TY  - JOUR
AU  - Pirković, Andrea
AU  - Lazić, Vesna
AU  - Spremo-Potparević, Biljana
AU  - Živković, Lada
AU  - Topalović, Dijana
AU  - Kuzman, Sanja
AU  - Antić-Stanković, Jelena
AU  - Božić, Dragana
AU  - Jovanović Krivokuća, Milica
AU  - Nedeljković, Jovan
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11219
AB  - Dry olive leaf extract (DOLE) and its active component oleuropein (OLE) were applied as reducing and stabilizing agents to prepare colloidal 20–25 nm silver nanoparticles (Ag NPs). The Ag NPs were characterized using transmission electron microscopy, X-ray diffraction analysis, and absorption spectroscopy. The cytotoxic actions of coated Ag NPs, and their inorganic and organic components, were examined against trophoblast cells and human peripheral blood lymphocytes (PBLs), Gram-positive, Gram-negative bacteria, and yeast. The genotoxic potential was evaluated in PBLs in vitro with the comet assay. Ag/DOLE and Ag/OLE induced cytotoxic effects in both types of cells after 24 h exposure when silver concentrations were 0.025–0.2 mM. However, the most pronounced cytotoxicity exhibits Ag/OLE. Both colloids also caused reduced ROS production in both cell types at 0.1 mM and 0.2 mM, while bare Ag NPs did not alter ROS levels at any of the conditions. Functionalized Ag/DOLE and Ag/OLE did not show genotoxic effects in PBLs, while bare AgNPs increased DNA damage significantly only at 0.2 mM. Regarding the antimicrobial effects, the Ag/OLE had MIC values for all evaluated microorganisms from 0.0625 to less than 0.0312 mM. Also, the antimicrobial effect of Ag/DOLE was significantly higher on Gram-negative bacteria and yeast than on Gram-positive bacteria. Obtained results indicate that Ag/OLE induced the most pronounced biological effects, beneficial for its application as an antimicrobial agent, but with potential risks from exposure to high concentrations that could induce cytotoxicity in healthy human cells.
T2  - Mutagenesis
T1  - Comparative analysis of Ag NPs functionalized with olive leaf extract and oleuropein and toxicity in human trophoblast cells and peripheral blood lymphocytes
VL  - 38
IS  - 3
SP  - 169
EP  - 181
DO  - 10.1093/mutage/gead013
ER  - 

@article{
author = "Pirković, Andrea and Lazić, Vesna and Spremo-Potparević, Biljana and Živković, Lada and Topalović, Dijana and Kuzman, Sanja and Antić-Stanković, Jelena and Božić, Dragana and Jovanović Krivokuća, Milica and Nedeljković, Jovan",
year = "2023",
abstract = "Dry olive leaf extract (DOLE) and its active component oleuropein (OLE) were applied as reducing and stabilizing agents to prepare colloidal 20–25 nm silver nanoparticles (Ag NPs). The Ag NPs were characterized using transmission electron microscopy, X-ray diffraction analysis, and absorption spectroscopy. The cytotoxic actions of coated Ag NPs, and their inorganic and organic components, were examined against trophoblast cells and human peripheral blood lymphocytes (PBLs), Gram-positive, Gram-negative bacteria, and yeast. The genotoxic potential was evaluated in PBLs in vitro with the comet assay. Ag/DOLE and Ag/OLE induced cytotoxic effects in both types of cells after 24 h exposure when silver concentrations were 0.025–0.2 mM. However, the most pronounced cytotoxicity exhibits Ag/OLE. Both colloids also caused reduced ROS production in both cell types at 0.1 mM and 0.2 mM, while bare Ag NPs did not alter ROS levels at any of the conditions. Functionalized Ag/DOLE and Ag/OLE did not show genotoxic effects in PBLs, while bare AgNPs increased DNA damage significantly only at 0.2 mM. Regarding the antimicrobial effects, the Ag/OLE had MIC values for all evaluated microorganisms from 0.0625 to less than 0.0312 mM. Also, the antimicrobial effect of Ag/DOLE was significantly higher on Gram-negative bacteria and yeast than on Gram-positive bacteria. Obtained results indicate that Ag/OLE induced the most pronounced biological effects, beneficial for its application as an antimicrobial agent, but with potential risks from exposure to high concentrations that could induce cytotoxicity in healthy human cells.",
journal = "Mutagenesis",
title = "Comparative analysis of Ag NPs functionalized with olive leaf extract and oleuropein and toxicity in human trophoblast cells and peripheral blood lymphocytes",
volume = "38",
number = "3",
pages = "169-181",
doi = "10.1093/mutage/gead013"
}

