TY  - JOUR
AU  - Soskić, Sanja S.
AU  - Stanković, Aleksandra
AU  - Đurić, Tamara
AU  - Živković, Maja
AU  - Ristić, P.
AU  - Anđelković, Z.
AU  - Šumarac-Dumanović, Mirjana
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4047
AB  - The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPAR gamma Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPAR gamma(2) 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population.
T2  - Archives of Biological Sciences
T1  - Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population
VL  - 62
IS  - 2
SP  - 263
EP  - 270
DO  - 10.2298/ABS1002263S
ER  - 

@article{
author = "Soskić, Sanja S. and Stanković, Aleksandra and Đurić, Tamara and Živković, Maja and Ristić, P. and Anđelković, Z. and Šumarac-Dumanović, Mirjana and Alavantić, Dragan",
year = "2010",
abstract = "The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a gene candidate for the onset of type 2 diabetes mellitus (T2DM). We investigated the association of the PPAR gamma Pro12Ala gene with the onset of T2DM for the first time in the Serbian population. The study population consisted of 197 controls and 163 T2DM patients. The 12Ala allele tended to be more frequent in the group of T2DM patients (0.11) compared to the control subjects (0.09). The results from this study indicate that the PPAR gamma(2) 12Ala allele presents a non-significant risk factor for T2DM development in the Serbian population.",
journal = "Archives of Biological Sciences",
title = "Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population",
volume = "62",
number = "2",
pages = "263-270",
doi = "10.2298/ABS1002263S"
}

Soskić, S. S., Stanković, A., Đurić, T., Živković, M., Ristić, P., Anđelković, Z., Šumarac-Dumanović, M.,& Alavantić, D.. (2010). Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population. in Archives of Biological Sciences, 62(2), 263-270.
https://doi.org/10.2298/ABS1002263S

Soskić SS, Stanković A, Đurić T, Živković M, Ristić P, Anđelković Z, Šumarac-Dumanović M, Alavantić D. Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population. in Archives of Biological Sciences. 2010;62(2):263-270.
doi:10.2298/ABS1002263S .

Soskić, Sanja S., Stanković, Aleksandra, Đurić, Tamara, Živković, Maja, Ristić, P., Anđelković, Z., Šumarac-Dumanović, Mirjana, Alavantić, Dragan, "Pro12ala Gene Polymorphism in the Peroxisome Proliferator-Activated Receptor Gamma as a Risk Factor for the Onset of Type 2 Diabetes Mellitus in the Serbian Population" in Archives of Biological Sciences, 62, no. 2 (2010):263-270,
https://doi.org/10.2298/ABS1002263S . .

TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Živković, Maja
AU  - Kostić, Mirjana M.
AU  - Atanackovic, Jasmina
AU  - Krstić, Zoran
AU  - Alavantić, Dragan
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3873
AB  - Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are common causes of chronic renal failure in children. The angiotensin II receptor type 2 (AT2R) is one of proposed candidate genes for CAKUT, but the expression was never explored in humans. The aim was to establish the AM gene expression in human CAKUT concerning -1332A/G polymorphism, which might affect alternative splicing. Design and methods: Forty-eight patients with CAKUT constitute the basis of this study. Genotyping for -1332A/G, RT-PCR for AT2R gene expression and confirmation sequencing were performed. Results: The expression of Ex 1/2/3 and Ex 1/3 transcript splice variants of the AT2R mRNA were detected in human CAKUT tissue. The pattern was observed independently of A to G transition. Conclusions: The expression of AT2R mRNA in human CAKUT was established for the first time and was not affected by -1332A/G polymorphism in children with CAKUT. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT
VL  - 43
IS  - 1-2
SP  - 71
EP  - 75
DO  - 10.1016/j.clinbiochem.2009.09.009
ER  - 

@article{
author = "Stanković, Aleksandra and Živković, Maja and Kostić, Mirjana M. and Atanackovic, Jasmina and Krstić, Zoran and Alavantić, Dragan",
year = "2010",
abstract = "Objectives: Congenital anomalies of the kidney and urinary tract (CAKUT) are common causes of chronic renal failure in children. The angiotensin II receptor type 2 (AT2R) is one of proposed candidate genes for CAKUT, but the expression was never explored in humans. The aim was to establish the AM gene expression in human CAKUT concerning -1332A/G polymorphism, which might affect alternative splicing. Design and methods: Forty-eight patients with CAKUT constitute the basis of this study. Genotyping for -1332A/G, RT-PCR for AT2R gene expression and confirmation sequencing were performed. Results: The expression of Ex 1/2/3 and Ex 1/3 transcript splice variants of the AT2R mRNA were detected in human CAKUT tissue. The pattern was observed independently of A to G transition. Conclusions: The expression of AT2R mRNA in human CAKUT was established for the first time and was not affected by -1332A/G polymorphism in children with CAKUT. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT",
volume = "43",
number = "1-2",
pages = "71-75",
doi = "10.1016/j.clinbiochem.2009.09.009"
}

Stanković, A., Živković, M., Kostić, M. M., Atanackovic, J., Krstić, Z.,& Alavantić, D.. (2010). Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT. in Clinical Biochemistry, 43(1-2), 71-75.
https://doi.org/10.1016/j.clinbiochem.2009.09.009

Stanković A, Živković M, Kostić MM, Atanackovic J, Krstić Z, Alavantić D. Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT. in Clinical Biochemistry. 2010;43(1-2):71-75.
doi:10.1016/j.clinbiochem.2009.09.009 .

