Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča)

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Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 451-03-68/2020-14/200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (en)
Ministarstvo prosvete, nauke i tehnološkog razvoja Republike Srbije, Ugovor br. 451-03-68/2020-14/200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (sr_RS)
Министарство просвете, науке и технолошког развоја Републике Србије, Уговор бр. 451-03-68/2020-14/200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (sr)
Authors

Publications

Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages

Chang, Nana; Gundogdu, Sinan; Leykam, Daniel; Angelakis, Dimitris G.; Kou, SuPeng; Flach, Sergej; Maluckov, Aleksandra

(2021)

TY  - JOUR
AU  - Chang, Nana
AU  - Gundogdu, Sinan
AU  - Leykam, Daniel
AU  - Angelakis, Dimitris G.
AU  - Kou, SuPeng
AU  - Flach, Sergej
AU  - Maluckov, Aleksandra
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9141
AB  - We study the properties of nonlinear Bloch waves in a diamond chain waveguide lattice in the presence of a synthetic magnetic flux. In the linear limit, the lattice exhibits a completely flat (wavevector k-independent) band structure, resulting in perfect wave localization, known as Aharonov-Bohm caging. We find that in the presence of nonlinearity, the Bloch waves become sensitive to k, exhibiting bifurcations and instabilities. Performing numerical beam propagation simulations using the tight-binding model, we show how the instabilities can result in either the spontaneous or controlled formation of localized modes, which are immobile and remain pinned in place due to the synthetic magnetic flux. © 2021 Author(s.
T2  - APL Photonics
T1  - Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages
VL  - 6
IS  - 3
SP  - 030801
DO  - 10.1063/5.0037767
ER  - 
@article{
author = "Chang, Nana and Gundogdu, Sinan and Leykam, Daniel and Angelakis, Dimitris G. and Kou, SuPeng and Flach, Sergej and Maluckov, Aleksandra",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9141",
abstract = "We study the properties of nonlinear Bloch waves in a diamond chain waveguide lattice in the presence of a synthetic magnetic flux. In the linear limit, the lattice exhibits a completely flat (wavevector k-independent) band structure, resulting in perfect wave localization, known as Aharonov-Bohm caging. We find that in the presence of nonlinearity, the Bloch waves become sensitive to k, exhibiting bifurcations and instabilities. Performing numerical beam propagation simulations using the tight-binding model, we show how the instabilities can result in either the spontaneous or controlled formation of localized modes, which are immobile and remain pinned in place due to the synthetic magnetic flux. © 2021 Author(s.",
journal = "APL Photonics",
title = "Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages",
volume = "6",
number = "3",
pages = "030801",
doi = "10.1063/5.0037767"
}
Chang, N., Gundogdu, S., Leykam, D., Angelakis, D. G., Kou, S., Flach, S.,& Maluckov, A. (2021). Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages.
APL Photonics, 6(3), 030801.
https://doi.org/10.1063/5.0037767
Chang N, Gundogdu S, Leykam D, Angelakis DG, Kou S, Flach S, Maluckov A. Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages. APL Photonics. 2021;6(3):030801
Chang Nana, Gundogdu Sinan, Leykam Daniel, Angelakis Dimitris G., Kou SuPeng, Flach Sergej, Maluckov Aleksandra, "Nonlinear Bloch wave dynamics in photonic Aharonov–Bohm cages" APL Photonics, 6, no. 3 (2021):030801,
https://doi.org/10.1063/5.0037767 .
1

Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

Houdová, Dominika; Soto, Juan; Castro, Rita; Rodrigues, João; Soledad Pino-González, Ma; Petković, Marijana; Bandosz, Teresa J; Algarra, Manuel

(2021)

