TY  - JOUR
AU  - Ćirić, Ana
AU  - Medarević, Đorđe 
AU  - Čalija, Bojan
AU  - Dobričić, Vladimir
AU  - Mitrić, Miodrag
AU  - Đekić, Ljiljana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8473
AB  - This study investigated the combined influence of pH adjusting agent type (hydrochloric, acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible chitosan/xanthan polyelectrolyte complexes (PECs), their characteristics in solid state and influence on in vitro ibuprofen release kinetics. Conductivity measurements and rheological characterization revealed generally higher extent of ionic interactions in PEC dispersions comprising acetic acid and at pH 3.6. Acid type and pH affected significantly the yield and particle size (100–250 μm) of the dried PECs. Differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD) analysis of the solid PECs confirmed exclusively physical (ionic, hydrogen bonds) interactions between chitosan and xanthan gum. PECs prepared with acetic acid at pH 4.6 and 5.6 had enhanced rehydration ability in phosphate buffer pH 7.2, and at PEC-to-drug mass ratio up to 1:2, enabled extended ibuprofen release from hard capsules during 10 h. © 2020 Elsevier B.V.
T2  - International Journal of Biological Macromolecules
T1  - Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics
VL  - 148
SP  - 942
EP  - 955
DO  - 10.1016/j.ijbiomac.2020.01.138
ER  - 

@article{
author = "Ćirić, Ana and Medarević, Đorđe  and Čalija, Bojan and Dobričić, Vladimir and Mitrić, Miodrag and Đekić, Ljiljana",
year = "2020",
abstract = "This study investigated the combined influence of pH adjusting agent type (hydrochloric, acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible chitosan/xanthan polyelectrolyte complexes (PECs), their characteristics in solid state and influence on in vitro ibuprofen release kinetics. Conductivity measurements and rheological characterization revealed generally higher extent of ionic interactions in PEC dispersions comprising acetic acid and at pH 3.6. Acid type and pH affected significantly the yield and particle size (100–250 μm) of the dried PECs. Differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD) analysis of the solid PECs confirmed exclusively physical (ionic, hydrogen bonds) interactions between chitosan and xanthan gum. PECs prepared with acetic acid at pH 4.6 and 5.6 had enhanced rehydration ability in phosphate buffer pH 7.2, and at PEC-to-drug mass ratio up to 1:2, enabled extended ibuprofen release from hard capsules during 10 h. © 2020 Elsevier B.V.",
journal = "International Journal of Biological Macromolecules",
title = "Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics",
volume = "148",
pages = "942-955",
doi = "10.1016/j.ijbiomac.2020.01.138"
}

Ćirić, A., Medarević, Đ., Čalija, B., Dobričić, V., Mitrić, M.,& Đekić, L.. (2020). Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics. in International Journal of Biological Macromolecules, 148, 942-955.
https://doi.org/10.1016/j.ijbiomac.2020.01.138

Ćirić A, Medarević Đ, Čalija B, Dobričić V, Mitrić M, Đekić L. Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics. in International Journal of Biological Macromolecules. 2020;148:942-955.
doi:10.1016/j.ijbiomac.2020.01.138 .

Ćirić, Ana, Medarević, Đorđe , Čalija, Bojan, Dobričić, Vladimir, Mitrić, Miodrag, Đekić, Ljiljana, "Study of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kinetics" in International Journal of Biological Macromolecules, 148 (2020):942-955,
https://doi.org/10.1016/j.ijbiomac.2020.01.138 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Kepić, Dejan P.
AU  - Matijašević, Danka M.
AU  - Pavlović, Vladimir B.
AU  - Jovanović, Svetlana P.
AU  - Stanković, Nenad K.
AU  - Milivojević, Dušan
AU  - Špitalsky, Zdenko
AU  - Holclajtner-Antunović, Ivanka D.
AU  - Bajuk-Bogdanović, Danica V.
AU  - Nikšić, Miomir P.
AU  - Todorović-Marković, Biljana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1650
AB  - Curcumin and its derivates are well-known for their different biological activities including antibacterial. On the other hand there are controversial reports concerning the antibacterial potential of graphene and, in particular, graphene oxide. In this study we have reported for the first time the antibacterial activity of curcumin/graphene nanomesh hybrids under ambient light conditions. The graphene nanomesh was synthesized by electrochemical exfoliation of highly oriented pyrolytic graphite in 1 M solution of ammonium persulfate and further functionalized by curcumin. Identical values of minimum inhibitory concentration (1 mg mL(-1)) were determined for pure curcumin and curcumin/graphene nanomesh hybrids toward Staphylococcus aureus. All tested samples had more pronounced antibacterial activity against Gram positive bacteria, Staphylococcus aureus compared to Escherichia coli as a representative of Gram negative strains. The poor antibacterial potential of exfoliated graphene improves significantly by the functionalization with curcumin, which allows for its usage as a antibacterial coating.
T2  - RSC Advances
T1  - Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids
VL  - 7
IS  - 57
SP  - 36081
EP  - 36092
DO  - 10.1039/c7ra05027e
ER  - 

