% of the human genes and have a role in crucial physiological processes such as human growth and development, cell proliferation, apoptosis, and metabolism. The number of miRNA molecules with a confirmed role in the pathogenesis of metabolic diseases is quickly expanding due to the availability of high-throughput methodologies for their identification. In this review, we present recent findings regarding the role of miRNAs as endocrine signaling molecules involved in the regulation of insulin production and fat metabolism. We discuss the potential of extracellular miRNAs present in biological fluids miRNAs as biomarkers for the prediction of diabetes and MetS. We also give an updated overview of therapeutic interventions based on antisense oligonucleotides and the CRISPR/Cas9 editing platform for manipulating levels of miRNAs involved in metabolic disorders. © 2023 Bentham Science Publishers.",
journal = "Current Medicinal Chemistry",
title = "The Role of miRNAs in Metabolic Diseases",
volume = "30",
number = "17",
pages = "1922-1944",
doi = "10.2174/0929867329666220801161536"
}

Mačvanin, M., Obradović, M. M., Zafirović, S., Stanimirović, J.,& Isenović, E. R.. (2023). The Role of miRNAs in Metabolic Diseases. in Current Medicinal Chemistry, 30(17), 1922-1944.
https://doi.org/10.2174/0929867329666220801161536

Mačvanin M, Obradović MM, Zafirović S, Stanimirović J, Isenović ER. The Role of miRNAs in Metabolic Diseases. in Current Medicinal Chemistry. 2023;30(17):1922-1944.
doi:10.2174/0929867329666220801161536 .

Mačvanin, Mirjana, Obradović, Milan M., Zafirović, Sonja, Stanimirović, Julijana, Isenović, Esma R., "The Role of miRNAs in Metabolic Diseases" in Current Medicinal Chemistry, 30, no. 17 (2023):1922-1944,
https://doi.org/10.2174/0929867329666220801161536 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Radovanović, Jelena
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10774
AB  - Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic and preventive strategies to mitigate the disease’s debilitating effects. Diabetic cardiomyopathy (DCMP) is among the leading causes of morbidity and mortality in diabetic patients globally. DCMP manifests as cardiomyocyte hypertrophy, apoptosis, and myocardial interstitial fibrosis before progressing to heart failure. Evidence suggests that non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. This paper reviewed the literature data from animal and human studies on the non-trivial roles of miRNAs and lncRNAs in the context of DCMP in diabetes and demonstrated their future potential in DCMP treatment in diabetic patients.
T2  - Frontiers in Endocrinology
T1  - Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs
VL  - 14
DO  - 10.3389/fendo.2023.1124613
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Radovanović, Jelena and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic and preventive strategies to mitigate the disease’s debilitating effects. Diabetic cardiomyopathy (DCMP) is among the leading causes of morbidity and mortality in diabetic patients globally. DCMP manifests as cardiomyocyte hypertrophy, apoptosis, and myocardial interstitial fibrosis before progressing to heart failure. Evidence suggests that non-coding RNAs, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), regulate diabetic cardiomyopathy-related processes such as insulin resistance, cardiomyocyte apoptosis and inflammation, emphasizing their heart-protective effects. This paper reviewed the literature data from animal and human studies on the non-trivial roles of miRNAs and lncRNAs in the context of DCMP in diabetes and demonstrated their future potential in DCMP treatment in diabetic patients.",
journal = "Frontiers in Endocrinology",
title = "Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs",
volume = "14",
doi = "10.3389/fendo.2023.1124613"
}

Mačvanin, M., Gluvić, Z., Radovanović, J., Essack, M., Gao, X.,& Isenović, E. R.. (2023). Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1124613

Mačvanin M, Gluvić Z, Radovanović J, Essack M, Gao X, Isenović ER. Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1124613 .

Mačvanin, Mirjana, Gluvić, Zoran, Radovanović, Jelena, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "Diabetic cardiomyopathy: The role of microRNAs and long non-coding RNAs" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1124613 . .

