TY  - JOUR
AU  - Krstić, Jelena
AU  - Radosavljević, Aleksandra
AU  - Spasojević, Jelena P.
AU  - Nikolić, Nikolina
AU  - Jovanović, Uroš D.
AU  - Abazović, Nadica
AU  - Kačarević-Popović, Zorica M.
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10183
AB  - Hydrogels consisting of radiation-degraded chitosan, poly(vinyl alcohol), and Ag nano-filler, were prepared by γ-irradiation in two-stage and single-stage procedures to examine the role of the synthesis procedure in improving the antibacterial activity. The light scattering method showed that radiation-degradation of chitosan occurred both by breaking the glucoside bonds and by Maillard's reaction. Elemental analysis indicated a reduction in the degree of deacetylation after degradation. The product of Amadori rearrangement and pigmented product melanoidins were determined by 1H NMR, FTIR, UV–Vis, and fluorescence spectroscopy. Enhancement of in vitro antibacterial activity of nanocomposites against Staphylococcus aureus and Escherichia coli was achieved by a single-stage procedure which results in greater mobility of radiation-modified chitosan in the network. This allows the exploitation of its potential, which is reflected in the possibility of the complexing of ultrasmall molecular Ag clusters. These complexes have a considerably stronger antibacterial effect. Ag in molecular form was confirmed by XPS analysis.
T2  - Radiation Physics and Chemistry
T1  - Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis
VL  - 194
SP  - 110045
DO  - 10.1016/j.radphyschem.2022.110045
ER  - 

@article{
author = "Krstić, Jelena and Radosavljević, Aleksandra and Spasojević, Jelena P. and Nikolić, Nikolina and Jovanović, Uroš D. and Abazović, Nadica and Kačarević-Popović, Zorica M.",
year = "2022",
abstract = "Hydrogels consisting of radiation-degraded chitosan, poly(vinyl alcohol), and Ag nano-filler, were prepared by γ-irradiation in two-stage and single-stage procedures to examine the role of the synthesis procedure in improving the antibacterial activity. The light scattering method showed that radiation-degradation of chitosan occurred both by breaking the glucoside bonds and by Maillard's reaction. Elemental analysis indicated a reduction in the degree of deacetylation after degradation. The product of Amadori rearrangement and pigmented product melanoidins were determined by 1H NMR, FTIR, UV–Vis, and fluorescence spectroscopy. Enhancement of in vitro antibacterial activity of nanocomposites against Staphylococcus aureus and Escherichia coli was achieved by a single-stage procedure which results in greater mobility of radiation-modified chitosan in the network. This allows the exploitation of its potential, which is reflected in the possibility of the complexing of ultrasmall molecular Ag clusters. These complexes have a considerably stronger antibacterial effect. Ag in molecular form was confirmed by XPS analysis.",
journal = "Radiation Physics and Chemistry",
title = "Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis",
volume = "194",
pages = "110045",
doi = "10.1016/j.radphyschem.2022.110045"
}

Krstić, J., Radosavljević, A., Spasojević, J. P., Nikolić, N., Jovanović, U. D., Abazović, N.,& Kačarević-Popović, Z. M.. (2022). Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis. in Radiation Physics and Chemistry, 194, 110045.
https://doi.org/10.1016/j.radphyschem.2022.110045

Krstić J, Radosavljević A, Spasojević JP, Nikolić N, Jovanović UD, Abazović N, Kačarević-Popović ZM. Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis. in Radiation Physics and Chemistry. 2022;194:110045.
doi:10.1016/j.radphyschem.2022.110045 .

Krstić, Jelena, Radosavljević, Aleksandra, Spasojević, Jelena P., Nikolić, Nikolina, Jovanović, Uroš D., Abazović, Nadica, Kačarević-Popović, Zorica M., "Improvement of antibacterial activity of Ag-poly(vinyl-alcohol)/chitosan hydrogel by optimizing the procedure of radiolytic synthesis" in Radiation Physics and Chemistry, 194 (2022):110045,
https://doi.org/10.1016/j.radphyschem.2022.110045 . .