@article{
author = "Marković, Zoran M. and Kepić, Dejan P. and Matijašević, Danka M. and Pavlović, Vladimir B. and Jovanović, Svetlana P. and Stanković, Nenad K. and Milivojević, Dušan and Špitalsky, Zdenko and Holclajtner-Antunović, Ivanka D. and Bajuk-Bogdanović, Danica V. and Nikšić, Miomir P. and Todorović-Marković, Biljana",
year = "2017",
abstract = "Curcumin and its derivates are well-known for their different biological activities including antibacterial. On the other hand there are controversial reports concerning the antibacterial potential of graphene and, in particular, graphene oxide. In this study we have reported for the first time the antibacterial activity of curcumin/graphene nanomesh hybrids under ambient light conditions. The graphene nanomesh was synthesized by electrochemical exfoliation of highly oriented pyrolytic graphite in 1 M solution of ammonium persulfate and further functionalized by curcumin. Identical values of minimum inhibitory concentration (1 mg mL(-1)) were determined for pure curcumin and curcumin/graphene nanomesh hybrids toward Staphylococcus aureus. All tested samples had more pronounced antibacterial activity against Gram positive bacteria, Staphylococcus aureus compared to Escherichia coli as a representative of Gram negative strains. The poor antibacterial potential of exfoliated graphene improves significantly by the functionalization with curcumin, which allows for its usage as a antibacterial coating.",
journal = "RSC Advances",
title = "Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids",
volume = "7",
number = "57",
pages = "36081-36092",
doi = "10.1039/c7ra05027e"
}

Marković, Z. M., Kepić, D. P., Matijašević, D. M., Pavlović, V. B., Jovanović, S. P., Stanković, N. K., Milivojević, D., Špitalsky, Z., Holclajtner-Antunović, I. D., Bajuk-Bogdanović, D. V., Nikšić, M. P.,& Todorović-Marković, B.. (2017). Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids. in RSC Advances, 7(57), 36081-36092.
https://doi.org/10.1039/c7ra05027e

Marković ZM, Kepić DP, Matijašević DM, Pavlović VB, Jovanović SP, Stanković NK, Milivojević D, Špitalsky Z, Holclajtner-Antunović ID, Bajuk-Bogdanović DV, Nikšić MP, Todorović-Marković B. Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids. in RSC Advances. 2017;7(57):36081-36092.
doi:10.1039/c7ra05027e .

Marković, Zoran M., Kepić, Dejan P., Matijašević, Danka M., Pavlović, Vladimir B., Jovanović, Svetlana P., Stanković, Nenad K., Milivojević, Dušan, Špitalsky, Zdenko, Holclajtner-Antunović, Ivanka D., Bajuk-Bogdanović, Danica V., Nikšić, Miomir P., Todorović-Marković, Biljana, "Ambient light induced antibacterial action of curcumin/graphene nanomesh hybrids" in RSC Advances, 7, no. 57 (2017):36081-36092,
https://doi.org/10.1039/c7ra05027e . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Matijašević, Danka
AU  - Pavlović, Vladimir B.
AU  - Jovanović, Svetlana P.
AU  - Holclajtner-Antunović, Ivanka D.
AU  - Špitalsky, Zdenko
AU  - Mičušik, Matej
AU  - Dramićanin, Miroslav
AU  - Milivojević, Dušan
AU  - Nikšić, Miomir P.
AU  - Todorović-Marković, Biljana
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1576
AB  - Electrochemically exfoliated graphene is functionalized graphene with potential application in biomedicine. Two most relevant biological features of this material are its electrical conductivity and excellent water dispersibility. In this study we have tried to establish the correlation between graphene structure and its antibacterial properties. The exfoliation process was performed in a two electrode-highly oriented pyrolytic graphite electrochemical cell. Solution of ammonium persulfate was used as an electrolyte. Exfoliated graphene sheets were dispersed in aqueous media and characterized by atomic force microscopy, scanning electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X photoelectron spectroscopy, X-ray diffraction, electron paramagnetic resonance, zeta potential, contact angle measurements and surface energy. Antibacterial assays have shown lack of the significant antibacterial activity. Major effect on bacteria was slight change of bacteria morphology. Membrane remained intact despite significant change of chemical content of membrane components. (C) 2017 Elsevier Inc. All rights reserved.
T2  - Journal of Colloid and Interface Science
T1  - Antibacterial potential of electrochemically exfoliated graphene sheets
VL  - 500
SP  - 30
EP  - 43
DO  - 10.1016/j.jcis.2017.03.110
ER  - 

@article{
author = "Marković, Zoran M. and Matijašević, Danka and Pavlović, Vladimir B. and Jovanović, Svetlana P. and Holclajtner-Antunović, Ivanka D. and Špitalsky, Zdenko and Mičušik, Matej and Dramićanin, Miroslav and Milivojević, Dušan and Nikšić, Miomir P. and Todorović-Marković, Biljana",
year = "2017",
abstract = "Electrochemically exfoliated graphene is functionalized graphene with potential application in biomedicine. Two most relevant biological features of this material are its electrical conductivity and excellent water dispersibility. In this study we have tried to establish the correlation between graphene structure and its antibacterial properties. The exfoliation process was performed in a two electrode-highly oriented pyrolytic graphite electrochemical cell. Solution of ammonium persulfate was used as an electrolyte. Exfoliated graphene sheets were dispersed in aqueous media and characterized by atomic force microscopy, scanning electron microscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, X photoelectron spectroscopy, X-ray diffraction, electron paramagnetic resonance, zeta potential, contact angle measurements and surface energy. Antibacterial assays have shown lack of the significant antibacterial activity. Major effect on bacteria was slight change of bacteria morphology. Membrane remained intact despite significant change of chemical content of membrane components. (C) 2017 Elsevier Inc. All rights reserved.",
journal = "Journal of Colloid and Interface Science",
title = "Antibacterial potential of electrochemically exfoliated graphene sheets",
volume = "500",
pages = "30-43",
doi = "10.1016/j.jcis.2017.03.110"
}