TY  - JOUR
AU  - Mačvanin, Mirjana
AU  - Gluvić, Zoran
AU  - Zarić, Božidarka
AU  - Essack, Magbubah
AU  - Gao, Xin
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11405
AB  - After the metabolic syndrome and its components, thyroid disorders represent the most common endocrine disorders, with increasing prevalence in the last two decades. Thyroid dysfunctions are distinguished by hyperthyroidism, hypothyroidism, or inflammation (thyroiditis) of the thyroid gland, in addition to the presence of thyroid nodules that can be benign or malignant. Thyroid cancer is typically detected via an ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) and cytological examination of the specimen. This approach has significant limitations due to the small sample size and inability to characterize follicular lesions adequately. Due to the rapid advancement of high-throughput molecular biology techniques, it is now possible to identify new biomarkers for thyroid neoplasms that can supplement traditional imaging modalities in postoperative surveillance and aid in the preoperative cytology examination of indeterminate or follicular lesions. Here, we review current knowledge regarding biomarkers that have been reliable in detecting thyroid neoplasms, making them valuable tools for assessing the efficacy of surgical procedures or adjunctive treatment after surgery. We are particularly interested in providing an up-to-date and systematic review of emerging biomarkers, such as mRNA and non-coding RNAs, that can potentially detect thyroid neoplasms in clinical settings. We discuss evidence for miRNA, lncRNA and circRNA dysregulation in several thyroid neoplasms and assess their potential for use as diagnostic and prognostic biomarkers.
T2  - Frontiers in Endocrinology
T1  - New biomarkers: prospect for diagnosis and monitoring of thyroid disease
VL  - 14
SP  - 1218320
DO  - 10.3389/fendo.2023.1218320
ER  - 

@article{
author = "Mačvanin, Mirjana and Gluvić, Zoran and Zarić, Božidarka and Essack, Magbubah and Gao, Xin and Isenović, Esma R.",
year = "2023",
abstract = "After the metabolic syndrome and its components, thyroid disorders represent the most common endocrine disorders, with increasing prevalence in the last two decades. Thyroid dysfunctions are distinguished by hyperthyroidism, hypothyroidism, or inflammation (thyroiditis) of the thyroid gland, in addition to the presence of thyroid nodules that can be benign or malignant. Thyroid cancer is typically detected via an ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) and cytological examination of the specimen. This approach has significant limitations due to the small sample size and inability to characterize follicular lesions adequately. Due to the rapid advancement of high-throughput molecular biology techniques, it is now possible to identify new biomarkers for thyroid neoplasms that can supplement traditional imaging modalities in postoperative surveillance and aid in the preoperative cytology examination of indeterminate or follicular lesions. Here, we review current knowledge regarding biomarkers that have been reliable in detecting thyroid neoplasms, making them valuable tools for assessing the efficacy of surgical procedures or adjunctive treatment after surgery. We are particularly interested in providing an up-to-date and systematic review of emerging biomarkers, such as mRNA and non-coding RNAs, that can potentially detect thyroid neoplasms in clinical settings. We discuss evidence for miRNA, lncRNA and circRNA dysregulation in several thyroid neoplasms and assess their potential for use as diagnostic and prognostic biomarkers.",
journal = "Frontiers in Endocrinology",
title = "New biomarkers: prospect for diagnosis and monitoring of thyroid disease",
volume = "14",
pages = "1218320",
doi = "10.3389/fendo.2023.1218320"
}

Mačvanin, M., Gluvić, Z., Zarić, B., Essack, M., Gao, X.,& Isenović, E. R.. (2023). New biomarkers: prospect for diagnosis and monitoring of thyroid disease. in Frontiers in Endocrinology, 14, 1218320.
https://doi.org/10.3389/fendo.2023.1218320

Mačvanin M, Gluvić Z, Zarić B, Essack M, Gao X, Isenović ER. New biomarkers: prospect for diagnosis and monitoring of thyroid disease. in Frontiers in Endocrinology. 2023;14:1218320.
doi:10.3389/fendo.2023.1218320 .

