High Energy Physics with the CMS Detector

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High Energy Physics with the CMS Detector (en)
Физика високих енергија са детектором CMS (sr)
Fizika visokih energija sa detektorom CMS (sr_RS)
Authors

Publications

Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model

Đorđević, Miloš; Milošević, Jovan; Nađđerđ, Laslo; Stojanović, Milan; Wang, F.; Zhu, X.

(2020)

TY  - JOUR
AU  - Đorđević, Miloš
AU  - Milošević, Jovan
AU  - Nađđerđ, Laslo
AU  - Stojanović, Milan
AU  - Wang, F.
AU  - Zhu, X.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8478
AB  - Correlations between azimuthal anisotropy Fourier harmonics vn (n=2,3,4) are studied using the events from PbPb collisions at sNN=2.76 TeV generated by the HYDJET++ and multiphase transport (AMPT) models, and compared to the corresponding experimental results obtained by the ATLAS Collaboration. The Fourier harmonics vn are measured over a wide centrality range using the two-particle azimuthal correlation method. The slopes of the v2-v3 correlation from both models are in a good agreement with the ATLAS data. The HYDJET++ model predicts a stronger slope for the v2-v4 and v3-v4 correlations than the ones experimentally measured, while the results from the AMPT model are in a rather good agreement with the experimental results. In contrast to the HYDJET++ predictions, the AMPT model predicts a boomeranglike shape in the structure of the correlations as found in the experimental data. © 2020 American Physical Society.
T2  - Physical Review C
T1  - Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model
VL  - 101
IS  - 1
SP  - 014908
DO  - 10.1103/PhysRevC.101.014908
ER  - 
@article{
author = "Đorđević, Miloš and Milošević, Jovan and Nađđerđ, Laslo and Stojanović, Milan and Wang, F. and Zhu, X.",
year = "2020",
abstract = "Correlations between azimuthal anisotropy Fourier harmonics vn (n=2,3,4) are studied using the events from PbPb collisions at sNN=2.76 TeV generated by the HYDJET++ and multiphase transport (AMPT) models, and compared to the corresponding experimental results obtained by the ATLAS Collaboration. The Fourier harmonics vn are measured over a wide centrality range using the two-particle azimuthal correlation method. The slopes of the v2-v3 correlation from both models are in a good agreement with the ATLAS data. The HYDJET++ model predicts a stronger slope for the v2-v4 and v3-v4 correlations than the ones experimentally measured, while the results from the AMPT model are in a rather good agreement with the experimental results. In contrast to the HYDJET++ predictions, the AMPT model predicts a boomeranglike shape in the structure of the correlations as found in the experimental data. © 2020 American Physical Society.",
journal = "Physical Review C",
title = "Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model",
volume = "101",
number = "1",
pages = "014908",
doi = "10.1103/PhysRevC.101.014908"
}
Đorđević, M., Milošević, J., Nađđerđ, L., Stojanović, M., Wang, F.,& Zhu, X.. (2020). Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model. in Physical Review C, 101(1), 014908.
https://doi.org/10.1103/PhysRevC.101.014908
Đorđević M, Milošević J, Nađđerđ L, Stojanović M, Wang F, Zhu X. Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model. in Physical Review C. 2020;101(1):014908.
doi:10.1103/PhysRevC.101.014908 .
Đorđević, Miloš, Milošević, Jovan, Nađđerđ, Laslo, Stojanović, Milan, Wang, F., Zhu, X., "Correlations between azimuthal anisotropy Fourier harmonics in PbPb collisions at sNN =2.76 TeV in the HYDJET++ model and in the multiphase transport model" in Physical Review C, 101, no. 1 (2020):014908,
https://doi.org/10.1103/PhysRevC.101.014908 . .
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Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA

Sakata, Dousatsu; Belov, Oleg; Bordage, Marie-Claude; Emfietzoglou, Dimitris; Guatelli, Susanna; Inaniwa, Taku; Ivanchenko, Vladimir; Karamitros, Mathieu; Kyriakou, Ioanna; Lampe, Nathanael; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Shin, Wook-Geun; Incerti, Sebastien

(2020)

TY  - JOUR
AU  - Sakata, Dousatsu
AU  - Belov, Oleg
AU  - Bordage, Marie-Claude
AU  - Emfietzoglou, Dimitris
AU  - Guatelli, Susanna
AU  - Inaniwa, Taku
AU  - Ivanchenko, Vladimir
AU  - Karamitros, Mathieu
AU  - Kyriakou, Ioanna
AU  - Lampe, Nathanael
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Shin, Wook-Geun
AU  - Incerti, Sebastien
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9751
AB  - Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation's track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integrated Monte Carlo (MC) simulations across physics, chemistry and biology. Hence, in this work, we have developed an application using the open source Geant4-DNA toolkit to propose a realistic "fully integrated" MC simulation to calculate both early DNA damage and subsequent biological responses with time. We had previously developed an application allowing simulations of radiation induced early DNA damage on a naked cell nucleus model. In the new version presented in this work, we have developed three additional important features: (1) modeling of a realistic cell geometry, (2) inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage and indirect damage scoring. The simulation results are validated with experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell. In addition, the yields of indirect DSBs are compatible with the experimental scavengeable damage fraction. The simulation application also demonstrates agreement with experimental data of gamma -H2AX yields for gamma ray irradiation. Using this application, it is now possible to predict biological response along time through track-structure MC simulations.
T2  - Scientific Reports
T1  - Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA
VL  - 10
IS  - 1
SP  - 20788
DO  - 10.1038/s41598-020-75982-x
ER  - 
@article{
author = "Sakata, Dousatsu and Belov, Oleg and Bordage, Marie-Claude and Emfietzoglou, Dimitris and Guatelli, Susanna and Inaniwa, Taku and Ivanchenko, Vladimir and Karamitros, Mathieu and Kyriakou, Ioanna and Lampe, Nathanael and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Shin, Wook-Geun and Incerti, Sebastien",
year = "2020",
abstract = "Ionising radiation induced DNA damage and subsequent biological responses to it depend on the radiation's track-structure and its energy loss distribution pattern. To investigate the underlying biological mechanisms involved in such complex system, there is need of predicting biological response by integrated Monte Carlo (MC) simulations across physics, chemistry and biology. Hence, in this work, we have developed an application using the open source Geant4-DNA toolkit to propose a realistic "fully integrated" MC simulation to calculate both early DNA damage and subsequent biological responses with time. We had previously developed an application allowing simulations of radiation induced early DNA damage on a naked cell nucleus model. In the new version presented in this work, we have developed three additional important features: (1) modeling of a realistic cell geometry, (2) inclusion of a biological repair model, (3) refinement of DNA damage parameters for direct damage and indirect damage scoring. The simulation results are validated with experimental data in terms of Single Strand Break (SSB) yields for plasmid and Double Strand Break (DSB) yields for plasmid/human cell. In addition, the yields of indirect DSBs are compatible with the experimental scavengeable damage fraction. The simulation application also demonstrates agreement with experimental data of gamma -H2AX yields for gamma ray irradiation. Using this application, it is now possible to predict biological response along time through track-structure MC simulations.",
journal = "Scientific Reports",
title = "Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA",
volume = "10",
number = "1",
pages = "20788",
doi = "10.1038/s41598-020-75982-x"
}
Sakata, D., Belov, O., Bordage, M., Emfietzoglou, D., Guatelli, S., Inaniwa, T., Ivanchenko, V., Karamitros, M., Kyriakou, I., Lampe, N., Petrović, I. M., Ristić-Fira, A., Shin, W.,& Incerti, S.. (2020). Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA. in Scientific Reports, 10(1), 20788.
https://doi.org/10.1038/s41598-020-75982-x
Sakata D, Belov O, Bordage M, Emfietzoglou D, Guatelli S, Inaniwa T, Ivanchenko V, Karamitros M, Kyriakou I, Lampe N, Petrović IM, Ristić-Fira A, Shin W, Incerti S. Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA. in Scientific Reports. 2020;10(1):20788.
doi:10.1038/s41598-020-75982-x .
Sakata, Dousatsu, Belov, Oleg, Bordage, Marie-Claude, Emfietzoglou, Dimitris, Guatelli, Susanna, Inaniwa, Taku, Ivanchenko, Vladimir, Karamitros, Mathieu, Kyriakou, Ioanna, Lampe, Nathanael, Petrović, Ivan M., Ristić-Fira, Aleksandra, Shin, Wook-Geun, Incerti, Sebastien, "Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA" in Scientific Reports, 10, no. 1 (2020):20788,
https://doi.org/10.1038/s41598-020-75982-x . .
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Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines

Keta, Otilija D.; Deljanin, Milena; Petković, Vladana; Zdunić, Gordana; Janković, Teodora; Živković, Jelena; Ristić-Fira, Aleksandra; Petrović, Ivan M.; Šavikin, Katarina

(2020)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Deljanin, Milena
AU  - Petković, Vladana
AU  - Zdunić, Gordana
AU  - Janković, Teodora
AU  - Živković, Jelena
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
AU  - Šavikin, Katarina
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8996
AB  - The aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.
T2  - Records of Natural Products
T1  - Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines
VL  - 14
IS  - 5
SP  - 326
EP  - 339
DO  - 10.25135/rnp.170.19.11.1477
ER  - 
@article{
author = "Keta, Otilija D. and Deljanin, Milena and Petković, Vladana and Zdunić, Gordana and Janković, Teodora and Živković, Jelena and Ristić-Fira, Aleksandra and Petrović, Ivan M. and Šavikin, Katarina",
year = "2020",
abstract = "The aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.",
journal = "Records of Natural Products",
title = "Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines",
volume = "14",
number = "5",
pages = "326-339",
doi = "10.25135/rnp.170.19.11.1477"
}
Keta, O. D., Deljanin, M., Petković, V., Zdunić, G., Janković, T., Živković, J., Ristić-Fira, A., Petrović, I. M.,& Šavikin, K.. (2020). Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines. in Records of Natural Products, 14(5), 326-339.
https://doi.org/10.25135/rnp.170.19.11.1477
Keta OD, Deljanin M, Petković V, Zdunić G, Janković T, Živković J, Ristić-Fira A, Petrović IM, Šavikin K. Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines. in Records of Natural Products. 2020;14(5):326-339.
doi:10.25135/rnp.170.19.11.1477 .
Keta, Otilija D., Deljanin, Milena, Petković, Vladana, Zdunić, Gordana, Janković, Teodora, Živković, Jelena, Ristić-Fira, Aleksandra, Petrović, Ivan M., Šavikin, Katarina, "Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines" in Records of Natural Products, 14, no. 5 (2020):326-339,
https://doi.org/10.25135/rnp.170.19.11.1477 . .
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Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model

Ćirković, Predrag; Milošević, Jovan; Nađđerđ, Laslo; Wang, Fuqiang; Zhu, Xiangrong

(2020)