Marković, Z. M., Matijašević, D., Pavlović, V. B., Jovanović, S. P., Holclajtner-Antunović, I. D., Špitalsky, Z., Mičušik, M., Dramićanin, M., Milivojević, D., Nikšić, M. P.,& Todorović-Marković, B.. (2017). Antibacterial potential of electrochemically exfoliated graphene sheets. in Journal of Colloid and Interface Science, 500, 30-43.
https://doi.org/10.1016/j.jcis.2017.03.110

Marković ZM, Matijašević D, Pavlović VB, Jovanović SP, Holclajtner-Antunović ID, Špitalsky Z, Mičušik M, Dramićanin M, Milivojević D, Nikšić MP, Todorović-Marković B. Antibacterial potential of electrochemically exfoliated graphene sheets. in Journal of Colloid and Interface Science. 2017;500:30-43.
doi:10.1016/j.jcis.2017.03.110 .

Marković, Zoran M., Matijašević, Danka, Pavlović, Vladimir B., Jovanović, Svetlana P., Holclajtner-Antunović, Ivanka D., Špitalsky, Zdenko, Mičušik, Matej, Dramićanin, Miroslav, Milivojević, Dušan, Nikšić, Miomir P., Todorović-Marković, Biljana, "Antibacterial potential of electrochemically exfoliated graphene sheets" in Journal of Colloid and Interface Science, 500 (2017):30-43,
https://doi.org/10.1016/j.jcis.2017.03.110 . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Voelker, Bernhard
AU  - Hohenwarter, Anton
AU  - Pippan, Reinhard
AU  - Veljović, Đorđe N.
AU  - Rakin, Marko P.
AU  - Bugarski, Branko M.
PY  - 2016
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/871
AB  - Significant enhancement of mechanical properties of metallic biomaterials can be achieved by grain refinement obtained by severe plastic deformation. The purpose of this study was to determine metallic ion release from commercially pure titanium (CPTi) and Ti-13Nb-13Zr alloy processed by high pressure torsion (HPT). The materials microstructures, in the initial state and after HPT deformation, were examined by scanning and transmission electron microscopy. The microhardness was determined along the radius of the disc-shaped samples of ultrafine-grained (UFG) CPTi and Ti-13Nb-13Zr alloy in order to evaluate homogeneity of HPT-processed materials. The quantities of released ions were determined using inductively coupled plasma-mass spectrophotometer for samples immersed in artificial saliva at 37 degrees C for 7 days. Also, the effect of artificial saliva pH value on metallic ion release was estimated. Obtained results revealed that the quantities of released ions from UFG CPTi and Ti-13Nb-13Zr alloy obtained by HPT process were higher than the quantities of released ions from CPTi and Ti-13Nb-13Zr alloy produced by traditional casting. This behavior can be explained by the fact that metallic ions are easily released from microstructure with smaller grains achieved by HPT process. (C) 2015 Elsevier Ltd. All rights reserved.
PB  - Elsevier
T2  - Materials and Design
T1  - Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion
VL  - 91
SP  - 340
EP  - 347
DO  - 10.1016/j.matdes.2015.11.088
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Voelker, Bernhard and Hohenwarter, Anton and Pippan, Reinhard and Veljović, Đorđe N. and Rakin, Marko P. and Bugarski, Branko M.",
year = "2016",
abstract = "Significant enhancement of mechanical properties of metallic biomaterials can be achieved by grain refinement obtained by severe plastic deformation. The purpose of this study was to determine metallic ion release from commercially pure titanium (CPTi) and Ti-13Nb-13Zr alloy processed by high pressure torsion (HPT). The materials microstructures, in the initial state and after HPT deformation, were examined by scanning and transmission electron microscopy. The microhardness was determined along the radius of the disc-shaped samples of ultrafine-grained (UFG) CPTi and Ti-13Nb-13Zr alloy in order to evaluate homogeneity of HPT-processed materials. The quantities of released ions were determined using inductively coupled plasma-mass spectrophotometer for samples immersed in artificial saliva at 37 degrees C for 7 days. Also, the effect of artificial saliva pH value on metallic ion release was estimated. Obtained results revealed that the quantities of released ions from UFG CPTi and Ti-13Nb-13Zr alloy obtained by HPT process were higher than the quantities of released ions from CPTi and Ti-13Nb-13Zr alloy produced by traditional casting. This behavior can be explained by the fact that metallic ions are easily released from microstructure with smaller grains achieved by HPT process. (C) 2015 Elsevier Ltd. All rights reserved.",
publisher = "Elsevier",
journal = "Materials and Design",
title = "Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion",
volume = "91",
pages = "340-347",
doi = "10.1016/j.matdes.2015.11.088"
}

Dimić, I., Cvijović-Alagić, I., Voelker, B., Hohenwarter, A., Pippan, R., Veljović, Đ. N., Rakin, M. P.,& Bugarski, B. M.. (2016). Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion. in Materials and Design
Elsevier., 91, 340-347.
https://doi.org/10.1016/j.matdes.2015.11.088

Dimić I, Cvijović-Alagić I, Voelker B, Hohenwarter A, Pippan R, Veljović ĐN, Rakin MP, Bugarski BM. Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion. in Materials and Design. 2016;91:340-347.
doi:10.1016/j.matdes.2015.11.088 .

