TY  - CONF
AU  - Bondžić, Aleksandra M.
AU  - Parac-Vogt, Tatjana
AU  - Vujačić Nikezić, Ana V.
AU  - Krstić, Danijela
AU  - Čolović, Mirjana
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12977
AB  - Inhibition of acetylcholinesterase (AChE) is presented as a promising strategy in the treatment of Alzheimer disease providing inspiration for new discoveries and investigations less toxic and more effective potential anti Alzheimer drugs. In this paper, it demonstrated that the activity of acetylcholinesterase can be effectively inhibited by polyoxometalates (POMs), 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA) without significant changes on the secondary structure of this enzyme. The obtained values of partition coefficient implicated on smooth pass of these POMs trough cell membrane and satisfied necessary criteria for the drugs used in the treatment of the central nervous system disease. Based on these obtained results it is possible to conclude that POM could represent new generation of potential anti Alzheimer drugs.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
T1  - Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase
VL  - 1
SP  - 503
EP  - 506
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12977
ER  - 

@conference{
author = "Bondžić, Aleksandra M. and Parac-Vogt, Tatjana and Vujačić Nikezić, Ana V. and Krstić, Danijela and Čolović, Mirjana",
year = "2018",
abstract = "Inhibition of acetylcholinesterase (AChE) is presented as a promising strategy in the treatment of Alzheimer disease providing inspiration for new discoveries and investigations less toxic and more effective potential anti Alzheimer drugs. In this paper, it demonstrated that the activity of acetylcholinesterase can be effectively inhibited by polyoxometalates (POMs), 12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA) without significant changes on the secondary structure of this enzyme. The obtained values of partition coefficient implicated on smooth pass of these POMs trough cell membrane and satisfied necessary criteria for the drugs used in the treatment of the central nervous system disease. Based on these obtained results it is possible to conclude that POM could represent new generation of potential anti Alzheimer drugs.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings",
title = "Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase",
volume = "1",
pages = "503-506",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12977"
}

Bondžić, A. M., Parac-Vogt, T., Vujačić Nikezić, A. V., Krstić, D.,& Čolović, M.. (2018). Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 503-506.
https://hdl.handle.net/21.15107/rcub_vinar_12977

Bondžić AM, Parac-Vogt T, Vujačić Nikezić AV, Krstić D, Čolović M. Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings. 2018;1:503-506.
https://hdl.handle.net/21.15107/rcub_vinar_12977 .

Bondžić, Aleksandra M., Parac-Vogt, Tatjana, Vujačić Nikezić, Ana V., Krstić, Danijela, Čolović, Mirjana, "Influence of 12-Tungstosilicic acid and 12-Tungstophosphoric acid on the activity and secondary structure of acetylcholinesterase" in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings, 1 (2018):503-506,
https://hdl.handle.net/21.15107/rcub_vinar_12977 .

TY  - CONF
AU  - Čolović, Mirjana
AU  - Krstić, Danijela
AU  - Luce, M.
AU  - Cricenti, A.
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12978
AB  - 12-tungstosilicic acid (SiW12) and decavanadate (V10) are polyoxometalate compounds (POMs) exhibiting biological activity. In vitro studies of the influence SiW12 and V10 on synaptic plasma membrane (SPM) acetylcholinesterase (AChE) and Na,K-ATPase, respectively, showed that these POMs inhibit the enzyme activities in submicromolar concentrations. As Na,K-ATPase and AChE are membrane associated enzymes, the inhibition of their activities can result from the membrane changes induced by the inhibitor binding. Thus, the effect of SiW12 and V10 on the membrane structure was investigated by using Atomic Force Microscopy (AFM) technique. The obtained results demonstrated that the calculated average roughness values for SiW12 and V10 treated SPM were significantly higher (about 6 and 1.5 times, respectively), compared to untreated SPM preparation. The obtained changes indicate that both investigated POMs bind to the plasma membranes, and consequently their approved strong inhibitory potencies toward the membrane bound enzymes might be assigned to the induced membrane modifications.
PB  - Belgrade : Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
T1  - Effect of polyoxometalates on synaptic plasma membrane structure
VL  - 1
SP  - 507
EP  - 510
UR  - https://hdl.handle.net/21.15107/rcub_vinar_12978
ER  - 

@conference{
author = "Čolović, Mirjana and Krstić, Danijela and Luce, M. and Cricenti, A.",
year = "2018",
abstract = "12-tungstosilicic acid (SiW12) and decavanadate (V10) are polyoxometalate compounds (POMs) exhibiting biological activity. In vitro studies of the influence SiW12 and V10 on synaptic plasma membrane (SPM) acetylcholinesterase (AChE) and Na,K-ATPase, respectively, showed that these POMs inhibit the enzyme activities in submicromolar concentrations. As Na,K-ATPase and AChE are membrane associated enzymes, the inhibition of their activities can result from the membrane changes induced by the inhibitor binding. Thus, the effect of SiW12 and V10 on the membrane structure was investigated by using Atomic Force Microscopy (AFM) technique. The obtained results demonstrated that the calculated average roughness values for SiW12 and V10 treated SPM were significantly higher (about 6 and 1.5 times, respectively), compared to untreated SPM preparation. The obtained changes indicate that both investigated POMs bind to the plasma membranes, and consequently their approved strong inhibitory potencies toward the membrane bound enzymes might be assigned to the induced membrane modifications.",
publisher = "Belgrade : Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings",
title = "Effect of polyoxometalates on synaptic plasma membrane structure",
volume = "1",
pages = "507-510",
url = "https://hdl.handle.net/21.15107/rcub_vinar_12978"
}

Čolović, M., Krstić, D., Luce, M.,& Cricenti, A.. (2018). Effect of polyoxometalates on synaptic plasma membrane structure. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings
Belgrade : Society of Physical Chemists of Serbia., 1, 507-510.
https://hdl.handle.net/21.15107/rcub_vinar_12978

Čolović M, Krstić D, Luce M, Cricenti A. Effect of polyoxometalates on synaptic plasma membrane structure. in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings. 2018;1:507-510.
https://hdl.handle.net/21.15107/rcub_vinar_12978 .

Čolović, Mirjana, Krstić, Danijela, Luce, M., Cricenti, A., "Effect of polyoxometalates on synaptic plasma membrane structure" in PHYSICAL CHEMISTRY 2018 : 14th international conference on fundamental and applied aspects of physical chemistry : Proceedings, 1 (2018):507-510,
https://hdl.handle.net/21.15107/rcub_vinar_12978 .