TY  - JOUR
AU  - Ćirković, Predrag
AU  - Milošević, Jovan
AU  - Nađđerđ, Laslo
AU  - Wang, Fuqiang
AU  - Zhu, Xiangrong
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8928
AB  - The elliptic flow (v(2)) event-by-event fluctuations in PbPb collisions at 5.02 TeV are analyzed within the HYDJET + + model. Using the multiparticle, so-called Q-cumulant method, v(2){2}, v(2){4}, v(2){6}, and v(2){8} are calculated and used to study their ratios and to construct skewness (gamma(exp)(1)) as a measure of the asymmetry of the elliptic flow distribution. Additionally, in order to check if there is a hydrodynamics nature in the elliptic collectivity generated by the HYDJET + + model, the ratio of v(2){6} - v(2){8} and v(2){4} - v(2){6} distributions is calculated. The analysis is performed as a function of the collision centrality. In order to check the HYDJET + + model responses, the results of this analysis are compared to the corresponding experimental measurements from the ALICE, ATLAS, and CMS experiments. A rather good qualitative agreement is found.
T2  - Physical Review C
T1  - Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model
VL  - 101
IS  - 3
SP  - 034907
DO  - 10.1103/PhysRevC.101.034907
ER  - 
@article{
author = "Ćirković, Predrag and Milošević, Jovan and Nađđerđ, Laslo and Wang, Fuqiang and Zhu, Xiangrong",
year = "2020",
abstract = "The elliptic flow (v(2)) event-by-event fluctuations in PbPb collisions at 5.02 TeV are analyzed within the HYDJET + + model. Using the multiparticle, so-called Q-cumulant method, v(2){2}, v(2){4}, v(2){6}, and v(2){8} are calculated and used to study their ratios and to construct skewness (gamma(exp)(1)) as a measure of the asymmetry of the elliptic flow distribution. Additionally, in order to check if there is a hydrodynamics nature in the elliptic collectivity generated by the HYDJET + + model, the ratio of v(2){6} - v(2){8} and v(2){4} - v(2){6} distributions is calculated. The analysis is performed as a function of the collision centrality. In order to check the HYDJET + + model responses, the results of this analysis are compared to the corresponding experimental measurements from the ALICE, ATLAS, and CMS experiments. A rather good qualitative agreement is found.",
journal = "Physical Review C",
title = "Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model",
volume = "101",
number = "3",
pages = "034907",
doi = "10.1103/PhysRevC.101.034907"
}
Ćirković, P., Milošević, J., Nađđerđ, L., Wang, F.,& Zhu, X.. (2020). Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model. in Physical Review C, 101(3), 034907.
https://doi.org/10.1103/PhysRevC.101.034907
Ćirković P, Milošević J, Nađđerđ L, Wang F, Zhu X. Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model. in Physical Review C. 2020;101(3):034907.
doi:10.1103/PhysRevC.101.034907 .
Ćirković, Predrag, Milošević, Jovan, Nađđerđ, Laslo, Wang, Fuqiang, Zhu, Xiangrong, "Skewness of the elliptic flow distribution in sNN =5.02 TeV PbPb collisions from the HYDJET++ model" in Physical Review C, 101, no. 3 (2020):034907,
https://doi.org/10.1103/PhysRevC.101.034907 . .
1

Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers

Petković, Vladana; Keta, Otilija D.; Vidosavljević, Marija Z.; Incerti, Sebastien; Ristić-Fira, Aleksandra; Petrović, Ivan M.

(2019)

TY  - JOUR
AU  - Petković, Vladana
AU  - Keta, Otilija D.
AU  - Vidosavljević, Marija Z.
AU  - Incerti, Sebastien
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8414
AB  - Purpose: Investigation of effects on DNA of γ-irradiated human cancer cells pretreated with free radical scavengers is aimed to create reference data which would enable assessment of the relative efficiency of high linear energy transfer (LET) radiations used in hadron therapy, i.e. protons and carbon ions. Materials and methods: MCF-7 breast and HTB177 lung cancer cells are irradiated with γ-rays. To minimize indirect effects of irradiation, dimethyl sulfoxide (DMSO) or glycerol are applied as free radical scavengers. Biological response to irradiation is evaluated through clonogenic cell survival, immunocytochemical and cell cycle analysis, as well as expression of proteins involved in DNA damage response. Results: Examined cell lines reveal similar level of radioresistance. Application of scavengers leads to the rise of cell survival and decreases the number of DNA double strand breaks in irradiated cells. Differences in cell cycle and protein expression between the two cell lines are probably caused by different DNA damage repair mechanisms that are activated. Conclusion: The obtained results show that DMSO and glycerol have good scavenging capacity, and may be used to minimize DNA damage induced by free radicals. Therefore, they will be used as the reference for comparison with high LET irradiations, as well as good experimental data suitable for validation of numerical simulations. © 2019, © 2019 Taylor & Francis Group, LLC.
T2  - International Journal of Radiation Biology
T1  - Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers
VL  - 95
IS  - 3
SP  - 274
EP  - 285
DO  - 10.1080/09553002.2019.1549753
ER  - 
@article{
author = "Petković, Vladana and Keta, Otilija D. and Vidosavljević, Marija Z. and Incerti, Sebastien and Ristić-Fira, Aleksandra and Petrović, Ivan M.",
year = "2019",
abstract = "Purpose: Investigation of effects on DNA of γ-irradiated human cancer cells pretreated with free radical scavengers is aimed to create reference data which would enable assessment of the relative efficiency of high linear energy transfer (LET) radiations used in hadron therapy, i.e. protons and carbon ions. Materials and methods: MCF-7 breast and HTB177 lung cancer cells are irradiated with γ-rays. To minimize indirect effects of irradiation, dimethyl sulfoxide (DMSO) or glycerol are applied as free radical scavengers. Biological response to irradiation is evaluated through clonogenic cell survival, immunocytochemical and cell cycle analysis, as well as expression of proteins involved in DNA damage response. Results: Examined cell lines reveal similar level of radioresistance. Application of scavengers leads to the rise of cell survival and decreases the number of DNA double strand breaks in irradiated cells. Differences in cell cycle and protein expression between the two cell lines are probably caused by different DNA damage repair mechanisms that are activated. Conclusion: The obtained results show that DMSO and glycerol have good scavenging capacity, and may be used to minimize DNA damage induced by free radicals. Therefore, they will be used as the reference for comparison with high LET irradiations, as well as good experimental data suitable for validation of numerical simulations. © 2019, © 2019 Taylor & Francis Group, LLC.",
journal = "International Journal of Radiation Biology",
title = "Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers",
volume = "95",
number = "3",
pages = "274-285",
doi = "10.1080/09553002.2019.1549753"
}
Petković, V., Keta, O. D., Vidosavljević, M. Z., Incerti, S., Ristić-Fira, A.,& Petrović, I. M.. (2019). Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. in International Journal of Radiation Biology, 95(3), 274-285.
https://doi.org/10.1080/09553002.2019.1549753
Petković V, Keta OD, Vidosavljević MZ, Incerti S, Ristić-Fira A, Petrović IM. Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. in International Journal of Radiation Biology. 2019;95(3):274-285.
doi:10.1080/09553002.2019.1549753 .
Petković, Vladana, Keta, Otilija D., Vidosavljević, Marija Z., Incerti, Sebastien, Ristić-Fira, Aleksandra, Petrović, Ivan M., "Biological outcomes of γ-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers" in International Journal of Radiation Biology, 95, no. 3 (2019):274-285,
https://doi.org/10.1080/09553002.2019.1549753 . .
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Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans

Žunić, Zora S.; Mishra, Rosaline; Čeliković, Igor T.; Stojanovska, Zdenka A.; Yarmoshenko, Ilia V.; Malinovsky, Georgy; Veselinović, Nenad; Gulan, Ljiljana; Ćurguz, Zoran; Vaupotič, Janja; Ujic, Predrag; Kolarž, Predrag M.; Milić, Gordana; Kovacs, Tibor; Sapra, Balvindar K.; Kavasi, Norbert; Sahoo, Sarata Kumar

(2019)

TY  - JOUR
AU  - Žunić, Zora S.
AU  - Mishra, Rosaline
AU  - Čeliković, Igor T.
AU  - Stojanovska, Zdenka A.
AU  - Yarmoshenko, Ilia V.
AU  - Malinovsky, Georgy
AU  - Veselinović, Nenad
AU  - Gulan, Ljiljana
AU  - Ćurguz, Zoran
AU  - Vaupotič, Janja
AU  - Ujic, Predrag
AU  - Kolarž, Predrag M.
AU  - Milić, Gordana
AU  - Kovacs, Tibor
AU  - Sapra, Balvindar K.
AU  - Kavasi, Norbert
AU  - Sahoo, Sarata Kumar
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8481
AB  - The main contribution to population exposure is due to radon and thoron progenies and not radon itself. The aim of this study was therefore to estimate annual effective dose using the results of Direct Radon and Thoron Progeny Sensors were exposed in 69 selected schools and 319 dwellings in several regions of Balkans: in Serbia: regions of Sokobanja and Kosovo and Metohija, Republic of Macedonia, Republic of Srpska and Slovenia. Obtained average total effective doses are in the range from 0.22 mSv a-1 (schools in Republic of Srpska) to 2.5 mSv a-1 (dwellings in Kosovo) and are below the reference level of 10 mSv a-1 recommended by International Commission on Radiological Protection. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
T2  - Radiation Protection Dosimetry
T1  - Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans
VL  - 185
IS  - 3
SP  - 387
EP  - 390
DO  - 10.1093/rpd/ncz025
ER  - 
@article{
author = "Žunić, Zora S. and Mishra, Rosaline and Čeliković, Igor T. and Stojanovska, Zdenka A. and Yarmoshenko, Ilia V. and Malinovsky, Georgy and Veselinović, Nenad and Gulan, Ljiljana and Ćurguz, Zoran and Vaupotič, Janja and Ujic, Predrag and Kolarž, Predrag M. and Milić, Gordana and Kovacs, Tibor and Sapra, Balvindar K. and Kavasi, Norbert and Sahoo, Sarata Kumar",
year = "2019",
abstract = "The main contribution to population exposure is due to radon and thoron progenies and not radon itself. The aim of this study was therefore to estimate annual effective dose using the results of Direct Radon and Thoron Progeny Sensors were exposed in 69 selected schools and 319 dwellings in several regions of Balkans: in Serbia: regions of Sokobanja and Kosovo and Metohija, Republic of Macedonia, Republic of Srpska and Slovenia. Obtained average total effective doses are in the range from 0.22 mSv a-1 (schools in Republic of Srpska) to 2.5 mSv a-1 (dwellings in Kosovo) and are below the reference level of 10 mSv a-1 recommended by International Commission on Radiological Protection. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
journal = "Radiation Protection Dosimetry",
title = "Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans",
volume = "185",
number = "3",
pages = "387-390",
doi = "10.1093/rpd/ncz025"
}
Žunić, Z. S., Mishra, R., Čeliković, I. T., Stojanovska, Z. A., Yarmoshenko, I. V., Malinovsky, G., Veselinović, N., Gulan, L., Ćurguz, Z., Vaupotič, J., Ujic, P., Kolarž, P. M., Milić, G., Kovacs, T., Sapra, B. K., Kavasi, N.,& Sahoo, S. K.. (2019). Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans. in Radiation Protection Dosimetry, 185(3), 387-390.
https://doi.org/10.1093/rpd/ncz025
Žunić ZS, Mishra R, Čeliković IT, Stojanovska ZA, Yarmoshenko IV, Malinovsky G, Veselinović N, Gulan L, Ćurguz Z, Vaupotič J, Ujic P, Kolarž PM, Milić G, Kovacs T, Sapra BK, Kavasi N, Sahoo SK. Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans. in Radiation Protection Dosimetry. 2019;185(3):387-390.
doi:10.1093/rpd/ncz025 .
Žunić, Zora S., Mishra, Rosaline, Čeliković, Igor T., Stojanovska, Zdenka A., Yarmoshenko, Ilia V., Malinovsky, Georgy, Veselinović, Nenad, Gulan, Ljiljana, Ćurguz, Zoran, Vaupotič, Janja, Ujic, Predrag, Kolarž, Predrag M., Milić, Gordana, Kovacs, Tibor, Sapra, Balvindar K., Kavasi, Norbert, Sahoo, Sarata Kumar, "Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans" in Radiation Protection Dosimetry, 185, no. 3 (2019):387-390,
https://doi.org/10.1093/rpd/ncz025 . .
2
2
1

Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS

Devetak, Damir

(Универзитет у Београду, Физички факултет, 2018)