Stanković, Aleksandra, Živković, Maja, Kostić, Mirjana M., Atanackovic, Jasmina, Krstić, Zoran, Alavantić, Dragan, "Expression profiling of the AT2R mRNA in affected tissue from children with CAKUT" in Clinical Biochemistry, 43, no. 1-2 (2010):71-75,
https://doi.org/10.1016/j.clinbiochem.2009.09.009 . .

TY  - JOUR
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Dinčić, Evica
AU  - Popović, Milan
AU  - Popovic, Smiljana
AU  - Raičević, Ranko
AU  - Alavantić, Dragan
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3771
AB  - Background: Recently a high-resolution HLA and SNP map was defined and the analysis provided informative tag SNPs that capture much of the common variation in the MHC region. This concept enables detection of smaller number of SNPs, making it surrogate markers for haplotype associated with certain disease. The SNP rs3135388 was proposed as a tagging SNP for DRB1*1501/DQB1*0602 alleles, associated with MS. The aim of the study was to investigate the HLA rs3135388 genotypes in association with MS in patients from Serbia. Methods: Two hundred sixty nine consecutive patients from Serbia with relapse-remitting and secondary progressive MS were recruited for the study. Genomic DNA was isolated from peripheral blood cells. We designed the TaqMan assay for high-throughput genotyping of HLA rs3135388 on 7500 Real-Time PCR System. Results: We found significantly higher frequency of rs3135388 A allele carriers in MS patients compared to controls (p LT 0.001, chi(2)). In our population the carriers of one A allele had adjusted OR 2.09 (95% CI 1.41-3.09, p LT 0.001) for MS susceptibility. Conclusion: We assessed significant association of rs3135388 A allele carriership with MS in patients from Serbia. This HLA-DRB1*1501 surrogate marker is useful in association studies in MS. (C) 2009 Elsevier B.V. All rights reserved.
T2  - Clinica Chimica Acta
T1  - The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR
VL  - 406
IS  - 1-2
SP  - 27
EP  - 30
DO  - 10.1016/j.cca.2009.05.004
ER  - 

@article{
author = "Živković, Maja and Stanković, Aleksandra and Dinčić, Evica and Popović, Milan and Popovic, Smiljana and Raičević, Ranko and Alavantić, Dragan",
year = "2009",
abstract = "Background: Recently a high-resolution HLA and SNP map was defined and the analysis provided informative tag SNPs that capture much of the common variation in the MHC region. This concept enables detection of smaller number of SNPs, making it surrogate markers for haplotype associated with certain disease. The SNP rs3135388 was proposed as a tagging SNP for DRB1*1501/DQB1*0602 alleles, associated with MS. The aim of the study was to investigate the HLA rs3135388 genotypes in association with MS in patients from Serbia. Methods: Two hundred sixty nine consecutive patients from Serbia with relapse-remitting and secondary progressive MS were recruited for the study. Genomic DNA was isolated from peripheral blood cells. We designed the TaqMan assay for high-throughput genotyping of HLA rs3135388 on 7500 Real-Time PCR System. Results: We found significantly higher frequency of rs3135388 A allele carriers in MS patients compared to controls (p LT 0.001, chi(2)). In our population the carriers of one A allele had adjusted OR 2.09 (95% CI 1.41-3.09, p LT 0.001) for MS susceptibility. Conclusion: We assessed significant association of rs3135388 A allele carriership with MS in patients from Serbia. This HLA-DRB1*1501 surrogate marker is useful in association studies in MS. (C) 2009 Elsevier B.V. All rights reserved.",
journal = "Clinica Chimica Acta",
title = "The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR",
volume = "406",
number = "1-2",
pages = "27-30",
doi = "10.1016/j.cca.2009.05.004"
}

Živković, M., Stanković, A., Dinčić, E., Popović, M., Popovic, S., Raičević, R.,& Alavantić, D.. (2009). The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR. in Clinica Chimica Acta, 406(1-2), 27-30.
https://doi.org/10.1016/j.cca.2009.05.004

Živković M, Stanković A, Dinčić E, Popović M, Popovic S, Raičević R, Alavantić D. The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR. in Clinica Chimica Acta. 2009;406(1-2):27-30.
doi:10.1016/j.cca.2009.05.004 .

Živković, Maja, Stanković, Aleksandra, Dinčić, Evica, Popović, Milan, Popovic, Smiljana, Raičević, Ranko, Alavantić, Dragan, "The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: Cost-effective high-throughput detection by real-time PCR" in Clinica Chimica Acta, 406, no. 1-2 (2009):27-30,
https://doi.org/10.1016/j.cca.2009.05.004 . .