TY  - JOUR
AU  - Houdová, Dominika
AU  - Soto, Juan
AU  - Castro, Rita
AU  - Rodrigues, João
AU  - Soledad Pino-González, Ma
AU  - Petković, Marijana
AU  - Bandosz, Teresa J
AU  - Algarra, Manuel
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9145
AB  - A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time-of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary system with 2,5-dihydroxybenzoic acid (DHB) to enhance the detection process. It was found that both COOH and NH2 groups on CDs surface contributed to the enhancement in the cholesterol detection by MALDI mass spectrometry in the presence of inorganic cations. Nevertheless, in the presence of NaCl, N-CDs led to a better reproducibility of results. It was due to the coexistence of positive and negative charge on N-CDs surface that led to a homogeneous analyte/substrate distribution, which is an important detection parameter. The enhancing effect of carbon dots was linked to a negative Gibbs energy of the complex formation between CDs, Na+, cholesterol and DHB, and it was supported by theoretical calculations. Moreover, upon the addition of CDs/N-CDs, such features as a low ionization potential, vertical excitation, dipole moment and oscillator strength positively affected the cholesterol detection by MALDI in the presence of Na+. © 2021 Elsevier Inc.
T2  - Journal of Colloid and Interface Science
T1  - Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry
VL  - 591
SP  - 373
EP  - 383
DO  - 10.1016/j.jcis.2021.02.004
ER  - 
@article{
author = "Houdová, Dominika and Soto, Juan and Castro, Rita and Rodrigues, João and Soledad Pino-González, Ma and Petković, Marijana and Bandosz, Teresa J and Algarra, Manuel",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9145",
abstract = "A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time-of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary system with 2,5-dihydroxybenzoic acid (DHB) to enhance the detection process. It was found that both COOH and NH2 groups on CDs surface contributed to the enhancement in the cholesterol detection by MALDI mass spectrometry in the presence of inorganic cations. Nevertheless, in the presence of NaCl, N-CDs led to a better reproducibility of results. It was due to the coexistence of positive and negative charge on N-CDs surface that led to a homogeneous analyte/substrate distribution, which is an important detection parameter. The enhancing effect of carbon dots was linked to a negative Gibbs energy of the complex formation between CDs, Na+, cholesterol and DHB, and it was supported by theoretical calculations. Moreover, upon the addition of CDs/N-CDs, such features as a low ionization potential, vertical excitation, dipole moment and oscillator strength positively affected the cholesterol detection by MALDI in the presence of Na+. © 2021 Elsevier Inc.",
journal = "Journal of Colloid and Interface Science",
title = "Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry",
volume = "591",
pages = "373-383",
doi = "10.1016/j.jcis.2021.02.004"
}
Houdová, D., Soto, J., Castro, R., Rodrigues, J., Soledad Pino-González, M., Petković, M., Bandosz, T. J.,& Algarra, M. (2021). Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry.
Journal of Colloid and Interface Science, 591, 373-383.
https://doi.org/10.1016/j.jcis.2021.02.004
Houdová D, Soto J, Castro R, Rodrigues J, Soledad Pino-González M, Petković M, Bandosz TJ, Algarra M. Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry. Journal of Colloid and Interface Science. 2021;591:373-383
Houdová Dominika, Soto Juan, Castro Rita, Rodrigues João, Soledad Pino-González Ma, Petković Marijana, Bandosz Teresa J, Algarra Manuel, "Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry" Journal of Colloid and Interface Science, 591 (2021):373-383,
https://doi.org/10.1016/j.jcis.2021.02.004 .

Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry

Houdová, Dominika; Soto, Juan; Castro, Rita; Rodrigues, João; Soledad Pino-González, Ma; Petković, Marijana; Bandosz, Teresa J; Algarra, Manuel

(2021)

TY  - JOUR
AU  - Houdová, Dominika
AU  - Soto, Juan
AU  - Castro, Rita
AU  - Rodrigues, João
AU  - Soledad Pino-González, Ma
AU  - Petković, Marijana
AU  - Bandosz, Teresa J
AU  - Algarra, Manuel
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9127
AB  - A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time-of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary system with 2,5-dihydroxybenzoic acid (DHB) to enhance the detection process. It was found that both COOH and NH2 groups on CDs surface contributed to the enhancement in the cholesterol detection by MALDI mass spectrometry in the presence of inorganic cations. Nevertheless, in the presence of NaCl, N-CDs led to a better reproducibility of results. It was due to the coexistence of positive and negative charge on N-CDs surface that led to a homogeneous analyte/substrate distribution, which is an important detection parameter. The enhancing effect of carbon dots was linked to a negative Gibbs energy of the complex formation between CDs, Na+, cholesterol and DHB, and it was supported by theoretical calculations. Moreover, upon the addition of CDs/N-CDs, such features as a low ionization potential, vertical excitation, dipole moment and oscillator strength positively affected the cholesterol detection by MALDI in the presence of Na+. © 2021 Elsevier Inc.
T2  - Journal of Colloid and Interface Science
T1  - Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry
VL  - 591
SP  - 373
EP  - 383
DO  - 10.1016/j.jcis.2021.02.004
ER  - 
@article{
author = "Houdová, Dominika and Soto, Juan and Castro, Rita and Rodrigues, João and Soledad Pino-González, Ma and Petković, Marijana and Bandosz, Teresa J and Algarra, Manuel",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9127",
abstract = "A binary system composed of carbon dots (CDs) and N-doped CDs (N-CDs) embedded in an organic matrix was used for the analysis of cholesterol by MALDI (matrix-assisted laser desorption and ionization time-of-flight) mass spectrometry, as a model for detection of small, biologically relevant molecules. The results showed that both CDs are sensitive to the cholesterol and can be used either alone or in a binary system with 2,5-dihydroxybenzoic acid (DHB) to enhance the detection process. It was found that both COOH and NH2 groups on CDs surface contributed to the enhancement in the cholesterol detection by MALDI mass spectrometry in the presence of inorganic cations. Nevertheless, in the presence of NaCl, N-CDs led to a better reproducibility of results. It was due to the coexistence of positive and negative charge on N-CDs surface that led to a homogeneous analyte/substrate distribution, which is an important detection parameter. The enhancing effect of carbon dots was linked to a negative Gibbs energy of the complex formation between CDs, Na+, cholesterol and DHB, and it was supported by theoretical calculations. Moreover, upon the addition of CDs/N-CDs, such features as a low ionization potential, vertical excitation, dipole moment and oscillator strength positively affected the cholesterol detection by MALDI in the presence of Na+. © 2021 Elsevier Inc.",
journal = "Journal of Colloid and Interface Science",
title = "Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry",
volume = "591",
pages = "373-383",
doi = "10.1016/j.jcis.2021.02.004"
}
Houdová, D., Soto, J., Castro, R., Rodrigues, J., Soledad Pino-González, M., Petković, M., Bandosz, T. J.,& Algarra, M. (2021). Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry.
Journal of Colloid and Interface Science, 591, 373-383.
https://doi.org/10.1016/j.jcis.2021.02.004
Houdová D, Soto J, Castro R, Rodrigues J, Soledad Pino-González M, Petković M, Bandosz TJ, Algarra M. Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry. Journal of Colloid and Interface Science. 2021;591:373-383
Houdová Dominika, Soto Juan, Castro Rita, Rodrigues João, Soledad Pino-González Ma, Petković Marijana, Bandosz Teresa J, Algarra Manuel, "Chemically heterogeneous carbon dots enhanced cholesterol detection by MALDI TOF mass spectrometry" Journal of Colloid and Interface Science, 591 (2021):373-383,
https://doi.org/10.1016/j.jcis.2021.02.004 .

Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

Stanišić, Jelena; Ivković, Tamara; Romić, Snježana Đ.; Zec, Manja; Ćulafić, Tijana; Stojiljković, Mojca D.; Korićanac, Goran

(2021)

TY  - JOUR
AU  - Stanišić, Jelena
AU  - Ivković, Tamara
AU  - Romić, Snježana Đ.
AU  - Zec, Manja
AU  - Ćulafić, Tijana
AU  - Stojiljković, Mojca D.
AU  - Korićanac, Goran
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9110
AB  - Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.
T2  - International Journal of Food Sciences and Nutrition
T1  - Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2
VL  - 72
IS  - 3
SP  - 324
EP  - 334
DO  - 10.1080/09637486.2020.1796931
ER  - 
@article{
author = "Stanišić, Jelena and Ivković, Tamara and Romić, Snježana Đ. and Zec, Manja and Ćulafić, Tijana and Stojiljković, Mojca D. and Korićanac, Goran",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9110",
abstract = "Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.",
journal = "International Journal of Food Sciences and Nutrition",
title = "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2",
volume = "72",
number = "3",
pages = "324-334",
doi = "10.1080/09637486.2020.1796931"
}
Stanišić, J., Ivković, T., Romić, S. Đ., Zec, M., Ćulafić, T., Stojiljković, M. D.,& Korićanac, G. (2021). Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2.
International Journal of Food Sciences and Nutrition, 72(3), 324-334.
https://doi.org/10.1080/09637486.2020.1796931
Stanišić J, Ivković T, Romić SĐ, Zec M, Ćulafić T, Stojiljković MD, Korićanac G. Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2. International Journal of Food Sciences and Nutrition. 2021;72(3):324-334
Stanišić Jelena, Ivković Tamara, Romić Snježana Đ., Zec Manja, Ćulafić Tijana, Stojiljković Mojca D., Korićanac Goran, "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2" International Journal of Food Sciences and Nutrition, 72, no. 3 (2021):324-334,
https://doi.org/10.1080/09637486.2020.1796931 .
3
2
1

Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2

Stanišić, Jelena; Ivković, Tamara; Romić, Snježana Đ.; Zec, Manja; Ćulafić, Tijana; Stojiljković, Mojca D.; Korićanac, Goran

(2021)

TY  - JOUR
AU  - Stanišić, Jelena
AU  - Ivković, Tamara
AU  - Romić, Snježana Đ.
AU  - Zec, Manja
AU  - Ćulafić, Tijana
AU  - Stojiljković, Mojca D.
AU  - Korićanac, Goran
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9103
AB  - Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.
T2  - International Journal of Food Sciences and Nutrition
T1  - Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2
VL  - 72
IS  - 3
SP  - 324
EP  - 334
DO  - 10.1080/09637486.2020.1796931
ER  - 
@article{
author = "Stanišić, Jelena and Ivković, Tamara and Romić, Snježana Đ. and Zec, Manja and Ćulafić, Tijana and Stojiljković, Mojca D. and Korićanac, Goran",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9103",
abstract = "Consumption of walnuts is beneficial for cardiovascular health. To study walnut effects on proteins involved in vascular tone regulation, control and fructose-fed rats were subjected to walnut diet for 6 weeks. In contrast with increased energy intake and body mass gain, aortic protein level of L-type calcium channel alpha subunit was decreased and the level of SUR2B subunit of ATP-sensitive K + channel was increased in healthy rats subjected to walnuts, together with improved Akt phosphorylation. Upon the walnut diet in rats subjected to fructose overload, the rise in energy intake and body mass gain, was followed by an increase in blood insulin. Although SUR2B level was elevated, the level of sodium-calcium exchanger NCX1 and inducible nitric oxide synthase were reduced and increased, respectively. In summary, walnut consumption was accompanied with moderate beneficial vascular effect in healthy rats, while an effect of walnut in rats with metabolic disturbances was rather controversial.",
journal = "International Journal of Food Sciences and Nutrition",
title = "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2",
volume = "72",
number = "3",
pages = "324-334",
doi = "10.1080/09637486.2020.1796931"
}
Stanišić, J., Ivković, T., Romić, S. Đ., Zec, M., Ćulafić, T., Stojiljković, M. D.,& Korićanac, G. (2021). Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2.
International Journal of Food Sciences and Nutrition, 72(3), 324-334.
https://doi.org/10.1080/09637486.2020.1796931
Stanišić J, Ivković T, Romić SĐ, Zec M, Ćulafić T, Stojiljković MD, Korićanac G. Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2. International Journal of Food Sciences and Nutrition. 2021;72(3):324-334
Stanišić Jelena, Ivković Tamara, Romić Snježana Đ., Zec Manja, Ćulafić Tijana, Stojiljković Mojca D., Korićanac Goran, "Beneficial effect of walnuts on vascular tone is associated with Akt signalling, voltage-dependent calcium channel LTCC and ATP-sensitive potassium channel Kv1.2" International Journal of Food Sciences and Nutrition, 72, no. 3 (2021):324-334,
https://doi.org/10.1080/09637486.2020.1796931 .
3
2
1

Antidepressants- and antipsychotics-induced hepatotoxicity

Todorović Vukotić, Nevena; Đorđević, Jelena; Pejić, Snežana; Đorđević, Neda O.; Pajović, Snežana B.