Pirković, A., Lazić, V., Spremo-Potparević, B., Živković, L., Topalović, D., Kuzman, S., Antić-Stanković, J., Božić, D., Jovanović Krivokuća, M.,& Nedeljković, J.. (2023). Comparative analysis of Ag NPs functionalized with olive leaf extract and oleuropein and toxicity in human trophoblast cells and peripheral blood lymphocytes. in Mutagenesis, 38(3), 169-181.
https://doi.org/10.1093/mutage/gead013

Pirković A, Lazić V, Spremo-Potparević B, Živković L, Topalović D, Kuzman S, Antić-Stanković J, Božić D, Jovanović Krivokuća M, Nedeljković J. Comparative analysis of Ag NPs functionalized with olive leaf extract and oleuropein and toxicity in human trophoblast cells and peripheral blood lymphocytes. in Mutagenesis. 2023;38(3):169-181.
doi:10.1093/mutage/gead013 .

Pirković, Andrea, Lazić, Vesna, Spremo-Potparević, Biljana, Živković, Lada, Topalović, Dijana, Kuzman, Sanja, Antić-Stanković, Jelena, Božić, Dragana, Jovanović Krivokuća, Milica, Nedeljković, Jovan, "Comparative analysis of Ag NPs functionalized with olive leaf extract and oleuropein and toxicity in human trophoblast cells and peripheral blood lymphocytes" in Mutagenesis, 38, no. 3 (2023):169-181,
https://doi.org/10.1093/mutage/gead013 . .

TY  - JOUR
AU  - Miletić, Mirjana
AU  - Vilotić, Aleksandra
AU  - Korićanac, Lela
AU  - Žakula, Jelena
AU  - Jovanović Krivokuća, Milica
AU  - Dohčević-Mitrović, Zorana
AU  - Aškrabić, Sonja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10542
AB  - Selective cytotoxicity of ZnO nanoparticles among different cell types and cancer and non-cancerous cells has been demonstrated earlier. In the view of anticancer potential of ZnO nanoparticles and their presence in numerous industrial products, it is of great importance to carefully evaluate their effects and mechanisms of action in both cancerous and healthy cells. In this paper, the effects of ZnO nanoparticles on cancerous HeLa and non-cancerous MRC-5 cells are investigated by studying the changes in the vibrational properties of the cells using Raman spectroscopy. Both types of cells were incubated with ZnO nanoparticles of average size 40 nm in the doses from the range 10–40 µg/ml for the period of 48 h, after which Raman spectra were collected. Raman modes’ intensity ratios I1659/I1444, I2855/I2933 and I1337/I1305 were determined as spectral markers of the cytotoxic effect of ZnO in both cell types. Non-negative principal component analysis was used instead of standard one for analysis and detection of spectral features characteristic for nanoparticle-treated cells. The first several non-negative loading vectors obtained in this analysis coincided remarkably well with the Raman spectra of particular biomolecules, showing increase of lipid and decrease of nucleic acids and protein content. Our study pointed out that Raman spectral markers of lipid unsaturation, especially I1270/I1300, are relevant for tracing the cytotoxic effect of ZnO nanoparticles on both cancerous and non-cancerous cells. The change of these spectral markers is correlated to the dose of applied nanoparticles and to the degree of cellular damage. Furthermore, great similarity of spectral features of increasing lipids to spectral features of phosphatidylserine, one of the main apoptotic markers, was recognized in treated cells. Finally, the results strongly indicated that the degree of lipid saturation, presented in the cells, plays an important role in the interaction of cells with nanoparticles.
T2  - Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy
T1  - Spectroscopic signature of ZnO NP-induced cell death modalities assessed by non-negative PCA
VL  - 288
SP  - 122180
DO  - 10.1016/j.saa.2022.122180
ER  - 

