@article{
author = "Adžić, Miroslav and Nićiforović, Ana and Nešković-Konstantinović, Zora and Radojčić, Marija B.",
year = "2004",
abstract = "Purpose: Radiation treatment of breast cancer (BC) often results in post-therapy complications. The undesired sequelae could be avoided by the diagnostic screening of biomarkers for prediction of ionizing radiation (IR)-linked injury of healthy tissues. Patients and methods: The expression of antioxidative defence enzymes CuZn- and Mn-superoxide dismutase (CuZnSOD, MnSOD) and tumor suppressor protein p53 was measured in blood cells of 19 women with BC (age groups 30-45 and 46-60 years) and of the respective controls. The proteins were detected by specific immunostaining and quantified by laser-scanning densitometry. Results: Constitutive expression of CuZnSOD was significantly elevated in the group of BC patients (up to 254 arbitrary units, AU/mL) relative to the control group (105-130 AU/mL). The constitutive expression of MnSOD was elevated (up to 94 AU/mL) in the group of BC patients relative to the controls (53-56 AU/mL). p53 was also constitutively more expressed in BC patients (35-42 AU/mL) than in controls (32-33 AU/mL). Both MnSOD and p53 were inducible by 60Co gamma-ray IR (up to 170 AU/mL and 51 AU/mL, respectively) in the BC patient group. The levels of IR-induced p53 correlated inversely with MnSOD levels. Conclusion: The constitutive expression of all 3 proteins could be a useful biomarker for the presence of BC, but only MnSOD overexpression may be the predictive biomarker for selection of BC patients that would be less susceptible to IR-linked complications. © 2004 Zerbinis Medical Publications.",
journal = "Journal of Balkan Union of Oncology.",
title = "Superoxide dismutases and p53 protein levels in blood cells of breast cancer patients",
volume = "9",
number = "3",
pages = "283-287",
url = "https://hdl.handle.net/21.15107/rcub_vinar_10582"
}
