TY  - JOUR
AU  - Đorđević, Miloš
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Ristić Fira, Aleksandra
AU  - Petrović, Ivan
AU  - Cuttone, Giacomo
AU  - Cirrone, G.A. Pablo
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12241
AB  - Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.
T2  - Physica Medica
T1  - Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams
VL  - 117
SP  - 103189
DO  - 10.1016/j.ejmp.2023.103189
ER  - 

@article{
author = "Đorđević, Miloš and Fattori, Serena and Petringa, Giada and Ristić Fira, Aleksandra and Petrović, Ivan and Cuttone, Giacomo and Cirrone, G.A. Pablo",
year = "2024",
abstract = "Purpose: The use of Monte Carlo (MC) simulations capable of reproducing radiobiological effects of ionising radiation on human cell lines is of great importance, especially for cases involving protons and heavier ion beams. In the latter, huge uncertainties can arise mainly related to the effects of the secondary particles produced in the beam-tissue interaction. This paper reports on a detailed MC study performed using Geant4-based approach on three cancer cell lines, the HTB-177, CRL-5876 and MCF-7, that were previously irradiated with therapeutic proton and carbon ion beams. Methods: A Geant4-based approach used jointly with analytical calculations has been developed to provide a more realistic estimation of the radiobiological damage produced by proton and carbon beams in tissues, reproducing available data obtained from in vitro cell irradiations. The MC “Hadrontherapy” Geant4 application and the Local Effect Model: LEM I, LEM II and LEM III coupled with the different numerical approaches: RapidRusso (RR) and RapidScholz (RS) were used in the study. Results: Experimental survival curves are compared with those evaluated using the highlighted Geant4 MC-based approach via chi-square statistical analysis, for the combinations of radiobiological models and numerical approaches, as outlined above. Conclusion: This study has presented a comparison of the survival data from MC simulations to experimental survival data for three cancer cell lines. An overall best level of agreement was obtained for the HTB-177 cells.",
journal = "Physica Medica",
title = "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams",
volume = "117",
pages = "103189",
doi = "10.1016/j.ejmp.2023.103189"
}

Đorđević, M., Fattori, S., Petringa, G., Ristić Fira, A., Petrović, I., Cuttone, G.,& Cirrone, G.A. P.. (2024). Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica, 117, 103189.
https://doi.org/10.1016/j.ejmp.2023.103189

Đorđević M, Fattori S, Petringa G, Ristić Fira A, Petrović I, Cuttone G, Cirrone GP. Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams. in Physica Medica. 2024;117:103189.
doi:10.1016/j.ejmp.2023.103189 .

Đorđević, Miloš, Fattori, Serena, Petringa, Giada, Ristić Fira, Aleksandra, Petrović, Ivan, Cuttone, Giacomo, Cirrone, G.A. Pablo, "Computational approaches in the estimation of radiobiological damage for human-malignant cells irradiated with clinical proton and carbon beams" in Physica Medica, 117 (2024):103189,
https://doi.org/10.1016/j.ejmp.2023.103189 . .

TY  - JOUR
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Agosteo, Stefano
AU  - Bortot, Davide
AU  - Conte, Valeria
AU  - Cuttone, Giacomo
AU  - Di Fini, Andrea
AU  - Farokhi, Fatemeh
AU  - Mazzucconi, Davide
AU  - Pandola, Luciano
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Rosenfeld, Anatoly
AU  - Weber, Uli
AU  - Cirrone, Giuseppe Pablo
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10393
AB  - In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
T2  - Physics in Medicine & Biology
T1  - 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification
VL  - 67
IS  - 16
SP  - 165003
DO  - 10.1088/1361-6560/ac776f
ER  - 

@article{
author = "Fattori, Serena and Petringa, Giada and Agosteo, Stefano and Bortot, Davide and Conte, Valeria and Cuttone, Giacomo and Di Fini, Andrea and Farokhi, Fatemeh and Mazzucconi, Davide and Pandola, Luciano and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Rosenfeld, Anatoly and Weber, Uli and Cirrone, Giuseppe Pablo",
year = "2022",
abstract = "In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.",
journal = "Physics in Medicine & Biology",
title = "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification",
volume = "67",
number = "16",
pages = "165003",
doi = "10.1088/1361-6560/ac776f"
}