TY  - THES
AU  - Devetak, Damir
PY  - 2018
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=6039
UR  - http://nardus.mpn.gov.rs/handle/123456789/10110
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:18359/bdef:Content/download
UR  - https://plus.sr.cobiss.net/opac7/bib/50048015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8728
AB  - У овоj тези представљена jе систематска анализа нарушења факторизациjе дугодометних азимуталних дво-честичних корелациjа у производ jедно-честичних анизотропиjа, као функциjа трансверзалног импулса (pT) и псеудорапидитета (η) за обечестице, и као функциjа мултиплицитета у PbPb и pPb сударима. За анализу сукоришћени подаци PbPb и pPb судара прикупљени на CMS експерименту при енергиjи центра масе 2.76 TeV и 5.02 TeV. Поред експерименталних података у анализи су коришћени PbPb подаци генерисани HYDJET++ моделом при истоj енергиjи центра масе 2.76 TeV. Експериментални резултати су упоређени са предвиђањима релативистичких хидродинамичких модела за различите вредности количника вискозности и ентропиjе η/sи различите почетне геометриjе судара. Резултати показуjу да се факторизациjа нарушава и заpTи заη, са израженом зависношћу одцентралности и мултиплицитета судара. Као функциjа pT, интензитет нарушења факторизациjе за други Fourier-ов хармоник достиже 20% за веома централне PbPb сударе, и драматично пада при смањивању мултиплицитета. Ови резултати су сагласни са предвиђањима релативистичке вискозне хидродинамике, коjа показуjе даjе ефекат нарушења факторизациjе првенствено повезан са флуктуациjама почетних стања унутар судараjућих jезгара. Као функциjа η, ефекат jе наjслабиjи за семи-централне PbPb сударе, али постаjе jачи за централниjе и периферниjе судара, као и за pPb сударе за догађаjе са високим мултиплицитетом. Интензитет нарушења факторизациjе jе квантификован Pearson-овим корелационим кеофициjентом rn, као функциjом дво-честичних Fourier хармоника рачунатих стандардном методом дво-честичних корелациjа. По први пут jе коришћена анализа главних компоненти за издваjање различитих ортогоналних модова дво-честичних Fourier хармоника, коjи представљаjу нове опсервабле директно повезане са ефектом нарушења факторизациjе. Прва два мода дво-честичних корелациjа, тзв. "водећи ток" и "подток",рачунати су за елиптичке и триангуларне анизотропиjе у PbPb и pPb сударима у функциjи pT за различите централности и мултиплицитете. Резултати показуjу да jе водећи ток практично еквивалентан анизотропном Fourier хармонику претходно добиjеним стандардном методом дво-честичних корелациjа. Подток представља нову експерименталну опсерваблу и наjвише доприноси интензитету нарушења факторизациjе за високе вредности трансверзалног импулса. Веза између ових резултата и претходних резултата нарушења факторизациjе jе дискутована. Елиптички и триангуларни модови рачунати су и са подацима генерисаним подацима HYDJET++ и показуjу слично понашање као експериментални подаци. Анализа главних компоненти jе такође примењена за флуктуациjе мултиплицитета, за PbPb сударе, где jе исто видљив други мод. Сви добиjени резултати се могу обjаснити флуктуациjама почетних стања коjе су пресудне за моделовање релативистичких судара тешких jезгара.
AB  - In this thesis systematic studies on factorization breaking of long-range azimuthal two-particle correlations into a product of single-particle anisotropies are presented, as a function of transverse momentum (pT) and pseudorapidity (η) of both particles, and as a function of the particle multiplicity in PbPb and pPb collisions. Data used in this thesis are collected on the CMS experiment for PbPb and pPb collisions at center-of-mass energy of 2.76 TeV and 5.02 TeV, respectively.  Furthermore, a heavy ion event generator HYDJET++ was used to generate data for PbPb collisions, at thesame center-of-mass energy 2.76 TeV, in order to compare with real experimental data. Results are compared with relativistic hydrodynamical predictions for different ratio values of viscosity and entropy η/s and different initial-state geometry conditions. The results show that factorization is broken for both the pT and η, with strong collision centrality and multiplicity dependence. As a function of pT, the magnitude of the factorization breakdown for the second Fourier harmonic reaches 20% for very central PbPb collisions but decreases rapidly as the multiplicity decreases. These results are consistent with relativistic viscous hydrodynamic calculations, which suggest that the effect of factorization breaking is primarily sensitive to the initial-state fluctuations present in the nuclei. As a function ofη, the effect is found to be weakest for mid-central PbPb events but becomes larger for more central or peripheral PbPb collisions, and also for very high-multiplicity pPb collisions. The magnitude of factorization breaking is quantified by the Pearson correlation coefficient rn, as a function of two-particle Fourier harmonics calculated using the standard two-particle correlation method. For the first time a principal-component analysis is used to separate out different orthogonal modes of the two-particle Fourier harmonics, which represent new observables brought in direct connection with the effect of factorization breaking. The first two modes (called "leading" and "subleading" flow) of two-particle correlations are presented for elliptical and triangular anisotropies in PbPb and pPb collisions as a function of pT for different centrality and multiplicity ranges. The leading mode is found to be essentially equivalent to the anisotropy Fourier harmonic previously extracted from the standard two-particle correlation method. The subleading mode represents a new experimental observable and is shown to account for a large fraction of the factorization breaking observed at high transverse momentum. The connection of these new results to previous studies of factorization is also presented. For comparison reasons, elliptical and triangular mode calculations are also conducted for the HYDJET++ generated data. The HYDJET++ results show similar behaviour similar to the one seen in the real data. The principal-component analysis technique has also been applied to multiplicity fluctuations, for PbPb collisions, where a subleading mode is also seen. All obtained results can be understood in frames of initial-state fluctuations which are essential in modeling relativistic heavy ion collisions.
PB  - Универзитет у Београду, Физички факултет
T2  - Универзитет у Београду
T1  - Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS
ER  - 
@phdthesis{
author = "Devetak, Damir",
year = "2018",
abstract = "У овоj тези представљена jе систематска анализа нарушења факторизациjе дугодометних азимуталних дво-честичних корелациjа у производ jедно-честичних анизотропиjа, као функциjа трансверзалног импулса (pT) и псеудорапидитета (η) за обечестице, и као функциjа мултиплицитета у PbPb и pPb сударима. За анализу сукоришћени подаци PbPb и pPb судара прикупљени на CMS експерименту при енергиjи центра масе 2.76 TeV и 5.02 TeV. Поред експерименталних података у анализи су коришћени PbPb подаци генерисани HYDJET++ моделом при истоj енергиjи центра масе 2.76 TeV. Експериментални резултати су упоређени са предвиђањима релативистичких хидродинамичких модела за различите вредности количника вискозности и ентропиjе η/sи различите почетне геометриjе судара. Резултати показуjу да се факторизациjа нарушава и заpTи заη, са израженом зависношћу одцентралности и мултиплицитета судара. Као функциjа pT, интензитет нарушења факторизациjе за други Fourier-ов хармоник достиже 20% за веома централне PbPb сударе, и драматично пада при смањивању мултиплицитета. Ови резултати су сагласни са предвиђањима релативистичке вискозне хидродинамике, коjа показуjе даjе ефекат нарушења факторизациjе првенствено повезан са флуктуациjама почетних стања унутар судараjућих jезгара. Као функциjа η, ефекат jе наjслабиjи за семи-централне PbPb сударе, али постаjе jачи за централниjе и периферниjе судара, као и за pPb сударе за догађаjе са високим мултиплицитетом. Интензитет нарушења факторизациjе jе квантификован Pearson-овим корелационим кеофициjентом rn, као функциjом дво-честичних Fourier хармоника рачунатих стандардном методом дво-честичних корелациjа. По први пут jе коришћена анализа главних компоненти за издваjање различитих ортогоналних модова дво-честичних Fourier хармоника, коjи представљаjу нове опсервабле директно повезане са ефектом нарушења факторизациjе. Прва два мода дво-честичних корелациjа, тзв. "водећи ток" и "подток",рачунати су за елиптичке и триангуларне анизотропиjе у PbPb и pPb сударима у функциjи pT за различите централности и мултиплицитете. Резултати показуjу да jе водећи ток практично еквивалентан анизотропном Fourier хармонику претходно добиjеним стандардном методом дво-честичних корелациjа. Подток представља нову експерименталну опсерваблу и наjвише доприноси интензитету нарушења факторизациjе за високе вредности трансверзалног импулса. Веза између ових резултата и претходних резултата нарушења факторизациjе jе дискутована. Елиптички и триангуларни модови рачунати су и са подацима генерисаним подацима HYDJET++ и показуjу слично понашање као експериментални подаци. Анализа главних компоненти jе такође примењена за флуктуациjе мултиплицитета, за PbPb сударе, где jе исто видљив други мод. Сви добиjени резултати се могу обjаснити флуктуациjама почетних стања коjе су пресудне за моделовање релативистичких судара тешких jезгара., In this thesis systematic studies on factorization breaking of long-range azimuthal two-particle correlations into a product of single-particle anisotropies are presented, as a function of transverse momentum (pT) and pseudorapidity (η) of both particles, and as a function of the particle multiplicity in PbPb and pPb collisions. Data used in this thesis are collected on the CMS experiment for PbPb and pPb collisions at center-of-mass energy of 2.76 TeV and 5.02 TeV, respectively.  Furthermore, a heavy ion event generator HYDJET++ was used to generate data for PbPb collisions, at thesame center-of-mass energy 2.76 TeV, in order to compare with real experimental data. Results are compared with relativistic hydrodynamical predictions for different ratio values of viscosity and entropy η/s and different initial-state geometry conditions. The results show that factorization is broken for both the pT and η, with strong collision centrality and multiplicity dependence. As a function of pT, the magnitude of the factorization breakdown for the second Fourier harmonic reaches 20% for very central PbPb collisions but decreases rapidly as the multiplicity decreases. These results are consistent with relativistic viscous hydrodynamic calculations, which suggest that the effect of factorization breaking is primarily sensitive to the initial-state fluctuations present in the nuclei. As a function ofη, the effect is found to be weakest for mid-central PbPb events but becomes larger for more central or peripheral PbPb collisions, and also for very high-multiplicity pPb collisions. The magnitude of factorization breaking is quantified by the Pearson correlation coefficient rn, as a function of two-particle Fourier harmonics calculated using the standard two-particle correlation method. For the first time a principal-component analysis is used to separate out different orthogonal modes of the two-particle Fourier harmonics, which represent new observables brought in direct connection with the effect of factorization breaking. The first two modes (called "leading" and "subleading" flow) of two-particle correlations are presented for elliptical and triangular anisotropies in PbPb and pPb collisions as a function of pT for different centrality and multiplicity ranges. The leading mode is found to be essentially equivalent to the anisotropy Fourier harmonic previously extracted from the standard two-particle correlation method. The subleading mode represents a new experimental observable and is shown to account for a large fraction of the factorization breaking observed at high transverse momentum. The connection of these new results to previous studies of factorization is also presented. For comparison reasons, elliptical and triangular mode calculations are also conducted for the HYDJET++ generated data. The HYDJET++ results show similar behaviour similar to the one seen in the real data. The principal-component analysis technique has also been applied to multiplicity fluctuations, for PbPb collisions, where a subleading mode is also seen. All obtained results can be understood in frames of initial-state fluctuations which are essential in modeling relativistic heavy ion collisions.",
publisher = "Универзитет у Београду, Физички факултет",
journal = "Универзитет у Београду",
title = "Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS"
}
Devetak, D.. (2018). Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS. in Универзитет у Београду
Универзитет у Београду, Физички факултет..
Devetak D. Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS. in Универзитет у Београду. 2018;..
Devetak, Damir, "Ефекти флуктуација почетних стања у сударима PbPb и pPb у експерим,енту CMS" in Универзитет у Београду (2018).

Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions

Keta, Otilija D.; Todorović, Danijela V.; Bulat, Tanja M.; Cirrone, Giuseppe Antonio Pablo; Romano, Francesco; Cuttone, Giacomo; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(2017)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Bulat, Tanja M.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1573
AB  - The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.
T2  - Experimental Biology and Medicine
T1  - Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions
VL  - 242
IS  - 10
SP  - 1015
EP  - 1024
DO  - 10.1177/1535370216669611
ER  - 
@article{
author = "Keta, Otilija D. and Todorović, Danijela V. and Bulat, Tanja M. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2017",
abstract = "The aim of this study was to investigate effects of irradiations with the therapeutic proton and carbon ion beams in two non-small cell lung cancers, CRL5876 adenocarcinoma and HTB177 large cell lung carcinoma. The DNA damage response dynamics, cell cycle regulation, and cell death pathway activation were followed. Viability of both cell lines was lower after carbon ions compared to the therapeutic proton irradiations. HTB177 cells showed higher recovery than CRL5876 cells seven days following the treatments, but the survival rates of both cell lines were lower after exposure to carbon ions with respect to therapeutic protons. When analyzing cell cycle distribution of both CRL5876 and HTB177 cells, it was noticed that therapeutic protons predominantly induced G1 arrest, while the cells after carbon ions were arrested in G2/M phase. The results illustrated that differences in the levels of phosphorylated H2AX, a double-strand break marker, exist after therapeutic proton and carbon ion irradiations. We also observed dose- and time-dependent increase in the p53 and p21 levels after applied irradiations. Carbon ions caused larger increase in the quantity of p53 and p21 compared to therapeutic protons. These results suggested that various repair mechanisms were induced in the treated cells. Considering the fact that we have not observed any distinct change in the Bax/Bcl-2 ratio following irradiations, it seemed that different types of cell death were involved in the response to the two types of irradiations that were applied.",
journal = "Experimental Biology and Medicine",
title = "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions",
volume = "242",
number = "10",
pages = "1015-1024",
doi = "10.1177/1535370216669611"
}
Keta, O. D., Todorović, D. V., Bulat, T. M., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2017). Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine, 242(10), 1015-1024.
https://doi.org/10.1177/1535370216669611
Keta OD, Todorović DV, Bulat TM, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions. in Experimental Biology and Medicine. 2017;242(10):1015-1024.
doi:10.1177/1535370216669611 .
Keta, Otilija D., Todorović, Danijela V., Bulat, Tanja M., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Comparison of human lung cancer cell radiosensitivity after irradiations with therapeutic protons and carbon ions" in Experimental Biology and Medicine, 242, no. 10 (2017):1015-1024,
https://doi.org/10.1177/1535370216669611 . .
10
10
9

Anisotropy in pPb and PbPb collisions from CMS

Milošević, Jovan

(2017)

TY  - CONF
AU  - Milošević, Jovan
PY  - 2017
UR  - http://www.worldscientific.com/doi/abs/10.1142/9789813224568_0070
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7724
AB  - The recent CMS results on anisotropic particle emission will be presented. A multi-particle nature of the long-range correlations observed in pPb collisions is revealed through consistency between the results obtained using four-, six and eight-particle correlation as well as the Lee-Yang zero method. The magnitude of the elliptic and triangular flow of strange particles from both pPb and PbPb collisions have been extracted by correlating an identified strange hadron (KS0 or Λ/Λ)with a charged particle separated by a large relative pseudorapidity. The results for strange, KS0 and Λ/Λ,particles scaled by the number of constituent quarks plotted as a function of transverse kinetic energy per number of constituent quarks are in a rather good mutual agreement for both v2and v3over a wide range of particle transverse kinetic energy and event multiplicities. The initial-state fluctuations induce that the event-plane angle is not any more a global quantity but depends on both, transverse momenta (pT) and pseudorapidity (η), which further induces the factorization breaking of the two-particle azimuthal anisotropy into a product of single-particle anisotropies. In the pTdirection, maximal effect of factorization breaking of about 20% is observed in ultra-central PbPb collisions. In the η direction, the effect is weakest for mid-central PbPb events and gets larger for more central or peripheral PbPb collisions as well as for high multiplicity pPb collisions. The experimental results are compared with recent hydrodynamic predictions which involve the factorization breakdown effect. The effect is sensitive to the initial-state conditions rather than the shear viscosity of the medium.
C3  - Particle Physics at the Year of Light
T1  - Anisotropy in pPb and PbPb collisions from CMS
IS  - 211889
SP  - 420
EP  - 427
DO  - 10.1142/9789813224568_0070
ER  - 
@conference{
author = "Milošević, Jovan",
year = "2017",
abstract = "The recent CMS results on anisotropic particle emission will be presented. A multi-particle nature of the long-range correlations observed in pPb collisions is revealed through consistency between the results obtained using four-, six and eight-particle correlation as well as the Lee-Yang zero method. The magnitude of the elliptic and triangular flow of strange particles from both pPb and PbPb collisions have been extracted by correlating an identified strange hadron (KS0 or Λ/Λ)with a charged particle separated by a large relative pseudorapidity. The results for strange, KS0 and Λ/Λ,particles scaled by the number of constituent quarks plotted as a function of transverse kinetic energy per number of constituent quarks are in a rather good mutual agreement for both v2and v3over a wide range of particle transverse kinetic energy and event multiplicities. The initial-state fluctuations induce that the event-plane angle is not any more a global quantity but depends on both, transverse momenta (pT) and pseudorapidity (η), which further induces the factorization breaking of the two-particle azimuthal anisotropy into a product of single-particle anisotropies. In the pTdirection, maximal effect of factorization breaking of about 20% is observed in ultra-central PbPb collisions. In the η direction, the effect is weakest for mid-central PbPb events and gets larger for more central or peripheral PbPb collisions as well as for high multiplicity pPb collisions. The experimental results are compared with recent hydrodynamic predictions which involve the factorization breakdown effect. The effect is sensitive to the initial-state conditions rather than the shear viscosity of the medium.",
journal = "Particle Physics at the Year of Light",
title = "Anisotropy in pPb and PbPb collisions from CMS",
number = "211889",
pages = "420-427",
doi = "10.1142/9789813224568_0070"
}
Milošević, J.. (2017). Anisotropy in pPb and PbPb collisions from CMS. in Particle Physics at the Year of Light(211889), 420-427.
https://doi.org/10.1142/9789813224568_0070
Milošević J. Anisotropy in pPb and PbPb collisions from CMS. in Particle Physics at the Year of Light. 2017;(211889):420-427.
doi:10.1142/9789813224568_0070 .
Milošević, Jovan, "Anisotropy in pPb and PbPb collisions from CMS" in Particle Physics at the Year of Light, no. 211889 (2017):420-427,
https://doi.org/10.1142/9789813224568_0070 . .

Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV

Adamova, D.; Agakichiev, G.; Andronic, A.; Antonczyk, D.; Appelshaeuser, H.; Belaga, V.; Bielcikova, J.; Braun-Munzinger, P.; Busch, O.; Cherlin, A.; Damjanović, Svetozar S.; Dietel, T.; Dietrich, L.; Drees, A.; Dubitzky, W.; Esumi, S. I.; Filimonov, K.; Fomenko, K.; Fraenkel, Z.; Garabatos, C.; Glaessel, P.; Hering, G.; Holeczek, J.; Kalisky, M.; Karpenko, Iu.; Krobath, G.; Kushpil, V.; Maas, A.; Marin, A.; Milošević, Jovan; Miskowiec, D.; Panebrattsev, Y.; Petchenova, O.; Petracek, V.; Radomski, S.; Rak, J.; Ravinovich, I.; Rehak, P.; Sako, H.; Schmitz, W.; Schuchmann, S.; Sedykh, S.; Shimansky, S.; Stachel, J.; Sumbera, M.; Tilsner, H.; Tserruya, I.; Tsiledakis, G.; Wessels, J. P.; Wienold, T.; Wurm, J. P.; Yurevich, S.; Yurevich, V.

(2017)

TY  - JOUR
AU  - Adamova, D.
AU  - Agakichiev, G.
AU  - Andronic, A.
AU  - Antonczyk, D.
AU  - Appelshaeuser, H.
AU  - Belaga, V.
AU  - Bielcikova, J.
AU  - Braun-Munzinger, P.
AU  - Busch, O.
AU  - Cherlin, A.
AU  - Damjanović, Svetozar S.
AU  - Dietel, T.
AU  - Dietrich, L.
AU  - Drees, A.
AU  - Dubitzky, W.
AU  - Esumi, S. I.
AU  - Filimonov, K.
AU  - Fomenko, K.
AU  - Fraenkel, Z.
AU  - Garabatos, C.
AU  - Glaessel, P.
AU  - Hering, G.
AU  - Holeczek, J.
AU  - Kalisky, M.
AU  - Karpenko, Iu.
AU  - Krobath, G.
AU  - Kushpil, V.
AU  - Maas, A.
AU  - Marin, A.
AU  - Milošević, Jovan
AU  - Miskowiec, D.
AU  - Panebrattsev, Y.
AU  - Petchenova, O.
AU  - Petracek, V.
AU  - Radomski, S.
AU  - Rak, J.
AU  - Ravinovich, I.
AU  - Rehak, P.
AU  - Sako, H.
AU  - Schmitz, W.
AU  - Schuchmann, S.
AU  - Sedykh, S.
AU  - Shimansky, S.
AU  - Stachel, J.
AU  - Sumbera, M.
AU  - Tilsner, H.
AU  - Tserruya, I.
AU  - Tsiledakis, G.
AU  - Wessels, J. P.
AU  - Wienold, T.
AU  - Wurm, J. P.
AU  - Yurevich, S.
AU  - Yurevich, V.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1368
AB  - Differential triangular flow, v(3)(p(T)), of negative pions is measured at root s(NN) = 17.3 GeV around midrapidity by the CERES/NA45 experiment at CERN in central PbAu collisions in the range 0-30% with a mean centrality of 5.5%. This is the first measurement as a function of transverse momentum of the triangular flow at SPS energies. The p(T) range extends from about 0.05 GeV/c to more than 2 GeV/c. The triangular flow magnitude, corrected for the HBT effects, is smaller by a factor of about 2 than the one measured by the PHENIX experiment at RHIC and the ALICE experiment at the LHC. Within the analyzed range of central collisions no significant centrality dependence is observed. The data are found to be well described by a viscous hydrodynamic calculation combined with an UrQMD cascade model for the late stages. (C) 2016 Elsevier B.V. All rights reserved.
T2  - Nuclear Physics A
T1  - Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV
VL  - 957
SP  - 99
EP  - 108
DO  - 10.1016/j.nuclphysa.2016.08.002
ER  - 
@article{
author = "Adamova, D. and Agakichiev, G. and Andronic, A. and Antonczyk, D. and Appelshaeuser, H. and Belaga, V. and Bielcikova, J. and Braun-Munzinger, P. and Busch, O. and Cherlin, A. and Damjanović, Svetozar S. and Dietel, T. and Dietrich, L. and Drees, A. and Dubitzky, W. and Esumi, S. I. and Filimonov, K. and Fomenko, K. and Fraenkel, Z. and Garabatos, C. and Glaessel, P. and Hering, G. and Holeczek, J. and Kalisky, M. and Karpenko, Iu. and Krobath, G. and Kushpil, V. and Maas, A. and Marin, A. and Milošević, Jovan and Miskowiec, D. and Panebrattsev, Y. and Petchenova, O. and Petracek, V. and Radomski, S. and Rak, J. and Ravinovich, I. and Rehak, P. and Sako, H. and Schmitz, W. and Schuchmann, S. and Sedykh, S. and Shimansky, S. and Stachel, J. and Sumbera, M. and Tilsner, H. and Tserruya, I. and Tsiledakis, G. and Wessels, J. P. and Wienold, T. and Wurm, J. P. and Yurevich, S. and Yurevich, V.",
year = "2017",
abstract = "Differential triangular flow, v(3)(p(T)), of negative pions is measured at root s(NN) = 17.3 GeV around midrapidity by the CERES/NA45 experiment at CERN in central PbAu collisions in the range 0-30% with a mean centrality of 5.5%. This is the first measurement as a function of transverse momentum of the triangular flow at SPS energies. The p(T) range extends from about 0.05 GeV/c to more than 2 GeV/c. The triangular flow magnitude, corrected for the HBT effects, is smaller by a factor of about 2 than the one measured by the PHENIX experiment at RHIC and the ALICE experiment at the LHC. Within the analyzed range of central collisions no significant centrality dependence is observed. The data are found to be well described by a viscous hydrodynamic calculation combined with an UrQMD cascade model for the late stages. (C) 2016 Elsevier B.V. All rights reserved.",
journal = "Nuclear Physics A",
title = "Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV",
volume = "957",
pages = "99-108",
doi = "10.1016/j.nuclphysa.2016.08.002"
}
Adamova, D., Agakichiev, G., Andronic, A., Antonczyk, D., Appelshaeuser, H., Belaga, V., Bielcikova, J., Braun-Munzinger, P., Busch, O., Cherlin, A., Damjanović, S. S., Dietel, T., Dietrich, L., Drees, A., Dubitzky, W., Esumi, S. I., Filimonov, K., Fomenko, K., Fraenkel, Z., Garabatos, C., Glaessel, P., Hering, G., Holeczek, J., Kalisky, M., Karpenko, Iu., Krobath, G., Kushpil, V., Maas, A., Marin, A., Milošević, J., Miskowiec, D., Panebrattsev, Y., Petchenova, O., Petracek, V., Radomski, S., Rak, J., Ravinovich, I., Rehak, P., Sako, H., Schmitz, W., Schuchmann, S., Sedykh, S., Shimansky, S., Stachel, J., Sumbera, M., Tilsner, H., Tserruya, I., Tsiledakis, G., Wessels, J. P., Wienold, T., Wurm, J. P., Yurevich, S.,& Yurevich, V.. (2017). Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV. in Nuclear Physics A, 957, 99-108.
https://doi.org/10.1016/j.nuclphysa.2016.08.002
Adamova D, Agakichiev G, Andronic A, Antonczyk D, Appelshaeuser H, Belaga V, Bielcikova J, Braun-Munzinger P, Busch O, Cherlin A, Damjanović SS, Dietel T, Dietrich L, Drees A, Dubitzky W, Esumi SI, Filimonov K, Fomenko K, Fraenkel Z, Garabatos C, Glaessel P, Hering G, Holeczek J, Kalisky M, Karpenko I, Krobath G, Kushpil V, Maas A, Marin A, Milošević J, Miskowiec D, Panebrattsev Y, Petchenova O, Petracek V, Radomski S, Rak J, Ravinovich I, Rehak P, Sako H, Schmitz W, Schuchmann S, Sedykh S, Shimansky S, Stachel J, Sumbera M, Tilsner H, Tserruya I, Tsiledakis G, Wessels JP, Wienold T, Wurm JP, Yurevich S, Yurevich V. Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV. in Nuclear Physics A. 2017;957:99-108.
doi:10.1016/j.nuclphysa.2016.08.002 .
Adamova, D., Agakichiev, G., Andronic, A., Antonczyk, D., Appelshaeuser, H., Belaga, V., Bielcikova, J., Braun-Munzinger, P., Busch, O., Cherlin, A., Damjanović, Svetozar S., Dietel, T., Dietrich, L., Drees, A., Dubitzky, W., Esumi, S. I., Filimonov, K., Fomenko, K., Fraenkel, Z., Garabatos, C., Glaessel, P., Hering, G., Holeczek, J., Kalisky, M., Karpenko, Iu., Krobath, G., Kushpil, V., Maas, A., Marin, A., Milošević, Jovan, Miskowiec, D., Panebrattsev, Y., Petchenova, O., Petracek, V., Radomski, S., Rak, J., Ravinovich, I., Rehak, P., Sako, H., Schmitz, W., Schuchmann, S., Sedykh, S., Shimansky, S., Stachel, J., Sumbera, M., Tilsner, H., Tserruya, I., Tsiledakis, G., Wessels, J. P., Wienold, T., Wurm, J. P., Yurevich, S., Yurevich, V., "Triangular flow of negative pions emitted in PbAu collisions at root s(NN)=17.3 GeV" in Nuclear Physics A, 957 (2017):99-108,
https://doi.org/10.1016/j.nuclphysa.2016.08.002 . .
1
2
2
2

Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model

Ćirković, Predrag; Devetak, Damir; Đorđević, Miloš; Milošević, Jovan; Stojanovic, M.

(2017)

TY  - JOUR
AU  - Ćirković, Predrag
AU  - Devetak, Damir
AU  - Đorđević, Miloš
AU  - Milošević, Jovan
AU  - Stojanovic, M.
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1652
AB  - Recent LHC results on the appearance of sub-leading flow modes in PbPb collisions at 2.76 TeV, related to initial-state fluctuations, are analyzed and interpreted within the HYDJET++ model. Using the newly introduced Principal Component Analysis (PCA) method applied to two-particle azimuthal correlations extracted from the model calculations, the leading and sub-leading flow modes are studied as a function of the transverse momentum (p(T)) over a wide centrality range. The leading modes of the elliptic (v(2)((1))) and triangular (v(3)((1))) flow calculated with the HYDJET++ model reproduce rather well the v(2){2} and v(3){2} coefficients measured experimentally using the two-particle correlations. Within the p(T) LT = 3 GeV/c range, where hydrodynamics dominates, the sub-leading flow effects are greatest at the highest p(T) of around 3 GeV/c. The sub-leading elliptic flow mode (v(2)((2))), which corresponds to the n = 2 harmonic, has a small non-zero value and slowly increases from central to peripheral collisions, while the sub-leading triangular flow mode (v(3)((2))), which corresponds to the n = 3 harmonic, is even smaller and does not depend on centrality. For n = 2, the relative magnitude of the effect measured with respect to the leading flow mode shows a shallow minimum for semi-central collisions and increases for very central and for peripheral collisions. For the n = 3 case, there is no centrality dependence. The sub-leading flow mode results obtained from the HYDJET++ model are in rather good agreement with the experimental measurements of the CMS Collaboration.
T2  - Chinese Physics C
T1  - Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model
VL  - 41
IS  - 7
DO  - 10.1088/1674-1137/41/7/0740001
ER  - 
@article{
author = "Ćirković, Predrag and Devetak, Damir and Đorđević, Miloš and Milošević, Jovan and Stojanovic, M.",
year = "2017",
abstract = "Recent LHC results on the appearance of sub-leading flow modes in PbPb collisions at 2.76 TeV, related to initial-state fluctuations, are analyzed and interpreted within the HYDJET++ model. Using the newly introduced Principal Component Analysis (PCA) method applied to two-particle azimuthal correlations extracted from the model calculations, the leading and sub-leading flow modes are studied as a function of the transverse momentum (p(T)) over a wide centrality range. The leading modes of the elliptic (v(2)((1))) and triangular (v(3)((1))) flow calculated with the HYDJET++ model reproduce rather well the v(2){2} and v(3){2} coefficients measured experimentally using the two-particle correlations. Within the p(T) LT = 3 GeV/c range, where hydrodynamics dominates, the sub-leading flow effects are greatest at the highest p(T) of around 3 GeV/c. The sub-leading elliptic flow mode (v(2)((2))), which corresponds to the n = 2 harmonic, has a small non-zero value and slowly increases from central to peripheral collisions, while the sub-leading triangular flow mode (v(3)((2))), which corresponds to the n = 3 harmonic, is even smaller and does not depend on centrality. For n = 2, the relative magnitude of the effect measured with respect to the leading flow mode shows a shallow minimum for semi-central collisions and increases for very central and for peripheral collisions. For the n = 3 case, there is no centrality dependence. The sub-leading flow mode results obtained from the HYDJET++ model are in rather good agreement with the experimental measurements of the CMS Collaboration.",
journal = "Chinese Physics C",
title = "Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model",
volume = "41",
number = "7",
doi = "10.1088/1674-1137/41/7/0740001"
}
Ćirković, P., Devetak, D., Đorđević, M., Milošević, J.,& Stojanovic, M.. (2017). Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model. in Chinese Physics C, 41(7).
https://doi.org/10.1088/1674-1137/41/7/0740001
Ćirković P, Devetak D, Đorđević M, Milošević J, Stojanovic M. Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model. in Chinese Physics C. 2017;41(7).
doi:10.1088/1674-1137/41/7/0740001 .
Ćirković, Predrag, Devetak, Damir, Đorđević, Miloš, Milošević, Jovan, Stojanovic, M., "Sub-leading flow modes in PbPb collisions at root s(NN)=2.76 TeV from the HYDJET plus plus model" in Chinese Physics C, 41, no. 7 (2017),
https://doi.org/10.1088/1674-1137/41/7/0740001 . .
5

Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells

Žakula, Jelena; Korićanac, Lela; Keta, Otilija D.; Todorović, Danijela V.; Cirrone, Giuseppe Antonio Pablo; Romano, Francesco; Cuttone, Giacomo; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(2016)

TY  - JOUR
AU  - Žakula, Jelena
AU  - Korićanac, Lela
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Romano, Francesco
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1290
AB  - Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.
T2  - Indian Journal of Medical Research
T1  - Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells
VL  - 143
SP  - 120
EP  - 128
DO  - 10.4103/0971-5916.191811
ER  - 
@article{
author = "Žakula, Jelena and Korićanac, Lela and Keta, Otilija D. and Todorović, Danijela V. and Cirrone, Giuseppe Antonio Pablo and Romano, Francesco and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "Background and objectives: The main goal when treating malignancies with radiation is to deprive tumour cells of their reproductive potential. One approach is to induce tumour cell apoptosis. This study was conducted to evaluate the ability of carbon ions (C-12) to induce apoptosis and cell cycle arrest in human HTB140 melanoma cells. Methods: In this in vitro study, human melanoma HTB140 cells were irradiated with the 62 MeV/n carbon (C-12) ion beam, having two different linear energy transfer (LET) values: 197 and 382 keV/mu m. The dose range was 2 to 16 Gy. Cell viability was estimated by the sulforhodamine B assay seven days after irradiation. The cell cycle and apoptosis were evaluated 48 h after irradiation using flow cytometry. At the same time point, protein and gene expression of apoptotic regulators were estimated using the Western blot and q-PCR methods, respectively. Results: Cell viability experiments indicated strong anti-tumour effects of C-12 ions. The analysis of cell cycle showed that C-12 ions blocked HTB140 cells in G2 phase and induced the dose dependent increase of apoptosis. The maximum value of 21.8 per cent was attained after irradiation with LET of 197 keV/mu m at the dose level of 16 Gy. Pro-apoptotic effects of C-12 ions were confirmed by changes of key apoptotic molecules: the p53, Bax, Bcl-2, poly ADP ribose polymerase (PARP) as well as nuclear factor kappa B (NF kappa B). At the level of protein expression, the results indicated significant increases of p53, NF kappa B and Bax/Bcl-2 ratio and PARP cleavage. The Bax/Bcl-2 mRNA ratio was also increased, while no change was detected in the level of NF kappa B mRNA. Interpretation and conclusions: The present results indicated that anti-tumour effects of C-12 ions in human melanoma HTB140 cells were accomplished through induction of the mitochondrial apoptotic pathway as well as G2 arrest.",
journal = "Indian Journal of Medical Research",
title = "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells",
volume = "143",
pages = "120-128",
doi = "10.4103/0971-5916.191811"
}
Žakula, J., Korićanac, L., Keta, O. D., Todorović, D. V., Cirrone, G. A. P., Romano, F., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2016). Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research, 143, 120-128.
https://doi.org/10.4103/0971-5916.191811
Žakula J, Korićanac L, Keta OD, Todorović DV, Cirrone GAP, Romano F, Cuttone G, Petrović IM, Ristić-Fira A. Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells. in Indian Journal of Medical Research. 2016;143:120-128.
doi:10.4103/0971-5916.191811 .
Žakula, Jelena, Korićanac, Lela, Keta, Otilija D., Todorović, Danijela V., Cirrone, Giuseppe Antonio Pablo, Romano, Francesco, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Carbon ions of different linear energy transfer (LET) values induce apoptosis and G2 cell cycle arrest in radio-resistant melanoma cells" in Indian Journal of Medical Research, 143 (2016):120-128,
https://doi.org/10.4103/0971-5916.191811 . .
3
1
2

