Ministry of Science and Technological Development of the Republic of Serbia [142006], Serbian-Slovenian Bilateral Scientific Collaboration

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Ministry of Science and Technological Development of the Republic of Serbia [142006], Serbian-Slovenian Bilateral Scientific Collaboration

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Publications

Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery

Vukomanovic, Marija; Škapin, Srečo Davor; Jančar, Boštjan; Maksin, Tatjana N.; Ignjatović, Nenad L.; Uskokovic, Vuk; Uskoković, Dragan

(2011)

TY  - JOUR
AU  - Vukomanovic, Marija
AU  - Škapin, Srečo Davor
AU  - Jančar, Boštjan
AU  - Maksin, Tatjana N.
AU  - Ignjatović, Nenad L.
AU  - Uskokovic, Vuk
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/4188
AB  - Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Colloids and Surfaces. B: Biointerfaces
T1  - Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery
VL  - 82
IS  - 2
SP  - 404
EP  - 413
DO  - 10.1016/j.colsurfb.2010.09.011
ER  - 
@article{
author = "Vukomanovic, Marija and Škapin, Srečo Davor and Jančar, Boštjan and Maksin, Tatjana N. and Ignjatović, Nenad L. and Uskokovic, Vuk and Uskoković, Dragan",
year = "2011",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/4188",
abstract = "Biodegradable poly(D,L-lactide-co-glycolide) (PLGA) and bioactive hydroxyapatite (HAP) are selected for the formation of a multifunctional system with the specific core-shell structure to be applied as a carrier of a drug. As a result, both components of PLGA/HAp core-shells are able to capture one part of the drug. Polymeric shells consisting of small nanospheres up to 20 nm in size act as a matrix in which one part of the drug is dispersed. In the same time, ceramic cores are formed of rod-like hydroxyapatite particles at the surface of which another part of the drug is adsorbed onto the interface between the polymer and the ceramics. The content of the loaded drug, as well as the selected solvent/non-solvent system, have a crucial influence on the resulting PLGA/HAp morphology and, finally, unimodal distribution of core-shells is obtained. The redistribution of the drug between the organic and inorganic parts of the material is expected to provide an interesting contribution to the kinetics of the drug release resulting in non-typical two-step drug release. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Colloids and Surfaces. B: Biointerfaces",
title = "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery",
volume = "82",
number = "2",
pages = "404-413",
doi = "10.1016/j.colsurfb.2010.09.011"
}
Vukomanovic, M., Škapin, S. D., Jančar, B., Maksin, T. N., Ignjatović, N. L., Uskokovic, V.,& Uskoković, D. (2011). Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery.
Colloids and Surfaces. B: Biointerfaces, 82(2), 404-413.
https://doi.org/10.1016/j.colsurfb.2010.09.011
Vukomanovic M, Škapin SD, Jančar B, Maksin TN, Ignjatović NL, Uskokovic V, Uskoković D. Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery. Colloids and Surfaces. B: Biointerfaces. 2011;82(2):404-413
Vukomanovic Marija, Škapin Srečo Davor, Jančar Boštjan, Maksin Tatjana N., Ignjatović Nenad L., Uskokovic Vuk, Uskoković Dragan, "Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanospheres. Part 1: A multifunctional system for controlled drug delivery" Colloids and Surfaces. B: Biointerfaces, 82, no. 2 (2011):404-413,
https://doi.org/10.1016/j.colsurfb.2010.09.011 .
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