@article{
author = "Miletić, Mirjana and Vilotić, Aleksandra and Korićanac, Lela and Žakula, Jelena and Jovanović Krivokuća, Milica and Dohčević-Mitrović, Zorana and Aškrabić, Sonja",
year = "2023",
abstract = "Selective cytotoxicity of ZnO nanoparticles among different cell types and cancer and non-cancerous cells has been demonstrated earlier. In the view of anticancer potential of ZnO nanoparticles and their presence in numerous industrial products, it is of great importance to carefully evaluate their effects and mechanisms of action in both cancerous and healthy cells. In this paper, the effects of ZnO nanoparticles on cancerous HeLa and non-cancerous MRC-5 cells are investigated by studying the changes in the vibrational properties of the cells using Raman spectroscopy. Both types of cells were incubated with ZnO nanoparticles of average size 40 nm in the doses from the range 10–40 µg/ml for the period of 48 h, after which Raman spectra were collected. Raman modes’ intensity ratios I1659/I1444, I2855/I2933 and I1337/I1305 were determined as spectral markers of the cytotoxic effect of ZnO in both cell types. Non-negative principal component analysis was used instead of standard one for analysis and detection of spectral features characteristic for nanoparticle-treated cells. The first several non-negative loading vectors obtained in this analysis coincided remarkably well with the Raman spectra of particular biomolecules, showing increase of lipid and decrease of nucleic acids and protein content. Our study pointed out that Raman spectral markers of lipid unsaturation, especially I1270/I1300, are relevant for tracing the cytotoxic effect of ZnO nanoparticles on both cancerous and non-cancerous cells. The change of these spectral markers is correlated to the dose of applied nanoparticles and to the degree of cellular damage. Furthermore, great similarity of spectral features of increasing lipids to spectral features of phosphatidylserine, one of the main apoptotic markers, was recognized in treated cells. Finally, the results strongly indicated that the degree of lipid saturation, presented in the cells, plays an important role in the interaction of cells with nanoparticles.",
journal = "Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy",
title = "Spectroscopic signature of ZnO NP-induced cell death modalities assessed by non-negative PCA",
volume = "288",
pages = "122180",
doi = "10.1016/j.saa.2022.122180"
}

Miletić, M., Vilotić, A., Korićanac, L., Žakula, J., Jovanović Krivokuća, M., Dohčević-Mitrović, Z.,& Aškrabić, S.. (2023). Spectroscopic signature of ZnO NP-induced cell death modalities assessed by non-negative PCA. in Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy, 288, 122180.
https://doi.org/10.1016/j.saa.2022.122180

Miletić M, Vilotić A, Korićanac L, Žakula J, Jovanović Krivokuća M, Dohčević-Mitrović Z, Aškrabić S. Spectroscopic signature of ZnO NP-induced cell death modalities assessed by non-negative PCA. in Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy. 2023;288:122180.
doi:10.1016/j.saa.2022.122180 .

Miletić, Mirjana, Vilotić, Aleksandra, Korićanac, Lela, Žakula, Jelena, Jovanović Krivokuća, Milica, Dohčević-Mitrović, Zorana, Aškrabić, Sonja, "Spectroscopic signature of ZnO NP-induced cell death modalities assessed by non-negative PCA" in Spectrochimica Acta. Part A: Molecular and Biomolecular Spectroscopy, 288 (2023):122180,
https://doi.org/10.1016/j.saa.2022.122180 . .