The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib

Keta, Otilija D.; Bulat, Tanja M.; Golic, Igor; Incerti, Sebastien; Korać, Aleksandra; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(Springer, 2016)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Bulat, Tanja M.
AU  - Golic, Igor
AU  - Incerti, Sebastien
AU  - Korać, Aleksandra
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1044
AB  - In most patients with lung cancer radiation treatment is used either as single agent or in combination with radiosensitizing drugs. However, the mechanisms underlying combined therapy and its impact on different modes of cell death have not yet been fully elucidated. We aimed to examine effects of single and combined treatments with gamma-rays and erlotinib on radioresistant CRL-5876 human lung adenocarcinoma cells with particular emphasis on cell death. CRL-5876 cells were treated with gamma-rays and/or erlotinib and changes in cell cycle, DNA repair dynamics, ultrastructure, nuclear morphology and protein expression were monitored at different time points. To reveal the relationship between types of cell death that arise after these treatments, autophagy was blocked with chloroquine. We found that higher dose of gamma-rays causes G2/M arrest while adding of erlotinib to this treatment decreases the number of cells in S phase. Impact of erlotinib on kinetics of disappearance of irradiation-induced DNA double strand breaks is reflected in the increase of residual gamma-H2AX foci after 24 h. gamma-rays provoke cytoprotective autophagy which precedes development of senescence. Erlotinib predominantly induces apoptosis and enlarges the number of apoptotic cells in the irradiated CRL-5876 cells. Chloroquine improved cytotoxicity induced by radiation and erlotinib, increased apoptosis and decreased senescence in the CRL-5876 cells. The results obtained on CRL-5876 cells indicate significant radiosensitizing effect of erlotinib and suggest that chloroquine in the combination with the above treatments may have an additional antitumor effect in lung adenocarcinoma.
PB  - Springer
T2  - Cell Biology and Toxicology
T1  - The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib
VL  - 32
IS  - 2
SP  - 83
EP  - 101
DO  - 10.1007/s10565-016-9319-z
ER  - 
@article{
author = "Keta, Otilija D. and Bulat, Tanja M. and Golic, Igor and Incerti, Sebastien and Korać, Aleksandra and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "In most patients with lung cancer radiation treatment is used either as single agent or in combination with radiosensitizing drugs. However, the mechanisms underlying combined therapy and its impact on different modes of cell death have not yet been fully elucidated. We aimed to examine effects of single and combined treatments with gamma-rays and erlotinib on radioresistant CRL-5876 human lung adenocarcinoma cells with particular emphasis on cell death. CRL-5876 cells were treated with gamma-rays and/or erlotinib and changes in cell cycle, DNA repair dynamics, ultrastructure, nuclear morphology and protein expression were monitored at different time points. To reveal the relationship between types of cell death that arise after these treatments, autophagy was blocked with chloroquine. We found that higher dose of gamma-rays causes G2/M arrest while adding of erlotinib to this treatment decreases the number of cells in S phase. Impact of erlotinib on kinetics of disappearance of irradiation-induced DNA double strand breaks is reflected in the increase of residual gamma-H2AX foci after 24 h. gamma-rays provoke cytoprotective autophagy which precedes development of senescence. Erlotinib predominantly induces apoptosis and enlarges the number of apoptotic cells in the irradiated CRL-5876 cells. Chloroquine improved cytotoxicity induced by radiation and erlotinib, increased apoptosis and decreased senescence in the CRL-5876 cells. The results obtained on CRL-5876 cells indicate significant radiosensitizing effect of erlotinib and suggest that chloroquine in the combination with the above treatments may have an additional antitumor effect in lung adenocarcinoma.",
publisher = "Springer",
journal = "Cell Biology and Toxicology",
title = "The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib",
volume = "32",
number = "2",
pages = "83-101",
doi = "10.1007/s10565-016-9319-z"
}
Keta, O. D., Bulat, T. M., Golic, I., Incerti, S., Korać, A., Petrović, I. M.,& Ristić-Fira, A.. (2016). The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib. in Cell Biology and Toxicology
Springer., 32(2), 83-101.
https://doi.org/10.1007/s10565-016-9319-z
Keta OD, Bulat TM, Golic I, Incerti S, Korać A, Petrović IM, Ristić-Fira A. The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib. in Cell Biology and Toxicology. 2016;32(2):83-101.
doi:10.1007/s10565-016-9319-z .
Keta, Otilija D., Bulat, Tanja M., Golic, Igor, Incerti, Sebastien, Korać, Aleksandra, Petrović, Ivan M., Ristić-Fira, Aleksandra, "The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib" in Cell Biology and Toxicology, 32, no. 2 (2016):83-101,
https://doi.org/10.1007/s10565-016-9319-z . .
1
17
18
17

Radiation dose determines the method for quantification of DNA double strand breaks

Bulat, Tanja M.; Keta, Otilija D.; Korićanac, Lela; Žakula, Jelena; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Todorović, Danijela V.

(2016)

TY  - JOUR
AU  - Bulat, Tanja M.
AU  - Keta, Otilija D.
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Todorović, Danijela V.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/970
AB  - Ionizing radiation induces DNA double strand breaks (DSBs) that trigger phosphorylation of the histone protein H2AX (gamma H2AX). Immunofluorescent staining visualizes formation of gamma H2AX foci, allowing their quantification. This method, as opposed to Western blot assay and Flow cytometry, provides more accurate analysis, by showing exact position and intensity of fluorescent signal in each single cell. In practice there are problems in quantification of gamma H2AX. This paper is based on two issues: the determination of which technique should be applied concerning the radiation dose, and how to analyze fluorescent microscopy images obtained by different microscopes. HTB140 melanoma cells were exposed to gamma-rays, in the dose range from 1 to 16 Gy. Radiation effects on the DNA level were analyzed at different time intervals after irradiation by Western blot analysis and immunofluorescence microscopy. Immunochemically stained cells were visualized with two types of microscopes: AxioVision (Zeiss, Germany) microscope, comprising an ApoTome software, and AxioImagerA1 microscope (Zeiss, Germany). Obtained results show that the level of gamma H2AX is time and dose dependent. Immunofluorescence microscopy provided better detection of DSBs for lower irradiation doses, while Western blot analysis was more reliable for higher irradiation doses. AxioVision microscope containing ApoTome software was more suitable for the detection of gamma H2AX foci.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Radiation dose determines the method for quantification of DNA double strand breaks
VL  - 88
IS  - 1
SP  - 127
EP  - 136
DO  - 10.1590/0001-3765201620140553
ER  - 
@article{
author = "Bulat, Tanja M. and Keta, Otilija D. and Korićanac, Lela and Žakula, Jelena and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Todorović, Danijela V.",
year = "2016",
abstract = "Ionizing radiation induces DNA double strand breaks (DSBs) that trigger phosphorylation of the histone protein H2AX (gamma H2AX). Immunofluorescent staining visualizes formation of gamma H2AX foci, allowing their quantification. This method, as opposed to Western blot assay and Flow cytometry, provides more accurate analysis, by showing exact position and intensity of fluorescent signal in each single cell. In practice there are problems in quantification of gamma H2AX. This paper is based on two issues: the determination of which technique should be applied concerning the radiation dose, and how to analyze fluorescent microscopy images obtained by different microscopes. HTB140 melanoma cells were exposed to gamma-rays, in the dose range from 1 to 16 Gy. Radiation effects on the DNA level were analyzed at different time intervals after irradiation by Western blot analysis and immunofluorescence microscopy. Immunochemically stained cells were visualized with two types of microscopes: AxioVision (Zeiss, Germany) microscope, comprising an ApoTome software, and AxioImagerA1 microscope (Zeiss, Germany). Obtained results show that the level of gamma H2AX is time and dose dependent. Immunofluorescence microscopy provided better detection of DSBs for lower irradiation doses, while Western blot analysis was more reliable for higher irradiation doses. AxioVision microscope containing ApoTome software was more suitable for the detection of gamma H2AX foci.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Radiation dose determines the method for quantification of DNA double strand breaks",
volume = "88",
number = "1",
pages = "127-136",
doi = "10.1590/0001-3765201620140553"
}
Bulat, T. M., Keta, O. D., Korićanac, L., Žakula, J., Petrović, I. M., Ristić-Fira, A.,& Todorović, D. V.. (2016). Radiation dose determines the method for quantification of DNA double strand breaks. in Anais de Academia Brasileira de Ciencias, 88(1), 127-136.
https://doi.org/10.1590/0001-3765201620140553
Bulat TM, Keta OD, Korićanac L, Žakula J, Petrović IM, Ristić-Fira A, Todorović DV. Radiation dose determines the method for quantification of DNA double strand breaks. in Anais de Academia Brasileira de Ciencias. 2016;88(1):127-136.
doi:10.1590/0001-3765201620140553 .
Bulat, Tanja M., Keta, Otilija D., Korićanac, Lela, Žakula, Jelena, Petrović, Ivan M., Ristić-Fira, Aleksandra, Todorović, Danijela V., "Radiation dose determines the method for quantification of DNA double strand breaks" in Anais de Academia Brasileira de Ciencias, 88, no. 1 (2016):127-136,
https://doi.org/10.1590/0001-3765201620140553 . .
7
5
7

Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays

Petković, Vladana; Keta, Otilija D.; Vojinović, N.; Incerti, S.; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(Society of Physical Chemists of Serbia, 2016)

TY  - CONF
AU  - Petković, Vladana
AU  - Keta, Otilija D.
AU  - Vojinović, N.
AU  - Incerti, S.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9207
AB  - Direct  effects  of  radiation  affect  the  DNA  molecule,  causing  DNAdamage and finally  cell death. We examined the role of DMSO and glycerol as free-radical scavengers in HTB177 cells irradiated with gamma rays. Direct effects of   radiation   were   estimated   through   DNA   double   strand   break   (DSB) quantification  and  cell  survival.  Results  of  this  work  revealed  that  chosen concentration   of   DMSO   exhibit   higher   protective   effect   comparing   to glycerol.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
T1  - Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays
SP  - 447
EP  - 450
ER  - 
@conference{
author = "Petković, Vladana and Keta, Otilija D. and Vojinović, N. and Incerti, S. and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2016",
abstract = "Direct  effects  of  radiation  affect  the  DNA  molecule,  causing  DNAdamage and finally  cell death. We examined the role of DMSO and glycerol as free-radical scavengers in HTB177 cells irradiated with gamma rays. Direct effects of   radiation   were   estimated   through   DNA   double   strand   break   (DSB) quantification  and  cell  survival.  Results  of  this  work  revealed  that  chosen concentration   of   DMSO   exhibit   higher   protective   effect   comparing   to glycerol.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry",
title = "Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays",
pages = "447-450"
}
Petković, V., Keta, O. D., Vojinović, N., Incerti, S., Petrović, I. M.,& Ristić-Fira, A.. (2016). Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry
Society of Physical Chemists of Serbia., 447-450.
Petković V, Keta OD, Vojinović N, Incerti S, Petrović IM, Ristić-Fira A. Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:447-450..
Petković, Vladana, Keta, Otilija D., Vojinović, N., Incerti, S., Petrović, Ivan M., Ristić-Fira, Aleksandra, "Radio-protective effect of DMSO glycerol in human non-small cell lung cancer irradiated with gamma rays" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):447-450.

A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line

Romano, Francesco; Cirrone, Giuseppe Antonio Pablo; Cuttone, Giacomo; Di Rosa, F.; Mazzaglia, S. E.; Petrović, Ivan M.; Ristić-Fira, Aleksandra; Varisano, A.