(2021)

TY  - JOUR
AU  - Todorović Vukotić, Nevena
AU  - Đorđević, Jelena
AU  - Pejić, Snežana
AU  - Đorđević, Neda O.
AU  - Pajović, Snežana B.
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9078
AB  - Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.
T2  - Archives of Toxicology
T1  - Antidepressants- and antipsychotics-induced hepatotoxicity
VL  - 95
IS  - 3
SP  - 767
EP  - 789
DO  - 10.1007/s00204-020-02963-4
ER  - 
@article{
author = "Todorović Vukotić, Nevena and Đorđević, Jelena and Pejić, Snežana and Đorđević, Neda O. and Pajović, Snežana B.",
year = "2021",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9078",
abstract = "Drug-induced liver injury (DILI) is a serious health burden. It has diverse clinical presentations that can escalate to acute liver failure. The worldwide increase in the use of psychotropic drugs, their long-term use on a daily basis, common comorbidities of psychiatric and metabolic disorders, and polypharmacy in psychiatric patients increase the incidence of psychotropics-induced DILI. During the last 2 decades, hepatotoxicity of various antidepressants (ADs) and antipsychotics (APs) received much attention. Comprehensive review and discussion of accumulated literature data concerning this issue are performed in this study, as hepatotoxic effects of most commonly prescribed ADs and APs are classified, described, and discussed. The review focuses on ADs and APs characterized by the risk of causing liver damage and highlights the ones found to cause life-threatening or severe DILI cases. In parallel, an overview of hepatic oxidative stress, inflammation, and steatosis underlying DILI is provided, followed by extensive review and discussion of the pathophysiology of AD- and AP-induced DILI revealed in case reports, and animal and in vitro studies. The consequences of some ADs and APs ability to affect drug-metabolizing enzymes and therefore provoke drug–drug interactions are also addressed. Continuous collecting of data on drugs, mechanisms, and risk factors for DILI, as well as critical data reviewing, is crucial for easier DILI diagnosis and more efficient risk assessment of AD- and AP-induced DILI. Higher awareness of ADs and APs hepatotoxicity is the prerequisite for their safe use and optimal dosing. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature.",
journal = "Archives of Toxicology",
title = "Antidepressants- and antipsychotics-induced hepatotoxicity",
volume = "95",
number = "3",
pages = "767-789",
doi = "10.1007/s00204-020-02963-4"
}
Todorović Vukotić, N., Đorđević, J., Pejić, S., Đorđević, N. O.,& Pajović, S. B. (2021). Antidepressants- and antipsychotics-induced hepatotoxicity.
Archives of Toxicology, 95(3), 767-789.
https://doi.org/10.1007/s00204-020-02963-4
Todorović Vukotić N, Đorđević J, Pejić S, Đorđević NO, Pajović SB. Antidepressants- and antipsychotics-induced hepatotoxicity. Archives of Toxicology. 2021;95(3):767-789
Todorović Vukotić Nevena, Đorđević Jelena, Pejić Snežana, Đorđević Neda O., Pajović Snežana B., "Antidepressants- and antipsychotics-induced hepatotoxicity" Archives of Toxicology, 95, no. 3 (2021):767-789,
https://doi.org/10.1007/s00204-020-02963-4 .
1
1

Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing

Jovanović, Svetlana P.; Dorontić, Slađana; Jovanović, Dragana J.; Ciasca, Gabriele; Budimir, Milica; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Todorović-Marković, Biljana

(2020)

