SAIA National Scholarship Programme of the Slovak Republic, [VEGA 2/0174/17], [APVV-15-0229], [APVV-15-0565]

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SAIA National Scholarship Programme of the Slovak Republic, [VEGA 2/0174/17], [APVV-15-0229], [APVV-15-0565]

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Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats

Romić, Snježana Đ.; Krskova, Katarina; Olszanecki, Rafal; Balazova, Lucia; Lory, Viktoria; Korićanac, Goran; Slamkova, Miroslava; Zorad, Stefan

(2017)

TY  - JOUR
AU  - Romić, Snježana Đ.
AU  - Krskova, Katarina
AU  - Olszanecki, Rafal
AU  - Balazova, Lucia
AU  - Lory, Viktoria
AU  - Korićanac, Goran
AU  - Slamkova, Miroslava
AU  - Zorad, Stefan
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1764
AB  - Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-kappa B) p65 protein content in quadriceps muscle of young and old obese Zuckerfa/fa rats and their lean controls were analyzed by immunoblot to define obesity- and aging-related alterations in FA uptake, their subsequent metabolic fate and potential to activate pro-inflammatory signaling. As expected, obesity increased FAT/CD36 content in plasma membrane in quadriceps muscle of fa/fa rats. Aging increased cytosolic lipin-1 content in both, obese rats and their lean controls. Also, old obese rats had decreased level of nuclear extract lipin-lcompared to that in old lean rats. Neither obesity nor age altered NF-kappa B p65 protein content in cytosol and nuclear extract of quadriceps muscle suggesting that obesity/aging-induced changes in FA handling are not accompanied by NF-kappa B-mediated inflammation. Increase in plasma membrane FAT/CD36 content in obese rats and failure in lipin-1 export to nucleus with progression of obesity, implying an increase in FA uptake and their different channeling into lipid intermediates synthesis pathway in old fa/fa rats versus FA usage in lean rats of the same age.
T2  - General Physiology and Biophysics
T1  - Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats
VL  - 36
IS  - 4
SP  - 399
EP  - 406
DO  - 10.4149/gpb_2017010
ER  - 
@article{
author = "Romić, Snježana Đ. and Krskova, Katarina and Olszanecki, Rafal and Balazova, Lucia and Lory, Viktoria and Korićanac, Goran and Slamkova, Miroslava and Zorad, Stefan",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1764",
abstract = "Fatty acid (FA) uptake and/or intramuscular triglyceride (TG) accumulation in skeletal muscle are increased in obesity, type 2 diabetes and aging. FA translocase (FAT/CD36) translocation, lipin-1 subcellular localization and nuclear factor kappa B (NF-kappa B) p65 protein content in quadriceps muscle of young and old obese Zuckerfa/fa rats and their lean controls were analyzed by immunoblot to define obesity- and aging-related alterations in FA uptake, their subsequent metabolic fate and potential to activate pro-inflammatory signaling. As expected, obesity increased FAT/CD36 content in plasma membrane in quadriceps muscle of fa/fa rats. Aging increased cytosolic lipin-1 content in both, obese rats and their lean controls. Also, old obese rats had decreased level of nuclear extract lipin-lcompared to that in old lean rats. Neither obesity nor age altered NF-kappa B p65 protein content in cytosol and nuclear extract of quadriceps muscle suggesting that obesity/aging-induced changes in FA handling are not accompanied by NF-kappa B-mediated inflammation. Increase in plasma membrane FAT/CD36 content in obese rats and failure in lipin-1 export to nucleus with progression of obesity, implying an increase in FA uptake and their different channeling into lipid intermediates synthesis pathway in old fa/fa rats versus FA usage in lean rats of the same age.",
journal = "General Physiology and Biophysics",
title = "Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats",
volume = "36",
number = "4",
pages = "399-406",
doi = "10.4149/gpb_2017010"
}
Romić, S. Đ., Krskova, K., Olszanecki, R., Balazova, L., Lory, V., Korićanac, G., Slamkova, M.,& Zorad, S. (2017). Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats.
General Physiology and Biophysics, 36(4), 399-406.
https://doi.org/10.4149/gpb_2017010
Romić SĐ, Krskova K, Olszanecki R, Balazova L, Lory V, Korićanac G, Slamkova M, Zorad S. Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats. General Physiology and Biophysics. 2017;36(4):399-406
Romić Snježana Đ., Krskova Katarina, Olszanecki Rafal, Balazova Lucia, Lory Viktoria, Korićanac Goran, Slamkova Miroslava, Zorad Stefan, "Obesity- and age-related alterations in FAT/CD36 translocation and lipin-1 subcellular localization in skeletal muscle of the Zucker rats" General Physiology and Biophysics, 36, no. 4 (2017):399-406,
https://doi.org/10.4149/gpb_2017010 .
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