TY  - JOUR
AU  - Janković, Bojan Ž.
AU  - Manić, Nebojša G.
AU  - Popović, Mina
AU  - Cvetković, Slobodan
AU  - Dželetović, Željko
AU  - Stojiljković, Dragoslava
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10611
AB  - This work provides insight into possibilities of maximum utilization of C3-C4 energy crops for thermo-chemical conversion (slow pyrolysis) into high value biochemicals, platform chemicals, drop-in fuels and combustible gases, using coupled kinetic and thermodynamic analyses. In order to examine the kinetics of decomposition of lignocellulosic components, model-free and model-based methods faded from thermal analysis data were used. Thermodynamic compensation was used for explicatory of entropy controlled process, where conformational changes and chemical exchange directly affect the type and distribution of obtained pyrolytic products. It was shown that external variable (i.e. the heating rate/temperature) does not change either an entire reaction mechanism (mechanistic nature of MG and AD pyrolyses) or transition state, but it changes activation enthalpy and activation entropy which lead to differences in terms of heat energy consumption, pyrolysis favorability and thus rates of generation of activated complex among feedstocks. To investigate the interplay of catalysts (present in feedstocks as minerals) and reactants, selective energy transfer (SET) model was applied. The model showed an activity of catalyst with different outputs towards two reactants, lignin part of the structure in MG and 1,8-cineole in AD. It was shown that AD is more convenient for thermal conversion than MG, regarding to lower transformation energy requirement, higher reactivity, as well as much faster accumulation of products. © 2023 Elsevier B.V.
T2  - Industrial Crops and Products
T1  - Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions
VL  - 194
DO  - 10.1016/j.indcrop.2023.116275
ER  - 

@article{
author = "Janković, Bojan Ž. and Manić, Nebojša G. and Popović, Mina and Cvetković, Slobodan and Dželetović, Željko and Stojiljković, Dragoslava",
year = "2023",
abstract = "This work provides insight into possibilities of maximum utilization of C3-C4 energy crops for thermo-chemical conversion (slow pyrolysis) into high value biochemicals, platform chemicals, drop-in fuels and combustible gases, using coupled kinetic and thermodynamic analyses. In order to examine the kinetics of decomposition of lignocellulosic components, model-free and model-based methods faded from thermal analysis data were used. Thermodynamic compensation was used for explicatory of entropy controlled process, where conformational changes and chemical exchange directly affect the type and distribution of obtained pyrolytic products. It was shown that external variable (i.e. the heating rate/temperature) does not change either an entire reaction mechanism (mechanistic nature of MG and AD pyrolyses) or transition state, but it changes activation enthalpy and activation entropy which lead to differences in terms of heat energy consumption, pyrolysis favorability and thus rates of generation of activated complex among feedstocks. To investigate the interplay of catalysts (present in feedstocks as minerals) and reactants, selective energy transfer (SET) model was applied. The model showed an activity of catalyst with different outputs towards two reactants, lignin part of the structure in MG and 1,8-cineole in AD. It was shown that AD is more convenient for thermal conversion than MG, regarding to lower transformation energy requirement, higher reactivity, as well as much faster accumulation of products. © 2023 Elsevier B.V.",
journal = "Industrial Crops and Products",
title = "Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions",
volume = "194",
doi = "10.1016/j.indcrop.2023.116275"
}

Janković, B. Ž., Manić, N. G., Popović, M., Cvetković, S., Dželetović, Ž.,& Stojiljković, D.. (2023). Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions. in Industrial Crops and Products, 194.
https://doi.org/10.1016/j.indcrop.2023.116275

Janković BŽ, Manić NG, Popović M, Cvetković S, Dželetović Ž, Stojiljković D. Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions. in Industrial Crops and Products. 2023;194.
doi:10.1016/j.indcrop.2023.116275 .

Janković, Bojan Ž., Manić, Nebojša G., Popović, Mina, Cvetković, Slobodan, Dželetović, Željko, Stojiljković, Dragoslava, "Kinetic and thermodynamic compensation phenomena in C3 and C4 energy crops pyrolysis: Implications on reaction mechanisms and product distributions" in Industrial Crops and Products, 194 (2023),
https://doi.org/10.1016/j.indcrop.2023.116275 . .