TY  - JOUR
AU  - Jovanović, Svetlana P.
AU  - Dorontić, Slađana
AU  - Jovanović, Dragana J.
AU  - Ciasca, Gabriele
AU  - Budimir, Milica
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Todorović-Marković, Biljana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9072
AB  - Due to the low consumption of chemicals, the absence of toxic residual side products, the procedure simplicity and time-saving aspects, gamma irradiation offers advantages over the classical chemical protocols. We successfully employed gamma irradiation in order to introduce N-atoms in Graphene Quantum Dots (GQDs). By irradiating GQDs water dispersions in the presence of isopropyl alcohol and ethylenediamine, at doses of 25, 50 and 200 kGy, we attached amino groups onto GQDs in a single synthetic step. At the same time, a chemical reduction is achieved, too. Selected conditions induced incorporation of N-atoms within GDQs atomic lattice (around 3 at%), at all applied doses. Additionally, the C-atoms percentage was highly increased, from 63 to 79 at % or higher. The zeta potential of dots changed from −34.6 to +9.1 mV, due to the modification of functionalizing groups localized at the surface. Produced chemical changes lead to the desired alteration of the GQDs optical properties, such as an increased photoluminescence intensity, a higher photoluminescence quantum yields (from 2.07 to 18.40%) and a narrowing of the spectral features in the emission spectra. The ability of gamma-irradiated GQDs to quench free radical species was investigated and positively assessed; additionally, non-enzymatic optical detection of Cu(II) ions using GQDs as a sensor was studied and the detection limits areherein reported. These results suggest that GQDs can be potentially applied as smart photoluminescent sensors for metal cations.
T2  - Ceramics International
T1  - Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing
VL  - 46
IS  - 15
SP  - 23611
EP  - 23622
DO  - 10.1016/j.ceramint.2020.06.133
ER  - 
@article{
author = "Jovanović, Svetlana P. and Dorontić, Slađana and Jovanović, Dragana J. and Ciasca, Gabriele and Budimir, Milica and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Todorović-Marković, Biljana",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9072",
abstract = "Due to the low consumption of chemicals, the absence of toxic residual side products, the procedure simplicity and time-saving aspects, gamma irradiation offers advantages over the classical chemical protocols. We successfully employed gamma irradiation in order to introduce N-atoms in Graphene Quantum Dots (GQDs). By irradiating GQDs water dispersions in the presence of isopropyl alcohol and ethylenediamine, at doses of 25, 50 and 200 kGy, we attached amino groups onto GQDs in a single synthetic step. At the same time, a chemical reduction is achieved, too. Selected conditions induced incorporation of N-atoms within GDQs atomic lattice (around 3 at%), at all applied doses. Additionally, the C-atoms percentage was highly increased, from 63 to 79 at % or higher. The zeta potential of dots changed from −34.6 to +9.1 mV, due to the modification of functionalizing groups localized at the surface. Produced chemical changes lead to the desired alteration of the GQDs optical properties, such as an increased photoluminescence intensity, a higher photoluminescence quantum yields (from 2.07 to 18.40%) and a narrowing of the spectral features in the emission spectra. The ability of gamma-irradiated GQDs to quench free radical species was investigated and positively assessed; additionally, non-enzymatic optical detection of Cu(II) ions using GQDs as a sensor was studied and the detection limits areherein reported. These results suggest that GQDs can be potentially applied as smart photoluminescent sensors for metal cations.",
journal = "Ceramics International",
title = "Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing",
volume = "46",
number = "15",
pages = "23611-23622",
doi = "10.1016/j.ceramint.2020.06.133"
}
Jovanović, S. P., Dorontić, S., Jovanović, D. J., Ciasca, G., Budimir, M., Bonasera, A., Scopelliti, M., Marković, O.,& Todorović-Marković, B. (2020). Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing.
Ceramics International, 46(15), 23611-23622.
https://doi.org/10.1016/j.ceramint.2020.06.133
Jovanović SP, Dorontić S, Jovanović DJ, Ciasca G, Budimir M, Bonasera A, Scopelliti M, Marković O, Todorović-Marković B. Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing. Ceramics International. 2020;46(15):23611-23622
Jovanović Svetlana P., Dorontić Slađana, Jovanović Dragana J., Ciasca Gabriele, Budimir Milica, Bonasera Aurelio, Scopelliti Michelangelo, Marković Olivera, Todorović-Marković Biljana, "Gamma irradiation of graphene quantum dots with ethylenediamine: Antioxidant for ion sensing" Ceramics International, 46, no. 15 (2020):23611-23622,
https://doi.org/10.1016/j.ceramint.2020.06.133 .
1
1

Drug delivery systems based on nanoparticles and related nanostructures

Vujačić Nikezić, Ana V.; Bondžić, Aleksandra; Vasić, Vesna M.

(2020)

TY  - JOUR
AU  - Vujačić Nikezić, Ana V.
AU  - Bondžić, Aleksandra
AU  - Vasić, Vesna M.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9049
AB  - A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.
T2  - European Journal of Pharmaceutical Sciences
T1  - Drug delivery systems based on nanoparticles and related nanostructures
VL  - 151
SP  - 105412
DO  - 10.1016/j.ejps.2020.105412
ER  - 
@article{
author = "Vujačić Nikezić, Ana V. and Bondžić, Aleksandra and Vasić, Vesna M.",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9049",
abstract = "A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Drug delivery systems based on nanoparticles and related nanostructures",
volume = "151",
pages = "105412",
doi = "10.1016/j.ejps.2020.105412"
}
Vujačić Nikezić, A. V., Bondžić, A.,& Vasić, V. M. (2020). Drug delivery systems based on nanoparticles and related nanostructures.
European Journal of Pharmaceutical Sciences, 151, 105412.
https://doi.org/10.1016/j.ejps.2020.105412
Vujačić Nikezić AV, Bondžić A, Vasić VM. Drug delivery systems based on nanoparticles and related nanostructures. European Journal of Pharmaceutical Sciences. 2020;151:105412
Vujačić Nikezić Ana V., Bondžić Aleksandra, Vasić Vesna M., "Drug delivery systems based on nanoparticles and related nanostructures" European Journal of Pharmaceutical Sciences, 151 (2020):105412,
https://doi.org/10.1016/j.ejps.2020.105412 .
1
9
8

Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro

Cvetković, Stefana; Todorović, Slađana; Nastasijević, Branislav J.; Mitić-Ćulafić, Dragana; Đukanović, Stefana; Knežević-Vukčević, Jelena; Nikolić, Biljana

(2020)

