Ministry of Science and Environmental Protection of the Republic of Serbia [142006], Serbian-Slovenian Bilateral Scientific Collaboration

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Ministry of Science and Environmental Protection of the Republic of Serbia [142006], Serbian-Slovenian Bilateral Scientific Collaboration

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Publications

Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite

Vukomanovic, Marija; Mitrić, Miodrag; Škapin, Srečo Davor; Zagar, Ema; Plavec, Janez; Ignjatović, Nenad L.; Uskoković, Dragan

(2010)

TY  - JOUR
AU  - Vukomanovic, Marija
AU  - Mitrić, Miodrag
AU  - Škapin, Srečo Davor
AU  - Zagar, Ema
AU  - Plavec, Janez
AU  - Ignjatović, Nenad L.
AU  - Uskoković, Dragan
PY  - 2010
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/3943
AB  - In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.
T2  - Ultrasonics Sonochemistry
T1  - Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite
VL  - 17
IS  - 5
SP  - 902
EP  - 908
DO  - 10.1016/j.ultsonch.2010.01.007
ER  - 
@article{
author = "Vukomanovic, Marija and Mitrić, Miodrag and Škapin, Srečo Davor and Zagar, Ema and Plavec, Janez and Ignjatović, Nenad L. and Uskoković, Dragan",
year = "2010",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/3943",
abstract = "In this work poly(D,L-lactide-co-glycolide) (PLGA) and a poly(D,L-lactide-co-glycolide)/hydroxyapatite (PLGA/HAp) composite processed in an ultrasonic field at higher (25 degrees C) and lower (8 degrees C) temperatures were studied with respect to the molecular properties of the obtained materials. The processing of the PLGA and the PLGA/HAp composite in an ultrasonic field resulted in a change of molar mass averages of the polymer/polymeric part of these materials, while an amorphous structure and a 50:50 lactide-to-glycolide co-monomer ratio were preserved without the formation of crystalline oligomers. However, mobility of polymeric chains obtained after ultrasonic processing was lower indicating ordering the structure of polymeric chains as a result of processing. Additionally, it was observed that the mobility of the PLGA macromolecules was lower within the composite in comparison with the mobility of the chains within the PLGA alone in the case when both were obtained after ultrasonic processing. This was a consequence of the structure formation through the interactions between the PLGA and the HAp. Based on these results different degradation rate of PLGA in composite can be expected, which is important in the application of this material for the controlled drug delivery of medicaments. (C) 2010 Elsevier B.V. All rights reserved.",
journal = "Ultrasonics Sonochemistry",
title = "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite",
volume = "17",
number = "5",
pages = "902-908",
doi = "10.1016/j.ultsonch.2010.01.007"
}
Vukomanovic, M., Mitrić, M., Škapin, S. D., Zagar, E., Plavec, J., Ignjatović, N. L.,& Uskoković, D. (2010). Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite.
Ultrasonics Sonochemistry, 17(5), 902-908.
https://doi.org/10.1016/j.ultsonch.2010.01.007
Vukomanovic M, Mitrić M, Škapin SD, Zagar E, Plavec J, Ignjatović NL, Uskoković D. Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite. Ultrasonics Sonochemistry. 2010;17(5):902-908
Vukomanovic Marija, Mitrić Miodrag, Škapin Srečo Davor, Zagar Ema, Plavec Janez, Ignjatović Nenad L., Uskoković Dragan, "Influence of ultrasonic processing on the macromolecular properties of poly (D,L-lactide-co-glycolide) alone and in its biocomposite with hydroxyapatite" Ultrasonics Sonochemistry, 17, no. 5 (2010):902-908,
https://doi.org/10.1016/j.ultsonch.2010.01.007 .
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