(2014)

TY  - JOUR
AU  - Romano, Francesco
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Di Rosa, F.
AU  - Mazzaglia, S. E.
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Varisano, A.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/6037
AB  - Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
T2  - Physics in Medicine and Biology
T1  - A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line
VL  - 59
IS  - 12
SP  - 2863
EP  - 2882
DO  - 10.1088/0031-9155/59/12/2863
ER  - 
@article{
author = "Romano, Francesco and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Di Rosa, F. and Mazzaglia, S. E. and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Varisano, A.",
year = "2014",
abstract = "Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An open source application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.",
journal = "Physics in Medicine and Biology",
title = "A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line",
volume = "59",
number = "12",
pages = "2863-2882",
doi = "10.1088/0031-9155/59/12/2863"
}
Romano, F., Cirrone, G. A. P., Cuttone, G., Di Rosa, F., Mazzaglia, S. E., Petrović, I. M., Ristić-Fira, A.,& Varisano, A.. (2014). A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. in Physics in Medicine and Biology, 59(12), 2863-2882.
https://doi.org/10.1088/0031-9155/59/12/2863
Romano F, Cirrone GAP, Cuttone G, Di Rosa F, Mazzaglia SE, Petrović IM, Ristić-Fira A, Varisano A. A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. in Physics in Medicine and Biology. 2014;59(12):2863-2882.
doi:10.1088/0031-9155/59/12/2863 .
Romano, Francesco, Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Di Rosa, F., Mazzaglia, S. E., Petrović, Ivan M., Ristić-Fira, Aleksandra, Varisano, A., "A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line" in Physics in Medicine and Biology, 59, no. 12 (2014):2863-2882,
https://doi.org/10.1088/0031-9155/59/12/2863 . .
1
55
48
49

Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons

Keta, Otilija D.; Todorović, Danijela V.; Popović, Nataša M.; Korićanac, Lela; Cuttone, Giacomo; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(2014)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Todorović, Danijela V.
AU  - Popović, Nataša M.
AU  - Korićanac, Lela
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5447
AB  - Introduction: Proton radiation offers physical advantages over conventional radiation. Radiosensitivity of human 59M ovarian cancer and HTB140 melanoma cells was investigated after exposure to gamma-rays and protons. Material and methods: Irradiations were performed in the middle of a 62 MeV therapeutic proton spread out Bragg peak with doses ranging from 2 to 16 Gy. The mean energy of protons was 34.88+/-2.15 MeV, corresponding to the linear energy transfer of 4.7+/-0.2 keV/mu m. Irradiations with gamma-rays were performed using the same doses. Viability, proliferation and survival were assessed 7 days after both types of irradiation while analyses of cell cycle and apoptosis were performed 48 h after irradiation. Results: Results showed that gamma-rays and protons reduced the number of viable cells for both cell lines, with stronger inactivation achieved after irradiation with protons. Surviving fractions for 59M were 0.91+/-0.01 for gamma-rays and 0.81+/-0.01 for protons, while those for HTB140 cells were 0.93+/-0.01 for gamma-rays and 0.86+/-0.01 for protons. Relative biological effectiveness of protons, being 2.47+/-0.22 for 59M and 2.08+/-0.36 for HTB140, indicated that protons provoked better cell elimination than gamma-rays. After proton irradiation proliferation capacity of the two cell lines was slightly higher as compared to gamma-rays. Proliferation was higher for 59M than for HTB140 cells after both types of irradiation. Induction of apoptosis and G2 arrest detected after proton irradiation were more prominent in 59M cells. Conclusions: The obtained results suggest that protons exert better antitumour effects on ovarian carcinoma and melanoma cells than gamma-rays. The dissimilar response of these cells to radiation is related to their different features.
T2  - Archives of Medical Science
T1  - Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons
VL  - 10
IS  - 3
SP  - 578
EP  - 586
DO  - 10.5114/aoms.2014.43751
ER  - 
@article{
author = "Keta, Otilija D. and Todorović, Danijela V. and Popović, Nataša M. and Korićanac, Lela and Cuttone, Giacomo and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2014",
abstract = "Introduction: Proton radiation offers physical advantages over conventional radiation. Radiosensitivity of human 59M ovarian cancer and HTB140 melanoma cells was investigated after exposure to gamma-rays and protons. Material and methods: Irradiations were performed in the middle of a 62 MeV therapeutic proton spread out Bragg peak with doses ranging from 2 to 16 Gy. The mean energy of protons was 34.88+/-2.15 MeV, corresponding to the linear energy transfer of 4.7+/-0.2 keV/mu m. Irradiations with gamma-rays were performed using the same doses. Viability, proliferation and survival were assessed 7 days after both types of irradiation while analyses of cell cycle and apoptosis were performed 48 h after irradiation. Results: Results showed that gamma-rays and protons reduced the number of viable cells for both cell lines, with stronger inactivation achieved after irradiation with protons. Surviving fractions for 59M were 0.91+/-0.01 for gamma-rays and 0.81+/-0.01 for protons, while those for HTB140 cells were 0.93+/-0.01 for gamma-rays and 0.86+/-0.01 for protons. Relative biological effectiveness of protons, being 2.47+/-0.22 for 59M and 2.08+/-0.36 for HTB140, indicated that protons provoked better cell elimination than gamma-rays. After proton irradiation proliferation capacity of the two cell lines was slightly higher as compared to gamma-rays. Proliferation was higher for 59M than for HTB140 cells after both types of irradiation. Induction of apoptosis and G2 arrest detected after proton irradiation were more prominent in 59M cells. Conclusions: The obtained results suggest that protons exert better antitumour effects on ovarian carcinoma and melanoma cells than gamma-rays. The dissimilar response of these cells to radiation is related to their different features.",
journal = "Archives of Medical Science",
title = "Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons",
volume = "10",
number = "3",
pages = "578-586",
doi = "10.5114/aoms.2014.43751"
}
Keta, O. D., Todorović, D. V., Popović, N. M., Korićanac, L., Cuttone, G., Petrović, I. M.,& Ristić-Fira, A.. (2014). Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons. in Archives of Medical Science, 10(3), 578-586.
https://doi.org/10.5114/aoms.2014.43751
Keta OD, Todorović DV, Popović NM, Korićanac L, Cuttone G, Petrović IM, Ristić-Fira A. Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons. in Archives of Medical Science. 2014;10(3):578-586.
doi:10.5114/aoms.2014.43751 .
Keta, Otilija D., Todorović, Danijela V., Popović, Nataša M., Korićanac, Lela, Cuttone, Giacomo, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Radiosensitivity of human ovarian carcinoma and melanoma cells to gamma-rays and protons" in Archives of Medical Science, 10, no. 3 (2014):578-586,
https://doi.org/10.5114/aoms.2014.43751 . .
8
8
10

Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition

Keta, Otilija D.; Bulat, Tanja M.; Korićanac, Lela; Žakula, Jelena; Cuttone, Giacomo; Privitera, Giuseppe; Petrović, Ivan M.; Ristić-Fira, Aleksandra

(2014)

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Bulat, Tanja M.
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Cuttone, Giacomo
AU  - Privitera, Giuseppe
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/167
AB  - Molecular targeted cancer therapy is a promising treatment strategy. Considering the central role of the epidermal growth factor receptor in cell proliferation and survival, there are indications that targeted agents like tyrosine kinase inhibitors, i. e., erlotinib, may enhance the antitumor treatment by radiation. The aim of this study is to analyze the inactivation effects of gamma-rays and to test the radiosensitizing potential of erlotinib on human lung adenocarcinoma cells in vitro. Irradiations were performed with doses ranging from 1 Gy to 8 Gy. In order to increase the radiosensitivity of CRL-5876 lung adenocarcinoma cells, the cells were treated with a clinically relevant concentration of 2 mu M erlotinib. The effects of single and combined treatments were monitored using clonogenic survival, cell viability and proliferation assays at different time points. For the detection and visualization of the phosphorylated histone H2AX (gamma-H2AX), an important biological marker of DNA double-strand break formation, fluorescence inununocytochemistry, was performed. The response to the treatment was monitored at four time points: 30 min, 2, 6, and 24 h. Irradiations with gamma-rays resulted in significant cell inactivation regarding all analyzed biological endpoints. Combined treatments revealed consistent cell inactivation. Moreover, compared to gamma-rays alone, elevated levels of gamma-H2AX foci were observed after pretreatment with erlotinib, indicating radiosensitization through impaired DNA repair.
T2  - Nuclear technology and radiation protection
T1  - Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition
VL  - 29
IS  - 3
SP  - 233
EP  - 241
DO  - 10.2298/NTRP1403233K
ER  - 
@article{
author = "Keta, Otilija D. and Bulat, Tanja M. and Korićanac, Lela and Žakula, Jelena and Cuttone, Giacomo and Privitera, Giuseppe and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2014",
abstract = "Molecular targeted cancer therapy is a promising treatment strategy. Considering the central role of the epidermal growth factor receptor in cell proliferation and survival, there are indications that targeted agents like tyrosine kinase inhibitors, i. e., erlotinib, may enhance the antitumor treatment by radiation. The aim of this study is to analyze the inactivation effects of gamma-rays and to test the radiosensitizing potential of erlotinib on human lung adenocarcinoma cells in vitro. Irradiations were performed with doses ranging from 1 Gy to 8 Gy. In order to increase the radiosensitivity of CRL-5876 lung adenocarcinoma cells, the cells were treated with a clinically relevant concentration of 2 mu M erlotinib. The effects of single and combined treatments were monitored using clonogenic survival, cell viability and proliferation assays at different time points. For the detection and visualization of the phosphorylated histone H2AX (gamma-H2AX), an important biological marker of DNA double-strand break formation, fluorescence inununocytochemistry, was performed. The response to the treatment was monitored at four time points: 30 min, 2, 6, and 24 h. Irradiations with gamma-rays resulted in significant cell inactivation regarding all analyzed biological endpoints. Combined treatments revealed consistent cell inactivation. Moreover, compared to gamma-rays alone, elevated levels of gamma-H2AX foci were observed after pretreatment with erlotinib, indicating radiosensitization through impaired DNA repair.",
journal = "Nuclear technology and radiation protection",
title = "Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition",
volume = "29",
number = "3",
pages = "233-241",
doi = "10.2298/NTRP1403233K"
}
Keta, O. D., Bulat, T. M., Korićanac, L., Žakula, J., Cuttone, G., Privitera, G., Petrović, I. M.,& Ristić-Fira, A.. (2014). Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition. in Nuclear technology and radiation protection, 29(3), 233-241.
https://doi.org/10.2298/NTRP1403233K
Keta OD, Bulat TM, Korićanac L, Žakula J, Cuttone G, Privitera G, Petrović IM, Ristić-Fira A. Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition. in Nuclear technology and radiation protection. 2014;29(3):233-241.
doi:10.2298/NTRP1403233K .
Keta, Otilija D., Bulat, Tanja M., Korićanac, Lela, Žakula, Jelena, Cuttone, Giacomo, Privitera, Giuseppe, Petrović, Ivan M., Ristić-Fira, Aleksandra, "Radiosensitization of Non-Small Cell Lung Carcinoma By Egfr Inhibition" in Nuclear technology and radiation protection, 29, no. 3 (2014):233-241,
https://doi.org/10.2298/NTRP1403233K . .
2
2
2

Masses of constituent quarks confined in open bottom hadrons

Borka Jovanović, Vesna; Borka, Duško; Jovanović, Predrag; Milošević, Jovan; Ignjatović, Siniša R

(2014)