Dimić, Ivana , Cvijović-Alagić, Ivana, Voelker, Bernhard, Hohenwarter, Anton, Pippan, Reinhard, Veljović, Đorđe N., Rakin, Marko P., Bugarski, Branko M., "Microstructure and metallic ion release of pure titanium and Ti-13Nb-13Zr alloy processed by high pressure torsion" in Materials and Design, 91 (2016):340-347,
https://doi.org/10.1016/j.matdes.2015.11.088 . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Obradović, Nataša
AU  - Petrović, Jelena
AU  - Putić, Slaviša S.
AU  - Rakin, Marko P.
AU  - Bugarski, Branko M.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/870
AB  - Metallic materials, such as Co-Cr-Mo alloys, are exposed to aggressive conditions in the oral cavity that represents an ideal environment for metallic ion release and biodegradation. The metallic ions released from dental materials can cause local and/or systemic adverse effects in the human body. Therefore, dental materials are required to possess appropriate mechanical, physical, chemical and biological properties. The biocompatibility of metallic materials is very important for dental applications. Accordingly, the aim of this study was to examine metallic ion release and cytotoxicity of Co-30Cr-5Mo cast alloy as the initial phase of biocompatibility evaluation. Determination of the viability of human (MRC-5) and animal (L929) fibroblast cells were conducted using three in vitro test methods: the colorimetric methyl-thiazol-tetrazolium (MTT) test, the dye exclusion test (DET) and the agar diffusion test (ADT). Furthermore, the morphology and growth of the cells were analyzed using scanning electron microscopy (SEM). The obtained results indicated that Co-30Cr-5Mo alloy did not release harmful elements in concentrations high enough to have detrimental effects on human and animal fibroblasts under the given experimental conditions. Moreover, the fibroblast cells showed good adhesion on the surface of the Co-30Cr-5Mo alloy. Therefore, it could be concluded that Co-30Cr-5Mo alloy is a biocompatible material that could be safely used in dentistry.
T2  - Journal of the Serbian Chemical Society
T1  - In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy
VL  - 80
IS  - 12
SP  - 1541
EP  - 1552
DO  - 10.2298/JSC150505070M
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Obradović, Nataša and Petrović, Jelena and Putić, Slaviša S. and Rakin, Marko P. and Bugarski, Branko M.",
year = "2015",
abstract = "Metallic materials, such as Co-Cr-Mo alloys, are exposed to aggressive conditions in the oral cavity that represents an ideal environment for metallic ion release and biodegradation. The metallic ions released from dental materials can cause local and/or systemic adverse effects in the human body. Therefore, dental materials are required to possess appropriate mechanical, physical, chemical and biological properties. The biocompatibility of metallic materials is very important for dental applications. Accordingly, the aim of this study was to examine metallic ion release and cytotoxicity of Co-30Cr-5Mo cast alloy as the initial phase of biocompatibility evaluation. Determination of the viability of human (MRC-5) and animal (L929) fibroblast cells were conducted using three in vitro test methods: the colorimetric methyl-thiazol-tetrazolium (MTT) test, the dye exclusion test (DET) and the agar diffusion test (ADT). Furthermore, the morphology and growth of the cells were analyzed using scanning electron microscopy (SEM). The obtained results indicated that Co-30Cr-5Mo alloy did not release harmful elements in concentrations high enough to have detrimental effects on human and animal fibroblasts under the given experimental conditions. Moreover, the fibroblast cells showed good adhesion on the surface of the Co-30Cr-5Mo alloy. Therefore, it could be concluded that Co-30Cr-5Mo alloy is a biocompatible material that could be safely used in dentistry.",
journal = "Journal of the Serbian Chemical Society",
title = "In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy",
volume = "80",
number = "12",
pages = "1541-1552",
doi = "10.2298/JSC150505070M"
}

Dimić, I., Cvijović-Alagić, I., Obradović, N., Petrović, J., Putić, S. S., Rakin, M. P.,& Bugarski, B. M.. (2015). In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy. in Journal of the Serbian Chemical Society, 80(12), 1541-1552.
https://doi.org/10.2298/JSC150505070M

Dimić I, Cvijović-Alagić I, Obradović N, Petrović J, Putić SS, Rakin MP, Bugarski BM. In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy. in Journal of the Serbian Chemical Society. 2015;80(12):1541-1552.
doi:10.2298/JSC150505070M .

Dimić, Ivana , Cvijović-Alagić, Ivana, Obradović, Nataša, Petrović, Jelena, Putić, Slaviša S., Rakin, Marko P., Bugarski, Branko M., "In vitro biocompatibility assessment of Co-Cr-Mo dental cast alloy" in Journal of the Serbian Chemical Society, 80, no. 12 (2015):1541-1552,
https://doi.org/10.2298/JSC150505070M . .

