TY  - JOUR
AU  - Simonović, Mladen
AU  - Ostojić, Sanja
AU  - Micić, Darko
AU  - Savić-Biserčić, Marjetka
AU  - Mix, Thorsten
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10665
AB  - This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .
T2  - Natural Product Research
T1  - A novel and effective natural product-based immunodetection tool for TNT-like compounds
VL  - 36
IS  - 3
SP  - 857
EP  - 861
DO  - 10.1080/14786419.2020.1806269
ER  - 

@article{
author = "Simonović, Mladen and Ostojić, Sanja and Micić, Darko and Savić-Biserčić, Marjetka and Mix, Thorsten and Glumac, Miodrag and Pejin, Boris",
year = "2022",
abstract = "This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .",
journal = "Natural Product Research",
title = "A novel and effective natural product-based immunodetection tool for TNT-like compounds",
volume = "36",
number = "3",
pages = "857-861",
doi = "10.1080/14786419.2020.1806269"
}

Simonović, M., Ostojić, S., Micić, D., Savić-Biserčić, M., Mix, T., Glumac, M.,& Pejin, B.. (2022). A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research, 36(3), 857-861.
https://doi.org/10.1080/14786419.2020.1806269

Simonović M, Ostojić S, Micić D, Savić-Biserčić M, Mix T, Glumac M, Pejin B. A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research. 2022;36(3):857-861.
doi:10.1080/14786419.2020.1806269 .

Simonović, Mladen, Ostojić, Sanja, Micić, Darko, Savić-Biserčić, Marjetka, Mix, Thorsten, Glumac, Miodrag, Pejin, Boris, "A novel and effective natural product-based immunodetection tool for TNT-like compounds" in Natural Product Research, 36, no. 3 (2022):857-861,
https://doi.org/10.1080/14786419.2020.1806269 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Todorović, Nevena
AU  - Novaković, Irena T.
AU  - Pezo, Lato
AU  - Pejin, Boris
AU  - Maraš, Vesna
AU  - Tešević, Vele V.
AU  - Pajović, Snežana B.
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/8/1971
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7858
AB  - Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.
T2  - Molecules
T1  - Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine
VL  - 23
IS  - 8
SP  - 1971
DO  - 10.3390/molecules23081971
ER  - 

@article{
author = "Đorđević, Neda O. and Todorović, Nevena and Novaković, Irena T. and Pezo, Lato and Pejin, Boris and Maraš, Vesna and Tešević, Vele V. and Pajović, Snežana B.",
year = "2018",
abstract = "Screens of antioxidant activity (AA) of various natural products have been a focus of the research community worldwide. This work aimed to differentiate selected samples of Merlot wines originated from Montenegro, with regard to phenolic profile and antioxidant capacity studied by survival rate, total sulfhydryl groups and activities of glutathione peroxidase (GPx), glutathione reductase and catalase in H2O2–stressed Saccharomyces cerevisiae cells. In this study, DPPH assay was also performed. Higher total phenolic content leads to an enhanced AA under both conditions. The same trend was observed for catechin and gallic acid, the most abundant phenolics in the examined wine samples. Finally, the findings of an Artificial Neural Network (ANN) model were in a good agreement (r2 = 0.978) with the experimental data. All tested samples exhibited a protective effect in H2O2–stressed yeast cells. Pre-treatment with examined wines increased survival in H2O2–stressed cells and shifted antioxidative defense towards GPx–mediated defense. Finally, sensitivity analysis of obtained ANN model highlights the complexity of the impact that variations in the concentrations of specific phenolic components have on the antioxidant defense system.",
journal = "Molecules",
title = "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine",
volume = "23",
number = "8",
pages = "1971",
doi = "10.3390/molecules23081971"
}

Đorđević, N. O., Todorović, N., Novaković, I. T., Pezo, L., Pejin, B., Maraš, V., Tešević, V. V.,& Pajović, S. B.. (2018). Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine. in Molecules, 23(8), 1971.
https://doi.org/10.3390/molecules23081971

Đorđević NO, Todorović N, Novaković IT, Pezo L, Pejin B, Maraš V, Tešević VV, Pajović SB. Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine. in Molecules. 2018;23(8):1971.
doi:10.3390/molecules23081971 .