TY  - JOUR
AU  - Sredojević, Dušan
AU  - Lazić, Vesna M.
AU  - Pirković, Andrea
AU  - Periša, Jovana
AU  - Murafa, Natalija
AU  - Spremo-Potparević, Biljana
AU  - Živković, Lada
AU  - Topalović, Dijana
AU  - Zarubica, Aleksandra
AU  - Jovanović Krivokuća, Milica
AU  - Nedeljković, Jovan
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10445
AB  - The antibacterial performance and cytotoxic examination of in situ prepared silver nanoparticles (Ag NPs), on inorganic-organic hybrid nanopowder consisting of zirconium dioxide nanoparticles (ZrO2 NPs) and dihydroquercetin (DHQ), was performed against Gram (−) bacteria Escherichia coli and Gram (+) bacteria Staphylococcus aureus, as well as against human cervical cancer cells HeLa and healthy MRC-5 human cells. The surface modification of ZrO2 NPs, synthesized by the sol-gel method, with DHQ leads to the interfacial charge transfer (ICT) complex formation indicated by the appearance of absorption in the visible spectral range. The prepared samples were thoroughly characterized (TEM, XRD, reflection spectroscopy), and, in addition, the spectroscopic observations are supported by the density functional theory (DFT) calculations using a cluster model. The concentration- and time-dependent antibacterial tests indicated a complete reduction of bacterial species, E. coli and S. aureus, for all investigated concentrations of silver (0.10, 0.25, and 0.50 mg/mL) after 24 h of contact. On the other side, the functionalized ZrO2 NPs with DHQ, before and after deposition of Ag NPs, do not display a significant decrease in the viability of HeLa MRC-5 cells in any of the used concentrations compared to the control.
T2  - Nanomaterials
T1  - Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin
VL  - 12
IS  - 18
SP  - 3195
DO  - 10.3390/nano12183195
ER  - 

@article{
author = "Sredojević, Dušan and Lazić, Vesna M. and Pirković, Andrea and Periša, Jovana and Murafa, Natalija and Spremo-Potparević, Biljana and Živković, Lada and Topalović, Dijana and Zarubica, Aleksandra and Jovanović Krivokuća, Milica and Nedeljković, Jovan",
year = "2022",
abstract = "The antibacterial performance and cytotoxic examination of in situ prepared silver nanoparticles (Ag NPs), on inorganic-organic hybrid nanopowder consisting of zirconium dioxide nanoparticles (ZrO2 NPs) and dihydroquercetin (DHQ), was performed against Gram (−) bacteria Escherichia coli and Gram (+) bacteria Staphylococcus aureus, as well as against human cervical cancer cells HeLa and healthy MRC-5 human cells. The surface modification of ZrO2 NPs, synthesized by the sol-gel method, with DHQ leads to the interfacial charge transfer (ICT) complex formation indicated by the appearance of absorption in the visible spectral range. The prepared samples were thoroughly characterized (TEM, XRD, reflection spectroscopy), and, in addition, the spectroscopic observations are supported by the density functional theory (DFT) calculations using a cluster model. The concentration- and time-dependent antibacterial tests indicated a complete reduction of bacterial species, E. coli and S. aureus, for all investigated concentrations of silver (0.10, 0.25, and 0.50 mg/mL) after 24 h of contact. On the other side, the functionalized ZrO2 NPs with DHQ, before and after deposition of Ag NPs, do not display a significant decrease in the viability of HeLa MRC-5 cells in any of the used concentrations compared to the control.",
journal = "Nanomaterials",
title = "Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin",
volume = "12",
number = "18",
pages = "3195",
doi = "10.3390/nano12183195"
}

Sredojević, D., Lazić, V. M., Pirković, A., Periša, J., Murafa, N., Spremo-Potparević, B., Živković, L., Topalović, D., Zarubica, A., Jovanović Krivokuća, M.,& Nedeljković, J.. (2022). Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin. in Nanomaterials, 12(18), 3195.
https://doi.org/10.3390/nano12183195

Sredojević D, Lazić VM, Pirković A, Periša J, Murafa N, Spremo-Potparević B, Živković L, Topalović D, Zarubica A, Jovanović Krivokuća M, Nedeljković J. Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin. in Nanomaterials. 2022;12(18):3195.
doi:10.3390/nano12183195 .