TY  - JOUR
AU  - Dimić, Ivana 
AU  - Cvijović-Alagić, Ivana
AU  - Kostic, Ivana T.
AU  - Perić-Grujić, Aleksandra A.
AU  - Rakin, Marko P.
AU  - Putić, Slaviša S.
AU  - Bugarski, Branko M.
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/310
AB  - Metallic biomaterials, which are mainly used for the damaged hard tissue replacements, are materials with high strength, excellent toughness and good wear resistance. The disadvantages of metals as implant materials are their susceptibility to corrosion, the elastic modulus mismatch between metals and human hard tissues, relatively high density and metallic ion release, which can cause serious health problems. The aim of this study was to examine metallic ion release from Co-Cr-Mo alloy in artificial saliva. In that purpose, alloy samples were immersed into artificial saliva with different pH values (4.0, 5.5 and 7.5). After a certain immersion period (1, 3 and 6 weeks) the concentrations of released ions were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The research findings were used in order to define the dependence between the concentration of released metallic ions, artificial saliva pH values and immersion time. The determined released metallic ions concentrations were compared with literature data in order to describe and better understand the phenomenon of metallic ion release from the biocom-patible cobalt-based alloy.
AB  - Metalni biomaterijali, koji se najčešće koriste za zamenu oštećenih čvrstih tkiva u organizmu čoveka, su materijali velike čvrstoće, žilavosti i otpornosti prema habanju. Nedostaci metala, kao implantnih materijala, su njihova podložnost koroziji, neusklađenost modula elastičnosti metala i čvrstih ljudskih tkiva, velika gustina i otpuštanje metalnih jona koje može da izazove ozbiljne zdravstvene probleme. Cilj ovog rada je bio da se ispita otpuštanje metalnih jona iz Co-Cr-Mo legure u rastvoru veštačke pljuvačke. Uzorci legure su potopljeni u rastvor veštačke pljuvačke različite pH vrednosti (4,0, 5,5 i 7,5). Nakon određenog vremena izlaganja legure veštačkoj pljuvačci (1, 3 i 6 nedelja) određene su koncentracije otpuštenih jona primenom indukcije spregnute plazme sa masenom spektrometrijom (ICP-MS). Dobijeni rezultati su iskorišćeni u cilju definisanja zavisnosti između koncentracije otpuštenih jona, pH vrednosti veštačke pljuvačke i dužine potapanja legure u rastvor veštačke pljuvačke. Osim toga, utvrđene koncentracije otpuštenih metalnih jona iz ispitivane legure su upoređene sa podacima dostupnim u literaturi u cilju što boljeg opisivanja i razumevanja fenomena otpuštanja metalnih jona iz biokompatibilne Co-Cr-Mo legure.
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Metallic Ion Release from Biocompatible Cobalt-Based Alloy
VL  - 20
IS  - 4
SP  - 571
EP  - 577
DO  - 10.2298/CICEQ130813039D
ER  - 

@article{
author = "Dimić, Ivana  and Cvijović-Alagić, Ivana and Kostic, Ivana T. and Perić-Grujić, Aleksandra A. and Rakin, Marko P. and Putić, Slaviša S. and Bugarski, Branko M.",
year = "2014",
abstract = "Metallic biomaterials, which are mainly used for the damaged hard tissue replacements, are materials with high strength, excellent toughness and good wear resistance. The disadvantages of metals as implant materials are their susceptibility to corrosion, the elastic modulus mismatch between metals and human hard tissues, relatively high density and metallic ion release, which can cause serious health problems. The aim of this study was to examine metallic ion release from Co-Cr-Mo alloy in artificial saliva. In that purpose, alloy samples were immersed into artificial saliva with different pH values (4.0, 5.5 and 7.5). After a certain immersion period (1, 3 and 6 weeks) the concentrations of released ions were determined using inductively coupled plasma-mass spectrometry (ICP-MS). The research findings were used in order to define the dependence between the concentration of released metallic ions, artificial saliva pH values and immersion time. The determined released metallic ions concentrations were compared with literature data in order to describe and better understand the phenomenon of metallic ion release from the biocom-patible cobalt-based alloy., Metalni biomaterijali, koji se najčešće koriste za zamenu oštećenih čvrstih tkiva u organizmu čoveka, su materijali velike čvrstoće, žilavosti i otpornosti prema habanju. Nedostaci metala, kao implantnih materijala, su njihova podložnost koroziji, neusklađenost modula elastičnosti metala i čvrstih ljudskih tkiva, velika gustina i otpuštanje metalnih jona koje može da izazove ozbiljne zdravstvene probleme. Cilj ovog rada je bio da se ispita otpuštanje metalnih jona iz Co-Cr-Mo legure u rastvoru veštačke pljuvačke. Uzorci legure su potopljeni u rastvor veštačke pljuvačke različite pH vrednosti (4,0, 5,5 i 7,5). Nakon određenog vremena izlaganja legure veštačkoj pljuvačci (1, 3 i 6 nedelja) određene su koncentracije otpuštenih jona primenom indukcije spregnute plazme sa masenom spektrometrijom (ICP-MS). Dobijeni rezultati su iskorišćeni u cilju definisanja zavisnosti između koncentracije otpuštenih jona, pH vrednosti veštačke pljuvačke i dužine potapanja legure u rastvor veštačke pljuvačke. Osim toga, utvrđene koncentracije otpuštenih metalnih jona iz ispitivane legure su upoređene sa podacima dostupnim u literaturi u cilju što boljeg opisivanja i razumevanja fenomena otpuštanja metalnih jona iz biokompatibilne Co-Cr-Mo legure.",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Metallic Ion Release from Biocompatible Cobalt-Based Alloy",
volume = "20",
number = "4",
pages = "571-577",
doi = "10.2298/CICEQ130813039D"
}

