TY  - JOUR
AU  - Janković, Drina
AU  - Vranješ-Đurić, Sanja
AU  - Đokić, Divna Đ.
AU  - Marković, Mirjana
AU  - Ajdinovic, Boris
AU  - Jaukovic, Ljiljana
AU  - Nikolić, Nadežda S.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4800
AB  - In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012
T2  - Journal of Pharmaceutical Sciences
T1  - 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats
VL  - 101
IS  - 6
SP  - 2194
EP  - 2203
DO  - 10.1002/jps.23114
ER  - 

@article{
author = "Janković, Drina and Vranješ-Đurić, Sanja and Đokić, Divna Đ. and Marković, Mirjana and Ajdinovic, Boris and Jaukovic, Ljiljana and Nikolić, Nadežda S.",
year = "2012",
abstract = "In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 (90Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF2, was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of 90YSnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 degrees C. The 90YSnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 degrees C up to 7 days. In vivo distribution studies in healthy male Wistar rats of 90YSnF-c (particles LT 1 mu m), following intravenous administration, revealed that the localization takes place preferably in the liver. The 90YSnF-c (particles GT 1 mu m) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of 90Y from the joint was 1.96% over this period. Because of high labeling yield and stability, 90YSnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies. (C) 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 101:21942203, 2012",
journal = "Journal of Pharmaceutical Sciences",
title = "90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats",
volume = "101",
number = "6",
pages = "2194-2203",
doi = "10.1002/jps.23114"
}

Janković, D., Vranješ-Đurić, S., Đokić, D. Đ., Marković, M., Ajdinovic, B., Jaukovic, L.,& Nikolić, N. S.. (2012). 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats. in Journal of Pharmaceutical Sciences, 101(6), 2194-2203.
https://doi.org/10.1002/jps.23114

Janković D, Vranješ-Đurić S, Đokić DĐ, Marković M, Ajdinovic B, Jaukovic L, Nikolić NS. 90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats. in Journal of Pharmaceutical Sciences. 2012;101(6):2194-2203.
doi:10.1002/jps.23114 .

Janković, Drina, Vranješ-Đurić, Sanja, Đokić, Divna Đ., Marković, Mirjana, Ajdinovic, Boris, Jaukovic, Ljiljana, Nikolić, Nadežda S., "90Y-labeled tin fluoride colloid as a promising therapeutic agent: Preparation, characterization, and biological study in rats" in Journal of Pharmaceutical Sciences, 101, no. 6 (2012):2194-2203,
https://doi.org/10.1002/jps.23114 . .