Sredojević, Dušan, Lazić, Vesna M., Pirković, Andrea, Periša, Jovana, Murafa, Natalija, Spremo-Potparević, Biljana, Živković, Lada, Topalović, Dijana, Zarubica, Aleksandra, Jovanović Krivokuća, Milica, Nedeljković, Jovan, "Toxicity of Silver Nanoparticles Supported by Surface-Modified Zirconium Dioxide with Dihydroquercetin" in Nanomaterials, 12, no. 18 (2022):3195,
https://doi.org/10.3390/nano12183195 . .

TY  - JOUR
AU  - Lazić, Vesna M.
AU  - Pirković, Andrea
AU  - Sredojević, Dušan
AU  - Marković, Jelena P.
AU  - Papan, Jelena
AU  - Ahrenkiel, S. Phillip
AU  - Janković-Častvan, Ivona
AU  - Dekanski, Dragana
AU  - Jovanović Krivokuća, Milica
AU  - Nedeljković, Jovan
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9897
AB  - The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3–4 nm in size primary particles organized in 30–60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).
T2  - Chemico-Biological Interactions
T1  - Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells
VL  - 347
SP  - 109618
DO  - 10.1016/j.cbi.2021.109618
ER  - 

@article{
author = "Lazić, Vesna M. and Pirković, Andrea and Sredojević, Dušan and Marković, Jelena P. and Papan, Jelena and Ahrenkiel, S. Phillip and Janković-Častvan, Ivona and Dekanski, Dragana and Jovanović Krivokuća, Milica and Nedeljković, Jovan",
year = "2021",
abstract = "The toxicity of hybrid nanoparticles, consisting of non-toxic components, zirconium dioxide nanoparticles (ZrO2 NPs), and caffeic acid (CA), was examined against four different cell lines (HTR-8 SV/Neo, JEG-3, JAR, and HeLa). Stable aqueous ZrO2 sol, synthesized by forced hydrolysis, consists of 3–4 nm in size primary particles organized in 30–60 nm in size snowflake-like particles, as determined by transmission electron microscopy and direct light scattering measurements. The surface modification of ZrO2 NPs with CA leads to the formation of an interfacial charge transfer (ICT) complex followed by the appearance of absorption in the visible spectral range. The spectroscopic observations are complemented with the density functional theory calculations using a cluster model. The ZrO2 NPs and CA are non-toxic against four different cell lines in investigated concentration range. Also, ZrO2 NPs promote the proliferation of HTR-8 SV/Neo, JAR, and HeLa cells. On the other hand, hybrid ZrO2/CA NPs induced a significant reduction of the viability of the JEG-3 cells (39 %) for the high concentration of components (1.6 mM ZrO2 and 0.4 mM CA).",
journal = "Chemico-Biological Interactions",
title = "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells",
volume = "347",
pages = "109618",
doi = "10.1016/j.cbi.2021.109618"
}

Lazić, V. M., Pirković, A., Sredojević, D., Marković, J. P., Papan, J., Ahrenkiel, S. P., Janković-Častvan, I., Dekanski, D., Jovanović Krivokuća, M.,& Nedeljković, J.. (2021). Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions, 347, 109618.
https://doi.org/10.1016/j.cbi.2021.109618

Lazić VM, Pirković A, Sredojević D, Marković JP, Papan J, Ahrenkiel SP, Janković-Častvan I, Dekanski D, Jovanović Krivokuća M, Nedeljković J. Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells. in Chemico-Biological Interactions. 2021;347:109618.
doi:10.1016/j.cbi.2021.109618 .

Lazić, Vesna M., Pirković, Andrea, Sredojević, Dušan, Marković, Jelena P., Papan, Jelena, Ahrenkiel, S. Phillip, Janković-Častvan, Ivona, Dekanski, Dragana, Jovanović Krivokuća, Milica, Nedeljković, Jovan, "Surface-modified ZrO2 nanoparticles with caffeic acid: Characterization and in vitro evaluation of biosafety for placental cells" in Chemico-Biological Interactions, 347 (2021):109618,
https://doi.org/10.1016/j.cbi.2021.109618 . .