Dimić, I., Cvijović-Alagić, I., Kostic, I. T., Perić-Grujić, A. A., Rakin, M. P., Putić, S. S.,& Bugarski, B. M.. (2014). Metallic Ion Release from Biocompatible Cobalt-Based Alloy. in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 20(4), 571-577.
https://doi.org/10.2298/CICEQ130813039D

Dimić I, Cvijović-Alagić I, Kostic IT, Perić-Grujić AA, Rakin MP, Putić SS, Bugarski BM. Metallic Ion Release from Biocompatible Cobalt-Based Alloy. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2014;20(4):571-577.
doi:10.2298/CICEQ130813039D .

Dimić, Ivana , Cvijović-Alagić, Ivana, Kostic, Ivana T., Perić-Grujić, Aleksandra A., Rakin, Marko P., Putić, Slaviša S., Bugarski, Branko M., "Metallic Ion Release from Biocompatible Cobalt-Based Alloy" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 20, no. 4 (2014):571-577,
https://doi.org/10.2298/CICEQ130813039D . .

TY  - JOUR
AU  - Lević, Steva
AU  - Obradović, Nina
AU  - Pavlović, Vladimir B.
AU  - Isailovic, Bojana
AU  - Kostic, Ivana
AU  - Mitrić, Miodrag
AU  - Bugarski, Branko M.
AU  - Nedovic, Viktor
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/183
AB  - In this study, polyvinyl alcohol (PVA) nanofibers with ethyl vanillin as an active compound were prepared using electrospinning technique. The final products of electrospinning process were in the form of nanofibers films. PVA/ethyl vanillin nanofibers, having fibers diameters in the range 100-1700 nm, were successfully electrospun from ethanol/water mixture of PVA and ethyl vanillin. The effects of immobilization process on ethyl vanillin thermal properties were investigated by differential scanning calorimetry (DSC). The results of DSC showed significant influence of immobilization process on thermal properties of ethyl vanillin. It was noticed that melting point of immobilized ethyl vanillin was lower (similar to 55 A degrees C) compared to free flavor (similar to 77 A degrees C). Our results showed that films based on PVA/ethyl vanillin nanofibers are mechanically stable.
T2  - Journal of Thermal Analysis and Calorimetry
T1  - Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process
VL  - 118
IS  - 2
SP  - 661
EP  - 668
DO  - 10.1007/s10973-014-4060-4
ER  - 

@article{
author = "Lević, Steva and Obradović, Nina and Pavlović, Vladimir B. and Isailovic, Bojana and Kostic, Ivana and Mitrić, Miodrag and Bugarski, Branko M. and Nedovic, Viktor",
year = "2014",
abstract = "In this study, polyvinyl alcohol (PVA) nanofibers with ethyl vanillin as an active compound were prepared using electrospinning technique. The final products of electrospinning process were in the form of nanofibers films. PVA/ethyl vanillin nanofibers, having fibers diameters in the range 100-1700 nm, were successfully electrospun from ethanol/water mixture of PVA and ethyl vanillin. The effects of immobilization process on ethyl vanillin thermal properties were investigated by differential scanning calorimetry (DSC). The results of DSC showed significant influence of immobilization process on thermal properties of ethyl vanillin. It was noticed that melting point of immobilized ethyl vanillin was lower (similar to 55 A degrees C) compared to free flavor (similar to 77 A degrees C). Our results showed that films based on PVA/ethyl vanillin nanofibers are mechanically stable.",
journal = "Journal of Thermal Analysis and Calorimetry",
title = "Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process",
volume = "118",
number = "2",
pages = "661-668",
doi = "10.1007/s10973-014-4060-4"
}

Lević, S., Obradović, N., Pavlović, V. B., Isailovic, B., Kostic, I., Mitrić, M., Bugarski, B. M.,& Nedovic, V.. (2014). Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process. in Journal of Thermal Analysis and Calorimetry, 118(2), 661-668.
https://doi.org/10.1007/s10973-014-4060-4

Lević S, Obradović N, Pavlović VB, Isailovic B, Kostic I, Mitrić M, Bugarski BM, Nedovic V. Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process. in Journal of Thermal Analysis and Calorimetry. 2014;118(2):661-668.
doi:10.1007/s10973-014-4060-4 .

Lević, Steva, Obradović, Nina, Pavlović, Vladimir B., Isailovic, Bojana, Kostic, Ivana, Mitrić, Miodrag, Bugarski, Branko M., Nedovic, Viktor, "Thermal, morphological, and mechanical properties of ethyl vanillin immobilized in polyvinyl alcohol by electrospinning process" in Journal of Thermal Analysis and Calorimetry, 118, no. 2 (2014):661-668,
https://doi.org/10.1007/s10973-014-4060-4 . .

