TY  - JOUR
AU  - Mijajlović, Aleksandar
AU  - Ognjanović, Miloš
AU  - Manojlović, Dragan
AU  - Vlahović, Filip
AU  - Ðurđić, Slađana
AU  - Stanković, Vesna
AU  - Stanković, Dalibor M.
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10692
AB  - There are ten million people in the world who have Parkinson’s disease. The most potent medicine for Parkinson’s disease is levodopa (L-DOPA). However, long-term consumption of L-DOPA leads to the appearance of side effects, as a result of which the control and monitoring of its concentrations are of great importance. In this work, we have designed a new electrochemical sensor for detecting L-DOPA using a carbon paste electrode (CPE) modified with Eu2O3@Cr2O3 composite nanoparticles. Rare earth elements, including Eu, are increasingly used to design new electrode nanocomposites with enhanced electrocatalytic properties. Europium has been considered a significant lanthanide element with greater redox reaction behavior. We conducted a hydrothermal synthesis of Eu2O3@Cr2O3 and, for the first time, the acquired nanoparticles were used to modify CPE. The proposed Eu2O3@Cr2O3/CPE electrode was investigated in terms of its electrocatalytic properties and then used to develop an analytical method for detecting and quantifying L-DOPA. The proposed sensor offers a wide linear range (1–100 µM), high sensitivity (1.38 µA µM−1 cm−2) and a low detection limit (0.72 µM). The practical application of the proposed sensor was investigated by analyzing commercially available pharmaceutical tablets of L-DOPA. The corresponding results indicate the excellent potential of the Eu2O3@Cr2O3/CPE sensor for application in real-time L-DOPA detection.
T2  - Biosensors
T1  - Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA
VL  - 13
IS  - 2
SP  - 201
DO  - 10.3390/bios13020201
ER  - 

@article{
author = "Mijajlović, Aleksandar and Ognjanović, Miloš and Manojlović, Dragan and Vlahović, Filip and Ðurđić, Slađana and Stanković, Vesna and Stanković, Dalibor M.",
year = "2023",
abstract = "There are ten million people in the world who have Parkinson’s disease. The most potent medicine for Parkinson’s disease is levodopa (L-DOPA). However, long-term consumption of L-DOPA leads to the appearance of side effects, as a result of which the control and monitoring of its concentrations are of great importance. In this work, we have designed a new electrochemical sensor for detecting L-DOPA using a carbon paste electrode (CPE) modified with Eu2O3@Cr2O3 composite nanoparticles. Rare earth elements, including Eu, are increasingly used to design new electrode nanocomposites with enhanced electrocatalytic properties. Europium has been considered a significant lanthanide element with greater redox reaction behavior. We conducted a hydrothermal synthesis of Eu2O3@Cr2O3 and, for the first time, the acquired nanoparticles were used to modify CPE. The proposed Eu2O3@Cr2O3/CPE electrode was investigated in terms of its electrocatalytic properties and then used to develop an analytical method for detecting and quantifying L-DOPA. The proposed sensor offers a wide linear range (1–100 µM), high sensitivity (1.38 µA µM−1 cm−2) and a low detection limit (0.72 µM). The practical application of the proposed sensor was investigated by analyzing commercially available pharmaceutical tablets of L-DOPA. The corresponding results indicate the excellent potential of the Eu2O3@Cr2O3/CPE sensor for application in real-time L-DOPA detection.",
journal = "Biosensors",
title = "Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA",
volume = "13",
number = "2",
pages = "201",
doi = "10.3390/bios13020201"
}

Mijajlović, A., Ognjanović, M., Manojlović, D., Vlahović, F., Ðurđić, S., Stanković, V.,& Stanković, D. M.. (2023). Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA. in Biosensors, 13(2), 201.
https://doi.org/10.3390/bios13020201

Mijajlović A, Ognjanović M, Manojlović D, Vlahović F, Ðurđić S, Stanković V, Stanković DM. Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA. in Biosensors. 2023;13(2):201.
doi:10.3390/bios13020201 .

Mijajlović, Aleksandar, Ognjanović, Miloš, Manojlović, Dragan, Vlahović, Filip, Ðurđić, Slađana, Stanković, Vesna, Stanković, Dalibor M., "Eu2O3@Cr2O3 Nanoparticles-Modified Carbon Paste Electrode for Efficient Electrochemical Sensing of Neurotransmitters Precursor L-DOPA" in Biosensors, 13, no. 2 (2023):201,
https://doi.org/10.3390/bios13020201 . .