Mačvanin, Mirjana, Gluvić, Zoran, Zarić, Božidarka, Essack, Magbubah, Gao, Xin, Isenović, Esma R., "New biomarkers: prospect for diagnosis and monitoring of thyroid disease" in Frontiers in Endocrinology, 14 (2023):1218320,
https://doi.org/10.3389/fendo.2023.1218320 . .

TY  - JOUR
AU  - Obradović, Milan M.
AU  - Samardžić, Vladimir
AU  - Mačvanin, Mirjana
AU  - Zafirović, Sonja
AU  - Gluvić, Zoran
AU  - Grubin, Jasmina
AU  - Gao, Xin
AU  - Essack, Magbubah
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11567
AB  - Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.Objective: The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.Results: Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.
T2  - Frontiers in Endocrinology
T1  - Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules
VL  - 14
DO  - 10.3389/fendo.2023.1241223
ER  - 

@article{
author = "Obradović, Milan M. and Samardžić, Vladimir and Mačvanin, Mirjana and Zafirović, Sonja and Gluvić, Zoran and Grubin, Jasmina and Gao, Xin and Essack, Magbubah and Isenović, Esma R.",
year = "2023",
abstract = "Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant.Objective: The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings.We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects.Results: Washout TG (TGw) level positively correlates with the cytology finding of the biopsy. A higher level of TGw correlates with higher categories of the Bethesda classification and indicates a higher malignant potential. The levels of serum NO (NOs), serum TG (TGs), serum CT (CTs), and washout CT (CTw) do not correlate with the cytology finding of the biopsy, and the higher levels of washout NO (NOw) correspond to the more suspicious ultrasound findings.The findings of our study suggest that TGw and NOw could be used as potential predictors of malignancy in TN.",
journal = "Frontiers in Endocrinology",
title = "Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules",
volume = "14",
doi = "10.3389/fendo.2023.1241223"
}

Obradović, M. M., Samardžić, V., Mačvanin, M., Zafirović, S., Gluvić, Z., Grubin, J., Gao, X., Essack, M.,& Isenović, E. R.. (2023). Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1241223

Obradović MM, Samardžić V, Mačvanin M, Zafirović S, Gluvić Z, Grubin J, Gao X, Essack M, Isenović ER. Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1241223 .

Obradović, Milan M., Samardžić, Vladimir, Mačvanin, Mirjana, Zafirović, Sonja, Gluvić, Zoran, Grubin, Jasmina, Gao, Xin, Essack, Magbubah, Isenović, Esma R., "Nitric oxide, thyroglobulin, and calcitonin: Unravelling the nature of thyroid nodules" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1241223 . .

TY  - JOUR
AU  - Mačvanin, Milena
AU  - Gluvić, Zoran
AU  - Zafirović, Sonja
AU  - Gao, Xin
AU  - Essack, Magbubah
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10613
AB  - An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.
T2  - Frontiers in Endocrinology
T1  - The protective role of nutritional antioxidants against oxidative stress in thyroid disorders
VL  - 13
DO  - 10.3389/fendo.2022.1092837
ER  - 

@article{
author = "Mačvanin, Milena and Gluvić, Zoran and Zafirović, Sonja and Gao, Xin and Essack, Magbubah and Isenović, Esma R.",
year = "2023",
abstract = "An imbalance between pro-oxidative and antioxidative cellular mechanisms is oxidative stress (OxS) which may be systemic or organ-specific. Although OxS is a consequence of normal body and organ physiology, severely impaired oxidative homeostasis results in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells’ function and viability. The thyroid gland is an organ that exhibits both oxidative and antioxidative processes. In terms of OxS severity, the thyroid gland’s response could be physiological (i.e. hormone production and secretion) or pathological (i.e. development of diseases, such as goitre, thyroid cancer, or thyroiditis). Protective nutritional antioxidants may benefit defensive antioxidative systems in resolving pro-oxidative dominance and redox imbalance, preventing or delaying chronic thyroid diseases. This review provides information on nutritional antioxidants and their protective roles against impaired redox homeostasis in various thyroid pathologies. We also review novel findings related to the connection between the thyroid gland and gut microbiome and analyze the effects of probiotics with antioxidant properties on thyroid diseases. Copyright © 2023 Macvanin, Gluvic, Zafirovic, Gao, Essack and Isenovic.",
journal = "Frontiers in Endocrinology",
title = "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders",
volume = "13",
doi = "10.3389/fendo.2022.1092837"
}