TY  - JOUR
AU  - Dimić, Ivana
AU  - Cvijović-Alagić, Ivana
AU  - Rakin, Marica
AU  - Perić-Grujić, Aleksandra
AU  - Rakin, Marko
AU  - Bugarski, Branko
AU  - Putić, Slaviša
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11338
AB  - Due to their excellent characteristics, such as chemical inertness, mechanical resistance, low Young's modulus, high corrosion resistance, and outstanding biocompatibility, titanium and its alloys are the most used metallic materials for biomedical applications. In dental practice, these materials have demonstrated success as biomedical devices which are used for repairing and replacing failed hard tissue. However, the oral cavity is constantly subjected to the changes in the pH value changes and such an environment is strongly corrosive for titanium dental implants. The objective of this study was to examine ion release from commercially pure titanium (cpTi) in artificial saliva with different pH values (4.0, 5.5 and 7.5). The concentrations of released titanium ions were determined after 1, 3 and 6 weeks using Inductively Coupled Plasma - Mass Spectrometry. The results indicate that the ion release from commercially pure titanium in the artificial saliva is dependent both on the pH of artificial saliva and duration of immersion.
AB  - Titan i njegove legure su najčešće korišćeni metalni materijali za biomedicinsku primenu zbog njihovih odličnih karakteristika, kao što su hemijska inertnost, mehanička otpornost, nizak Jungov modul, visoka otpornost na koroziju i izvanredna biokompatibilnost. U stomatološkoj praksi, titan i njegove legure su pokazali uspeh kao biomedicinski uređaji, koji se koriste za popravku ili zamenu oštećenih čvrstih tkiva. Međutim, usna duplja je stalno izložena promenama pH vrednosti i takva sredina je izuzetno koroziona za dentalne implantate izrađene od titana. Cilj ovog rada je bio da se ispita otpuštanje jona iz komercijalno čistog titana (cpTi) u veštačkoj pljuvačci različite pH vrednosti (4.0, 5.5 i 7.5). Koncentracije otpuštenih jona titana su određene posle 1, 3 i 6 nedelja korišćenjem induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Rezultati pokazuju da otpuštanje jona iz komercijalno čistog titana zavisi i od pH vrednosti veštačke pljuvačke i od dužine trajanja potapanja.
T2  - Acta periodica technologica
T1  - Effect of the pH of artificial saliva on ion release from commercially pure titanium
T1  - Uticaj pH vrednosti veštačke pljuvačke na otpuštanje jona iz komercijalno čistog titana
IS  - 44
SP  - 207
EP  - 215
DO  - 10.2298/APT1344207D
ER  - 

@article{
author = "Dimić, Ivana and Cvijović-Alagić, Ivana and Rakin, Marica and Perić-Grujić, Aleksandra and Rakin, Marko and Bugarski, Branko and Putić, Slaviša",
year = "2013",
abstract = "Due to their excellent characteristics, such as chemical inertness, mechanical resistance, low Young's modulus, high corrosion resistance, and outstanding biocompatibility, titanium and its alloys are the most used metallic materials for biomedical applications. In dental practice, these materials have demonstrated success as biomedical devices which are used for repairing and replacing failed hard tissue. However, the oral cavity is constantly subjected to the changes in the pH value changes and such an environment is strongly corrosive for titanium dental implants. The objective of this study was to examine ion release from commercially pure titanium (cpTi) in artificial saliva with different pH values (4.0, 5.5 and 7.5). The concentrations of released titanium ions were determined after 1, 3 and 6 weeks using Inductively Coupled Plasma - Mass Spectrometry. The results indicate that the ion release from commercially pure titanium in the artificial saliva is dependent both on the pH of artificial saliva and duration of immersion., Titan i njegove legure su najčešće korišćeni metalni materijali za biomedicinsku primenu zbog njihovih odličnih karakteristika, kao što su hemijska inertnost, mehanička otpornost, nizak Jungov modul, visoka otpornost na koroziju i izvanredna biokompatibilnost. U stomatološkoj praksi, titan i njegove legure su pokazali uspeh kao biomedicinski uređaji, koji se koriste za popravku ili zamenu oštećenih čvrstih tkiva. Međutim, usna duplja je stalno izložena promenama pH vrednosti i takva sredina je izuzetno koroziona za dentalne implantate izrađene od titana. Cilj ovog rada je bio da se ispita otpuštanje jona iz komercijalno čistog titana (cpTi) u veštačkoj pljuvačci različite pH vrednosti (4.0, 5.5 i 7.5). Koncentracije otpuštenih jona titana su određene posle 1, 3 i 6 nedelja korišćenjem induktivno spregnute plazme sa masenom spektrometrijom (ICP-MS). Rezultati pokazuju da otpuštanje jona iz komercijalno čistog titana zavisi i od pH vrednosti veštačke pljuvačke i od dužine trajanja potapanja.",
journal = "Acta periodica technologica",
title = "Effect of the pH of artificial saliva on ion release from commercially pure titanium, Uticaj pH vrednosti veštačke pljuvačke na otpuštanje jona iz komercijalno čistog titana",
number = "44",
pages = "207-215",
doi = "10.2298/APT1344207D"
}

Dimić, I., Cvijović-Alagić, I., Rakin, M., Perić-Grujić, A., Rakin, M., Bugarski, B.,& Putić, S.. (2013). Effect of the pH of artificial saliva on ion release from commercially pure titanium. in Acta periodica technologica(44), 207-215.
https://doi.org/10.2298/APT1344207D

Dimić I, Cvijović-Alagić I, Rakin M, Perić-Grujić A, Rakin M, Bugarski B, Putić S. Effect of the pH of artificial saliva on ion release from commercially pure titanium. in Acta periodica technologica. 2013;(44):207-215.
doi:10.2298/APT1344207D .