Đorđević, Neda O., Todorović, Nevena, Novaković, Irena T., Pezo, Lato, Pejin, Boris, Maraš, Vesna, Tešević, Vele V., Pajović, Snežana B., "Antioxidant Activity of Selected Polyphenolics in Yeast Cells: The Case Study of Montenegrin Merlot Wine" in Molecules, 23, no. 8 (2018):1971,
https://doi.org/10.3390/molecules23081971 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Živković, Marijana B.
AU  - Savić, Aleksandar
AU  - Mutić, Jelena J.
AU  - Tešević, Vele
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1923
AB  - This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.
T2  - Scientia Horticulturae
T1  - An insight into chemical composition and biological activity of Montenegrin Vranac red wine
VL  - 230
SP  - 142
EP  - 148
DO  - 10.1016/j.scienta.2017.11.033
ER  - 

@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Živković, Marijana B. and Savić, Aleksandar and Mutić, Jelena J. and Tešević, Vele",
year = "2018",
abstract = "This study aimed to describe quality and potential health benefits of three Vranac wines obtained from new grape clones (CI, CII and CIII) recently developed and recognised. In this aim, their phenolic profiles, anti-2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical activities along with metal compositions were analyzed. Compared with the commercial one, CII and CIII Vranac wines were found to contain both higher contents of total phenolics, flavonoids and monomeric anthocyanins as well as anti-DPPH radical activities. The most abundant phenolics were gallic acid (8.88-16.36 mg/L), catechin (12.42-24.35 mg/L) and epicatechin (4.30-7.79 mg/L). Finally, the metal content of all the analyzed samples was within the toxicological safety limits. Taken all together, Montenegrin Vranac wines represent a rich source of both phenolics and minerals exhibiting promising antioxidant potential. CII and CIII wines can be considered for commercialising due to their high amounts of gallic acid, catechin and epicatechin, significant K/Na ratios and favourable contents of essential metals making them products with health added values.",
journal = "Scientia Horticulturae",
title = "An insight into chemical composition and biological activity of Montenegrin Vranac red wine",
volume = "230",
pages = "142-148",
doi = "10.1016/j.scienta.2017.11.033"
}

Đorđević, N. O., Novaković, M. M., Pejin, B., Živković, M. B., Savić, A., Mutić, J. J.,& Tešević, V.. (2018). An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae, 230, 142-148.
https://doi.org/10.1016/j.scienta.2017.11.033

Đorđević NO, Novaković MM, Pejin B, Živković MB, Savić A, Mutić JJ, Tešević V. An insight into chemical composition and biological activity of Montenegrin Vranac red wine. in Scientia Horticulturae. 2018;230:142-148.
doi:10.1016/j.scienta.2017.11.033 .

Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Živković, Marijana B., Savić, Aleksandar, Mutić, Jelena J., Tešević, Vele, "An insight into chemical composition and biological activity of Montenegrin Vranac red wine" in Scientia Horticulturae, 230 (2018):142-148,
https://doi.org/10.1016/j.scienta.2017.11.033 . .

TY  - JOUR
AU  - Čakar, Uroš
AU  - Grozdanić, Nađa
AU  - Petrović, Aleksandar V.
AU  - Pejin, Boris
AU  - Nastasijević, Branislav J.
AU  - Marković, Bojan D.
AU  - Đorđević, Brižita
PY  - 2018
UR  - http://www.eurekaselect.com/161153/article
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7860
AB  - BACKGROUND: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. OBJECTIVES: Potential α-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. METHOD: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. RESULTS: Compared with acarbose used as a positive control (IC50 = 73.78 µg/mL), all fruit wine samples exhibited higher α-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 µg/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 µg/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to α-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent α-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. CONCLUSION: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
T2  - Current Pharmaceutical Biotechnology
T1  - Fruit Wines Inhibitory Activity Against α-Glucosidase
VL  - 18
IS  - 15
SP  - 1264
EP  - 1272
DO  - 10.2174/1389201019666180410112439
ER  - 

@article{
author = "Čakar, Uroš and Grozdanić, Nađa and Petrović, Aleksandar V. and Pejin, Boris and Nastasijević, Branislav J. and Marković, Bojan D. and Đorđević, Brižita",
year = "2018",
abstract = "BACKGROUND: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. OBJECTIVES: Potential α-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. METHOD: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. RESULTS: Compared with acarbose used as a positive control (IC50 = 73.78 µg/mL), all fruit wine samples exhibited higher α-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 µg/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 µg/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to α-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent α-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. CONCLUSION: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.",
journal = "Current Pharmaceutical Biotechnology",
title = "Fruit Wines Inhibitory Activity Against α-Glucosidase",
volume = "18",
number = "15",
pages = "1264-1272",
doi = "10.2174/1389201019666180410112439"
}

Čakar, U., Grozdanić, N., Petrović, A. V., Pejin, B., Nastasijević, B. J., Marković, B. D.,& Đorđević, B.. (2018). Fruit Wines Inhibitory Activity Against α-Glucosidase. in Current Pharmaceutical Biotechnology, 18(15), 1264-1272.
https://doi.org/10.2174/1389201019666180410112439

Čakar U, Grozdanić N, Petrović AV, Pejin B, Nastasijević BJ, Marković BD, Đorđević B. Fruit Wines Inhibitory Activity Against α-Glucosidase. in Current Pharmaceutical Biotechnology. 2018;18(15):1264-1272.
doi:10.2174/1389201019666180410112439 .

