TY  - JOUR
AU  - Bulat, Tanja
AU  - Zmejkoski, Danica
AU  - Marković, Zoran
AU  - Satzinger, Melissa
AU  - Kovač, Janez
AU  - Strobl, Birgit
AU  - Milivojević, Dušan
AU  - Todorović Marković, Biljana
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11831
AB  - Carbon quantum dots (CQDs) are well known as a promising therapeutic agent due to their excellent pro-oxidant, antioxidant, antibacterial and anticancer properties under visible light irradiation. This material is easy to produce by several bottom-up or top-down methods. In this study, we used citric acid as starting precursor to synthesize aqueous carbon quantum dots dispersion by pyrolysis at 210 ◦C. Atomic force microscopy and XPS analyses revealed that CQDs synthesized are quasi-spherical with typical diameter of 9 nm and lots of C–O and C––O functional groups distributed over the basal plane and edges of the dots. Here, we investigated the antiviral properties of CQDs against cytomegalovirus (CMV). The pre-treatment with CQDs upregulates interferonstimulated genes (ISG), resulting in better virus control. Cellular defence against cytomegalovirus of CQDs pre-treated cells is increased in a dose-dependent manner. Our results reveal high biocompatibility and potent in vitro antiviral properties of CQDs.
T2  - Materials Chemistry and Physics
T1  - Employing carbon quantum dots to combat cytomegalovirus
VL  - 311
SP  - 128495
DO  - 10.1016/j.matchemphys.2023.128495
ER  - 

@article{
author = "Bulat, Tanja and Zmejkoski, Danica and Marković, Zoran and Satzinger, Melissa and Kovač, Janez and Strobl, Birgit and Milivojević, Dušan and Todorović Marković, Biljana",
year = "2024",
abstract = "Carbon quantum dots (CQDs) are well known as a promising therapeutic agent due to their excellent pro-oxidant, antioxidant, antibacterial and anticancer properties under visible light irradiation. This material is easy to produce by several bottom-up or top-down methods. In this study, we used citric acid as starting precursor to synthesize aqueous carbon quantum dots dispersion by pyrolysis at 210 ◦C. Atomic force microscopy and XPS analyses revealed that CQDs synthesized are quasi-spherical with typical diameter of 9 nm and lots of C–O and C––O functional groups distributed over the basal plane and edges of the dots. Here, we investigated the antiviral properties of CQDs against cytomegalovirus (CMV). The pre-treatment with CQDs upregulates interferonstimulated genes (ISG), resulting in better virus control. Cellular defence against cytomegalovirus of CQDs pre-treated cells is increased in a dose-dependent manner. Our results reveal high biocompatibility and potent in vitro antiviral properties of CQDs.",
journal = "Materials Chemistry and Physics",
title = "Employing carbon quantum dots to combat cytomegalovirus",
volume = "311",
pages = "128495",
doi = "10.1016/j.matchemphys.2023.128495"
}

Bulat, T., Zmejkoski, D., Marković, Z., Satzinger, M., Kovač, J., Strobl, B., Milivojević, D.,& Todorović Marković, B.. (2024). Employing carbon quantum dots to combat cytomegalovirus. in Materials Chemistry and Physics, 311, 128495.
https://doi.org/10.1016/j.matchemphys.2023.128495

Bulat T, Zmejkoski D, Marković Z, Satzinger M, Kovač J, Strobl B, Milivojević D, Todorović Marković B. Employing carbon quantum dots to combat cytomegalovirus. in Materials Chemistry and Physics. 2024;311:128495.
doi:10.1016/j.matchemphys.2023.128495 .

Bulat, Tanja, Zmejkoski, Danica, Marković, Zoran, Satzinger, Melissa, Kovač, Janez, Strobl, Birgit, Milivojević, Dušan, Todorović Marković, Biljana, "Employing carbon quantum dots to combat cytomegalovirus" in Materials Chemistry and Physics, 311 (2024):128495,
https://doi.org/10.1016/j.matchemphys.2023.128495 . .