TY  - JOUR
AU  - Popović, Milan
AU  - Paskas, Svetlana
AU  - Živković, Maja
AU  - Đurić-Delić, Tamara
AU  - Stanković, Aleksandra
AU  - Burysek, L.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3864
AB  - We studied the effect of HCMV (AD-169) on the regulation of PAR1 reporter activity in HUVEC. In HUVEC, HCMV significantly induced activation of PAR1 reporter constructs carrying AP-2-like and two complexes of AP-2/Sp1-binding elements. Shorter constructs with no AP-2-like binding elements had lower activity upon virus inoculation. Moreover, activity of the shortest construct without binding elements was not significantly increased in virus-exposed cells. Furthermore, in HCMV-exposed cells, activity of the PARI reporter was significantly augmented upon p52/RelB transfection. Taken together, the data indicate that activity of the PAR1 promoter is highly dependent on AP-2/Sp1 binding elements and mediated by p52/RelB regulatory factors.
T2  - Archives of Biological Sciences
T1  - In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter
VL  - 61
IS  - 4
SP  - 613
EP  - 618
DO  - 10.2298/ABS0904613P
ER  - 

@article{
author = "Popović, Milan and Paskas, Svetlana and Živković, Maja and Đurić-Delić, Tamara and Stanković, Aleksandra and Burysek, L.",
year = "2009",
abstract = "We studied the effect of HCMV (AD-169) on the regulation of PAR1 reporter activity in HUVEC. In HUVEC, HCMV significantly induced activation of PAR1 reporter constructs carrying AP-2-like and two complexes of AP-2/Sp1-binding elements. Shorter constructs with no AP-2-like binding elements had lower activity upon virus inoculation. Moreover, activity of the shortest construct without binding elements was not significantly increased in virus-exposed cells. Furthermore, in HCMV-exposed cells, activity of the PARI reporter was significantly augmented upon p52/RelB transfection. Taken together, the data indicate that activity of the PAR1 promoter is highly dependent on AP-2/Sp1 binding elements and mediated by p52/RelB regulatory factors.",
journal = "Archives of Biological Sciences",
title = "In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter",
volume = "61",
number = "4",
pages = "613-618",
doi = "10.2298/ABS0904613P"
}

Popović, M., Paskas, S., Živković, M., Đurić-Delić, T., Stanković, A.,& Burysek, L.. (2009). In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter. in Archives of Biological Sciences, 61(4), 613-618.
https://doi.org/10.2298/ABS0904613P

Popović M, Paskas S, Živković M, Đurić-Delić T, Stanković A, Burysek L. In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter. in Archives of Biological Sciences. 2009;61(4):613-618.
doi:10.2298/ABS0904613P .

Popović, Milan, Paskas, Svetlana, Živković, Maja, Đurić-Delić, Tamara, Stanković, Aleksandra, Burysek, L., "In Hcmv-Exposed Huvec, P52/Relb Regulatory Factors Mediate Activation of the Human Par1 Gene Promoter" in Archives of Biological Sciences, 61, no. 4 (2009):613-618,
https://doi.org/10.2298/ABS0904613P . .