Čakar, Uroš, Grozdanić, Nađa, Petrović, Aleksandar V., Pejin, Boris, Nastasijević, Branislav J., Marković, Bojan D., Đorđević, Brižita, "Fruit Wines Inhibitory Activity Against α-Glucosidase" in Current Pharmaceutical Biotechnology, 18, no. 15 (2018):1264-1272,
https://doi.org/10.2174/1389201019666180410112439 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1863
AB  - The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.
T2  - Natural Product Research
T1  - Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro
VL  - 32
IS  - 3
SP  - 247
EP  - 251
DO  - 10.1080/14786419.2017.1347171
ER  - 

@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2018",
abstract = "The overall aim of this paper was to compare the multielement composition and antioxidant capacity of two Montenegrin Merlot wines obtained from specific vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011. Elemental composition was analysed using inductively coupled plasma optical emission spectrometry (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Additionally, antioxidant capacity was assessed by cyclic voltammetry. VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, all three wines are good source of essential elements and products with a significant antioxidant activity and specific geographical origin.",
journal = "Natural Product Research",
title = "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro",
volume = "32",
number = "3",
pages = "247-251",
doi = "10.1080/14786419.2017.1347171"
}

Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V.. (2018). Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research, 32(3), 247-251.
https://doi.org/10.1080/14786419.2017.1347171

Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro. in Natural Product Research. 2018;32(3):247-251.
doi:10.1080/14786419.2017.1347171 .

Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor M., Mutić, Jelena J., Pajović, Snežana B., Tešević, Vele V., "Multielement analysis and antioxidant capacity of Merlot wine clones developed in Montenegro" in Natural Product Research, 32, no. 3 (2018):247-251,
https://doi.org/10.1080/14786419.2017.1347171 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Pejin, Boris
AU  - Novaković, Miroslav M.
AU  - Stanković, Dalibor M.
AU  - Mutić, Jelena J.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1773
AB  - The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.
T2  - Scientia Horticulturae
T1  - Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro
VL  - 225
SP  - 505
EP  - 511
DO  - 10.1016/j.scienta.2017.07.045
ER  - 

@article{
author = "Đorđević, Neda O. and Pejin, Boris and Novaković, Miroslav M. and Stanković, Dalibor M. and Mutić, Jelena J. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
abstract = "The overall aim was to compare the quality of two Montenegrin Merlot wines obtained from new vine clones (VCR1 and VCR 101) along with commercial Merlot wine throughout the consecutive vintages in 2010 and 2011, due to preliminary screening of the potential of novel Merlot vine clones for the wine industry. The content of phenolic compounds was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Elemental composition was analysed using inductively coupled plasma optical emission spectrometery (ICP-OES) and inductively coupled plasma mass spectrometery (ICP-MS)]. Additionaly, antioxidant capacity was assessed by cyclic voltammetry. Compared with the commercial one, both wine clones contained higher percent of major phenolic compounds (namely, gallic acid and catechin) with top values recorded for VCR1 both in 2010 (30.46 +/- 0.42 mg/1) and 2011 (28.12 +/- 0.29 mg/1). The same wines were enriched with epicatechin, resveratrol, myricetin and quercetin. Furthermore, VCR 1 wine from 2011 stood out for its elemental composition. On the other hand, antioxidant capacity of VCR 101 wines was the highest one for the both vintages. According to the experimental data obtained, both new Montenegrin Merlot wines represent good candidates for the commercialised wines with an indication of geographical origin.",
journal = "Scientia Horticulturae",
title = "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro",
volume = "225",
pages = "505-511",
doi = "10.1016/j.scienta.2017.07.045"
}

Đorđević, N. O., Pejin, B., Novaković, M. M., Stanković, D. M., Mutić, J. J., Pajović, S. B.,& Tešević, V. V.. (2017). Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro. in Scientia Horticulturae, 225, 505-511.
https://doi.org/10.1016/j.scienta.2017.07.045

Đorđević NO, Pejin B, Novaković MM, Stanković DM, Mutić JJ, Pajović SB, Tešević VV. Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro. in Scientia Horticulturae. 2017;225:505-511.
doi:10.1016/j.scienta.2017.07.045 .