Fattori, S., Petringa, G., Agosteo, S., Bortot, D., Conte, V., Cuttone, G., Di Fini, A., Farokhi, F., Mazzucconi, D., Pandola, L., Petrović, I. M., Ristić-Fira, A., Rosenfeld, A., Weber, U.,& Cirrone, G. P.. (2022). 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology, 67(16), 165003.
https://doi.org/10.1088/1361-6560/ac776f

Fattori S, Petringa G, Agosteo S, Bortot D, Conte V, Cuttone G, Di Fini A, Farokhi F, Mazzucconi D, Pandola L, Petrović IM, Ristić-Fira A, Rosenfeld A, Weber U, Cirrone GP. 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology. 2022;67(16):165003.
doi:10.1088/1361-6560/ac776f .

Fattori, Serena, Petringa, Giada, Agosteo, Stefano, Bortot, Davide, Conte, Valeria, Cuttone, Giacomo, Di Fini, Andrea, Farokhi, Fatemeh, Mazzucconi, Davide, Pandola, Luciano, Petrović, Ivan M., Ristić-Fira, Aleksandra, Rosenfeld, Anatoly, Weber, Uli, Cirrone, Giuseppe Pablo, "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification" in Physics in Medicine & Biology, 67, no. 16 (2022):165003,
https://doi.org/10.1088/1361-6560/ac776f . .

TY  - JOUR
AU  - Fattori, Serena
AU  - Petringa, Giada
AU  - Agosteo, Stefano
AU  - Bortot, Davide
AU  - Conte, Valeria
AU  - Cuttone, Giacomo
AU  - Di Fini, Andrea
AU  - Farokhi, Fatemeh
AU  - Mazzucconi, Davide
AU  - Pandola, Luciano
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
AU  - Rosenfeld, Anatoly
AU  - Weber, Uli
AU  - Cirrone, Giuseppe Pablo
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10586
AB  - In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.
T2  - Physics in Medicine & Biology
T1  - 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification
VL  - 67
IS  - 16
SP  - 165003
DO  - 10.1088/1361-6560/ac776f
ER  - 

@article{
author = "Fattori, Serena and Petringa, Giada and Agosteo, Stefano and Bortot, Davide and Conte, Valeria and Cuttone, Giacomo and Di Fini, Andrea and Farokhi, Fatemeh and Mazzucconi, Davide and Pandola, Luciano and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Rosenfeld, Anatoly and Weber, Uli and Cirrone, Giuseppe Pablo",
year = "2022",
abstract = "In the present hadrontherapy scenario, there is a growing interest in exploring the capabilities of different ion species other than protons and carbons. The possibility of using different ions paves the way for new radiotherapy approaches, such as the multi-ions treatment, where radiation could vary according to target volume, shape, depth and histologic characteristics of the tumor. For these reasons, in this paper, the study and understanding of biological-relevant quantities was extended for the case of 4He ion. Approach. Geant4 Monte Carlo based algorithms for dose- and track-averaged LET (Linear Energy Transfer) calculations, were validated for 4He ions and for the case of a mixed field characterised by the presence of secondary ions from both target and projectile fragmentation. The simulated dose and track averaged LETs were compared with the corresponding dose and frequency mean values of the lineal energy, and , derived from experimental microdosimetric spectra. Two microdosimetric experimental campaigns were carried out at the Italian eye proton therapy facility of the Laboratori Nazionali del Sud of Istituto Nazionale di Fisica Nucleare (INFN-LNS, Catania, I) using two different microdosimeters: the MicroPlus probe and the nano-TEPC (Tissue Equivalent Proportional Counter). Main results. A good agreement of and with and experimentally measured with both microdosimetric detectors MicroPlus and nano-TEPC in two configurations: full energy and modulated 4He ion beam, was found. Significance. The results of this study certify the use of a very effective tool for the precise calculation of LET, given by a Monte Carlo approach which has the advantage of allowing detailed simulation and tracking of nuclear interactions, even in complex clinical scenarios.",
journal = "Physics in Medicine & Biology",
title = "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification",
volume = "67",
number = "16",
pages = "165003",
doi = "10.1088/1361-6560/ac776f"
}