Mačvanin, M., Gluvić, Z., Zafirović, S., Gao, X., Essack, M.,& Isenović, E. R.. (2023). The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology, 13.
https://doi.org/10.3389/fendo.2022.1092837

Mačvanin M, Gluvić Z, Zafirović S, Gao X, Essack M, Isenović ER. The protective role of nutritional antioxidants against oxidative stress in thyroid disorders. in Frontiers in Endocrinology. 2023;13.
doi:10.3389/fendo.2022.1092837 .

Mačvanin, Milena, Gluvić, Zoran, Zafirović, Sonja, Gao, Xin, Essack, Magbubah, Isenović, Esma R., "The protective role of nutritional antioxidants against oxidative stress in thyroid disorders" in Frontiers in Endocrinology, 13 (2023),
https://doi.org/10.3389/fendo.2022.1092837 . .

TY  - JOUR
AU  - Obradović, Milan M.
AU  - Sudar-Milovanović, Emina
AU  - Gluvić, Zoran
AU  - Banjac, Katarina
AU  - Rizzo, Manfredi
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10756
AB  - Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide. A sodium pump (Na + /K + -ATPase) is found in most eukaryotic cells’ membrane and controls many essential cellular functions directly or indirectly. This ion transporter and its isoforms are important in the pathogenesis of some pathological processes, including CMD. The structure and function of Na + /K + -ATPase, its expression and distribution in tissues, and its interactions with known ligands such as cardiotonic steroids and other suspected endogenous regulators are discussed in this review. In addition, we reviewed recent literature data related to the involvement of Na + /K + -ATPase activity dysfunction in CMD, focusing on the Na + /K + -ATPase as a potential therapeutic target in CMD.
T2  - Frontiers in Endocrinology
T1  - The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases
VL  - 14
DO  - 10.3389/fendo.2023.1150171
ER  - 

@article{
author = "Obradović, Milan M. and Sudar-Milovanović, Emina and Gluvić, Zoran and Banjac, Katarina and Rizzo, Manfredi and Isenović, Esma R.",
year = "2023",
abstract = "Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide. A sodium pump (Na + /K + -ATPase) is found in most eukaryotic cells’ membrane and controls many essential cellular functions directly or indirectly. This ion transporter and its isoforms are important in the pathogenesis of some pathological processes, including CMD. The structure and function of Na + /K + -ATPase, its expression and distribution in tissues, and its interactions with known ligands such as cardiotonic steroids and other suspected endogenous regulators are discussed in this review. In addition, we reviewed recent literature data related to the involvement of Na + /K + -ATPase activity dysfunction in CMD, focusing on the Na + /K + -ATPase as a potential therapeutic target in CMD.",
journal = "Frontiers in Endocrinology",
title = "The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases",
volume = "14",
doi = "10.3389/fendo.2023.1150171"
}

Obradović, M. M., Sudar-Milovanović, E., Gluvić, Z., Banjac, K., Rizzo, M.,& Isenović, E. R.. (2023). The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases. in Frontiers in Endocrinology, 14.
https://doi.org/10.3389/fendo.2023.1150171

Obradović MM, Sudar-Milovanović E, Gluvić Z, Banjac K, Rizzo M, Isenović ER. The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases. in Frontiers in Endocrinology. 2023;14.
doi:10.3389/fendo.2023.1150171 .