Dimić, Ivana, Cvijović-Alagić, Ivana, Rakin, Marica, Perić-Grujić, Aleksandra, Rakin, Marko, Bugarski, Branko, Putić, Slaviša, "Effect of the pH of artificial saliva on ion release from commercially pure titanium" in Acta periodica technologica, no. 44 (2013):207-215,
https://doi.org/10.2298/APT1344207D . .

TY  - JOUR
AU  - Dragosavac, Marijana M.
AU  - Holdich, Richard G.
AU  - Vladisavljević, Goran T.
AU  - Sovilj, Milan N.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4717
AB  - Stirred cell membrane emulsification was used to create double water-in-oil-in-water emulsions at the dispersed phase flux of up to 3200 L m(-2) h(-1). The oil phase was unrefined pumpkin seed oil or sunflower oil containing 30% by volume of internal water phase and the external water phase was 2% Tween 20 (polyoxyethylene sorbitan monolaurate) or 2% Pluronic F-68 (polyoxyethylene-polyoxypropylen copolymer). Using microengineered nickel membranes with pore sizes between 15 and 40 mu m, median drop sizes of double emulsion droplets were in the range between 100 and 430 mu m, depending mainly on the shear at the membrane surface and dispersed phase injection rate. In most cases the drops were very uniform, with span (i.e. 90% drop size minus 10% drop size divided by median size) values of around 0.5. This data is similar to what was obtained previously for simple O/W emulsions of the same materials. Hence, the internal water phase, and internal surfactant, 5% PGPR (polyglycerol polyricinoleate), did not adversely influence the emulsification process. A marker material, copper sulfate, was added to the internal water phase and the release of copper was monitored with respect to time. For both lipid systems, at the larger droplet size, there was a significant period of no copper release, followed by almost linear release with time. This initial period was absent when the drop size was close to 100 mu m. The initial entrapment efficiency of the copper, in all experiments, was higher than 94%. (C) 2011 Elsevier B. V. All rights reserved.
T2  - Journal of Membrane Science
T1  - Stirred cell membrane emulsification for multiple emulsions containing unrefined pumpkin seed oil with uniform droplet size
VL  - 392
SP  - 122
EP  - 129
DO  - 10.1016/j.memsci.2011.12.009
ER  - 

@article{
author = "Dragosavac, Marijana M. and Holdich, Richard G. and Vladisavljević, Goran T. and Sovilj, Milan N.",
year = "2012",
abstract = "Stirred cell membrane emulsification was used to create double water-in-oil-in-water emulsions at the dispersed phase flux of up to 3200 L m(-2) h(-1). The oil phase was unrefined pumpkin seed oil or sunflower oil containing 30% by volume of internal water phase and the external water phase was 2% Tween 20 (polyoxyethylene sorbitan monolaurate) or 2% Pluronic F-68 (polyoxyethylene-polyoxypropylen copolymer). Using microengineered nickel membranes with pore sizes between 15 and 40 mu m, median drop sizes of double emulsion droplets were in the range between 100 and 430 mu m, depending mainly on the shear at the membrane surface and dispersed phase injection rate. In most cases the drops were very uniform, with span (i.e. 90% drop size minus 10% drop size divided by median size) values of around 0.5. This data is similar to what was obtained previously for simple O/W emulsions of the same materials. Hence, the internal water phase, and internal surfactant, 5% PGPR (polyglycerol polyricinoleate), did not adversely influence the emulsification process. A marker material, copper sulfate, was added to the internal water phase and the release of copper was monitored with respect to time. For both lipid systems, at the larger droplet size, there was a significant period of no copper release, followed by almost linear release with time. This initial period was absent when the drop size was close to 100 mu m. The initial entrapment efficiency of the copper, in all experiments, was higher than 94%. (C) 2011 Elsevier B. V. All rights reserved.",
journal = "Journal of Membrane Science",
title = "Stirred cell membrane emulsification for multiple emulsions containing unrefined pumpkin seed oil with uniform droplet size",
volume = "392",
pages = "122-129",
doi = "10.1016/j.memsci.2011.12.009"
}

Dragosavac, M. M., Holdich, R. G., Vladisavljević, G. T.,& Sovilj, M. N.. (2012). Stirred cell membrane emulsification for multiple emulsions containing unrefined pumpkin seed oil with uniform droplet size. in Journal of Membrane Science, 392, 122-129.
https://doi.org/10.1016/j.memsci.2011.12.009

Dragosavac MM, Holdich RG, Vladisavljević GT, Sovilj MN. Stirred cell membrane emulsification for multiple emulsions containing unrefined pumpkin seed oil with uniform droplet size. in Journal of Membrane Science. 2012;392:122-129.
doi:10.1016/j.memsci.2011.12.009 .

Dragosavac, Marijana M., Holdich, Richard G., Vladisavljević, Goran T., Sovilj, Milan N., "Stirred cell membrane emulsification for multiple emulsions containing unrefined pumpkin seed oil with uniform droplet size" in Journal of Membrane Science, 392 (2012):122-129,
https://doi.org/10.1016/j.memsci.2011.12.009 . .