Đorđević, Neda O., Pejin, Boris, Novaković, Miroslav M., Stanković, Dalibor M., Mutić, Jelena J., Pajović, Snežana B., Tešević, Vele V., "Some chemical characteristics and antioxidant capacity of novel Merlot wine clones developed in Montenegro" in Scientia Horticulturae, 225 (2017):505-511,
https://doi.org/10.1016/j.scienta.2017.07.045 . .

TY  - JOUR
AU  - Đorđević, Neda O.
AU  - Novaković, Miroslav M.
AU  - Pejin, Boris
AU  - Mutić, Jelena J.
AU  - Vajs, Vlatka E.
AU  - Pajović, Snežana B.
AU  - Tešević, Vele V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1628
AB  - Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .
T2  - Natural Product Research
T1  - Comparative analytical study of the selected wine varieties grown in Montenegro
VL  - 31
IS  - 15
SP  - 1825
EP  - 1830
DO  - 10.1080/14786419.2017.1289209
ER  - 

@article{
author = "Đorđević, Neda O. and Novaković, Miroslav M. and Pejin, Boris and Mutić, Jelena J. and Vajs, Vlatka E. and Pajović, Snežana B. and Tešević, Vele V.",
year = "2017",
abstract = "Samples of the selected red wine varieties grown in Montenegro (Merlot, Cabernet Sauvignon and Vranac; vintages 2010-2012) were compared according to total phenolic content, anti-DPPH radical activity, phenolic profile and elemental composition. All the samples showed profound anti-DPPH radical activity, due to high content of total phenolic compounds (R=0.92). The most abundant phenolics were catechin and gallic acid with the highest values recorded for Merlot 2012 (43.22 and 28.65mg/L, respectively). In addition to this, the content of essential elements including the potentially toxic ones was within healthy (safe) level for all the samples analysed. This study has actually pointed out Merlot wine variety as the best quality one, though all three varieties may be used as safe and health-promoting nutritional products. [GRAPHICS] .",
journal = "Natural Product Research",
title = "Comparative analytical study of the selected wine varieties grown in Montenegro",
volume = "31",
number = "15",
pages = "1825-1830",
doi = "10.1080/14786419.2017.1289209"
}

Đorđević, N. O., Novaković, M. M., Pejin, B., Mutić, J. J., Vajs, V. E., Pajović, S. B.,& Tešević, V. V.. (2017). Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research, 31(15), 1825-1830.
https://doi.org/10.1080/14786419.2017.1289209

Đorđević NO, Novaković MM, Pejin B, Mutić JJ, Vajs VE, Pajović SB, Tešević VV. Comparative analytical study of the selected wine varieties grown in Montenegro. in Natural Product Research. 2017;31(15):1825-1830.
doi:10.1080/14786419.2017.1289209 .

Đorđević, Neda O., Novaković, Miroslav M., Pejin, Boris, Mutić, Jelena J., Vajs, Vlatka E., Pajović, Snežana B., Tešević, Vele V., "Comparative analytical study of the selected wine varieties grown in Montenegro" in Natural Product Research, 31, no. 15 (2017):1825-1830,
https://doi.org/10.1080/14786419.2017.1289209 . .

TY  - JOUR
AU  - Godevac, Dejan
AU  - Tešević, Vele V.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Zdunic, Gordana
AU  - Ordevic, Boban
AU  - Stanković, Miroslava
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4923
AB  - On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.
T2  - Journal of Food Science
T1  - Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA
VL  - 77
IS  - 7
SP  - C779
EP  - C783
DO  - 10.1111/j.1750-3841.2012.02756.x
ER  - 

@article{
author = "Godevac, Dejan and Tešević, Vele V. and Vajs, Vlatka and Milosavljević, Slobodan and Zdunic, Gordana and Ordevic, Boban and Stanković, Miroslava",
year = "2012",
abstract = "On the basis of LC/UV/MS analysis, 35 compounds from the extracts of seeds of black, red, and white currants (2 cultivars of each) were identified. Black currants cultivars contained protocatechuic acid and p-hydroxybenzoic acid, and traces of nitril containing phenolic acids. The presence of synapoyl glucoside was characteristic for cv. Malling Jewel. Sesquiterpenoid glycosides and carboxymethylindol glycosides were present mainly in white and red currant cultivars. Blackcurrant seeds contained higher amounts of flavonoids, especially rutin, isoquercetin, and taxifolin. The currant seed extracts were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The frequency of MN was scored in binucleated cells, and the cultivars of black currants showed the best antioxidant potential. At a concentration of only 0.17 mg/mL, extract of the seed cv. Malling Jewel effected a decrease in the frequency of MN of 60% compared with control cell cultures. Practical Application: Our results provide evidence of protective effects of currant seed extracts and isolated pure compounds on cytogenetic damages in human lymphocytes. Thus, currant seed extracts could exert beneficial effects in quite a few diseases, for many of the biological actions have been attributed to their antioxidant properties.",
journal = "Journal of Food Science",
title = "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA",
volume = "77",
number = "7",
pages = "C779-C783",
doi = "10.1111/j.1750-3841.2012.02756.x"
}