Fattori, S., Petringa, G., Agosteo, S., Bortot, D., Conte, V., Cuttone, G., Di Fini, A., Farokhi, F., Mazzucconi, D., Pandola, L., Petrović, I. M., Ristić-Fira, A., Rosenfeld, A., Weber, U.,& Cirrone, G. P.. (2022). 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology, 67(16), 165003.
https://doi.org/10.1088/1361-6560/ac776f

Fattori S, Petringa G, Agosteo S, Bortot D, Conte V, Cuttone G, Di Fini A, Farokhi F, Mazzucconi D, Pandola L, Petrović IM, Ristić-Fira A, Rosenfeld A, Weber U, Cirrone GP. 4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification. in Physics in Medicine & Biology. 2022;67(16):165003.
doi:10.1088/1361-6560/ac776f .

Fattori, Serena, Petringa, Giada, Agosteo, Stefano, Bortot, Davide, Conte, Valeria, Cuttone, Giacomo, Di Fini, Andrea, Farokhi, Fatemeh, Mazzucconi, Davide, Pandola, Luciano, Petrović, Ivan M., Ristić-Fira, Aleksandra, Rosenfeld, Anatoly, Weber, Uli, Cirrone, Giuseppe Pablo, "4He dose- and track-averaged linear energy transfer: Monte Carlo algorithms and experimental verification" in Physics in Medicine & Biology, 67, no. 16 (2022):165003,
https://doi.org/10.1088/1361-6560/ac776f . .

TY  - JOUR
AU  - Keta, Otilija D.
AU  - Petković, Vladana
AU  - Cirrone, Pablo
AU  - Petringa, Giada
AU  - Cuttone, Giacomo
AU  - Sakata, Dousatsu
AU  - Shin, Wook-Geun
AU  - Incerti, Sebastien
AU  - Petrović, Ivan M.
AU  - Ristić-Fira, Aleksandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9875
AB  - Purpose The complex relationship between linear energy transfer (LET) and cellular response to radiation is not yet fully elucidated. To better characterize DNA damage after irradiations with therapeutic protons, we monitored formation and disappearance of DNA double-strand breaks (DNA DSB) as a function of LET and time. Comparisons with conventional γ-rays and high LET carbon ions were also performed.Materials and Methods In the present work, we performed immunofluorescence-based assay to determine the amount of DNA DSB induced by different LET values along the 62 MeV therapeutic proton Spread out Bragg peak (SOBP) in three cancer cell lines, i.e. HTB140 melanoma, MCF-7 breast adenocarcinoma and HTB177 non-small lung cancer cells. Time dependence of foci formation was followed as well. To determine irradiation positions, corresponding to the desired LET values, numerical simulations were carried out using Geant4 toolkit. We compared γ-H2AX foci persistence after irradiations with protons to that of γ-rays and carbon ions.Results With the rise of LET values along the therapeutic proton SOBP, the increase of γ-H2AX foci number is detected in the three cell lines up to the distal end of the SOBP, while there is a decrease on its distal fall-off part. With the prolonged incubation time, the number of foci gradually drops tending to attain the residual level. For the maximum number of DNA DSB, irradiation with protons attain higher level than that of γ-rays. Carbon ions produce more DNA DSB than protons but not substantially. The number of residual foci produced by γ-rays is significantly lower than that of protons and particularly carbon ions. Carbon ions do not produce considerably higher number of foci than protons, as it could be expected due to their physical properties.Conclusions In situ visualization of γ-H2AX foci reveal creation of more lesions in the three cell lines by clinically relevant proton SOBP than γ-rays. The lack of significant differences in the number of γ-H2AX foci between the proton and carbon ion-irradiated samples suggests an increased complexity of DNA lesions and slower repair kinetics after carbon ions compared to protons. For all three irradiation types, there is no major difference between the three cell lines shortly after irradiations, while later on, the formation of residual foci starts to express the inherent nature of tested cells, therefore increasing discrepancy between them.
T2  - International Journal of Radiation Biology
T1  - DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time
VL  - 97
IS  - 9
SP  - 1229
EP  - 1240
DO  - 10.1080/09553002.2021.1948140
ER  - 