TY  - JOUR
AU  - Borka Jovanović, Vesna
AU  - Borka, Duško
AU  - Jovanović, Predrag
AU  - Milošević, Jovan
AU  - Ignjatović, Siniša R
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/284
AB  - We apply color-spin and flavor-spin quark-quark interactions to the meson and baryon constituent quarks, and calculate constituent quark masses, as well as the coupling constants of these interactions. The main goal of this paper was to determine constituent quark masses from light and open bottom hadron masses, using the fitting method we have developed and clustering of hadron groups. We use color-spin Fermi-Breit (FB) and flavor-spin Glozman-Riska (GR) hyperfine interaction (HFI) to determine constituent quark masses (especially b quark mass). Another aim was to discern between the FB and GR HFI because our previous findings had indicated that both interactions were satisfactory. Our improved fitting procedure of constituent quark masses showed that on average color-spin (FB) HFI yields better fits. The method also shows the way how the constituent quark masses and the strength of the interaction constants appear in different hadron environments.
T2  - Modern Physics Letters A
T1  - Masses of constituent quarks confined in open bottom hadrons
VL  - 29
IS  - 38
DO  - 10.1142/S0217732314502022
ER  - 
@article{
author = "Borka Jovanović, Vesna and Borka, Duško and Jovanović, Predrag and Milošević, Jovan and Ignjatović, Siniša R",
year = "2014",
abstract = "We apply color-spin and flavor-spin quark-quark interactions to the meson and baryon constituent quarks, and calculate constituent quark masses, as well as the coupling constants of these interactions. The main goal of this paper was to determine constituent quark masses from light and open bottom hadron masses, using the fitting method we have developed and clustering of hadron groups. We use color-spin Fermi-Breit (FB) and flavor-spin Glozman-Riska (GR) hyperfine interaction (HFI) to determine constituent quark masses (especially b quark mass). Another aim was to discern between the FB and GR HFI because our previous findings had indicated that both interactions were satisfactory. Our improved fitting procedure of constituent quark masses showed that on average color-spin (FB) HFI yields better fits. The method also shows the way how the constituent quark masses and the strength of the interaction constants appear in different hadron environments.",
journal = "Modern Physics Letters A",
title = "Masses of constituent quarks confined in open bottom hadrons",
volume = "29",
number = "38",
doi = "10.1142/S0217732314502022"
}
Borka Jovanović, V., Borka, D., Jovanović, P., Milošević, J.,& Ignjatović, S. R.. (2014). Masses of constituent quarks confined in open bottom hadrons. in Modern Physics Letters A, 29(38).
https://doi.org/10.1142/S0217732314502022
Borka Jovanović V, Borka D, Jovanović P, Milošević J, Ignjatović SR. Masses of constituent quarks confined in open bottom hadrons. in Modern Physics Letters A. 2014;29(38).
doi:10.1142/S0217732314502022 .
Borka Jovanović, Vesna, Borka, Duško, Jovanović, Predrag, Milošević, Jovan, Ignjatović, Siniša R, "Masses of constituent quarks confined in open bottom hadrons" in Modern Physics Letters A, 29, no. 38 (2014),
https://doi.org/10.1142/S0217732314502022 . .
1
1
1
1

Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method

Dordic, O.; Milošević, Jovan; Tveter, T. S.

(2014)

TY  - JOUR
AU  - Dordic, O.
AU  - Milošević, Jovan
AU  - Tveter, T. S.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/115
AB  - This paper presents the results of an attempt to measure the elliptic flow in the smallest collision system (pp) at the highest designed collision energy at the Large Hadron Collider (LHC) using the genuine collective correlation among a large number of particles. A huge non-flow effect introduced by a strong jet correlation in pp collisions makes the application of the standard event plane flow analysis non-feasible. Therefore, in order to measure a possible elliptic flow in pp collisions, the Lee-Yang zero method is used in HIJING-simulated events for the LHC top energy of root s = 14 TeV on which an additional subevent with elliptic flow is superimposed. The Lee-Yang zero method has been tested in two cases with different ratios between the numbers of particles generated in the two subevents. The applied method has successfully reproduced the shape of the differential eta and P-T elliptic flow dependencies, and on average its magnitude taking into account all involved particles, albeit with huge fluctuations.
T2  - Physica Scripta
T1  - Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method
VL  - 89
IS  - 7
DO  - 10.1088/0031-8949/89/7/075301
ER  - 
@article{
author = "Dordic, O. and Milošević, Jovan and Tveter, T. S.",
year = "2014",
abstract = "This paper presents the results of an attempt to measure the elliptic flow in the smallest collision system (pp) at the highest designed collision energy at the Large Hadron Collider (LHC) using the genuine collective correlation among a large number of particles. A huge non-flow effect introduced by a strong jet correlation in pp collisions makes the application of the standard event plane flow analysis non-feasible. Therefore, in order to measure a possible elliptic flow in pp collisions, the Lee-Yang zero method is used in HIJING-simulated events for the LHC top energy of root s = 14 TeV on which an additional subevent with elliptic flow is superimposed. The Lee-Yang zero method has been tested in two cases with different ratios between the numbers of particles generated in the two subevents. The applied method has successfully reproduced the shape of the differential eta and P-T elliptic flow dependencies, and on average its magnitude taking into account all involved particles, albeit with huge fluctuations.",
journal = "Physica Scripta",
title = "Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method",
volume = "89",
number = "7",
doi = "10.1088/0031-8949/89/7/075301"
}
Dordic, O., Milošević, J.,& Tveter, T. S.. (2014). Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method. in Physica Scripta, 89(7).
https://doi.org/10.1088/0031-8949/89/7/075301
Dordic O, Milošević J, Tveter TS. Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method. in Physica Scripta. 2014;89(7).
doi:10.1088/0031-8949/89/7/075301 .
Dordic, O., Milošević, Jovan, Tveter, T. S., "Feasibility of the elliptic flow measurements in pp"LHC using the Lee-Yang zero method" in Physica Scripta, 89, no. 7 (2014),
https://doi.org/10.1088/0031-8949/89/7/075301 . .
1

Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells

Korićanac, Lela; Žakula, Jelena; Keta, Otilija D.; Cirrone, Giuseppe Antonio Pablo; Cuttone, Giacomo; Ristić-Fira, Aleksandra; Petrović, Ivan M.

(2013)

TY  - JOUR
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Keta, Otilija D.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5593
AB  - This study was conducted in order to evaluate the ability of carbon ions to induce DNA double-strand breaks and apoptosis in the radio-resistant human HTB140 melanoma cells. The cells were irradiated with C-12 ions having the linear energy transfer of 258 keV/mu m. Irradiations were performed in the dose range from 2 to 16 Gy. Induction of DNA double-strand breaks was evaluated 2 hour after irradiation through expression of gamma H2AX protein. Increased level of gamma H2AX detected in irradiated samples was especially high after irradiation with 12 and 16 Gy. Dose dependent increase of apoptosis was detected 48 hour after irradiation by flow-cytometry, with the maximum value of 20.4% after irradiation with 16 Gy, and the apoptotic index of 9.3. Pro-apoptotic effects of carbon ion beams were confirmed by changes of key molecules of the mitochondrial apoptotic pathway, p53 protein expression, Bax/Bcl-2 ratio and caspase-3 activation.
T2  - Nuclear technology and radiation protection
T1  - Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells
VL  - 28
IS  - 2
SP  - 195
EP  - 203
DO  - 10.2298/NTRP1302195K
ER  - 
@article{
author = "Korićanac, Lela and Žakula, Jelena and Keta, Otilija D. and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Ristić-Fira, Aleksandra and Petrović, Ivan M.",
year = "2013",
abstract = "This study was conducted in order to evaluate the ability of carbon ions to induce DNA double-strand breaks and apoptosis in the radio-resistant human HTB140 melanoma cells. The cells were irradiated with C-12 ions having the linear energy transfer of 258 keV/mu m. Irradiations were performed in the dose range from 2 to 16 Gy. Induction of DNA double-strand breaks was evaluated 2 hour after irradiation through expression of gamma H2AX protein. Increased level of gamma H2AX detected in irradiated samples was especially high after irradiation with 12 and 16 Gy. Dose dependent increase of apoptosis was detected 48 hour after irradiation by flow-cytometry, with the maximum value of 20.4% after irradiation with 16 Gy, and the apoptotic index of 9.3. Pro-apoptotic effects of carbon ion beams were confirmed by changes of key molecules of the mitochondrial apoptotic pathway, p53 protein expression, Bax/Bcl-2 ratio and caspase-3 activation.",
journal = "Nuclear technology and radiation protection",
title = "Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells",
volume = "28",
number = "2",
pages = "195-203",
doi = "10.2298/NTRP1302195K"
}
Korićanac, L., Žakula, J., Keta, O. D., Cirrone, G. A. P., Cuttone, G., Ristić-Fira, A.,& Petrović, I. M.. (2013). Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells. in Nuclear technology and radiation protection, 28(2), 195-203.
https://doi.org/10.2298/NTRP1302195K
Korićanac L, Žakula J, Keta OD, Cirrone GAP, Cuttone G, Ristić-Fira A, Petrović IM. Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells. in Nuclear technology and radiation protection. 2013;28(2):195-203.
doi:10.2298/NTRP1302195K .
Korićanac, Lela, Žakula, Jelena, Keta, Otilija D., Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Ristić-Fira, Aleksandra, Petrović, Ivan M., "Carbon Ions Induce DNA Double Strand Breaks and Apoptosis in Htb140 Melanoma Cells" in Nuclear technology and radiation protection, 28, no. 2 (2013):195-203,
https://doi.org/10.2298/NTRP1302195K . .
2
2
2

Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons

Ristić-Fira, Aleksandra; Todorović, Danijela V.; Žakula, Jelena; Keta, Otilija D.; Cirrone, Giuseppe Antonio Pablo; Cuttone, Giacomo; Petrović, Ivan M.

(2011)

TY  - JOUR
AU  - Ristić-Fira, Aleksandra
AU  - Todorović, Danijela V.
AU  - Žakula, Jelena
AU  - Keta, Otilija D.
AU  - Cirrone, Giuseppe Antonio Pablo
AU  - Cuttone, Giacomo
AU  - Petrović, Ivan M.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4537
AB  - Conventional radiotherapy with X-and gamma-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and (12)C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with gamma-rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u (12)C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than gamma-rays. The best efficiency was obtained with (12)C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for (12)C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and (12)C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance.
T2  - Physiological Research
T1  - Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons
VL  - 60
SP  - S129
EP  - S135
ER  - 
@article{
author = "Ristić-Fira, Aleksandra and Todorović, Danijela V. and Žakula, Jelena and Keta, Otilija D. and Cirrone, Giuseppe Antonio Pablo and Cuttone, Giacomo and Petrović, Ivan M.",
year = "2011",
abstract = "Conventional radiotherapy with X-and gamma-rays is one of the common and effective treatments of cancer. High energy hadrons, i.e., charged particles like protons and (12)C ions, due to their specific physics and radiobiological advantages are increasingly used. In this study, effectiveness of different radiation types is evaluated on the radio-resistant human HTB140 melanoma cells. The cells were irradiated with gamma-rays, the 62 MeV protons at the Bragg peak and in the middle of the spread-out Bragg peak (SOBP), as well as with the 62 MeV/u (12)C ions. The doses ranged from 2 to 24 Gy. Cell survival and proliferation were assessed 7 days after irradiation, whereas apoptosis was evaluated after 48 h. The acquired results confirmed the high radio-resistance of cells, showing better effectiveness of protons than gamma-rays. The best efficiency was obtained with (12)C ions due to higher linear energy transfer. All analyzed radiation qualities reduced cell proliferation. The highest proliferation was detected for (12)C ions because of their large killing capacity followed by small induction of reparable lesions. This enabled unharmed cells to preserve proliferative activity. Irradiations with protons and (12)C ions revealed similar moderate pro-apoptotic ability that is in agreement with the level of cellular radio-resistance.",
journal = "Physiological Research",
title = "Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons",
volume = "60",
pages = "S129-S135"
}
Ristić-Fira, A., Todorović, D. V., Žakula, J., Keta, O. D., Cirrone, G. A. P., Cuttone, G.,& Petrović, I. M.. (2011). Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons. in Physiological Research, 60, S129-S135.
Ristić-Fira A, Todorović DV, Žakula J, Keta OD, Cirrone GAP, Cuttone G, Petrović IM. Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons. in Physiological Research. 2011;60:S129-S135..
Ristić-Fira, Aleksandra, Todorović, Danijela V., Žakula, Jelena, Keta, Otilija D., Cirrone, Giuseppe Antonio Pablo, Cuttone, Giacomo, Petrović, Ivan M., "Response of Human HTB140 Melanoma Cells to Conventional Radiation and Hadrons" in Physiological Research, 60 (2011):S129-S135.
6