TY  - JOUR
AU  - Cvetković, Stefana
AU  - Todorović, Slađana
AU  - Nastasijević, Branislav J.
AU  - Mitić-Ćulafić, Dragana
AU  - Đukanović, Stefana
AU  - Knežević-Vukčević, Jelena
AU  - Nikolić, Biljana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9046
AB  - Medicinal plant Gentiana lutea is considered as an official drug for gastrointestinal disorders in many pharmacopoeias. Its uncontrolled overexploitation led to the protection regime and encouraged development of in vitro culture. The aim of this work was to chemically characterize root and leaf methanol extracts of plant grown in plantation and in vitro conditions, and to determine their antigenotoxicity against heterocyclic aromatic amines IQ and PhIP, the food-borne mutagens that are formed during high temperature cooking of protein-reach foods. High yields and growth ratios were determined for in vitro plants. Higher content of polyphenols and flavonoids were determined in aerial parts, while UPLC-MS/MS analysis pointed at the richness of in vitro grown shoot extract (GLvS) in active constituents, and high amounts of gentiopicroside in all tested extracts. Notable amounts of sweroside were detected in plantation root extract (GLR) and in GLvS, and of loganic acid in plantation leaf extract (GLL) and GLvS. Two experimental models for genotoxicity/antigenotoxicity study, i.e. SOS/umuC test with metabolic activation (addition of rat liver S9 fraction) and alkaline comet assay on hepatocellur carcinoma HepG2 cells indicated dual effects: genotoxic of high and antigenotoxic of lower non-genotoxic doses. While in vitro extracts were genotoxic in both models, plantation extracts were active only in SOS/umuC with S9. In contrast, inhibition of genotoxicity was observed in both models for all extracts (up to 83 %). Results of DPPH assay indicated that antioxidativity could be responsible for antigenotoxic properties. In conclusion, genoprotective effect encourages further investigation of antigenotoxicity, while high growth ratio and richness of GLvS in active compounds justify the use of in vitro cultivation method.
T2  - Industrial Crops and Products
T1  - Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro
VL  - 154
SP  - 112690
DO  - 10.1016/j.indcrop.2020.112690
ER  - 
@article{
author = "Cvetković, Stefana and Todorović, Slađana and Nastasijević, Branislav J. and Mitić-Ćulafić, Dragana and Đukanović, Stefana and Knežević-Vukčević, Jelena and Nikolić, Biljana",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9046",
abstract = "Medicinal plant Gentiana lutea is considered as an official drug for gastrointestinal disorders in many pharmacopoeias. Its uncontrolled overexploitation led to the protection regime and encouraged development of in vitro culture. The aim of this work was to chemically characterize root and leaf methanol extracts of plant grown in plantation and in vitro conditions, and to determine their antigenotoxicity against heterocyclic aromatic amines IQ and PhIP, the food-borne mutagens that are formed during high temperature cooking of protein-reach foods. High yields and growth ratios were determined for in vitro plants. Higher content of polyphenols and flavonoids were determined in aerial parts, while UPLC-MS/MS analysis pointed at the richness of in vitro grown shoot extract (GLvS) in active constituents, and high amounts of gentiopicroside in all tested extracts. Notable amounts of sweroside were detected in plantation root extract (GLR) and in GLvS, and of loganic acid in plantation leaf extract (GLL) and GLvS. Two experimental models for genotoxicity/antigenotoxicity study, i.e. SOS/umuC test with metabolic activation (addition of rat liver S9 fraction) and alkaline comet assay on hepatocellur carcinoma HepG2 cells indicated dual effects: genotoxic of high and antigenotoxic of lower non-genotoxic doses. While in vitro extracts were genotoxic in both models, plantation extracts were active only in SOS/umuC with S9. In contrast, inhibition of genotoxicity was observed in both models for all extracts (up to 83 %). Results of DPPH assay indicated that antioxidativity could be responsible for antigenotoxic properties. In conclusion, genoprotective effect encourages further investigation of antigenotoxicity, while high growth ratio and richness of GLvS in active compounds justify the use of in vitro cultivation method.",
journal = "Industrial Crops and Products",
title = "Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro",
volume = "154",
pages = "112690",
doi = "10.1016/j.indcrop.2020.112690"
}
Cvetković, S., Todorović, S., Nastasijević, B. J., Mitić-Ćulafić, D., Đukanović, S., Knežević-Vukčević, J.,& Nikolić, B. (2020). Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro.
Industrial Crops and Products, 154, 112690.
https://doi.org/10.1016/j.indcrop.2020.112690
Cvetković S, Todorović S, Nastasijević BJ, Mitić-Ćulafić D, Đukanović S, Knežević-Vukčević J, Nikolić B. Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro. Industrial Crops and Products. 2020;154:112690
Cvetković Stefana, Todorović Slađana, Nastasijević Branislav J., Mitić-Ćulafić Dragana, Đukanović Stefana, Knežević-Vukčević Jelena, Nikolić Biljana, "Assessment of genoprotective effects of Gentiana lutea extracts prepared from plants grown in field and in vitro" Industrial Crops and Products, 154 (2020):112690,
https://doi.org/10.1016/j.indcrop.2020.112690 .
3
1
2

Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075

Stevanović, Sanja; Lekka, Maria; Lanzutti, Alex; Tasić, Nikola; Živković, Ljiljana; Fedrizzi, Lorenzo

(2020)