@article{
author = "Keta, Otilija D. and Petković, Vladana and Cirrone, Pablo and Petringa, Giada and Cuttone, Giacomo and Sakata, Dousatsu and Shin, Wook-Geun and Incerti, Sebastien and Petrović, Ivan M. and Ristić-Fira, Aleksandra",
year = "2021",
abstract = "Purpose The complex relationship between linear energy transfer (LET) and cellular response to radiation is not yet fully elucidated. To better characterize DNA damage after irradiations with therapeutic protons, we monitored formation and disappearance of DNA double-strand breaks (DNA DSB) as a function of LET and time. Comparisons with conventional γ-rays and high LET carbon ions were also performed.Materials and Methods In the present work, we performed immunofluorescence-based assay to determine the amount of DNA DSB induced by different LET values along the 62 MeV therapeutic proton Spread out Bragg peak (SOBP) in three cancer cell lines, i.e. HTB140 melanoma, MCF-7 breast adenocarcinoma and HTB177 non-small lung cancer cells. Time dependence of foci formation was followed as well. To determine irradiation positions, corresponding to the desired LET values, numerical simulations were carried out using Geant4 toolkit. We compared γ-H2AX foci persistence after irradiations with protons to that of γ-rays and carbon ions.Results With the rise of LET values along the therapeutic proton SOBP, the increase of γ-H2AX foci number is detected in the three cell lines up to the distal end of the SOBP, while there is a decrease on its distal fall-off part. With the prolonged incubation time, the number of foci gradually drops tending to attain the residual level. For the maximum number of DNA DSB, irradiation with protons attain higher level than that of γ-rays. Carbon ions produce more DNA DSB than protons but not substantially. The number of residual foci produced by γ-rays is significantly lower than that of protons and particularly carbon ions. Carbon ions do not produce considerably higher number of foci than protons, as it could be expected due to their physical properties.Conclusions In situ visualization of γ-H2AX foci reveal creation of more lesions in the three cell lines by clinically relevant proton SOBP than γ-rays. The lack of significant differences in the number of γ-H2AX foci between the proton and carbon ion-irradiated samples suggests an increased complexity of DNA lesions and slower repair kinetics after carbon ions compared to protons. For all three irradiation types, there is no major difference between the three cell lines shortly after irradiations, while later on, the formation of residual foci starts to express the inherent nature of tested cells, therefore increasing discrepancy between them.",
journal = "International Journal of Radiation Biology",
title = "DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time",
volume = "97",
number = "9",
pages = "1229-1240",
doi = "10.1080/09553002.2021.1948140"
}

Keta, O. D., Petković, V., Cirrone, P., Petringa, G., Cuttone, G., Sakata, D., Shin, W., Incerti, S., Petrović, I. M.,& Ristić-Fira, A.. (2021). DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. in International Journal of Radiation Biology, 97(9), 1229-1240.
https://doi.org/10.1080/09553002.2021.1948140

Keta OD, Petković V, Cirrone P, Petringa G, Cuttone G, Sakata D, Shin W, Incerti S, Petrović IM, Ristić-Fira A. DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time. in International Journal of Radiation Biology. 2021;97(9):1229-1240.
doi:10.1080/09553002.2021.1948140 .

Keta, Otilija D., Petković, Vladana, Cirrone, Pablo, Petringa, Giada, Cuttone, Giacomo, Sakata, Dousatsu, Shin, Wook-Geun, Incerti, Sebastien, Petrović, Ivan M., Ristić-Fira, Aleksandra, "DNA double-strand breaks in cancer cells as a function of proton linear energy transfer and its variation in time" in International Journal of Radiation Biology, 97, no. 9 (2021):1229-1240,
https://doi.org/10.1080/09553002.2021.1948140 . .