Obradović, Milan M., Sudar-Milovanović, Emina, Gluvić, Zoran, Banjac, Katarina, Rizzo, Manfredi, Isenović, Esma R., "The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases" in Frontiers in Endocrinology, 14 (2023),
https://doi.org/10.3389/fendo.2023.1150171 . .

TY  - JOUR
AU  - Petrović, Nina
AU  - Essack, Magbubah
AU  - Šami, Ahmad
AU  - Perry, George
AU  - Gojobori, Takashi
AU  - Isenović, Esma R.
AU  - Bajić, Vladan P.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11351
AB  - MicroRNAs (miRNAs) are involved in the regulation of various cellular processes including pathological conditions. MiRNA networks have been extensively researched in age-related degenerative diseases, such as cancer, Alzheimer’s disease (AD), and heart failure. Thus, miRNA has been studied from different approaches, in vivo, in vitro, and in silico including miRNA networks. Networks linking diverse biomedical entities unveil information not readily observable by other means. This work focuses on biological networks related to Breast cancer susceptibility 1 (BRCA1) in AD and breast cancer (BC). Using various bioinformatics approaches, we identified subnetworks common to AD and BC that suggest they are linked. According to our results, miR-107 was identified as a potentially good candidate for both AD and BC treatment (targeting BRCA1/2 and PTEN in both diseases), accompanied by miR-146a and miR-17. The analysis also confirmed the involvement of the miR-17-92 cluster, and miR-124-3p, and highlighted the importance of poorly researched miRNAs such as mir-6785 mir6127, mir-6870, or miR-8485. After filtering the in silico analysis results, we found 49 miRNA molecules that modulate the expression of at least five genes common to both BC and AD. Those 49 miRNAs regulate the expression of 122 genes in AD and 93 genes in BC, from which 26 genes are common genes for AD and BC involved in neuron differentiation and genesis, cell differentiation and migration, regulation of cell cycle, and cancer development. Additionally, the highly enriched pathway was associated with diabetic complications, pointing out possible interplay among molecules underlying BC, AD, and diabetes pathology
T2  - Computational Biology and Chemistry
T1  - MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment
VL  - 106
SP  - 107925
DO  - 10.1016/j.compbiolchem.2023.107925
ER  - 

@article{
author = "Petrović, Nina and Essack, Magbubah and Šami, Ahmad and Perry, George and Gojobori, Takashi and Isenović, Esma R. and Bajić, Vladan P.",
year = "2023",
abstract = "MicroRNAs (miRNAs) are involved in the regulation of various cellular processes including pathological conditions. MiRNA networks have been extensively researched in age-related degenerative diseases, such as cancer, Alzheimer’s disease (AD), and heart failure. Thus, miRNA has been studied from different approaches, in vivo, in vitro, and in silico including miRNA networks. Networks linking diverse biomedical entities unveil information not readily observable by other means. This work focuses on biological networks related to Breast cancer susceptibility 1 (BRCA1) in AD and breast cancer (BC). Using various bioinformatics approaches, we identified subnetworks common to AD and BC that suggest they are linked. According to our results, miR-107 was identified as a potentially good candidate for both AD and BC treatment (targeting BRCA1/2 and PTEN in both diseases), accompanied by miR-146a and miR-17. The analysis also confirmed the involvement of the miR-17-92 cluster, and miR-124-3p, and highlighted the importance of poorly researched miRNAs such as mir-6785 mir6127, mir-6870, or miR-8485. After filtering the in silico analysis results, we found 49 miRNA molecules that modulate the expression of at least five genes common to both BC and AD. Those 49 miRNAs regulate the expression of 122 genes in AD and 93 genes in BC, from which 26 genes are common genes for AD and BC involved in neuron differentiation and genesis, cell differentiation and migration, regulation of cell cycle, and cancer development. Additionally, the highly enriched pathway was associated with diabetic complications, pointing out possible interplay among molecules underlying BC, AD, and diabetes pathology",
journal = "Computational Biology and Chemistry",
title = "MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment",
volume = "106",
pages = "107925",
doi = "10.1016/j.compbiolchem.2023.107925"
}