TY  - JOUR
AU  - Stevanović, Sanja
AU  - Lekka, Maria
AU  - Lanzutti, Alex
AU  - Tasić, Nikola
AU  - Živković, Ljiljana
AU  - Fedrizzi, Lorenzo
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9047
AB  - Cerium-based conversion coatings have emerged as promising green alternatives to the harmful chromium-based ones, but the mechanism of corrosive protection still remains a subject of academic and industrial research. This study focuses at small scale phenomena of corrosion inhibition imparted by ceria (CeO2) to AA7075. Ceria nanoparticles were deposited from diluted and concentrated CeO2 sols by immersion. A multi-Analytical approach, combining Atomic Force microscopy (AFM), Scanning Kelvin Probe Force Microscopy, Glow Discharge Optical Emission Spectroscopy, open circuit potential and electrochemical impedance spectroscopy was employed. Deposition of ceria films led to deactivation of cathodic sites, i.e. decreased Volta potential difference, resulting in increased corrosion inhibition. In situ AFM real-Time monitoring revealed that during exposure to NaCl electrolyte, the changes in size of deposited ceria aggregates occurred: nanoparticles disintegrated/desorbed and re-deposited at the coating surface. The process was found to be dynamic in nature. Small particles size and inherent reactivity are believed to accelerate this phenomenon. Due to the greater CeO2 reservoir, this phenomenon was more pronounced with a thicker film, imparting longer term protection.
T2  - Journal of the Electrochemical Society
T1  - Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075
VL  - 167
IS  - 10
SP  - 101503
DO  - 10.1149/1945-7111/ab98af
ER  - 
@article{
author = "Stevanović, Sanja and Lekka, Maria and Lanzutti, Alex and Tasić, Nikola and Živković, Ljiljana and Fedrizzi, Lorenzo",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9047",
abstract = "Cerium-based conversion coatings have emerged as promising green alternatives to the harmful chromium-based ones, but the mechanism of corrosive protection still remains a subject of academic and industrial research. This study focuses at small scale phenomena of corrosion inhibition imparted by ceria (CeO2) to AA7075. Ceria nanoparticles were deposited from diluted and concentrated CeO2 sols by immersion. A multi-Analytical approach, combining Atomic Force microscopy (AFM), Scanning Kelvin Probe Force Microscopy, Glow Discharge Optical Emission Spectroscopy, open circuit potential and electrochemical impedance spectroscopy was employed. Deposition of ceria films led to deactivation of cathodic sites, i.e. decreased Volta potential difference, resulting in increased corrosion inhibition. In situ AFM real-Time monitoring revealed that during exposure to NaCl electrolyte, the changes in size of deposited ceria aggregates occurred: nanoparticles disintegrated/desorbed and re-deposited at the coating surface. The process was found to be dynamic in nature. Small particles size and inherent reactivity are believed to accelerate this phenomenon. Due to the greater CeO2 reservoir, this phenomenon was more pronounced with a thicker film, imparting longer term protection.",
journal = "Journal of the Electrochemical Society",
title = "Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075",
volume = "167",
number = "10",
pages = "101503",
doi = "10.1149/1945-7111/ab98af"
}
Stevanović, S., Lekka, M., Lanzutti, A., Tasić, N., Živković, L.,& Fedrizzi, L. (2020). Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075.
Journal of the Electrochemical Society, 167(10), 101503.
https://doi.org/10.1149/1945-7111/ab98af
Stevanović S, Lekka M, Lanzutti A, Tasić N, Živković L, Fedrizzi L. Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075. Journal of the Electrochemical Society. 2020;167(10):101503
Stevanović Sanja, Lekka Maria, Lanzutti Alex, Tasić Nikola, Živković Ljiljana, Fedrizzi Lorenzo, "Real-Time AFM and Impedance Corrosion Monitoring of Environmentally Friendly Ceria Films on AA7075" Journal of the Electrochemical Society, 167, no. 10 (2020):101503,
https://doi.org/10.1149/1945-7111/ab98af .
1
2
1

Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times

Miljković, Miljana; Kljajević, Ljiljana M.; Filipović, Suzana; Pavlović, Vladimir B.; Nenadović, Snežana S.

(2020)