TY  - JOUR
AU  - Milanović, Tamara J.
AU  - Čeliković, Igor T.
AU  - Michelagnoli, Caterina
AU  - de France, G.
AU  - Boso, A
AU  - Braunroth, T
AU  - Clément, E
AU  - Dewald, A
AU  - Georgiev, G
AU  - Ideguchi, E
AU  - Jacquot, B
AU  - Królas, W
AU  - Napoli, D
AU  - Lalović, N
AU  - Lee, K.Y.
AU  - Lemasson, A
AU  - Li, H
AU  - Ljungvall, J
AU  - Navin, A
AU  - Nori, A
AU  - Perez-Vidal, R.
AU  - Rejmund, M
AU  - Ujić, Predrag
AU  - Wilmsen, D
AU  - Yamamoto, Y
AU  - Zielińska, M
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9019
AB  - Lifetimes of low-lying states in 73Ga and 70,72,74Zn were measured using the Recoil Distance Doppler Shift (RDDS) method. These nuclei were produced in deep-inelastic reactions in inverse kinematics with a 208Pb beam impinging on a 76Ge target. Prompt γ rays were detected using the AGATA tracking array coupled to the VAMOS++ spectrometer. Lifetime of the 5/2- state in 73Ga, measured for the first time, provides additional evidence for the existence of a 1/2-, 3/2- ground-state doublet. The lifetimes of the 4+ states in 70,72,74Zn were remeasured in an attempt to understand the discrepancies observed between earlier measurements. Our results are in agreement with those of previous plunger experiments.
T2  - Acta Physica Polonica B
T1  - Lifetime measurements of low-lying states in 73Ga and 70,72,74Zn isotopes
VL  - 51
IS  - 3
SP  - 837
EP  - 842
DO  - 10.5506/APhysPolB.51.837
ER  - 

@article{
author = "Milanović, Tamara J. and Čeliković, Igor T. and Michelagnoli, Caterina and de France, G. and Boso, A and Braunroth, T and Clément, E and Dewald, A and Georgiev, G and Ideguchi, E and Jacquot, B and Królas, W and Napoli, D and Lalović, N and Lee, K.Y. and Lemasson, A and Li, H and Ljungvall, J and Navin, A and Nori, A and Perez-Vidal, R. and Rejmund, M and Ujić, Predrag and Wilmsen, D and Yamamoto, Y and Zielińska, M",
year = "2020",
abstract = "Lifetimes of low-lying states in 73Ga and 70,72,74Zn were measured using the Recoil Distance Doppler Shift (RDDS) method. These nuclei were produced in deep-inelastic reactions in inverse kinematics with a 208Pb beam impinging on a 76Ge target. Prompt γ rays were detected using the AGATA tracking array coupled to the VAMOS++ spectrometer. Lifetime of the 5/2- state in 73Ga, measured for the first time, provides additional evidence for the existence of a 1/2-, 3/2- ground-state doublet. The lifetimes of the 4+ states in 70,72,74Zn were remeasured in an attempt to understand the discrepancies observed between earlier measurements. Our results are in agreement with those of previous plunger experiments.",
journal = "Acta Physica Polonica B",
title = "Lifetime measurements of low-lying states in 73Ga and 70,72,74Zn isotopes",
volume = "51",
number = "3",
pages = "837-842",
doi = "10.5506/APhysPolB.51.837"
}

Milanović, T. J., Čeliković, I. T., Michelagnoli, C., de France, G., Boso, A., Braunroth, T., Clément, E., Dewald, A., Georgiev, G., Ideguchi, E., Jacquot, B., Królas, W., Napoli, D., Lalović, N., Lee, K.Y., Lemasson, A., Li, H., Ljungvall, J., Navin, A., Nori, A., Perez-Vidal, R., Rejmund, M., Ujić, P., Wilmsen, D., Yamamoto, Y.,& Zielińska, M.. (2020). Lifetime measurements of low-lying states in 73Ga and 70,72,74Zn isotopes. in Acta Physica Polonica B, 51(3), 837-842.
https://doi.org/10.5506/APhysPolB.51.837

Milanović TJ, Čeliković IT, Michelagnoli C, de France G, Boso A, Braunroth T, Clément E, Dewald A, Georgiev G, Ideguchi E, Jacquot B, Królas W, Napoli D, Lalović N, Lee K, Lemasson A, Li H, Ljungvall J, Navin A, Nori A, Perez-Vidal R, Rejmund M, Ujić P, Wilmsen D, Yamamoto Y, Zielińska M. Lifetime measurements of low-lying states in 73Ga and 70,72,74Zn isotopes. in Acta Physica Polonica B. 2020;51(3):837-842.
doi:10.5506/APhysPolB.51.837 .