Petrović, N., Essack, M., Šami, A., Perry, G., Gojobori, T., Isenović, E. R.,& Bajić, V. P.. (2023). MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment. in Computational Biology and Chemistry, 106, 107925.
https://doi.org/10.1016/j.compbiolchem.2023.107925

Petrović N, Essack M, Šami A, Perry G, Gojobori T, Isenović ER, Bajić VP. MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment. in Computational Biology and Chemistry. 2023;106:107925.
doi:10.1016/j.compbiolchem.2023.107925 .

Petrović, Nina, Essack, Magbubah, Šami, Ahmad, Perry, George, Gojobori, Takashi, Isenović, Esma R., Bajić, Vladan P., "MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment" in Computational Biology and Chemistry, 106 (2023):107925,
https://doi.org/10.1016/j.compbiolchem.2023.107925 . .

TY  - JOUR
AU  - Panić, Anastasija
AU  - Sudar-Milovanović, Emina
AU  - Stanimirović, Julijana
AU  - Obradović, Milan M.
AU  - Zafirović, Sonja
AU  - Soskić, Sanja S.
AU  - Isenović, Esma R.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10744
AB  - The liver is an organ in which many oxidative processes occur and represents an important target of oxidative stress (OxS). Under physiological conditions of normal mitochondrial homeostasis, hepatocytes effectively remove reactive oxygen species (ROS) by enabling metabolic adaptations and through the antioxidant defence system mechanisms. However, obesity-induced lipid accumulation in the hepatocytes causes significantly elevated production of ROS, reduces oxidative capacity, and increases oxidative stress (OxS). In men, compared with premenopausal women, the development of insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in obesity are more prevalent, where oestradiol (E2), the most potent female sex steroid, is proposed as the main culprit. Exogenous oestradiol (E2) administration exerts beneficial effects on antioxidant properties, restores total plasma antioxidant capacity and decreases biomarkers of OxS in ovariectomized animal models. Thus, we hypothesized that E2 treatment in states of obesity could have beneficial effects against OxS in the obese male's liver. We assumed that E2 could directly affect the level of OxS by increasing the level/activity of the AOS enzymes, particularly SOD1, SOD2, GPx, and CAT, in obese males' livers. In addition, we assumed that the level of malondialdehyde (MDA) and protein carbonyl content (PCC) in obese males' livers would be reduced after E2 treatment as a result of E2 inhibitory effect on lipid peroxidation and protein oxidation, respectively. To test our hypothesis, we used the liver of a high-fat (HF) diet-fed male Wistar rats as an animal model of obesity, treated with E2 intraperitoneally (40 μg/kg). Preliminary results from this study support our hypothesis that E2 increases liver protein expression of AOS enzymes: SOD1, GPx, and CAT, in control and HF male rats compared with their respective controls. The protein level of SOD2 and CAT activity was increased in HF treated with E2 compared with non-treated HF rats. Moreover, as we expected, E2 administration significantly decreased the MDA level in both E2-treated groups compared to their controls, while the PCC level was significantly decreased in HF treated group compared with untreated HF rats. In conclusion, the preliminary results we obtained in this study indicate that E2 administration can effectively inhibit the OxS-related processes in the liver in HF diet-induced obesity by increasing AOS enzymes levels and CAT activity, and also by decreasing levels of MDA and PCC. A consequence of our hypothesis is that treatment with E2 may be an innovative way to improve obesity-related liver disease prevention and healing. © 2023 Elsevier Ltd
T2  - Medical Hypotheses
T1  - Does oestradiol treatment alleviate obesity-induced oxidative stress in the male liver?
VL  - 174
SP  - 111049
DO  - 10.1016/j.mehy.2023.111049
ER  - 