TY  - JOUR
AU  - Miljković, Miljana
AU  - Kljajević, Ljiljana M.
AU  - Filipović, Suzana
AU  - Pavlović, Vladimir B.
AU  - Nenadović, Snežana S.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8916
AB  - The aim of the study was to investigate the influence of low heating temperatures with two different retention times to optimize the process for obtaining nanosized hydroxyapatite material that can possibly be used in the fields of biology and pharmacy. Nanosized hydroxyapatite was successfully obtained by wet chemical precipitation. The annealing of the material performed at 300 oC with two different retention times i.e. 3 and 6 hours in air atmosphere. Low annealing temperature with extended retention time was selected in terms to reduce energy consumption. FTIR spectroscopy was used to confirm characteristic vibrational bands of hydroxyapatite samples, and presence of carbonate bands of hydroxyapatite annealed for 3h and 6h. X-Ray powder diffraction analysis were used to examine phase composition, determine the size of unit cells and crystallite sizes, and SEMEDS methods were used to obtain particle size and arrangement also grain growth morphology and confirmed the presence of calcium, phosphorous oxygen and carbonate peaks. The results show that different retention time has influence on particle growth as well as unit cell parameters and crystallite sizes changes of hydroxyapatite material.
T2  - Science of Sintering
T1  - Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times
VL  - 52
IS  - 4
SP  - 405
EP  - 413
DO  - 10.2298/SOS2004405M
ER  - 
@article{
author = "Miljković, Miljana and Kljajević, Ljiljana M. and Filipović, Suzana and Pavlović, Vladimir B. and Nenadović, Snežana S.",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8916",
abstract = "The aim of the study was to investigate the influence of low heating temperatures with two different retention times to optimize the process for obtaining nanosized hydroxyapatite material that can possibly be used in the fields of biology and pharmacy. Nanosized hydroxyapatite was successfully obtained by wet chemical precipitation. The annealing of the material performed at 300 oC with two different retention times i.e. 3 and 6 hours in air atmosphere. Low annealing temperature with extended retention time was selected in terms to reduce energy consumption. FTIR spectroscopy was used to confirm characteristic vibrational bands of hydroxyapatite samples, and presence of carbonate bands of hydroxyapatite annealed for 3h and 6h. X-Ray powder diffraction analysis were used to examine phase composition, determine the size of unit cells and crystallite sizes, and SEMEDS methods were used to obtain particle size and arrangement also grain growth morphology and confirmed the presence of calcium, phosphorous oxygen and carbonate peaks. The results show that different retention time has influence on particle growth as well as unit cell parameters and crystallite sizes changes of hydroxyapatite material.",
journal = "Science of Sintering",
title = "Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times",
volume = "52",
number = "4",
pages = "405-413",
doi = "10.2298/SOS2004405M"
}
Miljković, M., Kljajević, L. M., Filipović, S., Pavlović, V. B.,& Nenadović, S. S. (2020). Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times.
Science of Sintering, 52(4), 405-413.
https://doi.org/10.2298/SOS2004405M
Miljković M, Kljajević LM, Filipović S, Pavlović VB, Nenadović SS. Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times. Science of Sintering. 2020;52(4):405-413
Miljković Miljana, Kljajević Ljiljana M., Filipović Suzana, Pavlović Vladimir B., Nenadović Snežana S., "Study of Nanosized Hydroxyapatite Material Annealing at Different Retention Times" Science of Sintering, 52, no. 4 (2020):405-413,
https://doi.org/10.2298/SOS2004405M .
1
1

A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition

Bondžić, Aleksandra; Lazarević-Pašti, Tamara; Leskovac, Andreja; Petrović, Sandra; Čolović, Mirjana B.; Parac Vogt, Tatjana N.; Janjić, Goran V.

(2020)

TY  - JOUR
AU  - Bondžić, Aleksandra
AU  - Lazarević-Pašti, Tamara
AU  - Leskovac, Andreja
AU  - Petrović, Sandra
AU  - Čolović, Mirjana B.
AU  - Parac Vogt, Tatjana N.
AU  - Janjić, Goran V.
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9028
AB  - Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.
T2  - European Journal of Pharmaceutical Sciences
T1  - A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition
VL  - 151
SP  - 105376
DO  - 10.1016/j.ejps.2020.105376
ER  - 
@article{
author = "Bondžić, Aleksandra and Lazarević-Pašti, Tamara and Leskovac, Andreja and Petrović, Sandra and Čolović, Mirjana B. and Parac Vogt, Tatjana N. and Janjić, Goran V.",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/9028",
abstract = "Acetylcholinesterase (AChE) inhibitors are important in the treatment of neurodegenerative diseases. Two inhibitors,12-tungstosilicic acid (WSiA) and 12-tungstophosphoric acid (WPA), which have polyoxometalate(POM) type structure, have been shown to inhibit AChE activity in nM concentration. Circular dichroism andtryptophan fluorescence spectroscopy demonstrated that the AChE inhibition was not accompanied by significantchanges in the secondary structure of the enzyme. The molecular docking approach has revealed a newallosteric binding site, termed β-allosteric site (β-AS), which is considered responsible for the inhibition of AChEby POMs. To the best of our knowledge, this is the first study reporting a new allosteric site that is consideredresponsible for AChE inhibition by voluminous and negatively charged molecules such as POMs. The selectedPOMs were further subjected to genotoxicity testing using human peripheral blood cells as a model system. Itwas shown that WSiA and WPA induced a mild cytostatic but not genotoxic effects in human lymphocytes, whichindicates their potential to be used as medicinal drugs. The identification of non-toxic compounds capable ofbinding to an allosteric site that so far has not been considered responsible for enzyme inhibition could befundamental for the development of new drug design strategies and the discovery of more efficient AChEmodulators.",
journal = "European Journal of Pharmaceutical Sciences",
title = "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition",
volume = "151",
pages = "105376",
doi = "10.1016/j.ejps.2020.105376"
}
Bondžić, A., Lazarević-Pašti, T., Leskovac, A., Petrović, S., Čolović, M. B., Parac Vogt, T. N.,& Janjić, G. V. (2020). A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition.
European Journal of Pharmaceutical Sciences, 151, 105376.
https://doi.org/10.1016/j.ejps.2020.105376
Bondžić A, Lazarević-Pašti T, Leskovac A, Petrović S, Čolović MB, Parac Vogt TN, Janjić GV. A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition. European Journal of Pharmaceutical Sciences. 2020;151:105376
Bondžić Aleksandra, Lazarević-Pašti Tamara, Leskovac Andreja, Petrović Sandra, Čolović Mirjana B., Parac Vogt Tatjana N., Janjić Goran V., "A new acetylcholinesterase allosteric site responsible for binding voluminous negatively charged molecules – the role in the mechanism of AChE inhibition" European Journal of Pharmaceutical Sciences, 151 (2020):105376,
https://doi.org/10.1016/j.ejps.2020.105376 .
3
1