Milanović, Tamara J., Čeliković, Igor T., Michelagnoli, Caterina, de France, G., Boso, A, Braunroth, T, Clément, E, Dewald, A, Georgiev, G, Ideguchi, E, Jacquot, B, Królas, W, Napoli, D, Lalović, N, Lee, K.Y., Lemasson, A, Li, H, Ljungvall, J, Navin, A, Nori, A, Perez-Vidal, R., Rejmund, M, Ujić, Predrag, Wilmsen, D, Yamamoto, Y, Zielińska, M, "Lifetime measurements of low-lying states in 73Ga and 70,72,74Zn isotopes" in Acta Physica Polonica B, 51, no. 3 (2020):837-842,
https://doi.org/10.5506/APhysPolB.51.837 . .

TY  - JOUR
AU  - Scholz, Michael
AU  - Friedrich, Thomas
AU  - Magrin, Giulio
AU  - Colautti, Paolo
AU  - Ristić-Fira, Aleksandra
AU  - Petrović, Ivan M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9614
AB  - The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation. On the macroscopic scale, the inverted dose profile with a Bragg peak and small lateral scattering allow a better conformation of the dose to the tumor. On the microscopic scale, the localized energy deposition around the trajectory of the particles leads to an enhanced biological effectiveness, typically expressed in terms of the relative biological effectiveness (RBE). Experimental investigations reveal complex dependencies of RBE on many physical and biological parameters, as e.g., ion species, dose, position in the field and cell or tissue type. In order to complement the experimental work, different approaches are used for the characterization of the specific physical and biological properties of ion beams. In a set of two papers, which are linked by activities within a European HORIZON 2020 project about nuclear science and application (ENSAR2), we describe recent developments in two fields playing a key role in characterizing the increased biological effectiveness. These comprise the biophysical modeling of RBE and the microdosimetric measurements in complex radiation fields. This first paper gives a brief introduction into these fields and then focuses on aspects of biophysical modeling of RBE, specifically on semi-empirical approaches that are currently used in treatment planning for ion beam therapy. It summarizes the status and recent developments of the Local Effect Model (LEM) and its conceptual framework and shows examples of model validation using recent experimental data. The model is compared to other approaches, e.g., to the Microdosimetric-Kinetic Model (MKM), that builds the bridge to the experimental microdosimetric work. © Copyright © 2020 Scholz, Friedrich, Magrin, Colautti, Ristić-Fira and Petrović.
T2  - Frontiers in Physics
T1  - Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV
VL  - 8
DO  - 10.3389/fphy.2020.00272
ER  - 

@article{
author = "Scholz, Michael and Friedrich, Thomas and Magrin, Giulio and Colautti, Paolo and Ristić-Fira, Aleksandra and Petrović, Ivan M.",
year = "2020",
abstract = "The specific advantages of ion beams for application in tumor therapy are attributed to their different macroscopic and microscopic energy deposition pattern as compared to conventional photon radiation. On the macroscopic scale, the inverted dose profile with a Bragg peak and small lateral scattering allow a better conformation of the dose to the tumor. On the microscopic scale, the localized energy deposition around the trajectory of the particles leads to an enhanced biological effectiveness, typically expressed in terms of the relative biological effectiveness (RBE). Experimental investigations reveal complex dependencies of RBE on many physical and biological parameters, as e.g., ion species, dose, position in the field and cell or tissue type. In order to complement the experimental work, different approaches are used for the characterization of the specific physical and biological properties of ion beams. In a set of two papers, which are linked by activities within a European HORIZON 2020 project about nuclear science and application (ENSAR2), we describe recent developments in two fields playing a key role in characterizing the increased biological effectiveness. These comprise the biophysical modeling of RBE and the microdosimetric measurements in complex radiation fields. This first paper gives a brief introduction into these fields and then focuses on aspects of biophysical modeling of RBE, specifically on semi-empirical approaches that are currently used in treatment planning for ion beam therapy. It summarizes the status and recent developments of the Local Effect Model (LEM) and its conceptual framework and shows examples of model validation using recent experimental data. The model is compared to other approaches, e.g., to the Microdosimetric-Kinetic Model (MKM), that builds the bridge to the experimental microdosimetric work. © Copyright © 2020 Scholz, Friedrich, Magrin, Colautti, Ristić-Fira and Petrović.",
journal = "Frontiers in Physics",
title = "Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV",
volume = "8",
doi = "10.3389/fphy.2020.00272"
}