@article{
author = "Panić, Anastasija and Sudar-Milovanović, Emina and Stanimirović, Julijana and Obradović, Milan M. and Zafirović, Sonja and Soskić, Sanja S. and Isenović, Esma R.",
year = "2023",
abstract = "The liver is an organ in which many oxidative processes occur and represents an important target of oxidative stress (OxS). Under physiological conditions of normal mitochondrial homeostasis, hepatocytes effectively remove reactive oxygen species (ROS) by enabling metabolic adaptations and through the antioxidant defence system mechanisms. However, obesity-induced lipid accumulation in the hepatocytes causes significantly elevated production of ROS, reduces oxidative capacity, and increases oxidative stress (OxS). In men, compared with premenopausal women, the development of insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in obesity are more prevalent, where oestradiol (E2), the most potent female sex steroid, is proposed as the main culprit. Exogenous oestradiol (E2) administration exerts beneficial effects on antioxidant properties, restores total plasma antioxidant capacity and decreases biomarkers of OxS in ovariectomized animal models. Thus, we hypothesized that E2 treatment in states of obesity could have beneficial effects against OxS in the obese male's liver. We assumed that E2 could directly affect the level of OxS by increasing the level/activity of the AOS enzymes, particularly SOD1, SOD2, GPx, and CAT, in obese males' livers. In addition, we assumed that the level of malondialdehyde (MDA) and protein carbonyl content (PCC) in obese males' livers would be reduced after E2 treatment as a result of E2 inhibitory effect on lipid peroxidation and protein oxidation, respectively. To test our hypothesis, we used the liver of a high-fat (HF) diet-fed male Wistar rats as an animal model of obesity, treated with E2 intraperitoneally (40 μg/kg). Preliminary results from this study support our hypothesis that E2 increases liver protein expression of AOS enzymes: SOD1, GPx, and CAT, in control and HF male rats compared with their respective controls. The protein level of SOD2 and CAT activity was increased in HF treated with E2 compared with non-treated HF rats. Moreover, as we expected, E2 administration significantly decreased the MDA level in both E2-treated groups compared to their controls, while the PCC level was significantly decreased in HF treated group compared with untreated HF rats. In conclusion, the preliminary results we obtained in this study indicate that E2 administration can effectively inhibit the OxS-related processes in the liver in HF diet-induced obesity by increasing AOS enzymes levels and CAT activity, and also by decreasing levels of MDA and PCC. A consequence of our hypothesis is that treatment with E2 may be an innovative way to improve obesity-related liver disease prevention and healing. © 2023 Elsevier Ltd",
journal = "Medical Hypotheses",
title = "Does oestradiol treatment alleviate obesity-induced oxidative stress in the male liver?",
volume = "174",
pages = "111049",
doi = "10.1016/j.mehy.2023.111049"
}

Panić, A., Sudar-Milovanović, E., Stanimirović, J., Obradović, M. M., Zafirović, S., Soskić, S. S.,& Isenović, E. R.. (2023). Does oestradiol treatment alleviate obesity-induced oxidative stress in the male liver?. in Medical Hypotheses, 174, 111049.
https://doi.org/10.1016/j.mehy.2023.111049

Panić A, Sudar-Milovanović E, Stanimirović J, Obradović MM, Zafirović S, Soskić SS, Isenović ER. Does oestradiol treatment alleviate obesity-induced oxidative stress in the male liver?. in Medical Hypotheses. 2023;174:111049.
doi:10.1016/j.mehy.2023.111049 .

Panić, Anastasija, Sudar-Milovanović, Emina, Stanimirović, Julijana, Obradović, Milan M., Zafirović, Sonja, Soskić, Sanja S., Isenović, Esma R., "Does oestradiol treatment alleviate obesity-induced oxidative stress in the male liver?" in Medical Hypotheses, 174 (2023):111049,
https://doi.org/10.1016/j.mehy.2023.111049 . .