Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200143 (University of Belgrade, Faculty of Veterinary Medicine)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200143 (University of Belgrade, Faculty of Veterinary Medicine) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200143 (Univerzitet u Beogradu, Fakultet veterinarske medicine) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200143 (Универзитет у Београду, Факултет ветеринарске медицине) (sr)
Authors

Publications

Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle

Prodanović, Radiša; Kirovski, Danijela; Vujanac, Ivan; Đorđević, Ana; Romić, Snježana Đ.; Pantelić, Marija; Korićanac, Goran

(2022)

TY  - JOUR
AU  - Prodanović, Radiša
AU  - Kirovski, Danijela
AU  - Vujanac, Ivan
AU  - Đorđević, Ana
AU  - Romić, Snježana Đ.
AU  - Pantelić, Marija
AU  - Korićanac, Goran
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10356
AB  - A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance, though it is evident that dry cow muscles may contain increased triglyceride content. The current study was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ), glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows. Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin 1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to this disposition.
T2  - Research in Veterinary Science
T1  - Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle
VL  - 150
SP  - 189
EP  - 194
DO  - 10.1016/j.rvsc.2022.04.012
ER  - 
@article{
author = "Prodanović, Radiša and Kirovski, Danijela and Vujanac, Ivan and Đorđević, Ana and Romić, Snježana Đ. and Pantelić, Marija and Korićanac, Goran",
year = "2022",
abstract = "A number of alterations have been identified in lipid metabolism within adipose tissue and liver in obesity. Less is known about the capacity of skeletal muscle for the metabolism of fatty acids in obesity-related insulin resistance, though it is evident that dry cow muscles may contain increased triglyceride content. The current study was therefore undertaken to evaluate the skeletal muscle expression of proteins of the fatty acid metabolism in dry cows with different body condition scores (BCS). Sixteen Holstein-Friesian close-up cows were divided into 2 equal groups based on their BCS as optimal (3.25 ≤ BCS ≤ 3.5) and high (4.0 ≤ BCS ≤ 4.25). Blood samples collection and skeletal muscle biopsies were carried out at day 10 before calving. Blood serum was assayed for concentration of resistin using a bovine specific ELISA. Protein expression of insulin receptor beta subunit (IRβ), glucose transporter 4 (GLUT4), fatty acid translocase (FAT/CD36), fatty acid transporter 1 (FATP1), carnitine palmitoyltransferase 1 (CPT1), AMP-acitvated protein kinase (AMPK) and lipin 1 were analyzed in semitendinosus muscle by immunoblot. Resistin differed non-significantly between high-BCS and optimal-BCS cows. Insulin-resistant lipid metabolism in obese cows was paralleled with increased skeletal muscle expression of lipin 1 and GLUT4, and decreased expression of IRβ and FATP1. These data suggest that in obesity-related insulin resistance, metabolic capacity in dry cow skeletal muscles appears to be organized towards the synthesis of signaling intermediates rather than fatty acids oxidation and that altered fatty acid uptake does not contribute to this disposition.",
journal = "Research in Veterinary Science",
title = "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle",
volume = "150",
pages = "189-194",
doi = "10.1016/j.rvsc.2022.04.012"
}
Prodanović, R., Kirovski, D., Vujanac, I., Đorđević, A., Romić, S. Đ., Pantelić, M.,& Korićanac, G.. (2022). Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science, 150, 189-194.
https://doi.org/10.1016/j.rvsc.2022.04.012
Prodanović R, Kirovski D, Vujanac I, Đorđević A, Romić SĐ, Pantelić M, Korićanac G. Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle. in Research in Veterinary Science. 2022;150:189-194.
doi:10.1016/j.rvsc.2022.04.012 .
Prodanović, Radiša, Kirovski, Danijela, Vujanac, Ivan, Đorđević, Ana, Romić, Snježana Đ., Pantelić, Marija, Korićanac, Goran, "Obesity-related prepartal insulin resistance in dairy cows is associated with increased lipin 1 and decreased FATP 1 expression in skeletal muscle" in Research in Veterinary Science, 150 (2022):189-194,
https://doi.org/10.1016/j.rvsc.2022.04.012 . .

Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe

Ajtić, Jelena V.; Zorko, Benjamin; Nečemer, Marijan; Sarvan, Darko Z.; Rajačić, Milica; Krneta-Nikolić, Jelena D.; Todorović, Dragana; Đurđević, Vladimir S.; Vodenik, Branko; Glavič-Cindro, Denis; Kožar Logar, Jasmina Koar

(2021)

TY  - JOUR
AU  - Ajtić, Jelena V.
AU  - Zorko, Benjamin
AU  - Nečemer, Marijan
AU  - Sarvan, Darko Z.
AU  - Rajačić, Milica
AU  - Krneta-Nikolić, Jelena D.
AU  - Todorović, Dragana
AU  - Đurđević, Vladimir S.
AU  - Vodenik, Branko
AU  - Glavič-Cindro, Denis
AU  - Kožar Logar, Jasmina Koar
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10075
AB  - This study investigates the beryllium-7, lead-210 and caesium-137 activity concentrations in aerosol filter samples collected monthly along the 45°N zonal belt over 1991–2019. Sampling was performed in three locations, one in Serbia and two in Slovenia, and the Slovenian data records are published here for the first time. The activity concentrations were determined by standard gamma spectrometry. The obtained results are in general agreement with the literature data for Europe. The data sets at different sites display similarities in measurement ranges, overall means and seasonal cycles. Still, statistical tests show significant differences among the radionuclides’ concentrations across the locations. To investigate underlying processes that affect radioactivity in the surface air in this region, multivariate statistical concepts are applied to the radionuclides’ concentrations and local meteorological parameters. Discriminant analysis shows that all three sites are well separated from each other. Principal component analysis gives common pattern of interconnection between the observables: temperature has a stronger influence on the behaviour of beryllium-7 and lead-210 than that of caesium-137, but a negative correlation of the radionuclides’ concentrations with precipitation seems the strongest for caesium-137. Principal component analysis also shows local differences in the degree of relationship between the meteorological parameters and activity concentrations of the investigated radionuclides. This is an important finding for future atmospheric transport studies.
T2  - International Journal of Environmental Science and Technology
T1  - Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe
DO  - 10.1007/s13762-021-03814-0
ER  - 
@article{
author = "Ajtić, Jelena V. and Zorko, Benjamin and Nečemer, Marijan and Sarvan, Darko Z. and Rajačić, Milica and Krneta-Nikolić, Jelena D. and Todorović, Dragana and Đurđević, Vladimir S. and Vodenik, Branko and Glavič-Cindro, Denis and Kožar Logar, Jasmina Koar",
year = "2021",
abstract = "This study investigates the beryllium-7, lead-210 and caesium-137 activity concentrations in aerosol filter samples collected monthly along the 45°N zonal belt over 1991–2019. Sampling was performed in three locations, one in Serbia and two in Slovenia, and the Slovenian data records are published here for the first time. The activity concentrations were determined by standard gamma spectrometry. The obtained results are in general agreement with the literature data for Europe. The data sets at different sites display similarities in measurement ranges, overall means and seasonal cycles. Still, statistical tests show significant differences among the radionuclides’ concentrations across the locations. To investigate underlying processes that affect radioactivity in the surface air in this region, multivariate statistical concepts are applied to the radionuclides’ concentrations and local meteorological parameters. Discriminant analysis shows that all three sites are well separated from each other. Principal component analysis gives common pattern of interconnection between the observables: temperature has a stronger influence on the behaviour of beryllium-7 and lead-210 than that of caesium-137, but a negative correlation of the radionuclides’ concentrations with precipitation seems the strongest for caesium-137. Principal component analysis also shows local differences in the degree of relationship between the meteorological parameters and activity concentrations of the investigated radionuclides. This is an important finding for future atmospheric transport studies.",
journal = "International Journal of Environmental Science and Technology",
title = "Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe",
doi = "10.1007/s13762-021-03814-0"
}
Ajtić, J. V., Zorko, B., Nečemer, M., Sarvan, D. Z., Rajačić, M., Krneta-Nikolić, J. D., Todorović, D., Đurđević, V. S., Vodenik, B., Glavič-Cindro, D.,& Kožar Logar, J. K.. (2021). Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe. in International Journal of Environmental Science and Technology.
https://doi.org/10.1007/s13762-021-03814-0
Ajtić JV, Zorko B, Nečemer M, Sarvan DZ, Rajačić M, Krneta-Nikolić JD, Todorović D, Đurđević VS, Vodenik B, Glavič-Cindro D, Kožar Logar JK. Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe. in International Journal of Environmental Science and Technology. 2021;.
doi:10.1007/s13762-021-03814-0 .
Ajtić, Jelena V., Zorko, Benjamin, Nečemer, Marijan, Sarvan, Darko Z., Rajačić, Milica, Krneta-Nikolić, Jelena D., Todorović, Dragana, Đurđević, Vladimir S., Vodenik, Branko, Glavič-Cindro, Denis, Kožar Logar, Jasmina Koar, "Characteristics of radioactivity in the surface air along the 45°N zonal belt in South-Eastern Europe" in International Journal of Environmental Science and Technology (2021),
https://doi.org/10.1007/s13762-021-03814-0 . .

Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols

Mitrović, Marko; Ciraj-Bjelac, Olivera; Jovanović, Z.; Krstić, N.; Nikezić, Dragoslav; Krstić, D.; Živković, M.; Lazarević-Macanović, Mirjana

(2021)

TY  - JOUR
AU  - Mitrović, Marko
AU  - Ciraj-Bjelac, Olivera
AU  - Jovanović, Z.
AU  - Krstić, N.
AU  - Nikezić, Dragoslav
AU  - Krstić, D.
AU  - Živković, M.
AU  - Lazarević-Macanović, Mirjana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9913
AB  - The objective of this work was to assess absorbed doses in organs and tissues of a rabbit, following computed tomography (CT) examinations, using a dedicated 3D voxel model. Absorbed doses in relevant organs were calculated using the MCNP5 Monte Carlo software. Calculations were perfomed for two standard CT protocols, using tube voltages of 110 kVp and 130 kVp. Absorbed doses were calculated in 11 organs and tissues, i.e., skin, bones, brain, muscles, heart, lungs, liver, spleen, kidney, testicles, and fat tissue. The doses ranged from 15.3 to 28.3 mGy, and from 40.2 to 74.3 mGy, in the two investigated protocols. The organs that received the highest dose were bones and kidneys. In contrast, brain and spleen were organs that received the smallest doses. Doses in organs which are stretched along the body did not change significantly with distance. On the other hand, doses in organs which are localized in the body showed maximums and minimums. Using the voxel model, it is possible to calculate the dose distribution in the rabbit’s body after CT scans, and study the potential biological effects of CT doses in certain organs. The voxel model presented in this work can be used to calculated doses in all radiation experiments in which rabbits are used as experimental animals.
T2  - Radiation and Environmental Biophysics
T1  - Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols
VL  - 60
IS  - 4
SP  - 631
EP  - 638
DO  - 10.1007/s00411-021-00941-7
ER  - 
@article{
author = "Mitrović, Marko and Ciraj-Bjelac, Olivera and Jovanović, Z. and Krstić, N. and Nikezić, Dragoslav and Krstić, D. and Živković, M. and Lazarević-Macanović, Mirjana",
year = "2021",
abstract = "The objective of this work was to assess absorbed doses in organs and tissues of a rabbit, following computed tomography (CT) examinations, using a dedicated 3D voxel model. Absorbed doses in relevant organs were calculated using the MCNP5 Monte Carlo software. Calculations were perfomed for two standard CT protocols, using tube voltages of 110 kVp and 130 kVp. Absorbed doses were calculated in 11 organs and tissues, i.e., skin, bones, brain, muscles, heart, lungs, liver, spleen, kidney, testicles, and fat tissue. The doses ranged from 15.3 to 28.3 mGy, and from 40.2 to 74.3 mGy, in the two investigated protocols. The organs that received the highest dose were bones and kidneys. In contrast, brain and spleen were organs that received the smallest doses. Doses in organs which are stretched along the body did not change significantly with distance. On the other hand, doses in organs which are localized in the body showed maximums and minimums. Using the voxel model, it is possible to calculate the dose distribution in the rabbit’s body after CT scans, and study the potential biological effects of CT doses in certain organs. The voxel model presented in this work can be used to calculated doses in all radiation experiments in which rabbits are used as experimental animals.",
journal = "Radiation and Environmental Biophysics",
title = "Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols",
volume = "60",
number = "4",
pages = "631-638",
doi = "10.1007/s00411-021-00941-7"
}
Mitrović, M., Ciraj-Bjelac, O., Jovanović, Z., Krstić, N., Nikezić, D., Krstić, D., Živković, M.,& Lazarević-Macanović, M.. (2021). Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols. in Radiation and Environmental Biophysics, 60(4), 631-638.
https://doi.org/10.1007/s00411-021-00941-7
Mitrović M, Ciraj-Bjelac O, Jovanović Z, Krstić N, Nikezić D, Krstić D, Živković M, Lazarević-Macanović M. Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols. in Radiation and Environmental Biophysics. 2021;60(4):631-638.
doi:10.1007/s00411-021-00941-7 .
Mitrović, Marko, Ciraj-Bjelac, Olivera, Jovanović, Z., Krstić, N., Nikezić, Dragoslav, Krstić, D., Živković, M., Lazarević-Macanović, Mirjana, "Voxel model of a rabbit: assessment of absorbed doses in organs after CT examination performed by two different protocols" in Radiation and Environmental Biophysics, 60, no. 4 (2021):631-638,
https://doi.org/10.1007/s00411-021-00941-7 . .
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