TY  - JOUR
AU  - Chatzipapas, Konstantinos
AU  - Đorđević, Miloš
AU  - Živković, Sara
AU  - Tran, Ngoc Hoang
AU  - Lampe, Nathanael
AU  - Sakata, Dousatsu
AU  - Petrović, Ivan
AU  - Ristić-Fira, Aleksandra
AU  - Shin, Wook-Geun
AU  - Zein, Sara
AU  - Brown, Jeremy M.C.
AU  - Kyriakou, Ioanna
AU  - Emfietzoglou, Dimitris
AU  - Guatelli, Susanna
AU  - Incerti, Sebastien
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11202
AB  - Purpose: This study aimed to develop a computational environment for the accurate simulation of human cancer cell irradiation using Geant4-DNA. New cell geometrical models were developed and irradiated by alpha particle beams to induce DNA damage. The proposed approach may help further investigation of the benefits of external alpha irradiation therapy. Methods: The Geant4-DNA Monte Carlo (MC) toolkit allows the simulation of cancer cell geometries that can be combined with accurate modelling of physical, physicochemical and chemical stages of liquid water irradiation, including radiolytic processes. Geant4-DNA is used to calculate direct and non-direct DNA damage yields, such as single and double strand breaks, produced by the deposition of energy or by the interaction of DNA with free radicals. Results: In this study, the “molecularDNA” example application of Geant4-DNA was used to quantify early DNA damage in human cancer cells upon irradiation with alpha particle beams, as a function of linear energy transfer (LET). The MC simulation results are compared to experimental data, as well as previously published simulation data. The simulation results agree well with the experimental data on DSB yields in the lower LET range, while the experimental data on DSB yields are lower than the results obtained with the “molecularDNA” example in the higher LET range. Conclusion: This study explored and demonstrated the possibilities of the Geant4-DNA toolkit together with the “molecularDNA” example to simulate the helium beam irradiation of cancer cell lines, to quantify the early DNA damage, or even the following DNA damage response. © 2023 Associazione Italiana di Fisica Medica e Sanitaria
T2  - Physica Medica
T1  - Geant4-DNA simulation of human cancer cells irradiation with helium ion beams
VL  - 112
DO  - 10.1016/j.ejmp.2023.102613
ER  - 

@article{
author = "Chatzipapas, Konstantinos and Đorđević, Miloš and Živković, Sara and Tran, Ngoc Hoang and Lampe, Nathanael and Sakata, Dousatsu and Petrović, Ivan and Ristić-Fira, Aleksandra and Shin, Wook-Geun and Zein, Sara and Brown, Jeremy M.C. and Kyriakou, Ioanna and Emfietzoglou, Dimitris and Guatelli, Susanna and Incerti, Sebastien",
year = "2023",
abstract = "Purpose: This study aimed to develop a computational environment for the accurate simulation of human cancer cell irradiation using Geant4-DNA. New cell geometrical models were developed and irradiated by alpha particle beams to induce DNA damage. The proposed approach may help further investigation of the benefits of external alpha irradiation therapy. Methods: The Geant4-DNA Monte Carlo (MC) toolkit allows the simulation of cancer cell geometries that can be combined with accurate modelling of physical, physicochemical and chemical stages of liquid water irradiation, including radiolytic processes. Geant4-DNA is used to calculate direct and non-direct DNA damage yields, such as single and double strand breaks, produced by the deposition of energy or by the interaction of DNA with free radicals. Results: In this study, the “molecularDNA” example application of Geant4-DNA was used to quantify early DNA damage in human cancer cells upon irradiation with alpha particle beams, as a function of linear energy transfer (LET). The MC simulation results are compared to experimental data, as well as previously published simulation data. The simulation results agree well with the experimental data on DSB yields in the lower LET range, while the experimental data on DSB yields are lower than the results obtained with the “molecularDNA” example in the higher LET range. Conclusion: This study explored and demonstrated the possibilities of the Geant4-DNA toolkit together with the “molecularDNA” example to simulate the helium beam irradiation of cancer cell lines, to quantify the early DNA damage, or even the following DNA damage response. © 2023 Associazione Italiana di Fisica Medica e Sanitaria",
journal = "Physica Medica",
title = "Geant4-DNA simulation of human cancer cells irradiation with helium ion beams",
volume = "112",
doi = "10.1016/j.ejmp.2023.102613"
}

Chatzipapas, K., Đorđević, M., Živković, S., Tran, N. H., Lampe, N., Sakata, D., Petrović, I., Ristić-Fira, A., Shin, W., Zein, S., Brown, J. M.C., Kyriakou, I., Emfietzoglou, D., Guatelli, S.,& Incerti, S.. (2023). Geant4-DNA simulation of human cancer cells irradiation with helium ion beams. in Physica Medica, 112.
https://doi.org/10.1016/j.ejmp.2023.102613

Chatzipapas K, Đorđević M, Živković S, Tran NH, Lampe N, Sakata D, Petrović I, Ristić-Fira A, Shin W, Zein S, Brown JM, Kyriakou I, Emfietzoglou D, Guatelli S, Incerti S. Geant4-DNA simulation of human cancer cells irradiation with helium ion beams. in Physica Medica. 2023;112.
doi:10.1016/j.ejmp.2023.102613 .

Chatzipapas, Konstantinos, Đorđević, Miloš, Živković, Sara, Tran, Ngoc Hoang, Lampe, Nathanael, Sakata, Dousatsu, Petrović, Ivan, Ristić-Fira, Aleksandra, Shin, Wook-Geun, Zein, Sara, Brown, Jeremy M.C., Kyriakou, Ioanna, Emfietzoglou, Dimitris, Guatelli, Susanna, Incerti, Sebastien, "Geant4-DNA simulation of human cancer cells irradiation with helium ion beams" in Physica Medica, 112 (2023),
https://doi.org/10.1016/j.ejmp.2023.102613 . .