TY  - JOUR
AU  - Đokić, Divna Đ.
AU  - Janković, Drina
AU  - Nikolić, Nadežda S.
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3645
AB  - Introduction: The aim of this study was to find out if Y-90 could form a stabile complex with meso-2,3-dimercaptosuccinic acid (DMSA) and if Y-90-DMSA may have potential for tumor therapy in the palliative treatment of bone metastases. Methods: The preparing of Y-90-DMSA was carried out by varying experimental parameters, such as ligand concentration, pH, time, and temperature of the reaction, in order to maximize the labeling yield. Analysis of the complexes enclosed the radiochemical quality control (instant thin-layer chromatography, paper chromatography, and high-performance liquid chromatography), determination of pharmacokinetical parameters as well as biodistrbution study in health male Wistar rats. In vitro stability of the complexes was tested too. Results: Y-90-DMSA could be prepared in high yields ( GT 95%) under optimized conditions of reaction. Stability studies in saline and human serum in vitro showed no significant release of activity from the ligand over 24 hours and 10 days, respectively. The preliminary biodistribution results in rat at 2 hours indicated that Y-90-DMSA, at both pH levels, was significantly retained into bone. The uptake in the kidneys was lower for Y-90-DMSA at pH 8.0 then at pH 3.0. The retention in other organs was negligible. Conclusions: Y-90 complexes could be made with ease with DMSA. Y-90-DMSA was obtained in good yield and was found to be very stable. A promising biodistribution result of this complex pointed at potential in the palliative treatment of bone metastases.
T2  - Cancer Biotherapy and Radiopharmaceuticals
T1  - Preparation and In Vivo Evaluation of Y-90-Meso-Dimercaptosuccinic Acid (Y-90-DMSA) for Possible Therapeutic Use: Comparison with Tc-99m-DMSA
VL  - 24
IS  - 1
SP  - 129
EP  - 136
DO  - 10.1089/cbr.2008.0499
ER  - 

@article{
author = "Đokić, Divna Đ. and Janković, Drina and Nikolić, Nadežda S.",
year = "2009",
abstract = "Introduction: The aim of this study was to find out if Y-90 could form a stabile complex with meso-2,3-dimercaptosuccinic acid (DMSA) and if Y-90-DMSA may have potential for tumor therapy in the palliative treatment of bone metastases. Methods: The preparing of Y-90-DMSA was carried out by varying experimental parameters, such as ligand concentration, pH, time, and temperature of the reaction, in order to maximize the labeling yield. Analysis of the complexes enclosed the radiochemical quality control (instant thin-layer chromatography, paper chromatography, and high-performance liquid chromatography), determination of pharmacokinetical parameters as well as biodistrbution study in health male Wistar rats. In vitro stability of the complexes was tested too. Results: Y-90-DMSA could be prepared in high yields ( GT 95%) under optimized conditions of reaction. Stability studies in saline and human serum in vitro showed no significant release of activity from the ligand over 24 hours and 10 days, respectively. The preliminary biodistribution results in rat at 2 hours indicated that Y-90-DMSA, at both pH levels, was significantly retained into bone. The uptake in the kidneys was lower for Y-90-DMSA at pH 8.0 then at pH 3.0. The retention in other organs was negligible. Conclusions: Y-90 complexes could be made with ease with DMSA. Y-90-DMSA was obtained in good yield and was found to be very stable. A promising biodistribution result of this complex pointed at potential in the palliative treatment of bone metastases.",
journal = "Cancer Biotherapy and Radiopharmaceuticals",
title = "Preparation and In Vivo Evaluation of Y-90-Meso-Dimercaptosuccinic Acid (Y-90-DMSA) for Possible Therapeutic Use: Comparison with Tc-99m-DMSA",
volume = "24",
number = "1",
pages = "129-136",
doi = "10.1089/cbr.2008.0499"
}

Đokić, D. Đ., Janković, D.,& Nikolić, N. S.. (2009). Preparation and In Vivo Evaluation of Y-90-Meso-Dimercaptosuccinic Acid (Y-90-DMSA) for Possible Therapeutic Use: Comparison with Tc-99m-DMSA. in Cancer Biotherapy and Radiopharmaceuticals, 24(1), 129-136.
https://doi.org/10.1089/cbr.2008.0499

Đokić DĐ, Janković D, Nikolić NS. Preparation and In Vivo Evaluation of Y-90-Meso-Dimercaptosuccinic Acid (Y-90-DMSA) for Possible Therapeutic Use: Comparison with Tc-99m-DMSA. in Cancer Biotherapy and Radiopharmaceuticals. 2009;24(1):129-136.
doi:10.1089/cbr.2008.0499 .

Đokić, Divna Đ., Janković, Drina, Nikolić, Nadežda S., "Preparation and In Vivo Evaluation of Y-90-Meso-Dimercaptosuccinic Acid (Y-90-DMSA) for Possible Therapeutic Use: Comparison with Tc-99m-DMSA" in Cancer Biotherapy and Radiopharmaceuticals, 24, no. 1 (2009):129-136,
https://doi.org/10.1089/cbr.2008.0499 . .