TY  - JOUR
AU  - Milovanović, Stoja
AU  - Marković, Darka
AU  - Mraković, Ana Đ.
AU  - Kuska, Robert
AU  - Žižović, Irena T.
AU  - Frerich, Sulamith
AU  - Ivanović, Jasna
PY  - 2019
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0928493117342169
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8041
AB  - Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO2) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO2 densities (273 kg/m3 and 630 kg/m3) and short processing times (2 h and 4 h) enabled thymol loading of 0.92%–6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 °C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4. © 2019 Elsevier B.V.
T2  - Materials Science and Engineering: C
T1  - Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release
VL  - 99
SP  - 394
EP  - 404
DO  - 10.1016/j.msec.2019.01.106
ER  - 

@article{
author = "Milovanović, Stoja and Marković, Darka and Mraković, Ana Đ. and Kuska, Robert and Žižović, Irena T. and Frerich, Sulamith and Ivanović, Jasna",
year = "2019",
abstract = "Amorphous, medical grade poly(D,L-lactic acid) (PLA) and poly(D,L-lactic-co-glycolic acid) (PLGA) were used to develop systems for controlled release of a natural bioactive substance - thymol. Supercritical carbon dioxide (scCO2) was successfully used both as an impregnation medium for thymol incorporation into the polymer matrix and a foaming agent in a single-step batch process. Impregnation of samples using low to moderate scCO2 densities (273 kg/m3 and 630 kg/m3) and short processing times (2 h and 4 h) enabled thymol loading of 0.92%–6.62% and formation of microcellular foams upon system depressurization. Thymol effect on structural and thermal properties on foamed samples was proven by FTIR and DSC. The effect of CO2 under elevated pressure on the neat polymers was analysed by high pressure DSC. Foaming of polymers with lower molecular weight by CO2 of higher density yielded foams with smaller pores. All tested foams released thymol in a controlled manner in phosphate buffered saline (PBS) at 37 °C within 3 to 6 weeks. Higher loading and lower cell density favoured thymol release rate, while its concentration in PBS for the tested period depended on foam interaction with the medium. Representative PLGA foam sample with the highest thymol loading (6.62%) showed controlled thymol release within 72 h in mediums having pH values from 1.1 to 7.4. © 2019 Elsevier B.V.",
journal = "Materials Science and Engineering: C",
title = "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release",
volume = "99",
pages = "394-404",
doi = "10.1016/j.msec.2019.01.106"
}

Milovanović, S., Marković, D., Mraković, A. Đ., Kuska, R., Žižović, I. T., Frerich, S.,& Ivanović, J.. (2019). Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science and Engineering: C, 99, 394-404.
https://doi.org/10.1016/j.msec.2019.01.106

Milovanović S, Marković D, Mraković AĐ, Kuska R, Žižović IT, Frerich S, Ivanović J. Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release. in Materials Science and Engineering: C. 2019;99:394-404.
doi:10.1016/j.msec.2019.01.106 .

Milovanović, Stoja, Marković, Darka, Mraković, Ana Đ., Kuska, Robert, Žižović, Irena T., Frerich, Sulamith, Ivanović, Jasna, "Supercritical CO2 - assisted production of PLA and PLGA foams for controlled thymol release" in Materials Science and Engineering: C, 99 (2019):394-404,
https://doi.org/10.1016/j.msec.2019.01.106 . .