Scholz, M., Friedrich, T., Magrin, G., Colautti, P., Ristić-Fira, A.,& Petrović, I. M.. (2020). Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV. in Frontiers in Physics, 8.
https://doi.org/10.3389/fphy.2020.00272

Scholz M, Friedrich T, Magrin G, Colautti P, Ristić-Fira A, Petrović IM. Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV. in Frontiers in Physics. 2020;8.
doi:10.3389/fphy.2020.00272 .

Scholz, Michael, Friedrich, Thomas, Magrin, Giulio, Colautti, Paolo, Ristić-Fira, Aleksandra, Petrović, Ivan M., "Characterizing Radiation Effectiveness in Ion Beam Therapy Part I: Introduction and Biophysical Modeling of RBE Using the LEMIV" in Frontiers in Physics, 8 (2020),
https://doi.org/10.3389/fphy.2020.00272 . .

TY  - JOUR
AU  - Ujić, Predrag
AU  - Cam, J.C.
AU  - Retailleau, B. M.
AU  - Traykov, E.
AU  - Standylo, L.
AU  - Choinski, Jaroslaw
AU  - Delahaye, Pierre
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8007
AB  - The recent test of a prototype of beam debuncher device for Electron Beam Ion Source (EBIS), designed within the EMILIE (Enhanced Multi-Ionization of short-Lived Ions for EURISOL) project, is presented in this paper. For a singly ionized Li+1 ion, high efficiency trapping times up to 1 s were established and a uniform ion extraction with intensity variation of less than 30% was achieved. The test gives promising results regarding the future introduction of debuncher devices to EBIS facilities. © 2018 The Authors
T2  - Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
T1  - EBIS debuncher experimental performance
VL  - 918
SP  - 30
EP  - 36
DO  - 10.1016/j.nima.2018.11.043
ER  - 

@article{
author = "Ujić, Predrag and Cam, J.C. and Retailleau, B. M. and Traykov, E. and Standylo, L. and Choinski, Jaroslaw and Delahaye, Pierre",
year = "2019",
abstract = "The recent test of a prototype of beam debuncher device for Electron Beam Ion Source (EBIS), designed within the EMILIE (Enhanced Multi-Ionization of short-Lived Ions for EURISOL) project, is presented in this paper. For a singly ionized Li+1 ion, high efficiency trapping times up to 1 s were established and a uniform ion extraction with intensity variation of less than 30% was achieved. The test gives promising results regarding the future introduction of debuncher devices to EBIS facilities. © 2018 The Authors",
journal = "Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",
title = "EBIS debuncher experimental performance",
volume = "918",
pages = "30-36",
doi = "10.1016/j.nima.2018.11.043"
}

Ujić, P., Cam, J.C., Retailleau, B. M., Traykov, E., Standylo, L., Choinski, J.,& Delahaye, P.. (2019). EBIS debuncher experimental performance. in Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 918, 30-36.
https://doi.org/10.1016/j.nima.2018.11.043

Ujić P, Cam J, Retailleau BM, Traykov E, Standylo L, Choinski J, Delahaye P. EBIS debuncher experimental performance. in Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2019;918:30-36.
doi:10.1016/j.nima.2018.11.043 .

Ujić, Predrag, Cam, J.C., Retailleau, B. M., Traykov, E., Standylo, L., Choinski, Jaroslaw, Delahaye, Pierre, "EBIS debuncher experimental performance" in Nuclear Instruments and Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 918 (2019):30-36,
https://doi.org/10.1016/j.nima.2018.11.043 . .