TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Stojiljković, Vesna
AU  - Todorović, Ana
AU  - Radosevic-Jelic, Ljiljana
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4107
AB  - Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
T2  - Clinical Biochemistry
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide
VL  - 43
IS  - 16-17
SP  - 1287
EP  - 1293
DO  - 10.1016/j.clinbiochem.2010.08.009
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Stojiljković, Vesna and Todorović, Ana and Radosevic-Jelic, Ljiljana and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2010",
abstract = "Objectives: Breast carcinoma is related to the increase of lipid peroxidation in plasma with concomitant decrease of antioxidant (AO) defense capacity in blood cells, which becomes more pronounced during aging of the patients. This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients. The level of CuZnSOD protein was assessed after the FAC therapy and radiotherapy of breast cancer. Design and methods: AO parameters were measured in the blood of 58 breast cancer patients and 60 healthy age-matched healthy subjects by biochemical and Western blot analyses. Results: Increased oxidative stress (LP: p LT 0.05) and decreased AO enzyme activities (CuZnSOD: p LT 0.01, GPx: p LT 0.05, GR: p LT 0.01) and GSH level (p LT 0.01) in the blood of breast cancer patients in response to FAC chemotherapy seem not to be age-dependent. CuZnSOD enzyme expression decreased after the FAC chemotherapy (p LT 0.05), while it increased after the radiotherapy of breast cancer (p LT 0.05). Conclusion: FAC chemotherapy and radiotherapy promote further oxidative shift, which potentiate already existing chronic oxidative stress linked to breast cancer. In these effects, impaired capacity for H2O2 detoxification (CAT. GPX and GSH) seems to have major contribution. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.",
journal = "Clinical Biochemistry",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide",
volume = "43",
number = "16-17",
pages = "1287-1293",
doi = "10.1016/j.clinbiochem.2010.08.009"
}

Kasapović, J., Pejić, S., Stojiljković, V., Todorović, A., Radosevic-Jelic, L., Saičić, Z. S.,& Pajović, S. B.. (2010). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry, 43(16-17), 1287-1293.
https://doi.org/10.1016/j.clinbiochem.2010.08.009

Kasapović J, Pejić S, Stojiljković V, Todorović A, Radosevic-Jelic L, Saičić ZS, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. in Clinical Biochemistry. 2010;43(16-17):1287-1293.
doi:10.1016/j.clinbiochem.2010.08.009 .

Kasapović, Jelena, Pejić, Snežana, Stojiljković, Vesna, Todorović, Ana, Radosevic-Jelic, Ljiljana, Saičić, Zorica S., Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide" in Clinical Biochemistry, 43, no. 16-17 (2010):1287-1293,
https://doi.org/10.1016/j.clinbiochem.2010.08.009 . .

TY  - JOUR
AU  - Kasapović, Jelena
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Pajović, Snežana B.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3524
AB  - Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.
T2  - Cell Biochemistry and Function
T1  - Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages
VL  - 26
IS  - 6
SP  - 723
EP  - 730
DO  - 10.1002/cbf.1499
ER  - 

@article{
author = "Kasapović, Jelena and Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Pajović, Snežana B.",
year = "2008",
abstract = "Oxidative stress is considered to be implicated in the pathophysiology of breast cancers. In this study we investigated the level of oxidative stress and antioxidant (AO) status in the blood of breast cancer patients of different ages. The level of lipid hydroperoxides (LP) was measured in blood plasma and the activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) enzymes, as well as the level of total glutathione (GSH) and CuZnSOD protein were measured in blood cells of breast cancer patients and age-matched healthy subjects. Our results showed that breast carcinoma is related to increase of lipid peroxidation in plasma with concomitant decrease of AO defense capacity in blood cells, which becomes more pronounced during aging of the patients. Suppression of CuZnSOD activity related to breast cancer is most likely caused by decreased de novo synthesis of this enzyme. Similar patterns of suppression in CuZnSOD and CAT activities related to aging were recorded both in controls and patients. Age-related decrease in CuZnSOD activity seems not to be caused by altered protein levels of this enzyme. Suppression of AO enzymes associated with breast cancer and aging is most likely the cause of increased levels of reactive oxygen species (ROS). Our results indicate significant role of oxidative-induced injury in the breast carcinogenesis, particularly during the later stages of aging. Overall, Our data Support the importance of endogenous AOs in the etiology of breast cancer across all levels of predicted risk. Copyright (C) 2008 John Wiley and Sons, Ltd.",
journal = "Cell Biochemistry and Function",
title = "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages",
volume = "26",
number = "6",
pages = "723-730",
doi = "10.1002/cbf.1499"
}

Kasapović, J., Pejić, S., Todorović, A., Stojiljković, V.,& Pajović, S. B.. (2008). Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function, 26(6), 723-730.
https://doi.org/10.1002/cbf.1499

Kasapović J, Pejić S, Todorović A, Stojiljković V, Pajović SB. Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages. in Cell Biochemistry and Function. 2008;26(6):723-730.
doi:10.1002/cbf.1499 .

Kasapović, Jelena, Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Pajović, Snežana B., "Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages" in Cell Biochemistry and Function, 26, no. 6 (2008):723-730,
https://doi.org/10.1002/cbf.1499 . .