Godevac, D., Tešević, V. V., Vajs, V., Milosavljević, S., Zdunic, G., Ordevic, B.,& Stanković, M.. (2012). Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science, 77(7), C779-C783.
https://doi.org/10.1111/j.1750-3841.2012.02756.x

Godevac D, Tešević VV, Vajs V, Milosavljević S, Zdunic G, Ordevic B, Stanković M. Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA. in Journal of Food Science. 2012;77(7):C779-C783.
doi:10.1111/j.1750-3841.2012.02756.x .

Godevac, Dejan, Tešević, Vele V., Vajs, Vlatka, Milosavljević, Slobodan, Zdunic, Gordana, Ordevic, Boban, Stanković, Miroslava, "Chemical Composition of Currant Seed Extracts and Their Protective Effect on Human Lymphocytes DNA" in Journal of Food Science, 77, no. 7 (2012):C779-C783,
https://doi.org/10.1111/j.1750-3841.2012.02756.x . .

TY  - JOUR
AU  - Godevac, Dejan
AU  - Tešević, Vele V.
AU  - Vajs, Vlatka
AU  - Milosavljević, Slobodan
AU  - Stanković, Miroslava
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4492
AB  - The tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H-6, and an ellagic acid derivative, 4-alpha-L-arabinofuranosylellagic acid, were isolated using semipreparative High-performance liquid chromatography. The structure elucidations were based on high resolution-mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 mu g/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity.
T2  - Journal of Food Science
T1  - Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA
VL  - 76
IS  - 7
SP  - C1039
EP  - C1043
DO  - 10.1111/j.1750-3841.2011.02305.x
ER  - 

@article{
author = "Godevac, Dejan and Tešević, Vele V. and Vajs, Vlatka and Milosavljević, Slobodan and Stanković, Miroslava",
year = "2011",
abstract = "The tentative identification of seed extracts from 3 cultivars of blackberry (blackberry seed extracts [BSEs]) constituents was performed by LC/UV/MS technique. The identified compounds belonged to ellagitannins, galic acid derivatives, and ellagic acid derivatives. Two ellagitannins, Lambertianin C and Sanguiniin H-6, and an ellagic acid derivative, 4-alpha-L-arabinofuranosylellagic acid, were isolated using semipreparative High-performance liquid chromatography. The structure elucidations were based on high resolution-mass spectrometry and nuclear magnetic resonance studies. The BSEs and 3 isolated pure compounds were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (MN) assay. The frequency of MN was scored in binucleated cells, and nuclear proliferation index was calculated. Among the tested extracts, the seeds of cv. Thornfree at concentration of 1 mu g/mL exhibit the most prominent effect decreasing the frequency of MN by 62.4%, when compared with the controls cell cultures. Antioxidant potential of pure ellagitannins cannot explain the strong effect of BSEs. The assumption was that better antioxidant effect of BSEs result from synergistic effects of individual compounds contained in the extracts and/or some minor components possessed strong activity.",
journal = "Journal of Food Science",
title = "Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA",
volume = "76",
number = "7",
pages = "C1039-C1043",
doi = "10.1111/j.1750-3841.2011.02305.x"
}

Godevac, D., Tešević, V. V., Vajs, V., Milosavljević, S.,& Stanković, M.. (2011). Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA. in Journal of Food Science, 76(7), C1039-C1043.
https://doi.org/10.1111/j.1750-3841.2011.02305.x

Godevac D, Tešević VV, Vajs V, Milosavljević S, Stanković M. Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA. in Journal of Food Science. 2011;76(7):C1039-C1043.
doi:10.1111/j.1750-3841.2011.02305.x .

Godevac, Dejan, Tešević, Vele V., Vajs, Vlatka, Milosavljević, Slobodan, Stanković, Miroslava, "Blackberry Seed Extracts and Isolated Polyphenolic Compounds Showing Protective Effect on Human Lymphocytes DNA" in Journal of Food Science, 76, no. 7 (2011):C1039-C1043,
https://doi.org/10.1111/j.1750-3841.2011.02305.x . .